Page last updated: 2024-10-30

mecamylamine and Aging

mecamylamine has been researched along with Aging in 15 studies

Mecamylamine: A nicotinic antagonist that is well absorbed from the gastrointestinal tract and crosses the blood-brain barrier. Mecamylamine has been used as a ganglionic blocker in treating hypertension, but, like most ganglionic blockers, is more often used now as a research tool.

Aging: The gradual irreversible changes in structure and function of an organism that occur as a result of the passage of time.

Research Excerpts

ExcerptRelevanceReference
" Although adolescents may exhibit a greater susceptibility to nicotine addiction, relatively little is known about the influence of the aversive effects of nicotine withdrawal in maintaining smoking behavior."3.74Interactions between age and the aversive effects of nicotine withdrawal under mecamylamine-precipitated and spontaneous conditions in male Wistar rats. ( Lê, AD; Li, Z; Shram, MJ; Siu, EC; Tyndale, RF, 2008)
" We compared nicotinic autoreceptor function (NAF) during maturation and aging and evaluated its potential modulation by the common OP insecticide, chlorpyrifos (CPF)."3.72Nicotinic autoreceptor function in rat brain during maturation and aging: possible differential sensitivity to organophosphorus anticholinesterases. ( Harp, P; Pope, CN; Wu, YJ; Yan, XR, 2003)
"We investigated the effect of nicotine, a nicotinic agonist, and D-cycloserine (DCS, a partial glycine-B agonist of the N-methyl-D-aspartate (NMDA) receptor complex) on aging-induced defects of water maze (WM) spatial navigation in rats."3.69Nicotine and D-cycloserine enhance acquisition of water maze spatial navigation in aged rats. ( Riekkinen, M; Riekkinen, P, 1997)

Research

Studies (15)

TimeframeStudies, this research(%)All Research%
pre-19901 (6.67)18.7374
1990's4 (26.67)18.2507
2000's4 (26.67)29.6817
2010's6 (40.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Rashid, H1
Mahboob, A1
Ahmed, T1
Uchida, S2
Kagitani, F2
Christensen, MH1
Kohlmeier, KA1
Tajik, A1
Rezayof, A1
Ghasemzadeh, Z1
Sardari, M1
Hotta, H1
Kondo, M1
Natividad, LA1
Tejeda, HA1
Torres, OV1
O'Dell, LE1
Morishita, H1
Miwa, JM1
Heintz, N1
Hensch, TK1
Wu, YJ1
Harp, P1
Yan, XR1
Pope, CN1
Dumas, J1
Hancur-Bucci, C1
Naylor, M1
Sites, C1
Newhouse, P1
Shram, MJ1
Siu, EC1
Li, Z1
Tyndale, RF1
Lê, AD1
Jones, DN1
Barnes, JC1
Kirkby, DL1
Higgins, GA1
Levin, ED1
Torry, D1
Riekkinen, M1
Riekkinen, P1
Titmus, MJ1
Tsai, HJ1
Lima, R1
Udin, SB1
Blozovski, D1
Hess, C1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Recovery From Amblyopia With Cholinesterase Inhibitors[NCT01584076]Phase 118 participants (Actual)Interventional2012-08-31Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trials

1 trial available for mecamylamine and Aging

ArticleYear
Estradiol interacts with the cholinergic system to affect verbal memory in postmenopausal women: evidence for the critical period hypothesis.
    Hormones and behavior, 2008, Volume: 53, Issue:1

    Topics: Aged; Aged, 80 and over; Aging; Analysis of Variance; Cholinergic Antagonists; Cognition; Critical P

2008

Other Studies

14 other studies available for mecamylamine and Aging

ArticleYear
Role of cholinergic receptors in memory retrieval depends on gender and age of memory.
    Behavioural brain research, 2017, 07-28, Volume: 331

    Topics: Aging; Animals; Cholinergic Agents; Fear; Female; Male; Maze Learning; Mecamylamine; Memory, Short-T

2017
Effect of acupuncture-like stimulation on cortical cerebral blood flow in aged rats.
    The journal of physiological sciences : JPS, 2015, Volume: 65, Issue:1

    Topics: Acetylcholine; Acupuncture Therapy; Afferent Pathways; Aging; Animals; Atropine; Blood Pressure; Cer

2015
Age-related changes in functional postsynaptic nicotinic acetylcholine receptor subunits in neurons of the laterodorsal tegmental nucleus, a nucleus important in drug addiction.
    Addiction biology, 2016, Volume: 21, Issue:2

    Topics: Acetylcholine; Aging; Animals; In Vitro Techniques; Mecamylamine; Membrane Potentials; Mice; Nerve T

2016
Activation of the dorsal hippocampal nicotinic acetylcholine receptors improves tamoxifen-induced memory retrieval impairment in adult female rats.
    Neuroscience, 2016, 07-07, Volume: 327

    Topics: Aging; Animals; Avoidance Learning; Female; Hippocampus; Mecamylamine; Memory; Memory Disorders; Nic

2016
Basal forebrain stimulation induces NGF secretion in ipsilateral parietal cortex via nicotinic receptor activation in adult, but not aged rats.
    Neuroscience research, 2009, Volume: 63, Issue:2

    Topics: Aging; Animals; Atropine; Dose-Response Relationship, Drug; Functional Laterality; Male; Mecamylamin

2009
Nicotine withdrawal produces a decrease in extracellular levels of dopamine in the nucleus accumbens that is lower in adolescent versus adult male rats.
    Synapse (New York, N.Y.), 2010, Volume: 64, Issue:2

    Topics: 3,4-Dihydroxyphenylacetic Acid; Aging; Animals; Bicuculline; Dopamine; Extracellular Space; GABA Ant

2010
Lynx1, a cholinergic brake, limits plasticity in adult visual cortex.
    Science (New York, N.Y.), 2010, Nov-26, Volume: 330, Issue:6008

    Topics: Adaptor Proteins, Signal Transducing; Aging; Amblyopia; Animals; Cholinesterase Inhibitors; Dominanc

2010
Nicotinic autoreceptor function in rat brain during maturation and aging: possible differential sensitivity to organophosphorus anticholinesterases.
    Chemico-biological interactions, 2003, Jan-06, Volume: 142, Issue:3

    Topics: Acetylcholine; Aging; Animals; Animals, Newborn; Atropine; Brain; Chlorpyrifos; Cholinesterase Inhib

2003
Interactions between age and the aversive effects of nicotine withdrawal under mecamylamine-precipitated and spontaneous conditions in male Wistar rats.
    Psychopharmacology, 2008, Volume: 198, Issue:2

    Topics: Aging; Animals; Avoidance Learning; Conditioning, Operant; Dose-Response Relationship, Drug; Injecti

2008
Age-associated impairments in a test of attention: evidence for involvement of cholinergic systems.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 1995, Volume: 15, Issue:11

    Topics: Aging; Animals; Attention; Behavior, Animal; Cholinergic Agents; Exploratory Behavior; Male; Mecamyl

1995
Acute and chronic nicotine effects on working memory in aged rats.
    Psychopharmacology, 1996, Volume: 123, Issue:1

    Topics: Age Factors; Aging; Animals; Dose-Response Relationship, Drug; Haloperidol; Male; Maze Learning; Mec

1996
Nicotine and D-cycloserine enhance acquisition of water maze spatial navigation in aged rats.
    Neuroreport, 1997, Feb-10, Volume: 8, Issue:3

    Topics: Aging; Analysis of Variance; Animals; Cycloserine; Excitatory Amino Acid Antagonists; Male; Maze Lea

1997
Effects of choline and other nicotinic agonists on the tectum of juvenile and adult Xenopus frogs: a patch-clamp study.
    Neuroscience, 1999, Volume: 91, Issue:2

    Topics: Aging; Alkaloids; Animals; Axons; Azocines; Carbachol; Choline; Excitatory Postsynaptic Potentials;

1999
Hippocampal nicotinic cholinergic mechanisms mediate spontaneous alternation and fear during ontogenesis but not later in the rat.
    Behavioural brain research, 1989, Dec-01, Volume: 35, Issue:3

    Topics: Aging; Animals; Behavior, Animal; Cholinergic Fibers; Fear; Female; Hexamethonium; Hexamethonium Com

1989