mecamylamine has been researched along with Chemical Dependence in 17 studies
Mecamylamine: A nicotinic antagonist that is well absorbed from the gastrointestinal tract and crosses the blood-brain barrier. Mecamylamine has been used as a ganglionic blocker in treating hypertension, but, like most ganglionic blockers, is more often used now as a research tool.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Both the antinociceptive and toxic effects (convulsions and hypertension) were abolished by pretreatment with the brain penetrant neuronal nAChR antagonist mecamylamine (1 mg/kg s." | 3.70 | Analgesic and toxic effects of ABT-594 resemble epibatidine and nicotine in rats. ( Boyce, S; Hill, RG; Rupniak, NMJ; Russell, MGN; Shepheard, SL; Webb, JK, 2000) |
| "Within the PTSD group, combat exposure was associated with increased drinking independent of the severity of PTSD symptoms." | 2.79 | Characteristics and drinking patterns of veterans with alcohol dependence with and without post-traumatic stress disorder. ( Arias, AJ; Fuehrlein, B; Jane, JS; O'Brien, E; Petrakis, IL; Ralevski, E, 2014) |
| "Pretreatment with mecamylamine blocked the expression of conditioned hyperactivity only in EC and SC rats and attenuated sensitization in all three rearing groups." | 1.35 | Effects of mecamylamine on nicotine-induced conditioned hyperactivity and sensitization in differentially reared rats. ( Cain, ME; Coolon, RA, 2009) |
| "The effects of chronic administration of nicotine (20 or 30 days) and its withdrawal on somatostatin-like immunorectivity and the binding of 125I-Tyr11-somatostatin in the frontoparietal cortex and hippocampus of the rat were investigated." | 1.28 | The effect of chronic administration of nicotine and withdrawal on somatostatin concentration and binding in brain of rat. ( Arilla, E; Barrios, V; Rodríguez-Sánchez, MN, 1990) |
| "Mecamylamine (MCL) has been shown to extinguish nicotine dependence in rats and monkeys." | 1.27 | Clinical evaluation of mecamylamine for withdrawal from nicotine dependence. ( Rawson, RA; Tarver, AL; Tennant, FS, 1984) |
| "Mecamylamine (MCL) has been shown to extinguish nicotine dependence in animals and produce smoking cessation in some humans." | 1.27 | Withdrawal from nicotine dependence using mecamylamine: comparison of three-week and six-week dosage schedules. ( Tarver, AL; Tennant, FS, 1984) |
| "), a nicotinic antagonist with both central and peripheral effects, shifted the nicotine dose-response curve to the right by about 1 log unit and blocked nicotine-induced emesis." | 1.27 | Maintenance of behavior by postponement of scheduled injections of nicotine in squirrel monkeys. ( Spealman, RD, 1983) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 6 (35.29) | 18.7374 |
| 1990's | 3 (17.65) | 18.2507 |
| 2000's | 4 (23.53) | 29.6817 |
| 2010's | 3 (17.65) | 24.3611 |
| 2020's | 1 (5.88) | 2.80 |
| Authors | Studies |
|---|---|
| Winger, G | 1 |
| Geste, JR | 1 |
| Pompilus, M | 1 |
| Febo, M | 1 |
| Bruijnzeel, AW | 1 |
| Fuehrlein, B | 1 |
| Ralevski, E | 1 |
| O'Brien, E | 1 |
| Jane, JS | 1 |
| Arias, AJ | 1 |
| Petrakis, IL | 1 |
| Papp, M | 1 |
| Gruca, P | 1 |
| Lason-Tyburkiewicz, M | 1 |
| Litwa, E | 1 |
| Willner, P | 1 |
| Coolon, RA | 1 |
| Cain, ME | 1 |
| Singh, A | 1 |
| Das, DK | 1 |
| Kelley, ME | 1 |
| Jerlhag, E | 1 |
| Egecioglu, E | 1 |
| Dickson, SL | 1 |
| Andersson, M | 1 |
| Svensson, L | 1 |
| Engel, JA | 1 |
| Henningfield, JE | 1 |
| Tennant, FS | 2 |
| Tarver, AL | 2 |
| Rawson, RA | 1 |
| Spealman, RD | 1 |
| Malin, DH | 1 |
| Lake, JR | 1 |
| Carter, VA | 1 |
| Cunningham, JS | 1 |
| Hebert, KM | 1 |
| Conrad, DL | 1 |
| Wilson, OB | 1 |
| Mariathasan, EA | 1 |
| Stolerman, IP | 1 |
| White, JA | 1 |
| Boyce, S | 1 |
| Webb, JK | 1 |
| Shepheard, SL | 1 |
| Russell, MGN | 1 |
| Hill, RG | 1 |
| Rupniak, NMJ | 1 |
| Hanson, HM | 1 |
| Ivester, CA | 1 |
| Morton, BR | 1 |
| Barrios, V | 1 |
| Rodríguez-Sánchez, MN | 1 |
| Arilla, E | 1 |
| Jhamandas, K | 1 |
| Dickinson, G | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Effects of Ghrelin on Alcohol Administration in Non-Treatment Seeking Heavy Drinkers[NCT01779024] | Phase 2 | 17 participants (Actual) | Interventional | 2012-12-13 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
The total number of alcohol infusions self-administered. (NCT01779024)
Timeframe: 120 minutes after the start of the infusion
| Intervention | Number of alcohol infusions (Mean) |
|---|---|
| Ghrelin | 10.45 |
| Placebo | 8.80 |
1 review available for mecamylamine and Chemical Dependence
| Article | Year |
|---|---|
Pharmacologic basis and treatment of cigarette smoking.
Topics: Animals; Chewing Gum; Compulsive Behavior; Conditioning, Operant; Drug Interactions; Humans; Mecamyl | 1984 |
1 trial available for mecamylamine and Chemical Dependence
| Article | Year |
|---|---|
Characteristics and drinking patterns of veterans with alcohol dependence with and without post-traumatic stress disorder.
Topics: Adolescent; Adrenergic alpha-Antagonists; Adult; Aged; Alcohol Drinking; Alcoholism; Comorbidity; Co | 2014 |
15 other studies available for mecamylamine and Chemical Dependence
| Article | Year |
|---|---|
Nicotinic aspects of the discriminative stimulus effects of arecoline.
Topics: Animals; Arecoline; Behavior, Animal; Dihydro-beta-Erythroidine; Discrimination Learning; Mecamylami | 2021 |
Self-administration of the synthetic cathinone MDPV enhances reward function via a nicotinic receptor dependent mechanism.
Topics: Anhedonia; Animals; Benzodioxoles; Brain; Conditioning, Operant; Dopamine Uptake Inhibitors; Feeding | 2018 |
Effects of chronic mild stress on the development of drug dependence in rats.
Topics: Animals; Chronic Disease; Citalopram; Depressive Disorder; Diazepam; Disease Models, Animal; Flumaze | 2014 |
Effects of mecamylamine on nicotine-induced conditioned hyperactivity and sensitization in differentially reared rats.
Topics: Animals; Conditioning, Psychological; Disease Models, Animal; Male; Mecamylamine; Motor Activity; Ni | 2009 |
Mecamylamine (Targacept).
Topics: Adolescent; Adult; Animals; Attention Deficit Disorder with Hyperactivity; Child; Dose-Response Rela | 2006 |
Ghrelin stimulates locomotor activity and accumbal dopamine-overflow via central cholinergic systems in mice: implications for its involvement in brain reward.
Topics: Afferent Pathways; Animals; Brain; Cholinergic Fibers; Dopamine; Feeding and Eating Disorders; Ghrel | 2006 |
Clinical evaluation of mecamylamine for withdrawal from nicotine dependence.
Topics: Adult; Dose-Response Relationship, Drug; Female; Humans; Male; Mecamylamine; Middle Aged; Nicotine; | 1984 |
Withdrawal from nicotine dependence using mecamylamine: comparison of three-week and six-week dosage schedules.
Topics: Adult; Drug Administration Schedule; Humans; Mecamylamine; Middle Aged; Nicotine; Smoking; Substance | 1984 |
Maintenance of behavior by postponement of scheduled injections of nicotine in squirrel monkeys.
Topics: Animals; Behavior, Animal; Brain; Electroshock; Hexamethonium Compounds; Humans; Injections, Intrave | 1983 |
The nicotinic antagonist mecamylamine precipitates nicotine abstinence syndrome in the rat.
Topics: Animals; Behavior, Animal; Male; Mecamylamine; Nicotine; Nicotinic Antagonists; Rats; Rats, Sprague- | 1994 |
Antagonism of AND and AND-OR drug mixture discriminations in rats.
Topics: Animals; Anti-Anxiety Agents; Association Learning; Conditioning, Operant; Discrimination Learning; | 1997 |
Analgesic and toxic effects of ABT-594 resemble epibatidine and nicotine in rats.
Topics: Analgesics, Non-Narcotic; Animals; Azetidines; Behavior, Animal; Body Temperature; Bridged Bicyclo C | 2000 |
Nicotine self-administration in rats.
Topics: Amphetamine; Animals; Caffeine; Chlordiazepoxide; Chlorpromazine; Drug Interactions; Drug Tolerance; | 1979 |
The effect of chronic administration of nicotine and withdrawal on somatostatin concentration and binding in brain of rat.
Topics: Animals; Binding, Competitive; Brain; Drug Administration Schedule; Hippocampus; Kinetics; Male; Mec | 1990 |
Modification of precipitated morphine and methadone abstinence in mice by acetylcholine antagonists.
Topics: Acetylcholine; Animals; Atropine; Drug Combinations; Humans; Mecamylamine; Methadone; Mice; Morphine | 1973 |