mecamylamine has been researched along with Disease Models, Animal in 85 studies
Mecamylamine: A nicotinic antagonist that is well absorbed from the gastrointestinal tract and crosses the blood-brain barrier. Mecamylamine has been used as a ganglionic blocker in treating hypertension, but, like most ganglionic blockers, is more often used now as a research tool.
Disease Models, Animal: Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The results indicate that nicotine enhances susceptibility to periodontitis via nAChRs, which may act via suppressing protective immune responses through the cholinergic anti-inflammatory pathway." | 7.75 | Nicotinic acetylcholine receptor activation mediates nicotine-induced enhancement of experimental periodontitis. ( Breivik, T; Gjermo, P; Gundersen, Y; Opstad, PK; von Hörsten, S, 2009) |
| "In concurrence with clinical findings proposing alleviation of withdrawal states as a possible mechanism of bupropion and nortriptyline's smoking cessation action, both drugs were found to ameliorate somatic signs of nicotine withdrawal in rodents." | 7.74 | Examining the clinical efficacy of bupropion and nortriptyline as smoking cessation agents in a rodent model of nicotine withdrawal. ( Shoaib, M; Wing, VC, 2007) |
| " In the present investigation, we used intrathecal administration of drugs to rats to show that muscarinic or nicotinic agonists such as bethanechol (BCh) and dimethylphenylpiperazinium (DM), respectively, dose-dependently increased the tail flick latency and reduced the pain produced by a surgical incision performed on the plantar aspect of a hind paw." | 7.72 | Antinociceptive effects of bethanechol or dimethylphenylpiperazinium in models of phasic or incisional pain in rats. ( Prado, WA; Segalla, DK, 2004) |
| " These receptors are also involved with the induction of nicotine-induced seizures." | 7.71 | Nicotine induced seizures blocked by mecamylamine and its stereoisomers. ( Manresa, JJ; Newman, MB; Sanberg, PR; Shytle, RD, 2001) |
| "The anxiolytic effects of aniracetam have not been proven in animals despite its clinical usefulness for post-stroke anxiety." | 7.71 | Anxiolytic effects of aniracetam in three different mouse models of anxiety and the underlying mechanism. ( Kurasawa, M; Nakamura, K, 2001) |
| "The repeated administration of nicotine at small doses, which do not produce whole body tremor or convulsion, causes tremor only in the tail (tail-tremor) of rats." | 7.69 | [Assessment of anti-tremorogenic drugs--nicotine-induced tail-tremor model]. ( Gomita, Y; Kawasaki, H; Suemaru, K, 1997) |
| " Using the multiple low-dose streptozotocin (MLD-STZ) model of experimental autoimmune diabetes, we previously reported that pretreatment with a specific acetylcholinesterase inhibitor (AChEI), paraoxon, prevented the development of hyperglycemia in C57BL/6 mice." | 3.91 | Involvement of Acetylcholine Receptors in Cholinergic Pathway-Mediated Protection Against Autoimmune Diabetes. ( Al-Mansori, A; Al-Ramadi, BK; Bashir, G; Fernández-Cabezudo, MJ; George, JA; Lorke, DE; Mohamed, YA; Petroianu, G; Qureshi, MM, 2019) |
| " The effect of topical or intraocular injection of mecamylamine, a nonspecific nAChR antagonist, or targeted deletion of α7- or α9-nAChRs on ischemia-induced retinal NV was determined by comparing the amount of retinal NV at P17 in these mice versus appropriate controls." | 3.85 | The Nicotinic Cholinergic Pathway Contributes to Retinal Neovascularization in a Mouse Model of Retinopathy of Prematurity. ( Abraham, S; Campochiaro, PA; Chadha, R; Cooke, JP; Fortmann, SD; Hackett, SF; Seidel, C, 2017) |
| " MEC prevented CRS-induced depressive-like behavior via increasing sucrose preference, body weight, and forced swim test (FST) struggling and swimming while reducing immobility in FST and hypothalamic-pituitary-adrenal (HPA) axis hyperactivity (adrenal gland weight and serum corticosterone)." | 3.81 | Behavioral effects of nicotinic antagonist mecamylamine in a rat model of depression: prefrontal cortex level of BDNF protein and monoaminergic neurotransmitters. ( Aboul-Fotouh, S, 2015) |
| " We analysed the time course of the global withdrawal score, the anxiety-like effects, monoamine concentrations, the brain-derived neurotrophic factor (BDNF) expression, the corticosterone plasmatic levels and [(3)H]epibatidine binding sites during NIC withdrawal precipitated by mecamylamine, a nicotinic receptor antagonist (MEC)." | 3.81 | Lack of GABAB receptors modifies behavioural and biochemical alterations induced by precipitated nicotine withdrawal. ( Antonelli, MC; Balerio, GN; Bettler, B; Machado, LM; Pedrón, VT; Varani, AP, 2015) |
| " Chronic intermittent non-contingent, second-hand exposure to cigarette smoke or e-cig vapour led to similar brain cotinine and nicotine levels, similar urine cotinine levels and the similar up-regulation of α4β2 nicotinic acetylcholine receptors in different brain areas, but had different effects on body weight, food intake, and the signs of mecamylamine-precipitated and spontaneous withdrawal episodic memory and emotional responses." | 3.81 | Different physiological and behavioural effects of e-cigarette vapour and cigarette smoke in mice. ( Braida, D; Cannazza, G; Castellana, CN; Clementi, F; Fasoli, F; Gallesi, G; Gotti, C; Lucini, V; Moretti, M; Mucchietto, V; Ponzoni, L; Sala, M; Zoli, M, 2015) |
| "Humans escalate their cigarette smoking over time, and a major obstacle in the field of pre-clinical nicotine addiction research has been the inability to produce escalated nicotine self-administration in rats." | 3.80 | Nicotine vapor inhalation escalates nicotine self-administration. ( Abdel, AY; Baynes, B; George, O; Gilpin, NW; Weil, MT; Whitaker, AM, 2014) |
| "Thus, it is suggested that src kinase is involved in the development of nicotine dependence-induced precipitation of its withdrawal syndrome and thus may serve as a viable pharmacological target to tackle the problem of nicotine addiction." | 3.78 | SU-6656, a selective Src kinase inhibitor, attenuates mecamylamine-precipitated nicotine withdrawal syndrome in mice. ( Arora, S; Rehni, AK; Singh, TG, 2012) |
| " Topiramate pretreatment significantly inhibited KA-induced seizures and brain lipid peroxidation with ED50 (95% CL) value of 21." | 3.77 | Nicotine reversal of anticonvulsant action of topiramate in kainic acid-induced seizure model in mice. ( Chakrabarti, A; Hota, D; Sahai, AK; Sood, N, 2011) |
| "The results indicate that nicotine enhances susceptibility to periodontitis via nAChRs, which may act via suppressing protective immune responses through the cholinergic anti-inflammatory pathway." | 3.75 | Nicotinic acetylcholine receptor activation mediates nicotine-induced enhancement of experimental periodontitis. ( Breivik, T; Gjermo, P; Gundersen, Y; Opstad, PK; von Hörsten, S, 2009) |
| "In concurrence with clinical findings proposing alleviation of withdrawal states as a possible mechanism of bupropion and nortriptyline's smoking cessation action, both drugs were found to ameliorate somatic signs of nicotine withdrawal in rodents." | 3.74 | Examining the clinical efficacy of bupropion and nortriptyline as smoking cessation agents in a rodent model of nicotine withdrawal. ( Shoaib, M; Wing, VC, 2007) |
| "5, 1, or 2 mg/kg) induced analgesia, with pain scores significantly lower than those seen after saline, lower doses of Sazetidine-A, and epibatidine (P < 0." | 3.74 | Analgesic effects of Sazetidine-A, a new nicotinic cholinergic drug. ( Cucchiaro, G; Gonzalez-Sulser, A; Kellar, KJ; Xiao, Y, 2008) |
| " In the present investigation, we used intrathecal administration of drugs to rats to show that muscarinic or nicotinic agonists such as bethanechol (BCh) and dimethylphenylpiperazinium (DM), respectively, dose-dependently increased the tail flick latency and reduced the pain produced by a surgical incision performed on the plantar aspect of a hind paw." | 3.72 | Antinociceptive effects of bethanechol or dimethylphenylpiperazinium in models of phasic or incisional pain in rats. ( Prado, WA; Segalla, DK, 2004) |
| "The symptom of "diminished interest or pleasure" in rewarding stimuli is an affective symptom of nicotine and amphetamine withdrawal, and a core symptom of depression." | 3.71 | Fluoxetine combined with a serotonin-1A receptor antagonist reversed reward deficits observed during nicotine and amphetamine withdrawal in rats. ( Harrison, AA; Liem, YT; Markou, A, 2001) |
| "The anxiolytic effects of aniracetam have not been proven in animals despite its clinical usefulness for post-stroke anxiety." | 3.71 | Anxiolytic effects of aniracetam in three different mouse models of anxiety and the underlying mechanism. ( Kurasawa, M; Nakamura, K, 2001) |
| " These receptors are also involved with the induction of nicotine-induced seizures." | 3.71 | Nicotine induced seizures blocked by mecamylamine and its stereoisomers. ( Manresa, JJ; Newman, MB; Sanberg, PR; Shytle, RD, 2001) |
| "The repeated administration of nicotine at small doses, which do not produce whole body tremor or convulsion, causes tremor only in the tail (tail-tremor) of rats." | 3.69 | [Assessment of anti-tremorogenic drugs--nicotine-induced tail-tremor model]. ( Gomita, Y; Kawasaki, H; Suemaru, K, 1997) |
| "Alcohol dependence and other alcohol use disorders are major public health problems." | 2.48 | Cholinergic receptor system as a target for treating alcohol abuse and dependence. ( Prendergast, MA; Rahman, S, 2012) |
| " The results indicated that the chronic administration of nicotine modulated sociability and repetitive behavior in BTBR T + tf/J mice while no effects observed in C57BL/6J mice." | 1.56 | The Role of Nicotinic Receptors in the Attenuation of Autism-Related Behaviors in a Murine BTBR T + tf/J Autistic Model. ( Albekairi, NA; Aldhalaan, HM; Alqasem, MA; Alshammari, MA; Alshammari, TK; AlSharari, SD; Mahmood, HM, 2020) |
| "Seizures were recorded inside the open field apparatus for an average of 10min." | 1.43 | Nicotinic and muscarinic cholinergic receptors are recruited by acetylcholine-mediated neurotransmission within the locus coeruleus during the organisation of post-ictal antinociception. ( Biagioni, AF; Coimbra, NC; de Oliveira, R; de Oliveira, RC; Dos Anjos-Garcia, T; Falconi-Sobrinho, LL, 2016) |
| "The nicotine plasma levels were also measured with or without methoxsalen pretreatment." | 1.40 | Effects of methoxsalen, a CYP2A5/6 inhibitor, on nicotine dependence behaviors in mice. ( Bagdas, D; Damaj, MI; Muldoon, PP; Tyndale, RF; Zhu, AZ, 2014) |
| "Cholestasis was induced by the ligation of the common bile duct." | 1.38 | Possible interaction between opioidergic and cholinergic systems of CA1 in cholestasis-induced amnesia in mice. ( Hoseindoost, S; Nasehi, M; Zarrindast, MR, 2012) |
| "Pre-treatment with mecamylamine (50 mug; i." | 1.35 | Peripheral administration of CDP-choline, phosphocholine or choline increases plasma adrenaline and noradrenaline concentrations. ( Cansev, M; Hamurtekin, E; Ilcol, YO; Ulus, IH; Yilmaz, MS, 2008) |
| "Pretreatment with mecamylamine blocked the expression of conditioned hyperactivity only in EC and SC rats and attenuated sensitization in all three rearing groups." | 1.35 | Effects of mecamylamine on nicotine-induced conditioned hyperactivity and sensitization in differentially reared rats. ( Cain, ME; Coolon, RA, 2009) |
| "Mecamylamine was effective on its own in some tests, but did not augment the effects of citalopram or reboxetine at the doses tested." | 1.35 | Nicotine, but not mecamylamine, enhances antidepressant-like effects of citalopram and reboxetine in the mouse forced swim and tail suspension tests. ( Andreasen, JT; Redrobe, JP, 2009) |
| "Nicotine was devoid of effects in the mTST, except in female C57BL/6J mice, where it increased immobility." | 1.35 | Antidepressant-like effects of nicotine and mecamylamine in the mouse forced swim and tail suspension tests: role of strain, test and sex. ( Andreasen, JT; Redrobe, JP, 2009) |
| "Finally, because anxiety and withdrawal symptoms are highly correlated in humans, we studied anxiety-like behaviors in alpha7 -/- mice using a battery of anxiety-related tests." | 1.34 | Decreased withdrawal symptoms but normal tolerance to nicotine in mice null for the alpha7 nicotinic acetylcholine receptor subunit. ( De Biasi, M; Gangitano, D; Main, A; Salas, R, 2007) |
| "Pretreatment with chlorisondamine (0." | 1.33 | ABT-594 (a nicotinic acetylcholine agonist): anti-allodynia in a rat chemotherapy-induced pain model. ( Decker, MW; Honore, P; Lynch, JJ; Mikusa, JP; Wade, CL, 2005) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (3.53) | 18.7374 |
| 1990's | 3 (3.53) | 18.2507 |
| 2000's | 30 (35.29) | 29.6817 |
| 2010's | 47 (55.29) | 24.3611 |
| 2020's | 2 (2.35) | 2.80 |
| Authors | Studies |
|---|---|
| Solinski, HJ | 1 |
| Dranchak, P | 1 |
| Oliphant, E | 1 |
| Gu, X | 1 |
| Earnest, TW | 1 |
| Braisted, J | 1 |
| Inglese, J | 1 |
| Hoon, MA | 1 |
| Abrams, RPM | 1 |
| Yasgar, A | 1 |
| Teramoto, T | 1 |
| Lee, MH | 1 |
| Dorjsuren, D | 1 |
| Eastman, RT | 1 |
| Malik, N | 1 |
| Zakharov, AV | 1 |
| Li, W | 2 |
| Bachani, M | 1 |
| Brimacombe, K | 1 |
| Steiner, JP | 1 |
| Hall, MD | 1 |
| Balasubramanian, A | 1 |
| Jadhav, A | 1 |
| Padmanabhan, R | 1 |
| Simeonov, A | 1 |
| Nath, A | 1 |
| Reno, CM | 1 |
| Bayles, J | 1 |
| Huang, Y | 1 |
| Oxspring, M | 1 |
| Hirahara, AM | 1 |
| Dosdall, DJ | 1 |
| Fisher, SJ | 1 |
| Mahmood, HM | 1 |
| Aldhalaan, HM | 1 |
| Alshammari, TK | 1 |
| Alqasem, MA | 1 |
| Alshammari, MA | 1 |
| Albekairi, NA | 1 |
| AlSharari, SD | 1 |
| Yuan, M | 1 |
| Malagon, AM | 1 |
| Yasuda, D | 1 |
| Belluzzi, JD | 1 |
| Leslie, FM | 1 |
| Zaveri, NT | 1 |
| Carcoba, LM | 1 |
| Flores, RJ | 1 |
| Natividad, LA | 1 |
| O'Dell, LE | 2 |
| Cai, J | 1 |
| Wang, BH | 1 |
| Huang, L | 1 |
| Fan, J | 1 |
| Wang, Y | 1 |
| Jackson, A | 1 |
| Papke, RL | 1 |
| Damaj, MI | 3 |
| Kwon, H | 1 |
| Jung, JW | 1 |
| Lee, YC | 1 |
| Ryu, JH | 1 |
| Kim, DH | 1 |
| Fernández-Cabezudo, MJ | 1 |
| George, JA | 1 |
| Bashir, G | 1 |
| Mohamed, YA | 1 |
| Al-Mansori, A | 1 |
| Qureshi, MM | 1 |
| Lorke, DE | 1 |
| Petroianu, G | 1 |
| Al-Ramadi, BK | 1 |
| Nunes, EJ | 2 |
| Bitner, L | 1 |
| Hughley, SM | 1 |
| Small, KM | 1 |
| Walton, SN | 1 |
| Rupprecht, LE | 1 |
| Addy, NA | 2 |
| Varani, AP | 3 |
| Antonelli, MC | 2 |
| Balerio, GN | 3 |
| Zarrindast, MR | 2 |
| Piri, M | 1 |
| Bananej, M | 1 |
| Shahab, Z | 1 |
| Zahmatkesh, M | 1 |
| Yankelevitch-Yahav, R | 1 |
| Roni, YY | 1 |
| Joel, D | 1 |
| Daphna, J | 1 |
| Bagdas, D | 1 |
| Muldoon, PP | 1 |
| Zhu, AZ | 1 |
| Tyndale, RF | 1 |
| Papp, M | 1 |
| Gruca, P | 1 |
| Lason-Tyburkiewicz, M | 1 |
| Litwa, E | 1 |
| Willner, P | 1 |
| Ghasemzadeh, Z | 1 |
| Rezayof, A | 1 |
| Aboul-Fotouh, S | 1 |
| Pedrón, VT | 1 |
| Machado, LM | 1 |
| Bettler, B | 1 |
| Perez, E | 1 |
| Quijano-Cardé, N | 1 |
| De Biasi, M | 2 |
| Wickham, RJ | 1 |
| Ponzoni, L | 1 |
| Moretti, M | 1 |
| Sala, M | 1 |
| Fasoli, F | 1 |
| Mucchietto, V | 1 |
| Lucini, V | 1 |
| Cannazza, G | 1 |
| Gallesi, G | 1 |
| Castellana, CN | 1 |
| Clementi, F | 1 |
| Zoli, M | 1 |
| Gotti, C | 1 |
| Braida, D | 1 |
| Singh, SP | 1 |
| Chand, HS | 1 |
| Gundavarapu, S | 1 |
| Saeed, AI | 1 |
| Langley, RJ | 1 |
| Tesfaigzi, Y | 1 |
| Mishra, NC | 1 |
| Sopori, ML | 1 |
| Miyauchi, M | 1 |
| Neugebauer, NM | 2 |
| Oyamada, Y | 1 |
| Meltzer, HY | 1 |
| de Moura, FB | 1 |
| McMahon, LR | 1 |
| Watterson, E | 1 |
| Spitzer, A | 1 |
| Watterson, LR | 1 |
| Brackney, RJ | 1 |
| Zavala, AR | 1 |
| Olive, MF | 1 |
| Sanabria, F | 1 |
| Qi, X | 1 |
| Guzhva, L | 1 |
| Yang, Z | 1 |
| Febo, M | 1 |
| Shan, Z | 1 |
| Wang, KKW | 1 |
| Bruijnzeel, AW | 3 |
| de Oliveira, RC | 2 |
| de Oliveira, R | 2 |
| Biagioni, AF | 1 |
| Falconi-Sobrinho, LL | 1 |
| Dos Anjos-Garcia, T | 1 |
| Coimbra, NC | 2 |
| Bordia, T | 1 |
| Zhang, D | 1 |
| Perez, XA | 1 |
| Quik, M | 1 |
| Di Cesare Mannelli, L | 2 |
| Micheli, L | 1 |
| Maresca, M | 1 |
| Cravotto, G | 1 |
| Bellumori, M | 1 |
| Innocenti, M | 1 |
| Mulinacci, N | 1 |
| Ghelardini, C | 2 |
| Hackett, SF | 1 |
| Seidel, C | 1 |
| Abraham, S | 1 |
| Chadha, R | 1 |
| Fortmann, SD | 1 |
| Campochiaro, PA | 2 |
| Cooke, JP | 2 |
| Calvani, M | 1 |
| Nicolai, R | 1 |
| Mosconi, L | 1 |
| Toscano, A | 1 |
| Pacini, A | 1 |
| Bartolini, A | 1 |
| Cucchiaro, G | 1 |
| Xiao, Y | 1 |
| Gonzalez-Sulser, A | 1 |
| Kellar, KJ | 1 |
| Andreasen, JT | 2 |
| Redrobe, JP | 2 |
| Yanagida, T | 1 |
| Takeuchi, H | 1 |
| Kitamura, Y | 1 |
| Takata, K | 1 |
| Minamino, H | 1 |
| Shibaike, T | 1 |
| Tsushima, J | 1 |
| Kishimoto, K | 1 |
| Yasui, H | 1 |
| Taniguchi, T | 1 |
| Shimohama, S | 1 |
| Breivik, T | 1 |
| Gundersen, Y | 1 |
| Gjermo, P | 1 |
| von Hörsten, S | 1 |
| Opstad, PK | 1 |
| Marcinkiewcz, CA | 1 |
| Prado, MM | 1 |
| Isaac, SK | 1 |
| Marshall, A | 1 |
| Rylkova, D | 1 |
| Park, JH | 1 |
| Kim, SK | 1 |
| Kim, HN | 1 |
| Sun, B | 1 |
| Koo, S | 1 |
| Choi, SM | 1 |
| Bae, H | 1 |
| Min, BI | 1 |
| Coolon, RA | 1 |
| Cain, ME | 1 |
| Farook, JM | 1 |
| Lewis, B | 1 |
| Gaddis, JG | 1 |
| Littleton, JM | 1 |
| Barron, S | 1 |
| Masuoka, T | 1 |
| Kamei, C | 1 |
| Andersson, DR | 1 |
| Björnsson, E | 1 |
| Bergquist, F | 1 |
| Nissbrandt, H | 1 |
| Munro, G | 1 |
| Dyhr, H | 1 |
| Grunnet, M | 1 |
| Wadenberg, ML | 1 |
| Fjällström, AK | 1 |
| Federley, M | 1 |
| Persson, P | 1 |
| Stenqvist, P | 1 |
| Levin, ED | 3 |
| Bushnell, PJ | 1 |
| Rezvani, AH | 1 |
| Moutinho, LM | 1 |
| Calvo, M | 1 |
| Sood, N | 1 |
| Hota, D | 1 |
| Sahai, AK | 1 |
| Chakrabarti, A | 1 |
| Zanandréa, PC | 1 |
| Paschoalin-Maurin, T | 1 |
| Gittis, AH | 1 |
| Leventhal, DK | 1 |
| Fensterheim, BA | 1 |
| Pettibone, JR | 1 |
| Berke, JD | 1 |
| Kreitzer, AC | 1 |
| Rehni, AK | 2 |
| Singh, TG | 2 |
| Arora, S | 2 |
| Hoseindoost, S | 1 |
| Nasehi, M | 1 |
| Rahman, S | 1 |
| Prendergast, MA | 1 |
| Ofek, K | 1 |
| Schoknecht, K | 1 |
| Melamed-Book, N | 1 |
| Heinemann, U | 1 |
| Friedman, A | 1 |
| Soreq, H | 1 |
| Pinheiro, MM | 1 |
| Boylan, F | 1 |
| Fernandes, PD | 1 |
| Kimura, M | 1 |
| Hayashida, K | 1 |
| Eisenach, JC | 1 |
| Saito, S | 1 |
| Obata, H | 1 |
| Gilpin, NW | 1 |
| Whitaker, AM | 1 |
| Baynes, B | 1 |
| Abdel, AY | 1 |
| Weil, MT | 1 |
| George, O | 1 |
| Bonfante-Cabarcas, R | 1 |
| López Hincapié, E | 1 |
| Jiménez Hernández, E | 1 |
| Fonseca Zambrano, R | 1 |
| Ferrer Mancini, L | 1 |
| Durand Mena, M | 1 |
| Rodríguez-Bonfante, C | 1 |
| Kao, W | 1 |
| Martin, BR | 1 |
| Ghozland, S | 1 |
| Markou, A | 3 |
| Koob, GF | 1 |
| Prado, WA | 1 |
| Segalla, DK | 1 |
| Dubé, GR | 1 |
| Kohlhaas, KL | 1 |
| Rueter, LE | 1 |
| Surowy, CS | 1 |
| Meyer, MD | 1 |
| Briggs, CA | 1 |
| Lynch, JJ | 1 |
| Wade, CL | 1 |
| Mikusa, JP | 2 |
| Decker, MW | 1 |
| Honore, P | 2 |
| Biala, G | 1 |
| Weglinska, B | 1 |
| DeNoble, VJ | 1 |
| Mele, PC | 1 |
| Liu, X | 1 |
| Caggiula, AR | 1 |
| Yee, SK | 1 |
| Nobuta, H | 1 |
| Poland, RE | 1 |
| Pechnick, RN | 1 |
| Zhang, Z | 1 |
| Crooks, PA | 1 |
| Dwoskin, LP | 1 |
| Bardo, MT | 1 |
| Hassel, B | 1 |
| Wing, VC | 1 |
| Shoaib, M | 1 |
| Salas, R | 1 |
| Main, A | 1 |
| Gangitano, D | 1 |
| Jonkman, S | 1 |
| Risbrough, VB | 1 |
| Geyer, MA | 1 |
| Joshi, SK | 1 |
| Weaver, B | 1 |
| Cansev, M | 1 |
| Ilcol, YO | 1 |
| Yilmaz, MS | 1 |
| Hamurtekin, E | 1 |
| Ulus, IH | 1 |
| Kiuchi, K | 1 |
| Matsuoka, M | 1 |
| Wu, JC | 1 |
| Lima e Silva, R | 1 |
| Kengatharan, M | 1 |
| Verghese, M | 1 |
| Ueno, S | 1 |
| Yokoi, K | 1 |
| Khu, NH | 1 |
| Jovanović-Mićić, D | 1 |
| Samardzić, R | 1 |
| Beleslin, DB | 1 |
| Chambers, RA | 1 |
| Moore, J | 1 |
| McEvoy, JP | 1 |
| Suemaru, K | 1 |
| Kawasaki, H | 1 |
| Gomita, Y | 1 |
| Harrison, AA | 1 |
| Liem, YT | 1 |
| Nakamura, K | 1 |
| Kurasawa, M | 1 |
| Newman, MB | 1 |
| Manresa, JJ | 1 |
| Sanberg, PR | 1 |
| Shytle, RD | 1 |
| Aceto, MD | 1 |
| Tucker, SM | 1 |
| Hinson, JR | 1 |
| Ferguson, GS | 1 |
| Stotland, LM | 1 |
| Share, NN | 1 |
| Liang, C | 1 |
| Huckabee, WE | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Effect of Varenicline on Smoking Cessation in Patients With Schizophrenia: Evaluation of Antipsychotic Drug-Induced Neurological Symptoms as Correlates of Response[NCT03495024] | Phase 4 | 10 participants (Anticipated) | Interventional | 2019-01-01 | Recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 reviews available for mecamylamine and Disease Models, Animal
| Article | Year |
|---|---|
Attention-modulating effects of cognitive enhancers.
Topics: Animals; Attention; Attention Deficit Disorder with Hyperactivity; Behavior, Animal; Disease Models, | 2011 |
Cholinergic receptor system as a target for treating alcohol abuse and dependence.
Topics: Alcohol Deterrents; Alcoholism; Animals; Disease Models, Animal; Humans; Mecamylamine; Molecular Tar | 2012 |
83 other studies available for mecamylamine and Disease Models, Animal
| Article | Year |
|---|---|
Inhibition of natriuretic peptide receptor 1 reduces itch in mice.
Topics: Animals; Behavior, Animal; Cell-Free System; Dermatitis, Contact; Disease Models, Animal; Ganglia, S | 2019 |
Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors.
Topics: Animals; Antiviral Agents; Artificial Intelligence; Chlorocebus aethiops; Disease Models, Animal; Dr | 2020 |
Severe Hypoglycemia-Induced Fatal Cardiac Arrhythmias Are Mediated by the Parasympathetic Nervous System in Rats.
Topics: Animals; Arrhythmias, Cardiac; Benzodiazepinones; Disease Models, Animal; Hypoglycemia; Male; Mecamy | 2019 |
The Role of Nicotinic Receptors in the Attenuation of Autism-Related Behaviors in a Murine BTBR T + tf/J Autistic Model.
Topics: Animals; Autism Spectrum Disorder; Brain; Disease Models, Animal; Grooming; Male; Mecamylamine; Mice | 2020 |
The α3β4 nAChR partial agonist AT-1001 attenuates stress-induced reinstatement of nicotine seeking in a rat model of relapse and induces minimal withdrawal in dependent rats.
Topics: Adrenergic alpha-2 Receptor Antagonists; Animals; Cholinergic Agonists; Conditioning, Operant; Disea | 2017 |
Amino acid modulation of dopamine in the nucleus accumbens mediates sex differences in nicotine withdrawal.
Topics: Amino Acids; Animals; Disease Models, Animal; Dopamine; Female; Glutamic Acid; Male; Mecamylamine; N | 2018 |
Antinociceptive effects of novel epibatidine analogs through activation of α4β2 nicotinic receptors.
Topics: Analgesics, Non-Narcotic; Animals; Binding, Competitive; Bridged Bicyclo Compounds, Heterocyclic; Co | 2018 |
Pharmacological modulation of the α7 nicotinic acetylcholine receptor in a mouse model of mecamylamine-precipitated nicotine withdrawal.
Topics: alpha7 Nicotinic Acetylcholine Receptor; Animals; Benzamides; Bridged Bicyclo Compounds; Disease Mod | 2018 |
Neuroprotective effect of the ethanol extract of Artemisia capillaris on transient forebrain ischemia in mice via nicotinic cholinergic receptor.
Topics: Acetylcholinesterase; Animals; Artemisia; Cell Death; Cholinergic Antagonists; Disease Models, Anima | 2018 |
Involvement of Acetylcholine Receptors in Cholinergic Pathway-Mediated Protection Against Autoimmune Diabetes.
Topics: Acetylcholinesterase; Animals; Atropine; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 1; | 2019 |
Cholinergic Receptor Blockade in the VTA Attenuates Cue-Induced Cocaine-Seeking and Reverses the Anxiogenic Effects of Forced Abstinence.
Topics: Animals; Anti-Anxiety Agents; Anxiety; Cholinergic Antagonists; Cocaine-Related Disorders; Disease M | 2019 |
Mecamylamine-precipitated nicotine withdrawal syndrome and its prevention with baclofen: an autoradiographic study of α4β2 nicotinic acetylcholine receptors in mice.
Topics: Analysis of Variance; Animals; Autoradiography; Baclofen; Brain; Cholinergic Agents; Disease Models, | 2013 |
Evaluation of functional relationship between mouse hippocampal cholinergic and nitrergic systems in anxiogenic-like behavior.
Topics: Analysis of Variance; Animals; Anxiety; Arginine; Cholinergic Agents; Disease Models, Animal; Dose-R | 2013 |
The role of the cholinergic system in the signal attenuation rat model of obsessive-compulsive disorder.
Topics: Acetylcholine; Animals; Behavior, Animal; Compulsive Behavior; Conditioning, Operant; Disease Models | 2013 |
Effects of methoxsalen, a CYP2A5/6 inhibitor, on nicotine dependence behaviors in mice.
Topics: Animals; Anxiety; Aryl Hydrocarbon Hydroxylases; Conditioning, Psychological; Cytochrome P450 Family | 2014 |
Effects of chronic mild stress on the development of drug dependence in rats.
Topics: Animals; Chronic Disease; Citalopram; Depressive Disorder; Diazepam; Disease Models, Animal; Flumaze | 2014 |
Ventral hippocampal nicotinic acetylcholine receptors mediate stress-induced analgesia in mice.
Topics: Analysis of Variance; Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Hippocampus | 2015 |
Behavioral effects of nicotinic antagonist mecamylamine in a rat model of depression: prefrontal cortex level of BDNF protein and monoaminergic neurotransmitters.
Topics: Animals; Behavior, Animal; Body Weight; Brain-Derived Neurotrophic Factor; Corticosterone; Depressiv | 2015 |
Lack of GABAB receptors modifies behavioural and biochemical alterations induced by precipitated nicotine withdrawal.
Topics: Animals; Anxiety; Brain; Brain-Derived Neurotrophic Factor; Corticosterone; Disease Models, Animal; | 2015 |
Nicotinic Mechanisms Modulate Ethanol Withdrawal and Modify Time Course and Symptoms Severity of Simultaneous Withdrawal from Alcohol and Nicotine.
Topics: Animals; Central Nervous System Depressants; Disease Models, Animal; Ethanol; Female; Habenula; Inte | 2015 |
Ventral tegmental area cholinergic mechanisms mediate behavioral responses in the forced swim test.
Topics: Acetylcholine; Animals; Cholinergic Antagonists; Cholinesterase Inhibitors; Depressive Disorder; Dis | 2015 |
Different physiological and behavioural effects of e-cigarette vapour and cigarette smoke in mice.
Topics: Animals; Body Weight; Brain; Cotinine; Disease Models, Animal; Eating; Electronic Nicotine Delivery | 2015 |
HIF-1α Plays a Critical Role in the Gestational Sidestream Smoke-Induced Bronchopulmonary Dysplasia in Mice.
Topics: Alveolar Epithelial Cells; Angiogenesis Inhibitors; Animals; Apoptosis; Apoptosis Regulatory Protein | 2015 |
Nicotinic receptors and lurasidone-mediated reversal of phencyclidine-induced deficit in novel object recognition.
Topics: alpha7 Nicotinic Acetylcholine Receptor; Animals; Azetidines; Benzamides; Bridged Bicyclo Compounds; | 2016 |
Differential antagonism and tolerance/cross-tolerance among nicotinic acetylcholine receptor agonists: scheduled-controlled responding and hypothermia in C57BL/6J mice.
Topics: Animals; Cocaine; Conditioning, Operant; Disease Models, Animal; Dose-Response Relationship, Drug; D | 2016 |
Nicotine-induced behavioral sensitization in an adult rat model of attention deficit/hyperactivity disorder (ADHD).
Topics: Animals; Attention Deficit Disorder with Hyperactivity; Behavior, Animal; Disease Models, Animal; Lo | 2016 |
Overexpression of CRF in the BNST diminishes dysphoria but not anxiety-like behavior in nicotine withdrawing rats.
Topics: Animals; Anxiety; Corticotropin-Releasing Hormone; Dependovirus; Disease Models, Animal; Genetic Vec | 2016 |
Nicotinic and muscarinic cholinergic receptors are recruited by acetylcholine-mediated neurotransmission within the locus coeruleus during the organisation of post-ictal antinociception.
Topics: Acetylcholine; Animals; Atropine; Disease Models, Animal; Dose-Response Relationship, Drug; Locus Co | 2016 |
Striatal cholinergic interneurons and D2 receptor-expressing GABAergic medium spiny neurons regulate tardive dyskinesia.
Topics: Animals; Antipsychotic Agents; Channelrhodopsins; Choline O-Acetyltransferase; Cholinergic Neurons; | 2016 |
Anti-neuropathic effects of Rosmarinus officinalis L. terpenoid fraction: relevance of nicotinic receptors.
Topics: Abietanes; Analgesics, Non-Narcotic; Animals; Chemical Fractionation; Disease Models, Animal; Mecamy | 2016 |
The Nicotinic Cholinergic Pathway Contributes to Retinal Neovascularization in a Mouse Model of Retinopathy of Prematurity.
Topics: Animals; Animals, Newborn; Cholinergic Agents; Disease Models, Animal; Ischemia; Mecamylamine; Mice; | 2017 |
Neuroprotective effects of acetyl-L-carnitine on neuropathic pain and apoptosis: a role for the nicotinic receptor.
Topics: Acetylcarnitine; Animals; Apoptosis; Atropine; Caspase 3; Cytochromes c; Disease Models, Animal; In | 2009 |
Analgesic effects of Sazetidine-A, a new nicotinic cholinergic drug.
Topics: Analgesics; Animals; Azetidines; Bridged Bicyclo Compounds, Heterocyclic; Cholinergic Agents; Diseas | 2008 |
Nicotine, but not mecamylamine, enhances antidepressant-like effects of citalopram and reboxetine in the mouse forced swim and tail suspension tests.
Topics: Adrenergic Uptake Inhibitors; Analysis of Variance; Animals; Antidepressive Agents; Behavior, Animal | 2009 |
Synergistic effect of galantamine on nicotine-induced neuroprotection in hemiparkinsonian rat model.
Topics: alpha7 Nicotinic Acetylcholine Receptor; Animals; Disease Models, Animal; Dopamine Uptake Inhibitors | 2008 |
Nicotinic acetylcholine receptor activation mediates nicotine-induced enhancement of experimental periodontitis.
Topics: Alveolar Bone Loss; Animals; Corticosterone; Disease Models, Animal; Disease Susceptibility; Escheri | 2009 |
Corticotropin-releasing factor within the central nucleus of the amygdala and the nucleus accumbens shell mediates the negative affective state of nicotine withdrawal in rats.
Topics: Amygdala; Animals; Corticotropin-Releasing Hormone; Disease Models, Animal; Dose-Response Relationsh | 2009 |
Spinal cholinergic mechanism of the relieving effects of electroacupuncture on cold and warm allodynia in a rat model of neuropathic pain.
Topics: Animals; Atropine; Cholinergic Agents; Cholinergic Fibers; Cold Temperature; Diamines; Disease Model | 2009 |
Effects of mecamylamine on nicotine-induced conditioned hyperactivity and sensitization in differentially reared rats.
Topics: Animals; Conditioning, Psychological; Disease Models, Animal; Male; Mecamylamine; Motor Activity; Ni | 2009 |
Antidepressant-like effects of nicotine and mecamylamine in the mouse forced swim and tail suspension tests: role of strain, test and sex.
Topics: Animals; Antidepressive Agents; Behavior, Animal; Disease Models, Animal; Female; Hindlimb Suspensio | 2009 |
Effects of mecamylamine on alcohol consumption and preference in male C57BL/6J mice.
Topics: Alcohol Drinking; Animals; Choice Behavior; Disease Models, Animal; Drinking; Drug Evaluation, Precl | 2009 |
The role of nicotinic receptors in the amelioration of cholinesterase inhibitors in scopolamine-induced memory deficits.
Topics: Animals; Cholinesterase Inhibitors; Disease Models, Animal; Donepezil; Dose-Response Relationship, D | 2009 |
Motor activity-induced dopamine release in the substantia nigra is regulated by muscarinic receptors.
Topics: Analysis of Variance; Animals; Area Under Curve; Brain Injuries; Chromatography, High Pressure Liqui | 2010 |
Selective potentiation of gabapentin-mediated antinociception in the rat formalin test by the nicotinic acetylcholine receptor agonist ABT-594.
Topics: Amines; Analgesics; Animals; Azetidines; Cyclohexanecarboxylic Acids; Disease Models, Animal; Dose-R | 2010 |
Effects of adjunct galantamine to risperidone, or haloperidol, in animal models of antipsychotic activity and extrapyramidal side-effect liability: involvement of the cholinergic muscarinic receptor.
Topics: Animals; Antipsychotic Agents; Avoidance Learning; Behavior, Animal; Catalepsy; Cholinergic Antagoni | 2011 |
Zebrafish assessment of cognitive improvement and anxiolysis: filling the gap between in vitro and rodent models for drug development.
Topics: Animals; Anti-Anxiety Agents; Anxiety; Attention; Buspirone; Disease Models, Animal; Dose-Response R | 2011 |
Ability of baclofen to prevent somatic manifestations and neurochemical changes during nicotine withdrawal.
Topics: Animals; Baclofen; Behavior, Animal; Disease Models, Animal; Drug Evaluation, Preclinical; Male; Mec | 2011 |
Nicotine reversal of anticonvulsant action of topiramate in kainic acid-induced seizure model in mice.
Topics: Animals; Anticonvulsants; Brain; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Inte | 2011 |
Acetylcholine-mediated neurotransmission within the nucleus raphe magnus exerts a key role in the organization of both interictal and postictal antinociception.
Topics: Acetylcholine; Animals; Atropine; Cholinergic Agonists; Cholinergic Antagonists; Disease Models, Ani | 2011 |
Selective inhibition of striatal fast-spiking interneurons causes dyskinesias.
Topics: Action Potentials; Adamantane; Analysis of Variance; Animals; Area Under Curve; Cholinergic Antagoni | 2011 |
SU-6656, a selective Src kinase inhibitor, attenuates mecamylamine-precipitated nicotine withdrawal syndrome in mice.
Topics: Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Indoles; Injections, Intr | 2012 |
Possible interaction between opioidergic and cholinergic systems of CA1 in cholestasis-induced amnesia in mice.
Topics: Amnesia; Animals; Animals, Outbred Strains; CA1 Region, Hippocampal; Cholestasis; Disease Models, An | 2012 |
Fluoxetine induces vasodilatation of cerebral arterioles by co-modulating NO/muscarinic signalling.
Topics: Acetylcholinesterase; Animals; Arterioles; Atropine; Calcium; Cells, Cultured; Cerebral Cortex; Dise | 2012 |
Antinociceptive effect of the Orbignya speciosa Mart. (Babassu) leaves: evidence for the involvement of apigenin.
Topics: Analgesics; Animals; Apigenin; Arecaceae; Aspirin; Atropine; Brazil; Disease Models, Animal; Dose-Re | 2012 |
Relief of hypersensitivity after nerve injury from systemic donepezil involves spinal cholinergic and γ-aminobutyric acid mechanisms.
Topics: Animals; Atropine; Bicuculline; Cholinergic Agents; Cholinesterase Inhibitors; Disease Models, Anima | 2013 |
Nicotine vapor inhalation escalates nicotine self-administration.
Topics: Analysis of Variance; Animals; Behavior, Animal; Conditioning, Operant; Disease Models, Animal; Dose | 2014 |
Ro 32-0432 attenuates mecamylamine-precipitated nicotine withdrawal syndrome in mice.
Topics: Animals; Behavior, Animal; Disease Models, Animal; Dose-Response Relationship, Drug; G-Protein-Coupl | 2013 |
Electrophysiological and pharmacological evaluation of the nicotinic cholinergic system in chagasic rats.
Topics: Animals; Bungarotoxins; Chagas Cardiomyopathy; Dihydro-beta-Erythroidine; Disease Models, Animal; El | 2013 |
Characterization of spontaneous and precipitated nicotine withdrawal in the mouse.
Topics: Animals; Disease Models, Animal; Male; Mecamylamine; Mice; Mice, Inbred ICR; Nicotine; Nicotinic Ant | 2003 |
Nicotine withdrawal in adolescent and adult rats.
Topics: Adolescent; Age Factors; Analysis of Variance; Animals; Blinking; Disease Models, Animal; Drug Admin | 2004 |
Antinociceptive effects of bethanechol or dimethylphenylpiperazinium in models of phasic or incisional pain in rats.
Topics: Acetylcholine; Analgesics; Analysis of Variance; Animals; Atropine; Bethanechol; Cholinergic Agonist | 2004 |
Loss of functional neuronal nicotinic receptors in dorsal root ganglion neurons in a rat model of neuropathic pain.
Topics: Acetylcholine; Animals; Azetidines; Cell Count; Cells, Cultured; Disease Models, Animal; Dose-Respon | 2005 |
ABT-594 (a nicotinic acetylcholine agonist): anti-allodynia in a rat chemotherapy-induced pain model.
Topics: Acetylcholine; Analgesia; Animals; Azetidines; Chlorisondamine; Disease Models, Animal; Dose-Respons | 2005 |
Blockade of the expression of mecamylamine-precipitated nicotine withdrawal by calcium channel antagonists.
Topics: Animals; Calcium Channel Blockers; Disease Models, Animal; Maze Learning; Mecamylamine; Mice; Motor | 2005 |
Intravenous nicotine self-administration in rats: effects of mecamylamine, hexamethonium and naloxone.
Topics: Animals; Association Learning; Brain; Conditioning, Operant; Disease Models, Animal; Dose-Response R | 2006 |
Reinstatement of nicotine-seeking behavior by drug-associated stimuli after extinction in rats.
Topics: Animals; Association Learning; Cues; Disease Models, Animal; Extinction, Psychological; Male; Mecamy | 2006 |
Effect of a novel nicotinic receptor antagonist, N,N'-dodecane-1,12-diyl-bis-3-picolinium dibromide, on nicotine self-administration and hyperactivity in rats.
Topics: Animals; Conditioning, Operant; Disease Models, Animal; Dose-Response Relationship, Drug; Infusions, | 2006 |
Nicotinic mechanisms contribute to soman-induced symptoms and lethality.
Topics: Acetylcholinesterase; Analysis of Variance; Animals; Behavior, Animal; Chemical Warfare Agents; Dise | 2006 |
Examining the clinical efficacy of bupropion and nortriptyline as smoking cessation agents in a rodent model of nicotine withdrawal.
Topics: Animals; Antidepressive Agents; Bupropion; Disease Models, Animal; Dose-Response Relationship, Drug; | 2007 |
Decreased withdrawal symptoms but normal tolerance to nicotine in mice null for the alpha7 nicotinic acetylcholine receptor subunit.
Topics: Aconitine; alpha7 Nicotinic Acetylcholine Receptor; Analysis of Variance; Anesthetics, Local; Animal | 2007 |
Spontaneous nicotine withdrawal potentiates the effects of stress in rats.
Topics: Acoustic Stimulation; Analysis of Variance; Animals; Behavior, Animal; Dihydro-beta-Erythroidine; Di | 2008 |
Morphine and ABT-594 (a nicotinic acetylcholine agonist) exert centrally mediated antinociception in the rat cyclophosphamide cystitis model of visceral pain.
Topics: Analgesics; Animals; Azetidines; Behavior, Animal; Brain; Chlorisondamine; Cyclophosphamide; Cystiti | 2008 |
Peripheral administration of CDP-choline, phosphocholine or choline increases plasma adrenaline and noradrenaline concentrations.
Topics: Adrenal Glands; Animals; Atropine Derivatives; Autonomic Nervous System; Central Nervous System; Cho | 2008 |
Mecamylamine suppresses Basal and nicotine-stimulated choroidal neovascularization.
Topics: Animals; Cells, Cultured; Choroid; Choroidal Neovascularization; Disease Models, Animal; Endothelium | 2008 |
The role of alpha-adrenergic mechanisms within the area postrema in dopamine-induced emesis.
Topics: Adrenergic alpha-Antagonists; alpha-Methyltyrosine; Animals; Atropine; Cats; Cerebral Ventricles; Di | 1995 |
Cognitive effects of neonatal hippocampal lesions in a rat model of schizophrenia.
Topics: Amphetamine; Animals; Behavior, Animal; Brain Diseases; Central Nervous System Stimulants; Disease M | 1996 |
[Assessment of anti-tremorogenic drugs--nicotine-induced tail-tremor model].
Topics: Adrenergic beta-Antagonists; Animals; Anti-Anxiety Agents; Clonazepam; Diazepam; Disease Models, Ani | 1997 |
Fluoxetine combined with a serotonin-1A receptor antagonist reversed reward deficits observed during nicotine and amphetamine withdrawal in rats.
Topics: Aminopyridines; Amphetamine; Amphetamine-Related Disorders; Animals; Body Weight; Brain; Depression; | 2001 |
Anxiolytic effects of aniracetam in three different mouse models of anxiety and the underlying mechanism.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Anti-Anxiety Agents; Anxiety; Behavior, Animal; Bro | 2001 |
Nicotine induced seizures blocked by mecamylamine and its stereoisomers.
Topics: Animals; Disease Models, Animal; Male; Mecamylamine; Molecular Conformation; Nicotine; Nicotinic Ant | 2001 |
Chronic nicotine exposure: studies on water intake, body weight, blood pressure and behavior.
Topics: Animals; Behavior, Animal; Blood Pressure; Body Weight; Disease Models, Animal; Dose-Response Relati | 1987 |
Pharmacological studies on active bronchial anaphylaxis in the rat.
Topics: Aluminum Hydroxide; Anaphylaxis; Animals; Atropine; Bordetella pertussis; Bronchial Spasm; Cromolyn | 1974 |
Mechanisms regulating the cardiac output response to cyanide infusion, a model of hypoxia.
Topics: Animals; Aorta; Blood Pressure; Bretylium Compounds; Cardiac Output; Catheterization; Cyanides; Dise | 1973 |