mebendazole has been researched along with Medulloblastoma in 5 studies
Mebendazole: A benzimidazole that acts by interfering with CARBOHYDRATE METABOLISM and inhibiting polymerization of MICROTUBULES.
mebendazole : A carbamate ester that is methyl 1H-benzimidazol-2-ylcarbamate substituted by a benzoyl group at position 5.
Medulloblastoma: A malignant neoplasm that may be classified either as a glioma or as a primitive neuroectodermal tumor of childhood (see NEUROECTODERMAL TUMOR, PRIMITIVE). The tumor occurs most frequently in the first decade of life with the most typical location being the cerebellar vermis. Histologic features include a high degree of cellularity, frequent mitotic figures, and a tendency for the cells to organize into sheets or form rosettes. Medulloblastoma have a high propensity to spread throughout the craniospinal intradural axis. (From DeVita et al., Cancer: Principles and Practice of Oncology, 5th ed, pp2060-1)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Mebendazole (MBZ) has a long safety record as antiparasitic in children and has been recently implicated in inhibition of various tyrosine kinases in vitro." | 5.42 | Effective treatment of diverse medulloblastoma models with mebendazole and its impact on tumor angiogenesis. ( Bai, RY; Bunz, F; Riggins, GJ; Rudin, CM; Staedtke, V, 2015) |
| " Here, we show that mebendazole, a benzamidazole with a long history of safe use against nematode infestations and hydatid disease, potently inhibited Hh signaling and slowed the growth of Hh-driven human medulloblastoma cells at clinically attainable concentrations." | 3.81 | Repurposing the antihelmintic mebendazole as a hedgehog inhibitor. ( Bai, RY; Borodovsky, A; Bunz, F; Chung, JH; Larsen, AR; Riggins, GJ; Rudin, CM, 2015) |
| "Mebendazole (MBZ), first used as an antiparasitic drug, shows preclinical efficacy in models of glioblastoma and medulloblastoma." | 3.81 | Brain Penetration and Efficacy of Different Mebendazole Polymorphs in a Mouse Brain Tumor Model. ( Bai, RY; Gallia, GL; Joshi, A; Riggins, GJ; Rudek, MA; Staedtke, V; Wanjiku, T, 2015) |
| "Mebendazole (MBZ) has a long safety record as antiparasitic in children and has been recently implicated in inhibition of various tyrosine kinases in vitro." | 1.42 | Effective treatment of diverse medulloblastoma models with mebendazole and its impact on tumor angiogenesis. ( Bai, RY; Bunz, F; Riggins, GJ; Rudin, CM; Staedtke, V, 2015) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 4 (80.00) | 24.3611 |
| 2020's | 1 (20.00) | 2.80 |
| Authors | Studies |
|---|---|
| Wen, J | 1 |
| Hadden, MK | 1 |
| Bai, RY | 3 |
| Staedtke, V | 2 |
| Rudin, CM | 2 |
| Bunz, F | 2 |
| Riggins, GJ | 3 |
| Larsen, AR | 1 |
| Chung, JH | 1 |
| Borodovsky, A | 1 |
| Bodhinayake, I | 1 |
| Symons, M | 1 |
| Boockvar, JA | 1 |
| Wanjiku, T | 1 |
| Rudek, MA | 1 |
| Joshi, A | 1 |
| Gallia, GL | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Phase I Study of Mebendazole Therapy for Recurrent/Progressive Pediatric Brain Tumors[NCT02644291] | Phase 1 | 16 participants (Actual) | Interventional | 2016-05-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for mebendazole and Medulloblastoma
| Article | Year |
|---|---|
Medulloblastoma drugs in development: Current leads, trials and drawbacks.
Topics: Animals; Antineoplastic Agents; Cell Line, Tumor; Cerebellar Neoplasms; Humans; Medulloblastoma; Pro | 2021 |
4 other studies available for mebendazole and Medulloblastoma
| Article | Year |
|---|---|
Effective treatment of diverse medulloblastoma models with mebendazole and its impact on tumor angiogenesis.
Topics: Animals; Antineoplastic Agents; Cell Line, Tumor; Cerebellar Neoplasms; Female; Humans; Mebendazole; | 2015 |
Repurposing the antihelmintic mebendazole as a hedgehog inhibitor.
Topics: Anilides; Animals; Antineoplastic Agents; Brain Neoplasms; Cell Line, Tumor; Cell Proliferation; Dru | 2015 |
Repurposing mebendazole for the treatment of medulloblastoma.
Topics: Animals; Anthelmintics; Antineoplastic Agents; Cerebellar Neoplasms; Humans; Mebendazole; Medullobla | 2015 |
Brain Penetration and Efficacy of Different Mebendazole Polymorphs in a Mouse Brain Tumor Model.
Topics: Animals; Brain Neoplasms; Chemistry, Pharmaceutical; Disease Models, Animal; Humans; Mebendazole; Me | 2015 |