mecamylamine has been researched along with Brain Ischemia in 2 studies
Mecamylamine: A nicotinic antagonist that is well absorbed from the gastrointestinal tract and crosses the blood-brain barrier. Mecamylamine has been used as a ganglionic blocker in treating hypertension, but, like most ganglionic blockers, is more often used now as a research tool.
Brain Ischemia: Localized reduction of blood flow to brain tissue due to arterial obstruction or systemic hypoperfusion. This frequently occurs in conjunction with brain hypoxia (HYPOXIA, BRAIN). Prolonged ischemia is associated with BRAIN INFARCTION.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Global cerebral ischemia/reperfusion (GCI/R) injury encompasses complex pathophysiological sequalae, inducing loss of hippocampal neurons and behavioural deficits." | 5.40 | Cholinergic receptor blockade by scopolamine and mecamylamine exacerbates global cerebral ischemia induced memory dysfunction in C57BL/6J mice. ( Katyal, A; Rai, S; Ray, RS, 2014) |
| "Global cerebral ischemia/reperfusion (GCI/R) injury encompasses complex pathophysiological sequalae, inducing loss of hippocampal neurons and behavioural deficits." | 1.40 | Cholinergic receptor blockade by scopolamine and mecamylamine exacerbates global cerebral ischemia induced memory dysfunction in C57BL/6J mice. ( Katyal, A; Rai, S; Ray, RS, 2014) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (50.00) | 29.6817 |
| 2010's | 1 (50.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Ray, RS | 1 |
| Rai, S | 1 |
| Katyal, A | 1 |
| Lorrio, S | 1 |
| Sobrado, M | 1 |
| Arias, E | 1 |
| Roda, JM | 1 |
| García, AG | 1 |
| López, MG | 1 |
2 other studies available for mecamylamine and Brain Ischemia
| Article | Year |
|---|---|
Cholinergic receptor blockade by scopolamine and mecamylamine exacerbates global cerebral ischemia induced memory dysfunction in C57BL/6J mice.
Topics: Acetylcholinesterase; Animals; Brain Ischemia; Choline O-Acetyltransferase; Cholinergic Antagonists; | 2014 |
Galantamine postischemia provides neuroprotection and memory recovery against transient global cerebral ischemia in gerbils.
Topics: Animals; Apoptosis; Brain Ischemia; Carotid Artery, Common; Caspase 3; Galantamine; Gerbillinae; Hip | 2007 |