mecamylamine has been researched along with Depressive Disorder in 6 studies
Mecamylamine: A nicotinic antagonist that is well absorbed from the gastrointestinal tract and crosses the blood-brain barrier. Mecamylamine has been used as a ganglionic blocker in treating hypertension, but, like most ganglionic blockers, is more often used now as a research tool.
Depressive Disorder: An affective disorder manifested by either a dysphoric mood or loss of interest or pleasure in usual activities. The mood disturbance is prominent and relatively persistent.
| Excerpt | Relevance | Reference |
|---|---|---|
| " To limit the potential adverse effects of alteration in cholinergic and nitric oxide (NO) systems, we investigated the combined efficacy of subthreshold doses of nAChR antagonist mecamylamine and NO ligands (L-arginine as agonist and l-NAME as an antagonist) on depression- and anxiety-related behaviors in male NMRI mice." | 3.96 | Better antidepressant efficacy of mecamylamine in combination with L-NAME than with L-arginine. ( Ebrahimi-Ghiri, M; Mohammadi-Mahdiabadi-Hasani, MH; Nasehi, M; Zarrindast, MR, 2020) |
| " MEC prevented CRS-induced depressive-like behavior via increasing sucrose preference, body weight, and forced swim test (FST) struggling and swimming while reducing immobility in FST and hypothalamic-pituitary-adrenal (HPA) axis hyperactivity (adrenal gland weight and serum corticosterone)." | 3.81 | Behavioral effects of nicotinic antagonist mecamylamine in a rat model of depression: prefrontal cortex level of BDNF protein and monoaminergic neurotransmitters. ( Aboul-Fotouh, S, 2015) |
| "Mecamylamine was effective on its own in some tests, but did not augment the effects of citalopram or reboxetine at the doses tested." | 1.35 | Nicotine, but not mecamylamine, enhances antidepressant-like effects of citalopram and reboxetine in the mouse forced swim and tail suspension tests. ( Andreasen, JT; Redrobe, JP, 2009) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (16.67) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (16.67) | 29.6817 |
| 2010's | 3 (50.00) | 24.3611 |
| 2020's | 1 (16.67) | 2.80 |
| Authors | Studies |
|---|---|
| Ebrahimi-Ghiri, M | 1 |
| Mohammadi-Mahdiabadi-Hasani, MH | 1 |
| Nasehi, M | 1 |
| Zarrindast, MR | 1 |
| Papp, M | 1 |
| Gruca, P | 1 |
| Lason-Tyburkiewicz, M | 1 |
| Litwa, E | 1 |
| Willner, P | 1 |
| Aboul-Fotouh, S | 1 |
| Addy, NA | 1 |
| Nunes, EJ | 1 |
| Wickham, RJ | 1 |
| Andreasen, JT | 1 |
| Redrobe, JP | 1 |
| BHARGAVA, KP | 1 |
| DHAWAN, KN | 1 |
6 other studies available for mecamylamine and Depressive Disorder
| Article | Year |
|---|---|
Better antidepressant efficacy of mecamylamine in combination with L-NAME than with L-arginine.
Topics: Animals; Animals, Outbred Strains; Antidepressive Agents; Anxiety; Arginine; Behavior, Animal; Choli | 2020 |
Effects of chronic mild stress on the development of drug dependence in rats.
Topics: Animals; Chronic Disease; Citalopram; Depressive Disorder; Diazepam; Disease Models, Animal; Flumaze | 2014 |
Behavioral effects of nicotinic antagonist mecamylamine in a rat model of depression: prefrontal cortex level of BDNF protein and monoaminergic neurotransmitters.
Topics: Animals; Behavior, Animal; Body Weight; Brain-Derived Neurotrophic Factor; Corticosterone; Depressiv | 2015 |
Ventral tegmental area cholinergic mechanisms mediate behavioral responses in the forced swim test.
Topics: Acetylcholine; Animals; Cholinergic Antagonists; Cholinesterase Inhibitors; Depressive Disorder; Dis | 2015 |
Nicotine, but not mecamylamine, enhances antidepressant-like effects of citalopram and reboxetine in the mouse forced swim and tail suspension tests.
Topics: Adrenergic Uptake Inhibitors; Analysis of Variance; Animals; Antidepressive Agents; Behavior, Animal | 2009 |
DEPRESSION OF THE VASOMOTOR CENTRE BY MECAMYLAMINE, INDEPENDENT OF ITS GANGLION-BLOCKING ACTIVITY.
Topics: Acetylcholine; Animals; Cats; Central Nervous System; Depression; Depressive Disorder; Dogs; Ganglia | 1963 |