mecamylamine has been researched along with Cocaine-Related Disorders in 7 studies
Mecamylamine: A nicotinic antagonist that is well absorbed from the gastrointestinal tract and crosses the blood-brain barrier. Mecamylamine has been used as a ganglionic blocker in treating hypertension, but, like most ganglionic blockers, is more often used now as a research tool.
Cocaine-Related Disorders: Disorders related or resulting from use of cocaine.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Mecamylamine was well tolerated, and study retention did not differ by treatment group." | 2.71 | A placebo controlled, double-blind study of mecamylamine treatment for cocaine dependence in patients enrolled in an opiate replacement program. ( Angrist, B; Baker, SA; Elkashef, A; Leiderman, D; Majewska, D; Montgomery, A; O'leary, S; Reid, MS; Robinson, J; Rotrosen, J; Schwartz, M; Stone, J, 2005) |
| "Varenicline is a low-efficacy, α4β2* subtype-selective nicotinic acetylcholine receptor (nAChR) agonist that has shown success in smoking cessation and promise in preclinical assessments relating to other drugs of abuse." | 1.37 | Effects of varenicline on the reinforcing and discriminative stimulus effects of cocaine in rhesus monkeys. ( Czoty, PW; Gould, RW; Nader, MA; Nader, SH, 2011) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (14.29) | 18.2507 |
| 2000's | 3 (42.86) | 29.6817 |
| 2010's | 3 (42.86) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Nunes, EJ | 1 |
| Bitner, L | 1 |
| Hughley, SM | 1 |
| Small, KM | 1 |
| Walton, SN | 1 |
| Rupprecht, LE | 1 |
| Addy, NA | 1 |
| Shinohara, F | 1 |
| Kihara, Y | 1 |
| Ide, S | 1 |
| Minami, M | 1 |
| Kaneda, K | 1 |
| You, ZB | 1 |
| Wang, B | 1 |
| Zitzman, D | 1 |
| Wise, RA | 1 |
| Gould, RW | 1 |
| Czoty, PW | 1 |
| Nader, SH | 1 |
| Nader, MA | 1 |
| Reid, MS | 2 |
| Angrist, B | 1 |
| Baker, SA | 1 |
| O'leary, S | 1 |
| Stone, J | 1 |
| Schwartz, M | 1 |
| Leiderman, D | 1 |
| Montgomery, A | 1 |
| Elkashef, A | 1 |
| Majewska, D | 1 |
| Robinson, J | 1 |
| Rotrosen, J | 1 |
| Mickalian, JD | 1 |
| Delucchi, KL | 1 |
| Berger, SP | 1 |
| Schoffelmeer, AN | 1 |
| De Vries, TJ | 1 |
| Wardeh, G | 1 |
| van de Ven, HW | 1 |
| Vanderschuren, LJ | 1 |
2 trials available for mecamylamine and Cocaine-Related Disorders
| Article | Year |
|---|---|
A placebo controlled, double-blind study of mecamylamine treatment for cocaine dependence in patients enrolled in an opiate replacement program.
Topics: Administration, Cutaneous; Cocaine; Cocaine-Related Disorders; Double-Blind Method; Drug Evaluation, | 2005 |
A nicotine antagonist, mecamylamine, reduces cue-induced cocaine craving in cocaine-dependent subjects.
Topics: Adolescent; Adult; Aged; Behavior, Addictive; Cocaine-Related Disorders; Cross-Over Studies; Cues; D | 1999 |
5 other studies available for mecamylamine and Cocaine-Related Disorders
| Article | Year |
|---|---|
Cholinergic Receptor Blockade in the VTA Attenuates Cue-Induced Cocaine-Seeking and Reverses the Anxiogenic Effects of Forced Abstinence.
Topics: Animals; Anti-Anxiety Agents; Anxiety; Cholinergic Antagonists; Cocaine-Related Disorders; Disease M | 2019 |
Critical role of cholinergic transmission from the laterodorsal tegmental nucleus to the ventral tegmental area in cocaine-induced place preference.
Topics: Acetylcholine; Animals; Carbachol; Cholinergic Agonists; Cocaine; Cocaine-Related Disorders; Conditi | 2014 |
Acetylcholine release in the mesocorticolimbic dopamine system during cocaine seeking: conditioned and unconditioned contributions to reward and motivation.
Topics: Acetylcholine; Analysis of Variance; Animals; Atropine; Behavior, Animal; Cholinergic Antagonists; C | 2008 |
Effects of varenicline on the reinforcing and discriminative stimulus effects of cocaine in rhesus monkeys.
Topics: Animals; Benzazepines; Cocaine; Cocaine-Related Disorders; Conditioning, Operant; Discrimination Lea | 2011 |
Psychostimulant-induced behavioral sensitization depends on nicotinic receptor activation.
Topics: Amphetamine; Amphetamine-Related Disorders; Animals; Association Learning; Behavior, Animal; Central | 2002 |