mecamylamine has been researched along with Absence Seizure in 19 studies
Mecamylamine: A nicotinic antagonist that is well absorbed from the gastrointestinal tract and crosses the blood-brain barrier. Mecamylamine has been used as a ganglionic blocker in treating hypertension, but, like most ganglionic blockers, is more often used now as a research tool.
| Excerpt | Relevance | Reference |
|---|---|---|
| " These receptors are also involved with the induction of nicotine-induced seizures." | 7.71 | Nicotine induced seizures blocked by mecamylamine and its stereoisomers. ( Manresa, JJ; Newman, MB; Sanberg, PR; Shytle, RD, 2001) |
| " The present study had explored the proconvulsive action of nicotine and its effect on the antiseizure efficacy of topiramate against kainic acid (KA)-induced seizures in mice." | 3.77 | Nicotine reversal of anticonvulsant action of topiramate in kainic acid-induced seizure model in mice. ( Chakrabarti, A; Hota, D; Sahai, AK; Sood, N, 2011) |
| "The authors' previous studies have shown that in nicotine-induced seizures sensitivity was decreased and blood-brain barrier (BBB) disruption was prevented as a consequence of nicotine pretreatment." | 3.72 | Tolerance to pentylentetrazol-induced convulsions and protection of cerebrovascular integrity by chronic nicotine. ( Bahçekapili, N; Diler, AS; Uzüm, G; Ziylan, YZ, 2004) |
| " These receptors are also involved with the induction of nicotine-induced seizures." | 3.71 | Nicotine induced seizures blocked by mecamylamine and its stereoisomers. ( Manresa, JJ; Newman, MB; Sanberg, PR; Shytle, RD, 2001) |
| " Both the antinociceptive and toxic effects (convulsions and hypertension) were abolished by pretreatment with the brain penetrant neuronal nAChR antagonist mecamylamine (1 mg/kg s." | 3.70 | Analgesic and toxic effects of ABT-594 resemble epibatidine and nicotine in rats. ( Boyce, S; Hill, RG; Rupniak, NMJ; Russell, MGN; Shepheard, SL; Webb, JK, 2000) |
| "Seizures were recorded inside the open field apparatus for an average of 10min." | 1.43 | Nicotinic and muscarinic cholinergic receptors are recruited by acetylcholine-mediated neurotransmission within the locus coeruleus during the organisation of post-ictal antinociception. ( Biagioni, AF; Coimbra, NC; de Oliveira, R; de Oliveira, RC; Dos Anjos-Garcia, T; Falconi-Sobrinho, LL, 2016) |
| " The pattern of shift of the dose-response curve for nicotine-induced convulsion in mice was determined in the presence of increasing concentrations of the anticholinergic antiparkinson drugs." | 1.30 | Anti-nicotinic properties of anticholinergic antiparkinson drugs. ( Cui, WY; Fan, QH; Gao, ZG; Li, LJ; Liu, BY; Liu, CG, 1998) |
| "Phencyclidine (PCP) has multifaceted actions on the cholinergic functions, including interaction with the central and peripheral cholinergic receptors." | 1.27 | Effects of mecamylamine, nicotine, atropine and physostigmine on the phencyclidine-induced behavioral toxicity. ( Chaturvedi, AK, 1984) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 9 (47.37) | 18.7374 |
| 1990's | 2 (10.53) | 18.2507 |
| 2000's | 5 (26.32) | 29.6817 |
| 2010's | 2 (10.53) | 24.3611 |
| 2020's | 1 (5.26) | 2.80 |
| Authors | Studies |
|---|---|
| Zapukhliak, O | 1 |
| Netsyk, O | 1 |
| Romanov, A | 1 |
| Maximyuk, O | 1 |
| Oz, M | 1 |
| Holmes, GL | 1 |
| Krishtal, O | 1 |
| Isaev, D | 1 |
| de Oliveira, RC | 1 |
| de Oliveira, R | 1 |
| Biagioni, AF | 1 |
| Falconi-Sobrinho, LL | 1 |
| Dos Anjos-Garcia, T | 1 |
| Coimbra, NC | 1 |
| Sood, N | 1 |
| Hota, D | 1 |
| Sahai, AK | 1 |
| Chakrabarti, A | 1 |
| Bontempi, B | 1 |
| Whelan, KT | 1 |
| Risbrough, VB | 1 |
| Lloyd, GK | 1 |
| Menzaghi, F | 1 |
| STONE, CA | 1 |
| TORCHIANA, ML | 1 |
| MECKELNBERG, KL | 1 |
| STAVORSKI, J | 1 |
| SLETZINGER, M | 1 |
| STEIN, GA | 1 |
| RUYLE, WV | 1 |
| REINHOLD, DF | 1 |
| GAINES, WA | 1 |
| ARNOLD, H | 1 |
| PFISTER, K | 1 |
| Uzüm, G | 1 |
| Bahçekapili, N | 1 |
| Diler, AS | 1 |
| Ziylan, YZ | 1 |
| Shin, EJ | 1 |
| Chae, JS | 1 |
| Jung, ME | 1 |
| Bing, G | 1 |
| Ko, KH | 1 |
| Kim, WK | 1 |
| Wie, MB | 1 |
| Cheon, MA | 1 |
| Nah, SY | 1 |
| Kim, HC | 1 |
| Chaturvedi, AK | 1 |
| Wang, DX | 1 |
| Sheu, SS | 1 |
| Sharma, VK | 1 |
| Rubin, L | 1 |
| Journet, M | 1 |
| Kende, AS | 1 |
| Abood, LG | 1 |
| Gao, ZG | 1 |
| Liu, BY | 1 |
| Cui, WY | 1 |
| Li, LJ | 1 |
| Fan, QH | 1 |
| Liu, CG | 1 |
| Boyce, S | 1 |
| Webb, JK | 1 |
| Shepheard, SL | 1 |
| Russell, MGN | 1 |
| Hill, RG | 1 |
| Rupniak, NMJ | 1 |
| Newman, MB | 1 |
| Manresa, JJ | 1 |
| Sanberg, PR | 1 |
| Shytle, RD | 1 |
| Rastogi, SK | 1 |
| Puri, JN | 1 |
| Sinha, JN | 1 |
| Bhargava, KP | 1 |
| Witkin, JM | 1 |
| Alvarado-Garcia, R | 1 |
| Lee, MA | 1 |
| Witkin, KM | 1 |
| Aceto, MD | 1 |
| Bentley, HC | 1 |
| Dembinski, JR | 1 |
| Phan, DV | 2 |
| Bite, A | 2 |
| György, L | 3 |
| Döda, M | 2 |
| Vazquez, AJ | 1 |
| Krip, G | 1 |
| Pinsky, C | 1 |
19 other studies available for mecamylamine and Absence Seizure
| Article | Year |
|---|---|
Mecamylamine inhibits seizure-like activity in CA1-CA3 hippocampus through antagonism to nicotinic receptors.
Topics: Animals; Bicuculline; CA1 Region, Hippocampal; CA3 Region, Hippocampal; Excitatory Amino Acid Antago | 2021 |
Nicotinic and muscarinic cholinergic receptors are recruited by acetylcholine-mediated neurotransmission within the locus coeruleus during the organisation of post-ictal antinociception.
Topics: Acetylcholine; Animals; Atropine; Disease Models, Animal; Dose-Response Relationship, Drug; Locus Co | 2016 |
Nicotine reversal of anticonvulsant action of topiramate in kainic acid-induced seizure model in mice.
Topics: Animals; Anticonvulsants; Brain; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Inte | 2011 |
Cognitive enhancing properties and tolerability of cholinergic agents in mice: a comparative study of nicotine, donepezil, and SIB-1553A, a subtype-selective ligand for nicotinic acetylcholine receptors.
Topics: Age Factors; Animals; Attention; Behavior, Animal; Choice Behavior; Cholinesterase Inhibitors; Cogni | 2003 |
CHEMISTRY AND STRUCTURE-ACTIVITY RELATIONSHIPS OF MECAMYLAMINE AND DERIVATIVES.
Topics: Animals; Cats; Chemical Phenomena; Chemistry; Ganglionic Blockers; Mecamylamine; Mice; Nictitating M | 1962 |
Tolerance to pentylentetrazol-induced convulsions and protection of cerebrovascular integrity by chronic nicotine.
Topics: Analysis of Variance; Animals; Blood Pressure; Blood-Brain Barrier; Brain; Capillary Permeability; C | 2004 |
Repeated intracerebroventricular infusion of nicotine prevents kainate-induced neurotoxicity by activating the alpha7 nicotinic acetylcholine receptor.
Topics: alpha7 Nicotinic Acetylcholine Receptor; Animals; Bungarotoxins; Dihydro-beta-Erythroidine; DNA; Hip | 2007 |
Effects of mecamylamine, nicotine, atropine and physostigmine on the phencyclidine-induced behavioral toxicity.
Topics: Animals; Atropine; Behavior, Animal; Dose-Response Relationship, Drug; Drug Interactions; Male; Meca | 1984 |
[3H]benzylpempidine, a new radioligand for probing a putative channel site on nicotinic cholinergic receptors.
Topics: Animals; Binding, Competitive; Brain; Calcium; Calcium Channels; Cattle; Cell Membrane; Ligands; Mec | 1997 |
Anti-nicotinic properties of anticholinergic antiparkinson drugs.
Topics: Animals; Antiparkinson Agents; Atropine; Brain; Cholinergic Antagonists; Dose-Response Relationship, | 1998 |
Analgesic and toxic effects of ABT-594 resemble epibatidine and nicotine in rats.
Topics: Analgesics, Non-Narcotic; Animals; Azetidines; Behavior, Animal; Body Temperature; Bridged Bicyclo C | 2000 |
Nicotine induced seizures blocked by mecamylamine and its stereoisomers.
Topics: Animals; Disease Models, Animal; Male; Mecamylamine; Molecular Conformation; Nicotine; Nicotinic Ant | 2001 |
Involvement of central cholinoceptors in Metrazol-induced convulsions.
Topics: Animals; Atropine; Female; Male; Mecamylamine; Mice; Neostigmine; Parasympatholytics; Pentylenetetra | 1979 |
Nonmuscarinic neurotoxicity of oxotremorine.
Topics: Animals; Arecoline; Atropine; Atropine Derivatives; Benactyzine; Benztropine; Crying; Diazepam; Dose | 1987 |
Effects of ganglion blocking agents on nicotine extensor convulsions and lethality in mice.
Topics: Animals; Atropine; Cerebral Ventricles; Chlorisondamine; Chlorpromazine; Decamethonium Compounds; Ga | 1969 |
Effect of oxotremorine on behaviour and EEG of reserpine-pretreated rats.
Topics: Animals; Atropine; Atropine Derivatives; Brain; Electroencephalography; Female; Male; Mecamylamine; | 1974 |
Effect of cholinesterase inhibitors on the susceptibility to pentetrazole of the mouse.
Topics: Animals; Atropine; Cholinesterase Inhibitors; Dose-Response Relationship, Drug; Drug Interactions; F | 1974 |
Antin ociceptive activity of nicotine.
Topics: Acetates; Analgesia; Animals; Dimethylphenylpiperazinium Iodide; Drug Tolerance; Injections, Intrape | 1973 |
[vidence for a muscarinic inhibitory mechanism in the cerebral cortex].
Topics: Acetylcholine; Animals; Atropine; Cats; Cerebral Cortex; Drug Antagonism; Electric Stimulation; Elec | 1969 |