mecamylamine has been researched along with Alcohol Drinking in 16 studies
Mecamylamine: A nicotinic antagonist that is well absorbed from the gastrointestinal tract and crosses the blood-brain barrier. Mecamylamine has been used as a ganglionic blocker in treating hypertension, but, like most ganglionic blockers, is more often used now as a research tool.
Alcohol Drinking: Behaviors associated with the ingesting of ALCOHOLIC BEVERAGES, including social drinking.
| Excerpt | Relevance | Reference |
|---|---|---|
| " We have performed a dose-response study for intrahippocampal nicotine (CA1) on acquisition and extinction of the lever-press response and antagonization test by co-administration of mecamylamine." | 5.33 | Intrahippocampal nicotine in alcohol drinking rats--effects on lever-press response. ( Darbra, S; Ferré, N; García-Rebollo, Y, 2005) |
| "Individuals had current alcohol dependence (n = 128), had an average age of 48." | 2.87 | Mecamylamine treatment for alcohol dependence: a randomized controlled trial. ( Arias, A; Gueorguieva, R; Jane, JS; Krystal, JH; O'Brien, E; O'Malley, SS; Petrakis, IL; Ralevski, E; Sevarino, KA, 2018) |
| "Mecamylamine is a nicotinic acetylcholine receptor (nAChR) antagonist that was recently used in a clinical trial to treat alcohol use disorder (AUD) in both smokers and non-smokers." | 2.87 | Tobacco use during a clinical trial of mecamylamine for alcohol dependence: Medication effects on smoking and associations with reductions in drinking. ( McKee, SA; Petrakis, IL; Ralevski, E; Roberts, W; Verplaetse, TL, 2018) |
| "Within the PTSD group, combat exposure was associated with increased drinking independent of the severity of PTSD symptoms." | 2.79 | Characteristics and drinking patterns of veterans with alcohol dependence with and without post-traumatic stress disorder. ( Arias, AJ; Fuehrlein, B; Jane, JS; O'Brien, E; Petrakis, IL; Ralevski, E, 2014) |
| " We have performed a dose-response study for intrahippocampal nicotine (CA1) on acquisition and extinction of the lever-press response and antagonization test by co-administration of mecamylamine." | 1.33 | Intrahippocampal nicotine in alcohol drinking rats--effects on lever-press response. ( Darbra, S; Ferré, N; García-Rebollo, Y, 2005) |
| " The lack of a clear dose-response relationship for the agonist and the antagonist indicates that the interaction between the NAc nicotinic system and ETOH self-administration is complex." | 1.30 | Effects of nicotine and mecamylamine microinjections into the nucleus accumbens on ethanol and sucrose self-administration. ( Chappell, AM; Nadal, R; Samson, HH, 1998) |
| "Nicotine was seen to produce a dose-dependent increase in ethanol drinking behavior which commenced at the 5% ethanol concentration and continued at 8% and again at 10%." | 1.30 | Exposure to nicotine enhances acquisition of ethanol drinking by laboratory rats in a limited access paradigm. ( Amit, Z; Gaskin, S; Horan, JT; Smith, BR, 1999) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 5 (31.25) | 18.2507 |
| 2000's | 7 (43.75) | 29.6817 |
| 2010's | 4 (25.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Petrakis, IL | 3 |
| Ralevski, E | 3 |
| Gueorguieva, R | 1 |
| O'Malley, SS | 1 |
| Arias, A | 1 |
| Sevarino, KA | 1 |
| Jane, JS | 2 |
| O'Brien, E | 2 |
| Krystal, JH | 1 |
| Roberts, W | 1 |
| Verplaetse, TL | 1 |
| McKee, SA | 1 |
| Fuehrlein, B | 1 |
| Arias, AJ | 1 |
| Maddux, JN | 1 |
| Chaudhri, N | 1 |
| Kuzmin, A | 1 |
| Jerlhag, E | 1 |
| Liljequist, S | 1 |
| Engel, J | 1 |
| Farook, JM | 1 |
| Lewis, B | 1 |
| Gaddis, JG | 1 |
| Littleton, JM | 1 |
| Barron, S | 1 |
| Ford, MM | 1 |
| Fretwell, AM | 1 |
| Nickel, JD | 1 |
| Mark, GP | 1 |
| Strong, MN | 1 |
| Yoneyama, N | 1 |
| Finn, DA | 1 |
| Chi, H | 2 |
| de Wit, H | 2 |
| García-Rebollo, Y | 1 |
| Darbra, S | 1 |
| Ferré, N | 1 |
| Young, EM | 1 |
| Mahler, S | 1 |
| Katner, SN | 1 |
| McBride, WJ | 1 |
| Lumeng, L | 1 |
| Li, TK | 2 |
| Murphy, JM | 1 |
| Nadal, R | 1 |
| Chappell, AM | 1 |
| Samson, HH | 1 |
| Ericson, M | 1 |
| Blomqvist, O | 1 |
| Engel, JA | 1 |
| Söderpalm, B | 1 |
| Smith, BR | 1 |
| Horan, JT | 1 |
| Gaskin, S | 1 |
| Amit, Z | 1 |
| Lê, AD | 1 |
| Corrigall, WA | 1 |
| Harding, JW | 1 |
| Juzytsch, W | 1 |
| Hodges, H | 1 |
| Allen, Y | 1 |
| Sinden, J | 1 |
| Mitchell, SN | 1 |
| Arendt, T | 1 |
| Lantos, PL | 1 |
| Gray, JA | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Does Varenicline Influence Alcohol Consumption in Alcohol Dependent Individuals?[NCT00846859] | Phase 2 | 162 participants (Actual) | Interventional | 2009-03-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
5 trials available for mecamylamine and Alcohol Drinking
| Article | Year |
|---|---|
Mecamylamine treatment for alcohol dependence: a randomized controlled trial.
Topics: Adult; Alcohol Drinking; Alcoholism; Ambulatory Care; Comorbidity; Craving; Double-Blind Method; Fem | 2018 |
Tobacco use during a clinical trial of mecamylamine for alcohol dependence: Medication effects on smoking and associations with reductions in drinking.
Topics: Adult; Alcohol Drinking; Alcoholism; Double-Blind Method; Female; Humans; Male; Mecamylamine; Middle | 2018 |
Characteristics and drinking patterns of veterans with alcohol dependence with and without post-traumatic stress disorder.
Topics: Adolescent; Adrenergic alpha-Antagonists; Adult; Aged; Alcohol Drinking; Alcoholism; Comorbidity; Co | 2014 |
Mecamylamine attenuates the subjective stimulant-like effects of alcohol in social drinkers.
Topics: Adult; Alcohol Drinking; Blood Pressure; Double-Blind Method; Drug Interactions; Ethanol; Female; He | 2003 |
Mecamylamine and ethanol preference in healthy volunteers.
Topics: Adult; Affect; Alcohol Drinking; Choice Behavior; Double-Blind Method; Ethanol; Female; Heart Rate; | 2005 |
11 other studies available for mecamylamine and Alcohol Drinking
| Article | Year |
|---|---|
Nicotine-induced enhancement of Pavlovian alcohol-seeking behavior in rats.
Topics: Alcohol Drinking; Animals; Conditioning, Classical; Cues; Drug-Seeking Behavior; Male; Mecamylamine; | 2017 |
Effects of subunit selective nACh receptors on operant ethanol self-administration and relapse-like ethanol-drinking behavior.
Topics: Aconitine; Administration, Oral; Alcohol Drinking; Alcoholism; Animals; Behavior, Animal; Central Ne | 2009 |
Effects of mecamylamine on alcohol consumption and preference in male C57BL/6J mice.
Topics: Alcohol Drinking; Animals; Choice Behavior; Disease Models, Animal; Drinking; Drug Evaluation, Precl | 2009 |
The influence of mecamylamine on ethanol and sucrose self-administration.
Topics: Alcohol Drinking; Analysis of Variance; Animals; Choice Behavior; Conditioning, Operant; Dose-Respon | 2009 |
Intrahippocampal nicotine in alcohol drinking rats--effects on lever-press response.
Topics: Alcohol Drinking; Analysis of Variance; Animals; Behavior, Animal; Conditioning, Operant; Dose-Respo | 2005 |
Effects of cholinergic agents on locomotor activity of P and NP rats.
Topics: Alcohol Drinking; Animals; Arousal; Brain; Cholinergic Agents; Dose-Response Relationship, Drug; Fem | 1996 |
Effects of nicotine and mecamylamine microinjections into the nucleus accumbens on ethanol and sucrose self-administration.
Topics: Acetylcholine; Alcohol Drinking; Animals; Dopamine; Dose-Response Relationship, Drug; Male; Mecamyla | 1998 |
Voluntary ethanol intake in the rat and the associated accumbal dopamine overflow are blocked by ventral tegmental mecamylamine.
Topics: Alcohol Drinking; Animals; Dopamine; Extracellular Space; Male; Mecamylamine; Microdialysis; Nicotin | 1998 |
Exposure to nicotine enhances acquisition of ethanol drinking by laboratory rats in a limited access paradigm.
Topics: Alcohol Drinking; Analysis of Variance; Animals; Male; Mecamylamine; Nicotine; Rats; Rats, Wistar; R | 1999 |
Involvement of nicotinic receptors in alcohol self-administration.
Topics: Alcohol Drinking; Animals; Conditioning, Operant; Dihydro-beta-Erythroidine; Male; Mecamylamine; Nic | 2000 |
The effects of cholinergic drugs and cholinergic-rich foetal neural transplants on alcohol-induced deficits in radial maze performance in rats.
Topics: Acetylcholine; Alcohol Drinking; Alcoholism; Animals; Brain Mapping; Brain Tissue Transplantation; C | 1991 |