mecamylamine has been researched along with Acute Confusional Senile Dementia in 6 studies
Mecamylamine: A nicotinic antagonist that is well absorbed from the gastrointestinal tract and crosses the blood-brain barrier. Mecamylamine has been used as a ganglionic blocker in treating hypertension, but, like most ganglionic blockers, is more often used now as a research tool.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Nefiracetam potentiated alpha4beta2-like ACh- and NMDA-induced currents at nanomolar concentrations forming bell-shaped dose-response curves with the maximum potentiation occurring at 1 and 10 nM, respectively." | 1.32 | Unique mechanism of action of Alzheimer's drugs on brain nicotinic acetylcholine receptors and NMDA receptors. ( Marszalec, W; Moriguchi, S; Narahashi, T; Yeh, JZ; Zhao, X, 2003) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (16.67) | 18.7374 |
| 1990's | 1 (16.67) | 18.2507 |
| 2000's | 3 (50.00) | 29.6817 |
| 2010's | 1 (16.67) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Brown, D | 1 |
| Ramlochansingh, C | 1 |
| Manaye, KF | 1 |
| Tizabi, Y | 1 |
| Narahashi, T | 1 |
| Marszalec, W | 1 |
| Moriguchi, S | 1 |
| Yeh, JZ | 1 |
| Zhao, X | 1 |
| Sapronov, NS | 1 |
| Fedotova, YO | 1 |
| Kuznetsova, NN | 1 |
| Little, JT | 1 |
| Johnson, DN | 1 |
| Minichiello, M | 1 |
| Weingartner, H | 1 |
| Sunderland, T | 1 |
| Ji, D | 1 |
| Lape, R | 1 |
| Dani, JA | 1 |
| Mastropaolo, J | 1 |
| Nadi, NS | 1 |
| Ostrowski, NL | 1 |
| Crawley, JN | 1 |
1 trial available for mecamylamine and Acute Confusional Senile Dementia
| Article | Year |
|---|---|
Combined nicotinic and muscarinic blockade in elderly normal volunteers: cognitive, behavioral, and physiologic responses.
Topics: Aged; Alzheimer Disease; Behavior; Blood Pressure; Brief Psychiatric Rating Scale; Cognition; Drug S | 1998 |
5 other studies available for mecamylamine and Acute Confusional Senile Dementia
| Article | Year |
|---|---|
Nicotine promotes survival of cells expressing amyloid precursor protein and presenilin: implication for Alzheimer's disease.
Topics: Alzheimer Disease; Amyloid beta-Protein Precursor; Animals; Cell Line, Tumor; Cell Survival; Mecamyl | 2013 |
Unique mechanism of action of Alzheimer's drugs on brain nicotinic acetylcholine receptors and NMDA receptors.
Topics: Acetylcholine; Aconitine; Alzheimer Disease; Animals; Brain Chemistry; Bungarotoxins; Dihydro-beta-E | 2003 |
Antiamnestic effect of alpha7-nicotinic receptor agonist RJR-2403 in middle-aged ovariectomized rats with Alzheimer type dementia.
Topics: Acetylcholine; Alzheimer Disease; Amnesia; Animals; Avoidance Learning; Drug Therapy, Combination; E | 2006 |
Timing and location of nicotinic activity enhances or depresses hippocampal synaptic plasticity.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Acetylcholine; alpha7 Nicotinic A | 2001 |
Galanin antagonizes acetylcholine on a memory task in basal forebrain-lesioned rats.
Topics: Acetylcholine; Alzheimer Disease; Animals; Atropine; Brain; Galanin; Injections, Intraventricular; M | 1988 |