mecamylamine has been researched along with Aging in 15 studies
Mecamylamine: A nicotinic antagonist that is well absorbed from the gastrointestinal tract and crosses the blood-brain barrier. Mecamylamine has been used as a ganglionic blocker in treating hypertension, but, like most ganglionic blockers, is more often used now as a research tool.
Aging: The gradual irreversible changes in structure and function of an organism that occur as a result of the passage of time.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Although adolescents may exhibit a greater susceptibility to nicotine addiction, relatively little is known about the influence of the aversive effects of nicotine withdrawal in maintaining smoking behavior." | 3.74 | Interactions between age and the aversive effects of nicotine withdrawal under mecamylamine-precipitated and spontaneous conditions in male Wistar rats. ( Lê, AD; Li, Z; Shram, MJ; Siu, EC; Tyndale, RF, 2008) |
| " We compared nicotinic autoreceptor function (NAF) during maturation and aging and evaluated its potential modulation by the common OP insecticide, chlorpyrifos (CPF)." | 3.72 | Nicotinic autoreceptor function in rat brain during maturation and aging: possible differential sensitivity to organophosphorus anticholinesterases. ( Harp, P; Pope, CN; Wu, YJ; Yan, XR, 2003) |
| "We investigated the effect of nicotine, a nicotinic agonist, and D-cycloserine (DCS, a partial glycine-B agonist of the N-methyl-D-aspartate (NMDA) receptor complex) on aging-induced defects of water maze (WM) spatial navigation in rats." | 3.69 | Nicotine and D-cycloserine enhance acquisition of water maze spatial navigation in aged rats. ( Riekkinen, M; Riekkinen, P, 1997) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (6.67) | 18.7374 |
| 1990's | 4 (26.67) | 18.2507 |
| 2000's | 4 (26.67) | 29.6817 |
| 2010's | 6 (40.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Rashid, H | 1 |
| Mahboob, A | 1 |
| Ahmed, T | 1 |
| Uchida, S | 2 |
| Kagitani, F | 2 |
| Christensen, MH | 1 |
| Kohlmeier, KA | 1 |
| Tajik, A | 1 |
| Rezayof, A | 1 |
| Ghasemzadeh, Z | 1 |
| Sardari, M | 1 |
| Hotta, H | 1 |
| Kondo, M | 1 |
| Natividad, LA | 1 |
| Tejeda, HA | 1 |
| Torres, OV | 1 |
| O'Dell, LE | 1 |
| Morishita, H | 1 |
| Miwa, JM | 1 |
| Heintz, N | 1 |
| Hensch, TK | 1 |
| Wu, YJ | 1 |
| Harp, P | 1 |
| Yan, XR | 1 |
| Pope, CN | 1 |
| Dumas, J | 1 |
| Hancur-Bucci, C | 1 |
| Naylor, M | 1 |
| Sites, C | 1 |
| Newhouse, P | 1 |
| Shram, MJ | 1 |
| Siu, EC | 1 |
| Li, Z | 1 |
| Tyndale, RF | 1 |
| Lê, AD | 1 |
| Jones, DN | 1 |
| Barnes, JC | 1 |
| Kirkby, DL | 1 |
| Higgins, GA | 1 |
| Levin, ED | 1 |
| Torry, D | 1 |
| Riekkinen, M | 1 |
| Riekkinen, P | 1 |
| Titmus, MJ | 1 |
| Tsai, HJ | 1 |
| Lima, R | 1 |
| Udin, SB | 1 |
| Blozovski, D | 1 |
| Hess, C | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Recovery From Amblyopia With Cholinesterase Inhibitors[NCT01584076] | Phase 1 | 18 participants (Actual) | Interventional | 2012-08-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 trial available for mecamylamine and Aging
| Article | Year |
|---|---|
Estradiol interacts with the cholinergic system to affect verbal memory in postmenopausal women: evidence for the critical period hypothesis.
Topics: Aged; Aged, 80 and over; Aging; Analysis of Variance; Cholinergic Antagonists; Cognition; Critical P | 2008 |
14 other studies available for mecamylamine and Aging
| Article | Year |
|---|---|
Role of cholinergic receptors in memory retrieval depends on gender and age of memory.
Topics: Aging; Animals; Cholinergic Agents; Fear; Female; Male; Maze Learning; Mecamylamine; Memory, Short-T | 2017 |
Effect of acupuncture-like stimulation on cortical cerebral blood flow in aged rats.
Topics: Acetylcholine; Acupuncture Therapy; Afferent Pathways; Aging; Animals; Atropine; Blood Pressure; Cer | 2015 |
Age-related changes in functional postsynaptic nicotinic acetylcholine receptor subunits in neurons of the laterodorsal tegmental nucleus, a nucleus important in drug addiction.
Topics: Acetylcholine; Aging; Animals; In Vitro Techniques; Mecamylamine; Membrane Potentials; Mice; Nerve T | 2016 |
Activation of the dorsal hippocampal nicotinic acetylcholine receptors improves tamoxifen-induced memory retrieval impairment in adult female rats.
Topics: Aging; Animals; Avoidance Learning; Female; Hippocampus; Mecamylamine; Memory; Memory Disorders; Nic | 2016 |
Basal forebrain stimulation induces NGF secretion in ipsilateral parietal cortex via nicotinic receptor activation in adult, but not aged rats.
Topics: Aging; Animals; Atropine; Dose-Response Relationship, Drug; Functional Laterality; Male; Mecamylamin | 2009 |
Nicotine withdrawal produces a decrease in extracellular levels of dopamine in the nucleus accumbens that is lower in adolescent versus adult male rats.
Topics: 3,4-Dihydroxyphenylacetic Acid; Aging; Animals; Bicuculline; Dopamine; Extracellular Space; GABA Ant | 2010 |
Lynx1, a cholinergic brake, limits plasticity in adult visual cortex.
Topics: Adaptor Proteins, Signal Transducing; Aging; Amblyopia; Animals; Cholinesterase Inhibitors; Dominanc | 2010 |
Nicotinic autoreceptor function in rat brain during maturation and aging: possible differential sensitivity to organophosphorus anticholinesterases.
Topics: Acetylcholine; Aging; Animals; Animals, Newborn; Atropine; Brain; Chlorpyrifos; Cholinesterase Inhib | 2003 |
Interactions between age and the aversive effects of nicotine withdrawal under mecamylamine-precipitated and spontaneous conditions in male Wistar rats.
Topics: Aging; Animals; Avoidance Learning; Conditioning, Operant; Dose-Response Relationship, Drug; Injecti | 2008 |
Age-associated impairments in a test of attention: evidence for involvement of cholinergic systems.
Topics: Aging; Animals; Attention; Behavior, Animal; Cholinergic Agents; Exploratory Behavior; Male; Mecamyl | 1995 |
Acute and chronic nicotine effects on working memory in aged rats.
Topics: Age Factors; Aging; Animals; Dose-Response Relationship, Drug; Haloperidol; Male; Maze Learning; Mec | 1996 |
Nicotine and D-cycloserine enhance acquisition of water maze spatial navigation in aged rats.
Topics: Aging; Analysis of Variance; Animals; Cycloserine; Excitatory Amino Acid Antagonists; Male; Maze Lea | 1997 |
Effects of choline and other nicotinic agonists on the tectum of juvenile and adult Xenopus frogs: a patch-clamp study.
Topics: Aging; Alkaloids; Animals; Axons; Azocines; Carbachol; Choline; Excitatory Postsynaptic Potentials; | 1999 |
Hippocampal nicotinic cholinergic mechanisms mediate spontaneous alternation and fear during ontogenesis but not later in the rat.
Topics: Aging; Animals; Behavior, Animal; Cholinergic Fibers; Fear; Female; Hexamethonium; Hexamethonium Com | 1989 |