mecamylamine has been researched along with Attention Deficit Disorder with Hyperactivity in 8 studies
Mecamylamine: A nicotinic antagonist that is well absorbed from the gastrointestinal tract and crosses the blood-brain barrier. Mecamylamine has been used as a ganglionic blocker in treating hypertension, but, like most ganglionic blockers, is more often used now as a research tool.
Attention Deficit Disorder with Hyperactivity: A behavior disorder originating in childhood in which the essential features are signs of developmentally inappropriate inattention, impulsivity, and hyperactivity. Although most individuals have symptoms of both inattention and hyperactivity-impulsivity, one or the other pattern may be predominant. The disorder is more frequent in males than females. Onset is in childhood. Symptoms often attenuate during late adolescence although a minority experience the full complement of symptoms into mid-adulthood. (From DSM-V)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Mecamylamine is a non-competitive nicotinic antagonist which is reported in several animal studies to have paradoxical positive effects on cognition at ultra-low doses." | 2.74 | Effects of acute ultra-low dose mecamylamine on cognition in adult attention-deficit/hyperactivity disorder (ADHD). ( Newhouse, PA; Potter, AS; Ryan, KK, 2009) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 4 (50.00) | 29.6817 |
| 2010's | 4 (50.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Buoli, M | 1 |
| Serati, M | 1 |
| Cahn, W | 1 |
| Watterson, E | 1 |
| Spitzer, A | 1 |
| Watterson, LR | 1 |
| Brackney, RJ | 1 |
| Zavala, AR | 1 |
| Olive, MF | 1 |
| Sanabria, F | 1 |
| Potter, AS | 2 |
| Ryan, KK | 2 |
| Newhouse, PA | 1 |
| Levin, ED | 1 |
| Bushnell, PJ | 1 |
| Rezvani, AH | 1 |
| Dube, SL | 1 |
| Shytle, RD | 1 |
| Silver, AA | 1 |
| Sheehan, KH | 1 |
| Sheehan, DV | 1 |
| Sanberg, PR | 1 |
| Singh, A | 1 |
| Das, DK | 1 |
| Kelley, ME | 1 |
| Ueno, K | 1 |
| Togashi, H | 1 |
| Matsumoto, M | 1 |
| Ohashi, S | 1 |
| Saito, H | 1 |
| Yoshioka, M | 1 |
2 reviews available for mecamylamine and Attention Deficit Disorder with Hyperactivity
| Article | Year |
|---|---|
Alternative pharmacological strategies for adult ADHD treatment: a systematic review.
Topics: Adrenergic alpha-Agonists; Adult; Amphetamines; Antidepressive Agents; Attention Deficit Disorder wi | 2016 |
Attention-modulating effects of cognitive enhancers.
Topics: Animals; Attention; Attention Deficit Disorder with Hyperactivity; Behavior, Animal; Disease Models, | 2011 |
3 trials available for mecamylamine and Attention Deficit Disorder with Hyperactivity
| Article | Year |
|---|---|
Effects of acute ultra-low dose mecamylamine on cognition in adult attention-deficit/hyperactivity disorder (ADHD).
Topics: Adolescent; Affect; Attention Deficit Disorder with Hyperactivity; Behavior; Choice Behavior; Cognit | 2009 |
Rate dependent effects of acute nicotine on risk taking in young adults are not related to ADHD diagnosis.
Topics: Administration, Cutaneous; Adolescent; Adult; Attention Deficit Disorder with Hyperactivity; Double- | 2013 |
Neuronal nicotinic receptor inhibition for treating mood disorders: preliminary controlled evidence with mecamylamine.
Topics: Adolescent; Attention Deficit Disorder with Hyperactivity; Child; Depressive Disorder, Major; Double | 2002 |
3 other studies available for mecamylamine and Attention Deficit Disorder with Hyperactivity
| Article | Year |
|---|---|
Nicotine-induced behavioral sensitization in an adult rat model of attention deficit/hyperactivity disorder (ADHD).
Topics: Animals; Attention Deficit Disorder with Hyperactivity; Behavior, Animal; Disease Models, Animal; Lo | 2016 |
Mecamylamine (Targacept).
Topics: Adolescent; Adult; Animals; Attention Deficit Disorder with Hyperactivity; Child; Dose-Response Rela | 2006 |
Alpha4beta2 nicotinic acetylcholine receptor activation ameliorates impairment of spontaneous alternation behavior in stroke-prone spontaneously hypertensive rats, an animal model of attention deficit hyperactivity disorder.
Topics: alpha7 Nicotinic Acetylcholine Receptor; Animals; Attention Deficit Disorder with Hyperactivity; Beh | 2002 |