mecamylamine has been researched along with Anesthesia in 17 studies
Mecamylamine: A nicotinic antagonist that is well absorbed from the gastrointestinal tract and crosses the blood-brain barrier. Mecamylamine has been used as a ganglionic blocker in treating hypertension, but, like most ganglionic blockers, is more often used now as a research tool.
Anesthesia: A state characterized by loss of feeling or sensation. This depression of nerve function is usually the result of pharmacologic action and is induced to allow performance of surgery or other painful procedures.
| Excerpt | Relevance | Reference |
|---|---|---|
| ") nicotine on the single unit activity of midbrain dopamine (DA) neurons was studied in rats under either local or general anesthesia." | 3.67 | Preferential stimulation of ventral tegmental area dopaminergic neurons by nicotine. ( Boi, V; Gessa, GL; Mereu, G; Naes, L; Westfall, TC; Yoon, KW, 1987) |
| "Pretreatment with mecamylamine (ganglionic blocker, 10 mg/kg i." | 1.34 | Vasodilator mechanism of intermedin/adrenomedullin-2 in anesthetized rats. ( Abdelrahman, AM; Pang, CC, 2007) |
| "Mecamylamine is a well-described non specific antagonist of nicotinic acetylcholine receptors (nAChRs), used in therapy and in psychopharmacological studies." | 1.33 | Evaluation in rats and primates of [11C]-mecamylamine, a potential nicotinic acetylcholine receptor radioligand for positron emission tomography. ( Barré, L; Camsonne, R; Chazalviel, L; Debruyne, D; Dhilly, M; Kakiuchi, T; Sobrio, F; Tsukada, H, 2005) |
| "Nicotine responses were completely blocked by prior sequential microinjections of alpha-BT and mecamylamine into the NTS." | 1.31 | Receptor subtypes mediating depressor responses to microinjections of nicotine into medial NTS of the rat. ( Dhar, S; McIntosh, JM; Nagy, F; Sapru, HN, 2000) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 10 (58.82) | 18.7374 |
| 1990's | 2 (11.76) | 18.2507 |
| 2000's | 5 (29.41) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Abdelrahman, AM | 2 |
| Pang, CC | 2 |
| PAYNE, JP | 1 |
| HUEGIN, W | 1 |
| Sobrio, F | 1 |
| Debruyne, D | 1 |
| Dhilly, M | 1 |
| Chazalviel, L | 1 |
| Camsonne, R | 1 |
| Kakiuchi, T | 1 |
| Tsukada, H | 1 |
| Barré, L | 1 |
| Feniuk, W | 1 |
| Hare, J | 1 |
| Humphrey, PP | 1 |
| Mitchell, SN | 1 |
| Kinney, GG | 1 |
| Dhar, S | 1 |
| Nagy, F | 1 |
| McIntosh, JM | 1 |
| Sapru, HN | 1 |
| Inoue, H | 1 |
| Yano, K | 1 |
| Ikeo, T | 1 |
| Noto, T | 1 |
| Kikkawa, K | 1 |
| Cosnier, D | 1 |
| Duchene-Marullaz, P | 1 |
| Grimal, J | 1 |
| Rispat, G | 1 |
| Streichenberger, G | 1 |
| Cao, WH | 1 |
| Inanami, O | 1 |
| Sato, A | 1 |
| Sato, Y | 1 |
| Sloan, JW | 1 |
| Martin, WR | 1 |
| Bostwick, M | 1 |
| Mereu, G | 1 |
| Yoon, KW | 1 |
| Boi, V | 1 |
| Gessa, GL | 1 |
| Naes, L | 1 |
| Westfall, TC | 1 |
| Antonaccio, MJ | 1 |
| Hatch, RC | 1 |
| McCance, I | 1 |
| Phillis, JW | 1 |
1 review available for mecamylamine and Anesthesia
| Article | Year |
|---|---|
[PROBLEMS OF ANESTHESIA IN PATIENTS UNDER TREATMENT OF HYPERTENSION].
Topics: Anesthesia; Antihypertensive Agents; Bretylium Compounds; Cardiovascular Diseases; Chlorothiazide; C | 1963 |
16 other studies available for mecamylamine and Anesthesia
| Article | Year |
|---|---|
Vasodilator mechanism of intermedin/adrenomedullin-2 in anesthetized rats.
Topics: Adrenomedullin; Anesthesia; Animals; Arginine; Blood Pressure; Enzyme Inhibitors; Heart Rate; Indome | 2007 |
The influence of mecamylamine on the action of certain other ganglionic blocking agents.
Topics: Anesthesia; Anesthesia, Local; Anesthesiology; Autonomic Agents; Autonomic Nervous System; Ganglioni | 1957 |
Evaluation in rats and primates of [11C]-mecamylamine, a potential nicotinic acetylcholine receptor radioligand for positron emission tomography.
Topics: Anesthesia; Anesthetics; Animals; Binding Sites; Binding, Competitive; Blood-Brain Barrier; Brain; C | 2005 |
An analysis of the mechanism of 5-hydroxytryptamine-induced vasopressor responses in ganglion-blocked anaesthetized dogs.
Topics: Adrenalectomy; Anesthesia; Animals; Blood Pressure; Catecholamines; Cyproheptadine; Dogs; Dose-Respo | 1981 |
Role of the locus coeruleus in the noradrenergic response to a systemic administration of nicotine.
Topics: Amino Acids; Anesthesia; Animals; Chromatography, High Pressure Liquid; Extracellular Space; Hippoca | 1993 |
Peripheral nicotine administration increases rubral firing rates in the urethane-anesthetized rat.
Topics: Anesthesia; Animals; Deoxyglucose; Dose-Response Relationship, Drug; Electrophysiology; Glucose; Mal | 1995 |
Receptor subtypes mediating depressor responses to microinjections of nicotine into medial NTS of the rat.
Topics: alpha7 Nicotinic Acetylcholine Receptor; Anesthesia; Animals; Blood Pressure; Bungarotoxins; Calcium | 2000 |
T-1032, a novel specific phosphodiesterase type 5 inhibitor, increases venous compliance in anesthetized rats.
Topics: Anesthesia; Animals; Blood Pressure; Diltiazem; Dose-Response Relationship, Drug; Ganglionic Blocker | 2001 |
Involvement of the nitric oxide/L-arginine and sympathetic nervous systems on the vasodepressor action of human urotensin II in anesthetized rats.
Topics: Adrenergic beta-Antagonists; Anesthesia; Animals; Arginine; Blood Pressure; Dose-Response Relationsh | 2002 |
Pharmacological properties of 2-(2-chloro-p-toluidino)-2-imidazoline-nitrate (Tolonidine), a new antihypertensive agent. I. Action on blood pressure and heart rate.
Topics: Anesthesia; Animals; Antihypertensive Agents; Blood Pressure; Cats; Clonidine; Dogs; Dose-Response R | 1975 |
Stimulation of the septal complex increases local cerebral blood flow in the hippocampus in anesthetized rats.
Topics: Anesthesia; Animals; Cerebrovascular Circulation; Electric Stimulation; Glutamates; Glutamic Acid; H | 1989 |
Mechanisms involved in the respiratory depressant actions of nicotine in anesthetized rats.
Topics: Anesthesia; Animals; Female; Hexamethonium; Hexamethonium Compounds; Mecamylamine; Naltrexone; Nicot | 1989 |
Preferential stimulation of ventral tegmental area dopaminergic neurons by nicotine.
Topics: Action Potentials; Anesthesia; Animals; Apomorphine; Dopamine; Male; Mecamylamine; Neurons; Nicotine | 1987 |
Paradoxical vagal tachycardia in ganglion-blocked anesthetized dogs.
Topics: Adrenergic beta-Antagonists; Anesthesia; Animals; Atropine; Blood Pressure; Bretylium Compounds; Chl | 1974 |
Ketamine catalepsy and anesthesia in dogs pretreated with antiserotonergic or antidopaminergic neuroleptics or with anticholinergic agents.
Topics: Anesthesia; Animals; Atropine; Catalepsy; Chlorpromazine; Dibenzothiepins; Dihydroxyphenylalanine; D | 1974 |
The action of acetylcholine on cells in cat cerebellar cortex.
Topics: Acetylcholine; Anesthesia; Animals; Cats; Cerebellar Cortex; Cholinesterase Inhibitors; Electrophysi | 1964 |