mecamylamine has been researched along with Ataxia in 3 studies
Mecamylamine: A nicotinic antagonist that is well absorbed from the gastrointestinal tract and crosses the blood-brain barrier. Mecamylamine has been used as a ganglionic blocker in treating hypertension, but, like most ganglionic blockers, is more often used now as a research tool.
Ataxia: Impairment of the ability to perform smoothly coordinated voluntary movements. This condition may affect the limbs, trunk, eyes, pharynx, larynx, and other structures. Ataxia may result from impaired sensory or motor function. Sensory ataxia may result from posterior column injury or PERIPHERAL NERVE DISEASES. Motor ataxia may be associated with CEREBELLAR DISEASES; CEREBRAL CORTEX diseases; THALAMIC DISEASES; BASAL GANGLIA DISEASES; injury to the RED NUCLEUS; and other conditions.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Clinical studies have reported that the nicotinic receptor agonist varenicline improves balance and coordination in patients with several types of ataxia, but confirmation in an animal model has not been demonstrated." | 3.79 | Neuronal nicotinic receptor agonists improve gait and balance in olivocerebellar ataxia. ( Antilla, JC; Bickford, PC; Engberg, ME; Hudson, CE; Kang, CW; Lambert, CS; Philpot, RM; Rowell, PP; Wecker, L; Zesiewicz, TA, 2013) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (33.33) | 18.7374 |
| 1990's | 1 (33.33) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (33.33) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Wecker, L | 1 |
| Engberg, ME | 1 |
| Philpot, RM | 1 |
| Lambert, CS | 1 |
| Kang, CW | 1 |
| Antilla, JC | 1 |
| Bickford, PC | 1 |
| Hudson, CE | 1 |
| Zesiewicz, TA | 1 |
| Rowell, PP | 1 |
| Dilts, SL | 1 |
| Smith, KM | 1 |
| Mitchell, SN | 1 |
| Joseph, MH | 1 |
3 other studies available for mecamylamine and Ataxia
| Article | Year |
|---|---|
Neuronal nicotinic receptor agonists improve gait and balance in olivocerebellar ataxia.
Topics: Animals; Ataxia; Benzazepines; Cerebellum; Dose-Response Relationship, Drug; Gait; Male; Mecamylamin | 2013 |
Berry CA: Effect of cholinergic drugs on passive avoidance in the mouse.
Topics: Animals; Ataxia; Atropine; Avoidance Learning; Galvanic Skin Response; Locomotion; Male; Mecamylamin | 1967 |
Effects of chronic and subchronic nicotine on tyrosine hydroxylase activity in noradrenergic and dopaminergic neurones in the rat brain.
Topics: Animals; Ataxia; Brain; Dopamine; Drug Administration Schedule; Hexamethonium; Hexamethonium Compoun | 1991 |