mecamylamine has been researched along with Brain Edema in 2 studies
Mecamylamine: A nicotinic antagonist that is well absorbed from the gastrointestinal tract and crosses the blood-brain barrier. Mecamylamine has been used as a ganglionic blocker in treating hypertension, but, like most ganglionic blockers, is more often used now as a research tool.
Brain Edema: Increased intracellular or extracellular fluid in brain tissue. Cytotoxic brain edema (swelling due to increased intracellular fluid) is indicative of a disturbance in cell metabolism, and is commonly associated with hypoxic or ischemic injuries (see HYPOXIA, BRAIN). An increase in extracellular fluid may be caused by increased brain capillary permeability (vasogenic edema), an osmotic gradient, local blockages in interstitial fluid pathways, or by obstruction of CSF flow (e.g., obstructive HYDROCEPHALUS). (From Childs Nerv Syst 1992 Sep; 8(6):301-6)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Rivastigmine (2 mg/kg) reduced cerebral edema by at least 50% (p < 0." | 1.30 | Rivastigmine, a brain-selective acetylcholinesterase inhibitor, ameliorates cognitive and motor deficits induced by closed-head injury in the mouse. ( Chen, Y; Constantini, S; Shohami, E; Weinstock, M, 1998) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (50.00) | 18.7374 |
| 1990's | 1 (50.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Chen, Y | 1 |
| Shohami, E | 1 |
| Constantini, S | 1 |
| Weinstock, M | 1 |
| Griffith, ER | 1 |
| Taylor, N | 1 |
| DeLateur, BJ | 1 |
| Lehmann, JF | 1 |
2 other studies available for mecamylamine and Brain Edema
| Article | Year |
|---|---|
Rivastigmine, a brain-selective acetylcholinesterase inhibitor, ameliorates cognitive and motor deficits induced by closed-head injury in the mouse.
Topics: Animals; Brain Edema; Carbamates; Cholinergic Antagonists; Cholinesterase Inhibitors; Cognition Diso | 1998 |
Orthostatic hypertension following brain trauma: report of a case.
Topics: Adolescent; Brain Edema; Brain Injuries; Follow-Up Studies; Guanethidine; Hematoma, Subdural; Humans | 1971 |