Page last updated: 2024-10-30

mecamylamine and Affective Disorders

mecamylamine has been researched along with Affective Disorders in 2 studies

Mecamylamine: A nicotinic antagonist that is well absorbed from the gastrointestinal tract and crosses the blood-brain barrier. Mecamylamine has been used as a ganglionic blocker in treating hypertension, but, like most ganglionic blockers, is more often used now as a research tool.

Research Excerpts

Excerpt	Relevance	Reference
"Primary efficacy measures included the Tourette's Disorder Scale-Clinician Rated (TODS-CR) and 21-point Clinical Global Improvement scale; secondary efficacy measures included the Yale Global Tic Severity Scale and a rage-attack scale (RAScal)."	2.70	Multicenter, double-blind, placebo-controlled study of mecamylamine monotherapy for Tourette's disorder. ( Ramos, A; Sanberg, PR; Sheehan, DV; Sheehan, KH; Shytle, RD; Silver, AA, 2001)

Research

Studies (2)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	2 (100.00)	29.6817
2010's	0 (0.00)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Marcinkiewcz, CA	1
Prado, MM	1
Isaac, SK	1
Marshall, A	1
Rylkova, D	1
Bruijnzeel, AW	1
Silver, AA	1
Shytle, RD	1
Sheehan, KH	1
Sheehan, DV	1
Ramos, A	1
Sanberg, PR	1

Trials

1 trial available for mecamylamine and Affective Disorders

Article	Year
Multicenter, double-blind, placebo-controlled study of mecamylamine monotherapy for Tourette's disorder. Journal of the American Academy of Child and Adolescent Psychiatry, 2001, Volume: 40, Issue:9 Topics: Adolescent; Child; Comorbidity; Depression; Double-Blind Method; Female; Ganglionic Blockers; Heart	2001

Other Studies

1 other study available for mecamylamine and Affective Disorders

Article	Year
Corticotropin-releasing factor within the central nucleus of the amygdala and the nucleus accumbens shell mediates the negative affective state of nicotine withdrawal in rats. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2009, Volume: 34, Issue:7 Topics: Amygdala; Animals; Corticotropin-Releasing Hormone; Disease Models, Animal; Dose-Response Relationsh	2009

Article

Year

Corticotropin-releasing factor within the central nucleus of the amygdala and the nucleus accumbens shell mediates the negative affective state of nicotine withdrawal in rats.

Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2009, Volume: 34, Issue:7

Topics: Amygdala; Animals; Corticotropin-Releasing Hormone; Disease Models, Animal; Dose-Response Relationsh

2009