Page last updated: 2024-10-30

mebendazole and Melanoma

mebendazole has been researched along with Melanoma in 7 studies

Mebendazole: A benzimidazole that acts by interfering with CARBOHYDRATE METABOLISM and inhibiting polymerization of MICROTUBULES.
mebendazole : A carbamate ester that is methyl 1H-benzimidazol-2-ylcarbamate substituted by a benzoyl group at position 5.

Melanoma: A malignant neoplasm derived from cells that are capable of forming melanin, which may occur in the skin of any part of the body, in the eye, or, rarely, in the mucous membranes of the genitalia, anus, oral cavity, or other sites. It occurs mostly in adults and may originate de novo or from a pigmented nevus or malignant lentigo. Melanomas frequently metastasize widely, and the regional lymph nodes, liver, lungs, and brain are likely to be involved. The incidence of malignant skin melanomas is rising rapidly in all parts of the world. (Stedman, 25th ed; from Rook et al., Textbook of Dermatology, 4th ed, p2445)

Research Excerpts

ExcerptRelevanceReference
" the apoptosis as well as autophagy and their related signaling in several stabilized cell lines as well as human explant melanoma cells treated with flubendazole (FLU)."7.96An analysis of mitotic catastrophe induced cell responses in melanoma cells exposed to flubendazole. ( Rudolf, E; Rudolf, K, 2020)
" We find that MBZ synergizes with the MEK inhibitor trametinib to inhibit growth of BRAFWT-NRASQ61K melanoma cells in culture and in xenografts, and markedly decreased MEK and ERK phosphorylation."7.85The repurposed anthelmintic mebendazole in combination with trametinib suppresses refractory NRASQ61K melanoma. ( Abdussamad, M; Atkins, MB; Byers, SW; Calvert, V; Chen, YS; Dakshanamurthy, S; Fang, HB; Gaur, A; Petricoin, EF; Rosenthal, DS; Simbulan-Rosenthal, CM; Zapas, J; Zhou, H, 2017)
"Mebendazole (MBZ) was identified as a promising therapeutic on the basis of its ability to induce apoptosis in melanoma cell lines through a B-cell lymphoma 2 (BCL2)-dependent mechanism."7.79XIAP downregulation accompanies mebendazole growth inhibition in melanoma xenografts. ( Byron, SA; Doudican, NA; Orlow, SJ; Pollock, PM, 2013)
"In recent years, treatment of melanoma and a range of other deadly cancers has involved immunotherapy with programmed cell death protein-1 (PD-1)/PD-1 ligand (PD-L1) checkpoint blockade which has improved survival."5.51The anthelmintic flubendazole blocks human melanoma growth and metastasis and suppresses programmed cell death protein-1 and myeloid-derived suppressor cell accumulation. ( Acharya, G; Elahy, M; Khachigian, LM; Li, Y; Xin, H, 2019)
"Flubendazole (FLU) is a widely used anthelmintic drug belonging to benzimidazole group."5.48Flubendazole induces mitotic catastrophe and apoptosis in melanoma cells. ( Čáňová, K; Rozkydalová, L; Rudolf, E; Vokurková, D, 2018)
"Mebendazole was prioritized to further characterize its mechanism of melanoma growth inhibition based on its favorable pharmacokinetic profile."5.35Mebendazole induces apoptosis via Bcl-2 inactivation in chemoresistant melanoma cells. ( Doudican, N; Orlow, SJ; Osman, I; Rodriguez, A, 2008)
" the apoptosis as well as autophagy and their related signaling in several stabilized cell lines as well as human explant melanoma cells treated with flubendazole (FLU)."3.96An analysis of mitotic catastrophe induced cell responses in melanoma cells exposed to flubendazole. ( Rudolf, E; Rudolf, K, 2020)
" We find that MBZ synergizes with the MEK inhibitor trametinib to inhibit growth of BRAFWT-NRASQ61K melanoma cells in culture and in xenografts, and markedly decreased MEK and ERK phosphorylation."3.85The repurposed anthelmintic mebendazole in combination with trametinib suppresses refractory NRASQ61K melanoma. ( Abdussamad, M; Atkins, MB; Byers, SW; Calvert, V; Chen, YS; Dakshanamurthy, S; Fang, HB; Gaur, A; Petricoin, EF; Rosenthal, DS; Simbulan-Rosenthal, CM; Zapas, J; Zhou, H, 2017)
"Mebendazole (MBZ) was identified as a promising therapeutic on the basis of its ability to induce apoptosis in melanoma cell lines through a B-cell lymphoma 2 (BCL2)-dependent mechanism."3.79XIAP downregulation accompanies mebendazole growth inhibition in melanoma xenografts. ( Byron, SA; Doudican, NA; Orlow, SJ; Pollock, PM, 2013)
"In recent years, treatment of melanoma and a range of other deadly cancers has involved immunotherapy with programmed cell death protein-1 (PD-1)/PD-1 ligand (PD-L1) checkpoint blockade which has improved survival."1.51The anthelmintic flubendazole blocks human melanoma growth and metastasis and suppresses programmed cell death protein-1 and myeloid-derived suppressor cell accumulation. ( Acharya, G; Elahy, M; Khachigian, LM; Li, Y; Xin, H, 2019)
"Flubendazole (FLU) is a widely used anthelmintic drug belonging to benzimidazole group."1.48Flubendazole induces mitotic catastrophe and apoptosis in melanoma cells. ( Čáňová, K; Rozkydalová, L; Rudolf, E; Vokurková, D, 2018)
"Mebendazole was prioritized to further characterize its mechanism of melanoma growth inhibition based on its favorable pharmacokinetic profile."1.35Mebendazole induces apoptosis via Bcl-2 inactivation in chemoresistant melanoma cells. ( Doudican, N; Orlow, SJ; Osman, I; Rodriguez, A, 2008)

Research

Studies (7)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's1 (14.29)29.6817
2010's5 (71.43)24.3611
2020's1 (14.29)2.80

Authors

AuthorsStudies
Rudolf, K1
Rudolf, E2
Čáňová, K1
Rozkydalová, L1
Vokurková, D1
Li, Y1
Acharya, G1
Elahy, M1
Xin, H1
Khachigian, LM1
Barrett, JE1
Kim, FJ1
Simbulan-Rosenthal, CM1
Dakshanamurthy, S1
Gaur, A1
Chen, YS1
Fang, HB1
Abdussamad, M1
Zhou, H1
Zapas, J1
Calvert, V1
Petricoin, EF1
Atkins, MB1
Byers, SW1
Rosenthal, DS1
Doudican, N1
Rodriguez, A1
Osman, I1
Orlow, SJ2
Doudican, NA1
Byron, SA1
Pollock, PM1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
A Phase I Study of Mebendazole for the Treatment of Pediatric Gliomas[NCT01837862]Phase 1/Phase 236 participants (Anticipated)Interventional2013-10-22Recruiting
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Other Studies

7 other studies available for mebendazole and Melanoma

ArticleYear
An analysis of mitotic catastrophe induced cell responses in melanoma cells exposed to flubendazole.
    Toxicology in vitro : an international journal published in association with BIBRA, 2020, Volume: 68

    Topics: Aged; Antineoplastic Agents; Apoptosis; Autophagy; Cell Cycle; Cell Line, Tumor; Cytochromes c; Huma

2020
Flubendazole induces mitotic catastrophe and apoptosis in melanoma cells.
    Toxicology in vitro : an international journal published in association with BIBRA, 2018, Volume: 46

    Topics: Antinematodal Agents; Apoptosis; Cell Line, Tumor; Cell Proliferation; Humans; Mebendazole; Melanoma

2018
The anthelmintic flubendazole blocks human melanoma growth and metastasis and suppresses programmed cell death protein-1 and myeloid-derived suppressor cell accumulation.
    Cancer letters, 2019, 09-10, Volume: 459

    Topics: Animals; Antinematodal Agents; Antineoplastic Agents; Cell Growth Processes; Cell Line, Tumor; Femal

2019
The purpose of repurposing.
    Oncotarget, 2017, 02-21, Volume: 8, Issue:8

    Topics: Anthelmintics; Humans; Mebendazole; Melanoma; Pyridones; Pyrimidinones

2017
The repurposed anthelmintic mebendazole in combination with trametinib suppresses refractory NRASQ61K melanoma.
    Oncotarget, 2017, Feb-21, Volume: 8, Issue:8

    Topics: Animals; Antinematodal Agents; Antineoplastic Combined Chemotherapy Protocols; Cell Line, Tumor; Cel

2017
Mebendazole induces apoptosis via Bcl-2 inactivation in chemoresistant melanoma cells.
    Molecular cancer research : MCR, 2008, Volume: 6, Issue:8

    Topics: Animals; Apoptosis; bcl-2-Associated X Protein; Benzimidazoles; Cell Line, Tumor; Cell Proliferation

2008
XIAP downregulation accompanies mebendazole growth inhibition in melanoma xenografts.
    Anti-cancer drugs, 2013, Volume: 24, Issue:2

    Topics: Animals; Apoptosis; Cell Line, Tumor; Dacarbazine; Down-Regulation; Drug Resistance, Neoplasm; Femal

2013