Page last updated: 2024-10-30

mecamylamine and Ache

mecamylamine has been researched along with Ache in 52 studies

Mecamylamine: A nicotinic antagonist that is well absorbed from the gastrointestinal tract and crosses the blood-brain barrier. Mecamylamine has been used as a ganglionic blocker in treating hypertension, but, like most ganglionic blockers, is more often used now as a research tool.

Research Excerpts

ExcerptRelevanceReference
" In the present investigation, we used intrathecal administration of drugs to rats to show that muscarinic or nicotinic agonists such as bethanechol (BCh) and dimethylphenylpiperazinium (DM), respectively, dose-dependently increased the tail flick latency and reduced the pain produced by a surgical incision performed on the plantar aspect of a hind paw."7.72Antinociceptive effects of bethanechol or dimethylphenylpiperazinium in models of phasic or incisional pain in rats. ( Prado, WA; Segalla, DK, 2004)
"To assess the possible role of nicotinergic control in nociception and pain, experiments were carried out on rats under urethane anesthesia in which nociceptive activity was elicited by electrical stimulation of afferent C fibers in the sural nerve and recorded from single neurones in the thalamus and from ascending axons in the spinal cord."7.68Depression by nicotine of pain-related nociceptive activity in the rat thalamus and spinal cord. ( Baldauf, J; Jurna, I; Krauss, P, 1993)
") 1 h prior to testing, produced dose-dependent inhibition of acetic acid-induced visceral pain, with ID50 value of 241."3.75Mechanisms involved in the antinociception caused by ethanolic extract obtained from the leaves of Melissa officinalis (lemon balm) in mice. ( Calixto, JB; Chaves, J; Ferreira, VM; Guginski, G; Luiz, AP; Martins, DF; Massaro, M; Mattos, RW; Santos, AR; Silva, MD; Silveira, D, 2009)
"Antinociceptive activity of coniine was tested dose in Hotplate test (thermal pain model) and in Writhing test (chemical pain model) in different nociception models."3.75Antinociceptive activity of coniine in mice. ( Arihan, O; Boz, M; Ilhan, M; Iskit, AB, 2009)
"5, 1, or 2 mg/kg) induced analgesia, with pain scores significantly lower than those seen after saline, lower doses of Sazetidine-A, and epibatidine (P < 0."3.74Analgesic effects of Sazetidine-A, a new nicotinic cholinergic drug. ( Cucchiaro, G; Gonzalez-Sulser, A; Kellar, KJ; Xiao, Y, 2008)
" In the present investigation, we used intrathecal administration of drugs to rats to show that muscarinic or nicotinic agonists such as bethanechol (BCh) and dimethylphenylpiperazinium (DM), respectively, dose-dependently increased the tail flick latency and reduced the pain produced by a surgical incision performed on the plantar aspect of a hind paw."3.72Antinociceptive effects of bethanechol or dimethylphenylpiperazinium in models of phasic or incisional pain in rats. ( Prado, WA; Segalla, DK, 2004)
"Physostigmine has different effects on allodynia and nociception, which suggests that different cholinergic (muscarinic) mechanisms may be involved in neuropathic and nociceptive pain."3.70Systemic physostigmine shows antiallodynic effects in neuropathic rats. ( Kalso, E; Kontinen, VK; Paananen, S; Pöyhiä, R; Xu, M, 1999)
"Nicotine evokes pain in the skin and oral mucosa and excites a subpopulation of cutaneous nociceptors, but little is known about the central transmission of chemogenic pain."3.70Activation of spinal wide dynamic range neurons by intracutaneous microinjection of nicotine. ( Carstens, E; Jinks, SL, 1999)
"To characterize the role of neuronal nicotinic acetylcholine receptors (nAChRs) in oral irritation and pain, we employed the method of c-fos immunohistochemistry to map the locations and numbers of brainstem neurons that express the immediate-early gene, c-fos, after application of nicotine to the tongue, either alone or after pretreatment with cholinergic antagonists."3.70Role of neuronal nicotinic-acetylcholine receptors in the activation of neurons in trigeminal subnucleus caudalis by nicotine delivered to the oral mucosa. ( Carstens, E; Carstens, MI; Dessirier, JM; Jinks, SL; Simons, CT, 2000)
"To assess the possible role of nicotinergic control in nociception and pain, experiments were carried out on rats under urethane anesthesia in which nociceptive activity was elicited by electrical stimulation of afferent C fibers in the sural nerve and recorded from single neurones in the thalamus and from ascending axons in the spinal cord."3.68Depression by nicotine of pain-related nociceptive activity in the rat thalamus and spinal cord. ( Baldauf, J; Jurna, I; Krauss, P, 1993)
"Pretreatment with atropine at 5 mg/kg, but not at 2."1.37Involvement of cholinergic system in suppression of formalin-induced inflammatory pain by cobratoxin. ( Feng, YL; Lin, HM; Liu, YL; Qin, ZH; Reid, PF; Shi, GN; Yang, SL, 2011)
" This hypothesis was further established with methyllycaconitine completely inhibited the agonist effect when dosed intrathecally (1% +/- 7%)."1.35Activation of the alpha7-nicotinic acetylcholine receptor reverses complete freund adjuvant-induced mechanical hyperalgesia in the rat via a central site of action. ( Billinton, A; Bingham, S; Chessell, IP; Clayton, NM; Hatcher, JP; Hille, CJ; Medhurst, SJ, 2008)
" In the abdominal constriction test, LXM-10 had a significant dose-response effect, and the maximal inhibition ratio was 79."1.34Antinociceptive effects of the novel spirocyclopiperazinium salt compound LXM-10 in mice. ( Li, CL; Li, RT; Sun, Q; Ye, J; Yue, CQ, 2007)
"Pretreatment with chlorisondamine (0."1.33ABT-594 (a nicotinic acetylcholine agonist): anti-allodynia in a rat chemotherapy-induced pain model. ( Decker, MW; Honore, P; Lynch, JJ; Mikusa, JP; Wade, CL, 2005)
" This study examines the hypothesis for the first time that the neonicotinoid insecticides and their imine metabolites and analogs display analgesic (antinociceptive) activity or adverse toxic effects associated with their action on binding to the alpha 4 beta 2 nicotinic acetylcholine receptor (AChR) subtype."1.31Analgesic and toxic effects of neonicotinoid insecticides in mice. ( Casida, JE; Cowan, A; Tomizawa, M, 2001)
"Development of analgesic agents for the treatment of severe pain requires the identification of compounds that are devoid of opioid receptor liabilities."1.30Broad-spectrum, non-opioid analgesic activity by selective modulation of neuronal nicotinic acetylcholine receptors. ( Arneric, SP; Bannon, AW; Bitner, RS; Curzon, P; Decker, MW; Diaz, A; Dickenson, AH; Donnelly-Roberts, D; Holladay, MW; Porsolt, RD; Puttfarcken, PS; Williams, M, 1998)

Research

Studies (52)

TimeframeStudies, this research(%)All Research%
pre-19906 (11.54)18.7374
1990's12 (23.08)18.2507
2000's24 (46.15)29.6817
2010's9 (17.31)24.3611
2020's1 (1.92)2.80

Authors

AuthorsStudies
Tobaldini, G1
Andersen, EOL1
Polato, JJ1
Guilhen, VA1
Gaspar, JC1
Lazzarim, MK1
Sardi, NF1
Fischer, L1
Li, W1
Cai, J1
Wang, BH1
Huang, L1
Fan, J1
Wang, Y1
Hirotsu, C1
Pedroni, MN1
Berro, LF1
Tufik, S1
Andersen, ML1
Papke, RL1
Stokes, C1
Muldoon, P1
Imad Damaj, M1
Giorno, TBS1
Silva, BVD1
Pinto, ADC1
Fernandes, PD2
Cucchiaro, G1
Xiao, Y1
Gonzalez-Sulser, A1
Kellar, KJ1
Guginski, G1
Luiz, AP1
Silva, MD1
Massaro, M1
Martins, DF1
Chaves, J1
Mattos, RW1
Silveira, D1
Ferreira, VM1
Calixto, JB1
Santos, AR1
Arihan, O1
Boz, M1
Iskit, AB1
Ilhan, M1
Gear, RW1
Levine, JD1
Munro, G1
Dyhr, H1
Grunnet, M1
Shi, GN1
Liu, YL1
Lin, HM1
Yang, SL1
Feng, YL1
Reid, PF1
Qin, ZH1
Motta, PG1
Perez, AC1
Alves, DP1
Duarte, ID1
Petronilho, A1
Reis, GM1
Dias, QM1
Fais, RS1
Prado, WA3
Pinheiro, MM1
Boylan, F1
Dussor, GO1
Helesic, G1
Hargreaves, KM1
Flores, CM1
Caban, AJ1
Hama, AT2
Lee, JW1
Sagen, J2
Segalla, DK1
Dubé, GR1
Kohlhaas, KL1
Rueter, LE2
Surowy, CS1
Meyer, MD2
Briggs, CA1
Lynch, JJ1
Wade, CL1
Mikusa, JP2
Decker, MW4
Honore, P2
Simons, CT2
Cuellar, JM1
Moore, JA1
Pinkerton, KE1
Uyeminami, D1
Carstens, MI2
Carstens, E4
Damaj, MI2
Fonck, C1
Marks, MJ1
Deshpande, P1
Labarca, C1
Lester, HA1
Collins, AC1
Martin, BR2
Yue, CQ1
Ye, J1
Li, CL1
Li, RT1
Sun, Q1
Jafari, MR1
Golmohammadi, S1
Ghiasvand, F1
Zarrindast, MR1
Djahanguiri, B1
Kiguchi, N1
Maeda, T1
Tsuruga, M1
Yamamoto, A1
Yamamoto, C1
Ozaki, M1
Kishioka, S1
Joshi, SK1
Weaver, B1
Medhurst, SJ1
Hatcher, JP1
Hille, CJ1
Bingham, S1
Clayton, NM1
Billinton, A1
Chessell, IP1
Watkins, LR1
Katayama, Y1
Kinscheck, IB1
Mayer, DJ1
Hayes, RL1
Jurna, I1
Krauss, P1
Baldauf, J1
Franco, AC1
Bannon, AW2
Holladay, MW2
Curzon, P1
Donnelly-Roberts, D1
Puttfarcken, PS1
Bitner, RS1
Diaz, A1
Dickenson, AH1
Porsolt, RD1
Williams, M2
Arneric, SP2
Buckley, MJ1
Kim, DJ1
Ryther, KB1
Lin, NH1
Wasicak, JT1
Khan, IM1
Buerkle, H1
Taylor, P1
Yaksh, TL1
Lawand, NB1
Lu, Y1
Westlund, KN1
Pöyhiä, R1
Xu, M1
Kontinen, VK1
Paananen, S1
Kalso, E1
Jinks, SL2
Hentall, ID1
Dessirier, JM1
Meyer, EM1
Hama, A1
Menzaghi, F2
Lloyd, GK1
Tomizawa, M1
Cowan, A1
Casida, JE1
Eger, EI1
Zhang, Y1
Laster, M1
Flood, P1
Kendig, JJ1
Sonner, JM1
Rodgers, RJ1
Zhuo, M1
Gebhart, GF1
Cooley, JE1
Villarosa, GA1
Lombardo, TW1
Moss, RA1
Fowler, SC1
Sult, S1
Christensen, MK1
Smith, DF1
Sansone, M1
Castellano, C1
Battaglia, M1
Ammassari-Teule, M1
Blinowska, KJ1
Kowalczyk, M1
Franaszczuk, PJ1
Mitraszewski, P1
Yamada, S1
Kagawa, Y1
Takayanagi, N1
Hayashi, E1
Tsuji, K1
Kosuge, T1
Phan, DV1
Dóda, M1
Bite, A1
György, L1

Other Studies

52 other studies available for mecamylamine and Ache

ArticleYear
Pain and stress: functional evidence that supra-spinal mechanisms involved in pain-induced analgesia mediate stress-induced analgesia.
    Behavioural pharmacology, 2020, Volume: 31, Issue:2&3

    Topics: Analgesia; Animals; Capsaicin; Cholinergic Neurons; Hyperalgesia; Male; Mecamylamine; Nicotine; Noci

2020
Antinociceptive effects of novel epibatidine analogs through activation of α4β2 nicotinic receptors.
    Science China. Life sciences, 2018, Volume: 61, Issue:6

    Topics: Analgesics, Non-Narcotic; Animals; Binding, Competitive; Bridged Bicyclo Compounds, Heterocyclic; Co

2018
Nicotine and sleep deprivation: impact on pain sensitivity and immune modulation in rats.
    Scientific reports, 2018, 09-14, Volume: 8, Issue:1

    Topics: Animals; Hyperalgesia; Immunity; Interleukin-4; Interleukin-6; Male; Mecamylamine; Nicotine; Pain; P

2018
Similar activity of mecamylamine stereoisomers in vitro and in vivo.
    European journal of pharmacology, 2013, Nov-15, Volume: 720, Issue:1-3

    Topics: Analgesics; Animals; Hot Temperature; Humans; Male; Mecamylamine; Mice; Mice, Inbred ICR; Nicotinic

2013
Antinociceptive effect and mechanism of action of isatin, N-methyl isatin and oxopropyl isatin in mice.
    Life sciences, 2016, Apr-15, Volume: 151

    Topics: Analgesics; Animals; Atropine; Dose-Response Relationship, Drug; Isatin; Mecamylamine; Mice; Morphin

2016
Analgesic effects of Sazetidine-A, a new nicotinic cholinergic drug.
    Anesthesiology, 2008, Volume: 109, Issue:3

    Topics: Analgesics; Animals; Azetidines; Bridged Bicyclo Compounds, Heterocyclic; Cholinergic Agents; Diseas

2008
Mechanisms involved in the antinociception caused by ethanolic extract obtained from the leaves of Melissa officinalis (lemon balm) in mice.
    Pharmacology, biochemistry, and behavior, 2009, Volume: 93, Issue:1

    Topics: Acetic Acid; Analgesics; Animals; Arginine; Atropine; Cinnamates; Depsides; Dose-Response Relationsh

2009
Antinociceptive activity of coniine in mice.
    Journal of ethnopharmacology, 2009, Sep-07, Volume: 125, Issue:2

    Topics: Acetic Acid; Alkaloids; Analgesics; Animals; Conium; Drug Synergism; Male; Mecamylamine; Mice; Morph

2009
Rostral ventral medulla cholinergic mechanism in pain-induced analgesia.
    Neuroscience letters, 2009, Oct-30, Volume: 464, Issue:3

    Topics: Analgesia; Animals; Electromyography; Male; Mecamylamine; Medulla Oblongata; Microinjections; Neural

2009
Selective potentiation of gabapentin-mediated antinociception in the rat formalin test by the nicotinic acetylcholine receptor agonist ABT-594.
    Neuropharmacology, 2010, Volume: 59, Issue:3

    Topics: Amines; Analgesics; Animals; Azetidines; Cyclohexanecarboxylic Acids; Disease Models, Animal; Dose-R

2010
Involvement of cholinergic system in suppression of formalin-induced inflammatory pain by cobratoxin.
    Acta pharmacologica Sinica, 2011, Volume: 32, Issue:10

    Topics: Aconitine; Adjuvants, Anesthesia; Analgesics; Animals; Antihypertensive Agents; Atropine; Cobra Neur

2011
Modulation of peripheral inflammatory pain thresholds by M(1) and nicotinic receptor antagonists.
    Pharmacology, 2011, Volume: 88, Issue:5-6

    Topics: Acetylcholine; Animals; Carrageenan; Dinoprostone; Hyperalgesia; Inflammation; Male; Mecamylamine; N

2011
Antinociceptive effect of stimulating the zona incerta with glutamate in rats.
    Pharmacology, biochemistry, and behavior, 2012, Volume: 101, Issue:3

    Topics: Analgesics; Animals; Atropine; Glutamic Acid; Haloperidol; Male; Mecamylamine; Methysergide; Microin

2012
Antinociceptive effect of the Orbignya speciosa Mart. (Babassu) leaves: evidence for the involvement of apigenin.
    Life sciences, 2012, Sep-24, Volume: 91, Issue:9-10

    Topics: Analgesics; Animals; Apigenin; Arecaceae; Aspirin; Atropine; Brazil; Disease Models, Animal; Dose-Re

2012
Cholinergic modulation of nociceptive responses in vivo and neuropeptide release in vitro at the level of the primary sensory neuron.
    Pain, 2004, Volume: 107, Issue:1-2

    Topics: Acetylcholine; Analysis of Variance; Animals; Arecoline; Atropine; Behavior, Animal; Bungarotoxins;

2004
Enhanced antinociception by nicotinic receptor agonist epibatidine and adrenal medullary transplants in the spinal subarachnoid space.
    Neuropharmacology, 2004, Volume: 47, Issue:1

    Topics: Adrenal Medulla; Analgesics; Animals; Bridged Bicyclo Compounds, Heterocyclic; Male; Mecamylamine; N

2004
Antinociceptive effects of bethanechol or dimethylphenylpiperazinium in models of phasic or incisional pain in rats.
    Brain research, 2004, Aug-27, Volume: 1018, Issue:2

    Topics: Acetylcholine; Analgesics; Analysis of Variance; Animals; Atropine; Bethanechol; Cholinergic Agonist

2004
Loss of functional neuronal nicotinic receptors in dorsal root ganglion neurons in a rat model of neuropathic pain.
    Neuroscience letters, 2005, Mar-07, Volume: 376, Issue:1

    Topics: Acetylcholine; Animals; Azetidines; Cell Count; Cells, Cultured; Disease Models, Animal; Dose-Respon

2005
ABT-594 (a nicotinic acetylcholine agonist): anti-allodynia in a rat chemotherapy-induced pain model.
    European journal of pharmacology, 2005, Feb-10, Volume: 509, Issue:1

    Topics: Acetylcholine; Analgesia; Animals; Azetidines; Chlorisondamine; Disease Models, Animal; Dose-Respons

2005
Nicotinic receptor involvement in antinociception induced by exposure to cigarette smoke.
    Neuroscience letters, 2005, Dec-02, Volume: 389, Issue:2

    Topics: Analgesics; Animals; Dose-Response Relationship, Drug; Drug Tolerance; Male; Mecamylamine; Naltrexon

2005
Genetic approaches identify differential roles for alpha4beta2* nicotinic receptors in acute models of antinociception in mice.
    The Journal of pharmacology and experimental therapeutics, 2007, Volume: 321, Issue:3

    Topics: Alkaloids; Analgesics; Animals; Azocines; Binding, Competitive; Bridged Bicyclo Compounds, Heterocyc

2007
Antinociceptive effects of the novel spirocyclopiperazinium salt compound LXM-10 in mice.
    Pharmacology, biochemistry, and behavior, 2007, Volume: 86, Issue:4

    Topics: Analgesics; Animals; Atropine; Atropine Derivatives; Body Temperature; Drug Evaluation, Preclinical;

2007
Influence of nicotinic receptor modulators on CB2 cannabinoid receptor agonist (JWH133)-induced antinociception in mice.
    Behavioural pharmacology, 2007, Volume: 18, Issue:7

    Topics: Animals; Cannabinoids; Dose-Response Relationship, Drug; Formaldehyde; Male; Mecamylamine; Mice; Mot

2007
Involvement of spinal Met-enkephalin in nicotine-induced antinociception in mice.
    Brain research, 2008, Jan-16, Volume: 1189

    Topics: Analgesics; Animals; Dose-Response Relationship, Drug; Down-Regulation; Dynorphins; Enkephalin, Meth

2008
Morphine and ABT-594 (a nicotinic acetylcholine agonist) exert centrally mediated antinociception in the rat cyclophosphamide cystitis model of visceral pain.
    The journal of pain, 2008, Volume: 9, Issue:2

    Topics: Analgesics; Animals; Azetidines; Behavior, Animal; Brain; Chlorisondamine; Cyclophosphamide; Cystiti

2008
Activation of the alpha7-nicotinic acetylcholine receptor reverses complete freund adjuvant-induced mechanical hyperalgesia in the rat via a central site of action.
    The journal of pain, 2008, Volume: 9, Issue:7

    Topics: Aconitine; alpha7 Nicotinic Acetylcholine Receptor; Animals; Behavior, Animal; Benzofurans; Dose-Res

2008
Muscarinic cholinergic mediation of opiate and non-opiate environmentally induced analgesias.
    Brain research, 1984, May-23, Volume: 300, Issue:2

    Topics: Analgesia; Animals; Central Nervous System; Cholinergic Fibers; Conditioning, Classical; Electroshoc

1984
Depression by nicotine of pain-related nociceptive activity in the rat thalamus and spinal cord.
    The Clinical investigator, 1993, Volume: 72, Issue:1

    Topics: Afferent Pathways; Analgesics; Animals; Atropine; Blood Pressure; Electric Stimulation; Female; Inje

1993
Antinociceptive effects of stimulation of discrete sites in the rat hypothalamus: evidence for the participation of the lateral hypothalamus area in descending pain suppression mechanisms.
    Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas, 1996, Volume: 29, Issue:11

    Topics: Adrenergic alpha-Antagonists; Analgesia; Analgesics, Opioid; Animals; Atropine; Dopamine Antagonists

1996
Broad-spectrum, non-opioid analgesic activity by selective modulation of neuronal nicotinic acetylcholine receptors.
    Science (New York, N.Y.), 1998, Jan-02, Volume: 279, Issue:5347

    Topics: Analgesics, Non-Narcotic; Animals; Azetidines; Bridged Bicyclo Compounds, Heterocyclic; Capsaicin; D

1998
Antinociceptive effects of the novel neuronal nicotinic acetylcholine receptor agonist, ABT-594, in mice.
    European journal of pharmacology, 1998, Apr-03, Volume: 346, Issue:1

    Topics: Analgesics, Non-Narcotic; Animals; Azetidines; Hexamethonium; Lethal Dose 50; Male; Maze Learning; M

1998
Nociceptive and antinociceptive responses to intrathecally administered nicotinic agonists.
    Neuropharmacology, 1998, Volume: 37, Issue:12

    Topics: Alkaloids; Analgesia; Animals; Azocines; Bridged Bicyclo Compounds, Heterocyclic; Escape Reaction; H

1998
Nicotinic cholinergic receptors: potential targets for inflammatory pain relief.
    Pain, 1999, Volume: 80, Issue:1-2

    Topics: Analgesics, Non-Narcotic; Animals; Arthritis, Experimental; Behavior, Animal; Bridged Bicyclo Compou

1999
Systemic physostigmine shows antiallodynic effects in neuropathic rats.
    Anesthesia and analgesia, 1999, Volume: 89, Issue:2

    Topics: Analgesics; Analgesics, Opioid; Animals; Atropine; Cholinergic Antagonists; Dose-Response Relationsh

1999
Activation of spinal wide dynamic range neurons by intracutaneous microinjection of nicotine.
    Journal of neurophysiology, 1999, Volume: 82, Issue:6

    Topics: Action Potentials; Animals; Azetidines; Histamine; Histamine H1 Antagonists; Hot Temperature; Male;

1999
Spinal CSF from rats with painful peripheral neuropathy evokes catecholamine release from chromaffin cells in vitro.
    Neuroscience letters, 2000, Jun-02, Volume: 286, Issue:2

    Topics: Adrenal Medulla; Animals; Catecholamines; Cattle; Cells, Cultured; Cerebrospinal Fluid; Cerebrospina

2000
Role of neuronal nicotinic-acetylcholine receptors in the activation of neurons in trigeminal subnucleus caudalis by nicotine delivered to the oral mucosa.
    Experimental brain research, 2000, Volume: 132, Issue:3

    Topics: Administration, Oral; Animals; Atropine; Male; Mecamylamine; Mouth Mucosa; Muscarinic Antagonists; N

2000
Spinal mechanisms underlying A-85380-induced effects on acute thermal pain.
    Brain research, 2000, Jul-28, Volume: 872, Issue:1-2

    Topics: Adrenergic alpha-Agonists; Animals; Azetidines; Behavior, Animal; Bridged Bicyclo Compounds, Heteroc

2000
The antinociceptive effects of alpha7 nicotinic agonists in an acute pain model.
    Neuropharmacology, 2000, Volume: 39, Issue:13

    Topics: alpha7 Nicotinic Acetylcholine Receptor; Analgesics; Animals; Benzylidene Compounds; Bungarotoxins;

2000
Antagonist of nicotinic acetylcholine receptors (nAChR) enhances formalin-induced nociception in rats: tonic role of nAChRs in the control of pain following injury.
    Brain research, 2001, Jan-05, Volume: 888, Issue:1

    Topics: Acute Disease; Animals; Chronic Disease; Male; Mecamylamine; Nicotinic Antagonists; Nociceptors; Pai

2001
The antinociceptive effect of intrathecal administration of epibatidine with clonidine or neostigmine in the formalin test in rats.
    Pain, 2001, Volume: 91, Issue:1-2

    Topics: Analgesics; Analgesics, Non-Narcotic; Animals; Behavior, Animal; Bridged Bicyclo Compounds, Heterocy

2001
Analgesic and toxic effects of neonicotinoid insecticides in mice.
    Toxicology and applied pharmacology, 2001, Nov-15, Volume: 177, Issue:1

    Topics: Analgesics, Non-Narcotic; Animals; Bridged Bicyclo Compounds, Heterocyclic; Cells, Cultured; Dose-Re

2001
Acetylcholine receptors do not mediate the immobilization produced by inhaled anesthetics.
    Anesthesia and analgesia, 2002, Volume: 94, Issue:6

    Topics: Anesthetics, Inhalation; Animals; Atropine; Cholinergic Antagonists; Injections, Intraperitoneal; In

2002
Effects of nicotine, mecamylamine, and hexamethonium on shock-induced fighting, pain reactivity, and locomotor behaviour in rats.
    Psychopharmacology, 1979, Volume: 66, Issue:1

    Topics: Aggression; Animals; Electroshock; Hexamethonium Compounds; Humans; Male; Mecamylamine; Motor Activi

1979
Spinal serotonin receptors mediate descending facilitation of a nociceptive reflex from the nuclei reticularis gigantocellularis and gigantocellularis pars alpha in the rat.
    Brain research, 1991, May-31, Volume: 550, Issue:1

    Topics: Amidines; Analysis of Variance; Animals; Atropine; Blood Pressure; Brain; Electric Stimulation; Hear

1991
Effect of pCPA on nicotine-induced analgesia.
    Pharmacology, biochemistry, and behavior, 1990, Volume: 36, Issue:2

    Topics: Analgesia; Animals; Drug Interactions; Fenclonine; Male; Mecamylamine; Naloxone; Nicotine; Pain; Rat

1990
Antinociceptive effects of the stereoisomers of nicotine given intrathecally in spinal rats.
    Journal of neural transmission. General section, 1990, Volume: 80, Issue:3

    Topics: Analgesia; Animals; Injections, Spinal; Male; Mecamylamine; Nicotine; Pain; Pain Measurement; Rats;

1990
Oxiracetam prevents mecamylamine-induced impairment of active, but not passive, avoidance learning in mice.
    Pharmacology, biochemistry, and behavior, 1990, Volume: 36, Issue:2

    Topics: Animals; Avoidance Learning; Drug Interactions; Electric Stimulation; Male; Mecamylamine; Mice; Mice

1990
The EEG time series parametrization method in the study of nociception.
    Acta neurobiologiae experimentalis, 1989, Volume: 49, Issue:4

    Topics: Algorithms; Animals; Atropine; Brain; Cholinergic Fibers; Electroencephalography; Male; Mecamylamine

1989
Inhibition by neosurugatoxin of nicotine-induced antinociception.
    Brain research, 1986, Jun-11, Volume: 375, Issue:2

    Topics: Animals; Central Nervous System; Hexamethonium; Hexamethonium Compounds; Male; Mecamylamine; Mice; M

1986
[Antihypertensive agents].
    Die Pharmazie, 1972, Volume: 27, Issue:11

    Topics: Acetazolamide; Antihypertensive Agents; Bis-Trimethylammonium Compounds; Bretylium Compounds; Chlori

1972
Antin ociceptive activity of nicotine.
    Acta physiologica Academiae Scientiarum Hungaricae, 1973, Volume: 44, Issue:1

    Topics: Acetates; Analgesia; Animals; Dimethylphenylpiperazinium Iodide; Drug Tolerance; Injections, Intrape

1973