mecamylamine has been researched along with Amnesia in 12 studies
Mecamylamine: A nicotinic antagonist that is well absorbed from the gastrointestinal tract and crosses the blood-brain barrier. Mecamylamine has been used as a ganglionic blocker in treating hypertension, but, like most ganglionic blockers, is more often used now as a research tool.
Amnesia: Pathologic partial or complete loss of the ability to recall past experiences (AMNESIA, RETROGRADE) or to form new memories (AMNESIA, ANTEROGRADE). This condition may be of organic or psychologic origin. Organic forms of amnesia are usually associated with dysfunction of the DIENCEPHALON or HIPPOCAMPUS. (From Adams et al., Principles of Neurology, 6th ed, pp426-7)
| Excerpt | Relevance | Reference |
|---|---|---|
| "The present study was designed to investigate possible involvement of the central amygdala (CeA) nicotinic acetylcholine (nACh) and 5-hydroxytryptamine 1A (5-HT1A) receptors in the reversal effect of nicotine and 3,4-methylenedioxy-N-methylamphetamine (MDMA or ecstasy) on morphine-induced amnesia." | 7.80 | Central amygdala nicotinic and 5-HT1A receptors mediate the reversal effect of nicotine and MDMA on morphine-induced amnesia. ( Rezayof, A; Tirgar, F; Zarrindast, MR, 2014) |
| "The effects of nicotine on carbon monoxide (CO)-induced amnesia in mice were investigated using a step-down type passive avoidance task." | 7.69 | Nootropic effect of nicotine on carbon monoxide (CO)-induced delayed amnesia in mice. ( Hiramatsu, M; Kameyama, T; Nabeshima, T; Satoh, H, 1994) |
| "The present study was designed to investigate possible involvement of the central amygdala (CeA) nicotinic acetylcholine (nACh) and 5-hydroxytryptamine 1A (5-HT1A) receptors in the reversal effect of nicotine and 3,4-methylenedioxy-N-methylamphetamine (MDMA or ecstasy) on morphine-induced amnesia." | 3.80 | Central amygdala nicotinic and 5-HT1A receptors mediate the reversal effect of nicotine and MDMA on morphine-induced amnesia. ( Rezayof, A; Tirgar, F; Zarrindast, MR, 2014) |
| "The present study evaluated the possible role of nicotinic acetylcholine receptors of the dorsal hippocampus on morphine-induced amnesia and morphine state-dependent memory in adult male Wistar rats." | 3.74 | Involvement of dorsal hippocampal nicotinic receptors in the effect of morphine on memory retrieval in passive avoidance task. ( Khajehpour, L; Rezayof, A; Zarrindast, MR, 2008) |
| "The effects of nicotine on carbon monoxide (CO)-induced amnesia in mice were investigated using a step-down type passive avoidance task." | 3.69 | Nootropic effect of nicotine on carbon monoxide (CO)-induced delayed amnesia in mice. ( Hiramatsu, M; Kameyama, T; Nabeshima, T; Satoh, H, 1994) |
| "Cholestasis was induced by the ligation of the common bile duct." | 1.38 | Possible interaction between opioidergic and cholinergic systems of CA1 in cholestasis-induced amnesia in mice. ( Hoseindoost, S; Nasehi, M; Zarrindast, MR, 2012) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 3 (25.00) | 18.2507 |
| 2000's | 6 (50.00) | 29.6817 |
| 2010's | 3 (25.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Tirgar, F | 1 |
| Rezayof, A | 3 |
| Zarrindast, MR | 5 |
| Nasehi, M | 2 |
| Sharifi, S | 1 |
| Hoseindoost, S | 1 |
| Hsieh, MT | 1 |
| Kuo, LH | 1 |
| Tsai, FH | 1 |
| Wang, WH | 1 |
| Wu, CR | 1 |
| Sapronov, NS | 1 |
| Fedotova, YO | 1 |
| Kuznetsova, NN | 1 |
| Khajehpour, L | 1 |
| Darbandi, N | 1 |
| Hiramatsu, M | 2 |
| Satoh, H | 1 |
| Kameyama, T | 2 |
| Nabeshima, T | 2 |
| Sasaki, M | 1 |
| Manetti, D | 1 |
| Ghelardini, C | 1 |
| Bartolini, A | 1 |
| Bellucci, C | 1 |
| Dei, S | 1 |
| Galeotti, N | 1 |
| Gualtieri, F | 1 |
| Romanelli, MN | 1 |
| Scapecchi, S | 1 |
| Teodori, E | 1 |
| Mohamed, AF | 1 |
| Matsumoto, K | 1 |
| Tabata, K | 1 |
| Takayama, H | 1 |
| Kitajima, M | 1 |
| Watanabe, H | 1 |
| Elrod, K | 1 |
| Buccafusco, JJ | 1 |
12 other studies available for mecamylamine and Amnesia
| Article | Year |
|---|---|
Central amygdala nicotinic and 5-HT1A receptors mediate the reversal effect of nicotine and MDMA on morphine-induced amnesia.
Topics: Amnesia; Animals; Central Amygdaloid Nucleus; Dose-Response Relationship, Drug; Male; Mecamylamine; | 2014 |
Involvement of the cholinergic system of CA1 on harmane-induced amnesia in the step-down passive avoidance test.
Topics: Amnesia; Animals; Anxiety; Avoidance Learning; CA1 Region, Hippocampal; Cholinergic Fibers; Dose-Res | 2012 |
Possible interaction between opioidergic and cholinergic systems of CA1 in cholestasis-induced amnesia in mice.
Topics: Amnesia; Animals; Animals, Outbred Strains; CA1 Region, Hippocampal; Cholestasis; Disease Models, An | 2012 |
Effects of puerarin on scopolamine-, mecamylamine-, p-chloroamphetamine- and dizocilpine-induced inhibitory avoidance performance impairment in rats.
Topics: Amnesia; Animals; Avoidance Learning; Behavior, Animal; Dizocilpine Maleate; Dose-Response Relations | 2002 |
Antiamnestic effect of alpha7-nicotinic receptor agonist RJR-2403 in middle-aged ovariectomized rats with Alzheimer type dementia.
Topics: Acetylcholine; Alzheimer Disease; Amnesia; Animals; Avoidance Learning; Drug Therapy, Combination; E | 2006 |
Involvement of dorsal hippocampal nicotinic receptors in the effect of morphine on memory retrieval in passive avoidance task.
Topics: Amnesia; Analgesics, Opioid; Animals; Behavior, Animal; Conditioning, Psychological; Dose-Response R | 2008 |
Nicotinic acetylcholine receptors of the ventral tegmental area are involved in mediating morphine-state-dependent learning.
Topics: Amnesia; Analgesics, Opioid; Animals; Avoidance Learning; Dose-Response Relationship, Drug; Drug Int | 2008 |
Nootropic effect of nicotine on carbon monoxide (CO)-induced delayed amnesia in mice.
Topics: Amnesia; Animals; Avoidance Learning; Carbon Monoxide Poisoning; Electroshock; Male; Mecamylamine; M | 1994 |
Effects of dynorphin A (1-13) on carbon monoxide-induced delayed amnesia in mice.
Topics: Amnesia; Animals; Carbon Monoxide Poisoning; Dizocilpine Maleate; Dynorphins; Excitatory Amino Acid | 1997 |
Design, synthesis, and preliminary pharmacological evaluation of 1, 4-diazabicyclo[4.3.0]nonan-9-ones as a new class of highly potent nootropic agents.
Topics: Adrenergic alpha-Agonists; Amnesia; Animals; Avoidance Learning; Baclofen; Clonidine; Dose-Response | 2000 |
Effects of Uncaria tomentosa total alkaloid and its components on experimental amnesia in mice: elucidation using the passive avoidance test.
Topics: Alkaloids; Amnesia; Animals; Avoidance Learning; Cat's Claw; Diazepam; Dose-Response Relationship, D | 2000 |
Correlation of the amnestic effects of nicotinic antagonists with inhibition of regional brain acetylcholine synthesis in rats.
Topics: Acetylcholine; Amnesia; Animals; Avoidance Learning; Blood Pressure; Brain; Dose-Response Relationsh | 1991 |