mecamylamine and Chronic Motor and Vocal Tic Disorder studies

mecamylamine and Chronic Motor and Vocal Tic Disorder

Mecamylamine: A nicotinic antagonist that is well absorbed from the gastrointestinal tract and crosses the blood-brain barrier. Mecamylamine has been used as a ganglionic blocker in treating hypertension, but, like most ganglionic blockers, is more often used now as a research tool.

Research Excerpts

Excerpt	Relevance	Reference
"Donepezil is an acetylcholinesterase inhibitor approved for use in mild to moderate Alzheimer's disease."	5.32	Effects of donepezil on DOI-induced head twitch response in mice: implications for Tourette syndrome. ( Hayslett, RL; Tizabi, Y, 2003)
"Primary efficacy measures included the Tourette's Disorder Scale-Clinician Rated (TODS-CR) and 21-point Clinical Global Improvement scale; secondary efficacy measures included the Yale Global Tic Severity Scale and a rage-attack scale (RAScal)."	2.70	Multicenter, double-blind, placebo-controlled study of mecamylamine monotherapy for Tourette's disorder. ( Ramos, A; Sanberg, PR; Sheehan, DV; Sheehan, KH; Shytle, RD; Silver, AA, 2001)
"Donepezil is an acetylcholinesterase inhibitor approved for use in mild to moderate Alzheimer's disease."	1.32	Effects of donepezil on DOI-induced head twitch response in mice: implications for Tourette syndrome. ( Hayslett, RL; Tizabi, Y, 2003)

Research

Studies (8)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	1 (12.50)	18.2507
2000's	6 (75.00)	29.6817
2010's	1 (12.50)	24.3611
2020's	0 (0.00)	2.80

Timeframe

Studies, this research(%)

All Research%

pre-1990

0 (0.00)

18.7374

1990's

1 (12.50)

18.2507

2000's

6 (75.00)

29.6817

2010's

1 (12.50)

24.3611

2020's

0 (0.00)

2.80

Authors

Authors	Studies
Sanberg, PR	6
Vindrola-Padros, C	1
Shytle, RD	6
Silver, AA	5
Sheehan, KH	2
Sheehan, DV	2
Hayslett, RL	1
Tizabi, Y	1
Singh, A	1
Das, DK	1
Kelley, ME	1
Ramos, A	1

Studies

Sanberg, PR

Vindrola-Padros, C

Shytle, RD

Silver, AA

Sheehan, KH

Sheehan, DV

Hayslett, RL

Tizabi, Y

Singh, A

Das, DK

Kelley, ME

Ramos, A

Clinical Trials (1)

Trial Overview

Trial	Phase	Enrollment	Study Type	Start Date	Status
Pilot Examination of Galantamine in the Management of Tic Disorders[NCT00226824]	Phase 4	1 participants (Actual)	Interventional	2005-09-30	Terminated (stopped due to Unable to recruit subjects into the trial.)
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial

Phase

Enrollment

Study Type

Start Date

Status

Pilot Examination of Galantamine in the Management of Tic Disorders[NCT00226824]

Phase 4

1 participants (Actual)

Interventional

2005-09-30

Terminated (stopped due to Unable to recruit subjects into the trial.)

[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

Article	Year
Translating laboratory discovery to the clinic: from nicotine and mecamylamine to Tourette's, depression, and beyond. Physiology & behavior, 2012, Dec-05, Volume: 107, Issue:5 Topics: Animals; Basal Ganglia; Depression; Humans; Mecamylamine; Nicotine; Tourette Syndrome; Translational	2012

Article

Year

Translating laboratory discovery to the clinic: from nicotine and mecamylamine to Tourette's, depression, and beyond.

Physiology & behavior, 2012, Dec-05, Volume: 107, Issue:5

Topics: Animals; Basal Ganglia; Depression; Humans; Mecamylamine; Nicotine; Tourette Syndrome; Translational

2012

Trials

Article	Year
Neuronal nicotinic receptor inhibition for treating mood disorders: preliminary controlled evidence with mecamylamine. Depression and anxiety, 2002, Volume: 16, Issue:3 Topics: Adolescent; Attention Deficit Disorder with Hyperactivity; Child; Depressive Disorder, Major; Double	2002
Mecamylamine in Tourette's syndrome: a two-year retrospective case study. Journal of child and adolescent psychopharmacology, 2000,Summer, Volume: 10, Issue:2 Topics: Adolescent; Adult; Age Factors; Child; Drug Therapy, Combination; Female; Humans; Male; Mecamylamine	2000
Multicenter, double-blind, placebo-controlled study of mecamylamine monotherapy for Tourette's disorder. Journal of the American Academy of Child and Adolescent Psychiatry, 2001, Volume: 40, Issue:9 Topics: Adolescent; Child; Comorbidity; Depression; Double-Blind Method; Female; Ganglionic Blockers; Heart	2001

Article

Year

Neuronal nicotinic receptor inhibition for treating mood disorders: preliminary controlled evidence with mecamylamine.

Depression and anxiety, 2002, Volume: 16, Issue:3

Topics: Adolescent; Attention Deficit Disorder with Hyperactivity; Child; Depressive Disorder, Major; Double

2002

Mecamylamine in Tourette's syndrome: a two-year retrospective case study.

Journal of child and adolescent psychopharmacology, 2000,Summer, Volume: 10, Issue:2

Topics: Adolescent; Adult; Age Factors; Child; Drug Therapy, Combination; Female; Humans; Male; Mecamylamine

2000

Multicenter, double-blind, placebo-controlled study of mecamylamine monotherapy for Tourette's disorder.

Journal of the American Academy of Child and Adolescent Psychiatry, 2001, Volume: 40, Issue:9

Topics: Adolescent; Child; Comorbidity; Depression; Double-Blind Method; Female; Ganglionic Blockers; Heart

2001

Other Studies

4 other studies available for mecamylamine and Chronic Motor and Vocal Tic Disorder

Article	Year
Effects of donepezil on DOI-induced head twitch response in mice: implications for Tourette syndrome. Pharmacology, biochemistry, and behavior, 2003, Volume: 76, Issue:3-4 Topics: Amphetamines; Animals; Donepezil; Drug Synergism; Head Movements; Indans; Male; Mecamylamine; Mice;	2003
Mecamylamine (Targacept). IDrugs : the investigational drugs journal, 2006, Volume: 9, Issue:3 Topics: Adolescent; Adult; Animals; Attention Deficit Disorder with Hyperactivity; Child; Dose-Response Rela	2006
Treatment of Tourette's syndrome with mecamylamine. Lancet (London, England), 1998, Aug-29, Volume: 352, Issue:9129 Topics: Adolescent; Adult; Female; Humans; Male; Mecamylamine; Nicotinic Antagonists; Retrospective Studies;	1998
Comorbid bipolar disorder in Tourette's syndrome responds to the nicotinic receptor antagonist mecamylamine (Inversine). Biological psychiatry, 2000, Nov-15, Volume: 48, Issue:10 Topics: Adolescent; Adult; Bipolar Disorder; Female; Humans; Male; Mecamylamine; Nicotinic Antagonists; Psyc	2000

Article

Year

Effects of donepezil on DOI-induced head twitch response in mice: implications for Tourette syndrome.

Pharmacology, biochemistry, and behavior, 2003, Volume: 76, Issue:3-4

Topics: Amphetamines; Animals; Donepezil; Drug Synergism; Head Movements; Indans; Male; Mecamylamine; Mice;

2003

Mecamylamine (Targacept).

IDrugs : the investigational drugs journal, 2006, Volume: 9, Issue:3

Topics: Adolescent; Adult; Animals; Attention Deficit Disorder with Hyperactivity; Child; Dose-Response Rela

2006

Treatment of Tourette's syndrome with mecamylamine.

Lancet (London, England), 1998, Aug-29, Volume: 352, Issue:9129

Topics: Adolescent; Adult; Female; Humans; Male; Mecamylamine; Nicotinic Antagonists; Retrospective Studies;

1998

Comorbid bipolar disorder in Tourette's syndrome responds to the nicotinic receptor antagonist mecamylamine (Inversine).

Biological psychiatry, 2000, Nov-15, Volume: 48, Issue:10

Topics: Adolescent; Adult; Bipolar Disorder; Female; Humans; Male; Mecamylamine; Nicotinic Antagonists; Psyc

2000