mecamylamine has been researched along with Alcoholism in 9 studies
Mecamylamine: A nicotinic antagonist that is well absorbed from the gastrointestinal tract and crosses the blood-brain barrier. Mecamylamine has been used as a ganglionic blocker in treating hypertension, but, like most ganglionic blockers, is more often used now as a research tool.
Alcoholism: A primary, chronic disease with genetic, psychosocial, and environmental factors influencing its development and manifestations. The disease is often progressive and fatal. It is characterized by impaired control over drinking, preoccupation with the drug alcohol, use of alcohol despite adverse consequences, and distortions in thinking, most notably denial. Each of these symptoms may be continuous or periodic. (Morse & Flavin for the Joint Commission of the National Council on Alcoholism and Drug Dependence and the American Society of Addiction Medicine to Study the Definition and Criteria for the Diagnosis of Alcoholism: in JAMA 1992;268:1012-4)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Individuals had current alcohol dependence (n = 128), had an average age of 48." | 2.87 | Mecamylamine treatment for alcohol dependence: a randomized controlled trial. ( Arias, A; Gueorguieva, R; Jane, JS; Krystal, JH; O'Brien, E; O'Malley, SS; Petrakis, IL; Ralevski, E; Sevarino, KA, 2018) |
| "Mecamylamine is a nicotinic acetylcholine receptor (nAChR) antagonist that was recently used in a clinical trial to treat alcohol use disorder (AUD) in both smokers and non-smokers." | 2.87 | Tobacco use during a clinical trial of mecamylamine for alcohol dependence: Medication effects on smoking and associations with reductions in drinking. ( McKee, SA; Petrakis, IL; Ralevski, E; Roberts, W; Verplaetse, TL, 2018) |
| "Within the PTSD group, combat exposure was associated with increased drinking independent of the severity of PTSD symptoms." | 2.79 | Characteristics and drinking patterns of veterans with alcohol dependence with and without post-traumatic stress disorder. ( Arias, AJ; Fuehrlein, B; Jane, JS; O'Brien, E; Petrakis, IL; Ralevski, E, 2014) |
| "Alcohol dependence and other alcohol use disorders are major public health problems." | 2.48 | Cholinergic receptor system as a target for treating alcohol abuse and dependence. ( Prendergast, MA; Rahman, S, 2012) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (11.11) | 18.2507 |
| 2000's | 1 (11.11) | 29.6817 |
| 2010's | 7 (77.78) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Petrakis, IL | 3 |
| Ralevski, E | 3 |
| Gueorguieva, R | 1 |
| O'Malley, SS | 1 |
| Arias, A | 1 |
| Sevarino, KA | 1 |
| Jane, JS | 2 |
| O'Brien, E | 2 |
| Krystal, JH | 1 |
| Weera, MM | 1 |
| Agim, ZS | 1 |
| Cannon, JR | 1 |
| Chester, JA | 1 |
| Roberts, W | 1 |
| Verplaetse, TL | 1 |
| McKee, SA | 1 |
| Fuehrlein, B | 1 |
| Arias, AJ | 1 |
| Kuzmin, A | 1 |
| Jerlhag, E | 1 |
| Liljequist, S | 1 |
| Engel, J | 1 |
| Chatterjee, S | 1 |
| Bartlett, SE | 1 |
| Bhutada, P | 1 |
| Mundhada, Y | 1 |
| Ghodki, Y | 1 |
| Dixit, P | 1 |
| Umathe, S | 1 |
| Jain, K | 1 |
| Rahman, S | 1 |
| Prendergast, MA | 1 |
| Hodges, H | 1 |
| Allen, Y | 1 |
| Sinden, J | 1 |
| Mitchell, SN | 1 |
| Arendt, T | 1 |
| Lantos, PL | 1 |
| Gray, JA | 1 |
2 reviews available for mecamylamine and Alcoholism
| Article | Year |
|---|---|
Neuronal nicotinic acetylcholine receptors as pharmacotherapeutic targets for the treatment of alcohol use disorders.
Topics: Alcohol-Induced Disorders, Nervous System; Alcoholism; Animals; Benzazepines; Brain; Humans; Mecamyl | 2010 |
Cholinergic receptor system as a target for treating alcohol abuse and dependence.
Topics: Alcohol Deterrents; Alcoholism; Animals; Disease Models, Animal; Humans; Mecamylamine; Molecular Tar | 2012 |
3 trials available for mecamylamine and Alcoholism
| Article | Year |
|---|---|
Mecamylamine treatment for alcohol dependence: a randomized controlled trial.
Topics: Adult; Alcohol Drinking; Alcoholism; Ambulatory Care; Comorbidity; Craving; Double-Blind Method; Fem | 2018 |
Tobacco use during a clinical trial of mecamylamine for alcohol dependence: Medication effects on smoking and associations with reductions in drinking.
Topics: Adult; Alcohol Drinking; Alcoholism; Double-Blind Method; Female; Humans; Male; Mecamylamine; Middle | 2018 |
Characteristics and drinking patterns of veterans with alcohol dependence with and without post-traumatic stress disorder.
Topics: Adolescent; Adrenergic alpha-Antagonists; Adult; Aged; Alcohol Drinking; Alcoholism; Comorbidity; Co | 2014 |
4 other studies available for mecamylamine and Alcoholism
| Article | Year |
|---|---|
Genetic correlations between nicotine reinforcement-related behaviors and propensity toward high or low alcohol preference in two replicate mouse lines.
Topics: Alcoholism; Animals; Biogenic Monoamines; Female; Genotype; Male; Mecamylamine; Mice; Nicotine; Nico | 2019 |
Effects of subunit selective nACh receptors on operant ethanol self-administration and relapse-like ethanol-drinking behavior.
Topics: Aconitine; Administration, Oral; Alcohol Drinking; Alcoholism; Animals; Behavior, Animal; Central Ne | 2009 |
Acquisition, expression, and reinstatement of ethanol-induced conditioned place preference in mice: effects of exposure to stress and modulation by mecamylamine.
Topics: Alcoholism; Animals; Conditioning, Psychological; Ethanol; Male; Mecamylamine; Mice; Motor Activity; | 2012 |
The effects of cholinergic drugs and cholinergic-rich foetal neural transplants on alcohol-induced deficits in radial maze performance in rats.
Topics: Acetylcholine; Alcohol Drinking; Alcoholism; Animals; Brain Mapping; Brain Tissue Transplantation; C | 1991 |