Page last updated: 2024-10-30

mebendazole and Loiasis

mebendazole has been researched along with Loiasis in 9 studies

Mebendazole: A benzimidazole that acts by interfering with CARBOHYDRATE METABOLISM and inhibiting polymerization of MICROTUBULES.
mebendazole : A carbamate ester that is methyl 1H-benzimidazol-2-ylcarbamate substituted by a benzoyl group at position 5.

Loiasis: A parasitic infection caused by the nematode Loa loa. The vector in the transmission of this infection is the horsefly (Tabanus) or the deerfly or mango fly (Chrysops). The larvae may be seen just beneath the skin or passing through the conjunctiva. Eye lesions are not uncommon. The disease is generally mild and painless.

Research Excerpts

ExcerptRelevanceReference
"The effectiveness of mebendazole as a microfilaricide in patients with loiasis was studied."9.06Failure of high dose mebendazole as a microfilaricide in patients with loiasis. ( Burchard, GD; Kern, P, 1987)
"Mebendazole (Vermox 500) in long duration treatment 2 g/day for 3 to 4 weeks, is sometimes indicated in therapy of Loa Loa filariasis but remains the only active therapy on M."7.67[Filariasis in Gabon: treatment with mebendazole of filariasis due to M. perstans and Loa loa]. ( Burnier, I; Kombila, M; Maganga, ML; Richard-Lenoble, D, 1985)
"Flubendazole (FLBZ) is a potent and efficacious macrofilaricide after parenteral administration."5.48Potential Role for Flubendazole in Limiting Filariasis Transmission: Observations of Microfilarial Sensitivity. ( Burkman, E; Dzimianski, M; Geary, TG; Kengne-Ouafo, JA; Mackenzie, CD; Moorhead, A; Ndongmo, PC; Njouendou, JA; O'Neill, M; Wanji, S, 2018)
"Treatment with mebendazole (1."5.27Treatment of recurrent, filarial, Calabar-type oedema with mebendazole. ( Flocard, F; Van Hoegaerden, M, 1986)
"The effectiveness of mebendazole as a microfilaricide in patients with loiasis was studied."5.06Failure of high dose mebendazole as a microfilaricide in patients with loiasis. ( Burchard, GD; Kern, P, 1987)
"Mebendazole (Vermox 500) in long duration treatment 2 g/day for 3 to 4 weeks, is sometimes indicated in therapy of Loa Loa filariasis but remains the only active therapy on M."3.67[Filariasis in Gabon: treatment with mebendazole of filariasis due to M. perstans and Loa loa]. ( Burnier, I; Kombila, M; Maganga, ML; Richard-Lenoble, D, 1985)
"loa L3 and treated with 10 mg/kg FLBZ once daily for 5 consecutive days."1.51Effect of flubendazole on developing stages of Loa loa in vitro and in vivo: a new approach for screening filaricidal agents. ( Chunda, VC; Enyong, P; Fombad, FF; Gandjui, NVT; Hoerauf, A; Mackenzie, CD; Metuge, HM; Ndongmo, PC; Njiokou, F; Njouendou, AJ; Ritter, M; Wanji, S, 2019)
"Flubendazole (FLBZ) is a potent and efficacious macrofilaricide after parenteral administration."1.48Potential Role for Flubendazole in Limiting Filariasis Transmission: Observations of Microfilarial Sensitivity. ( Burkman, E; Dzimianski, M; Geary, TG; Kengne-Ouafo, JA; Mackenzie, CD; Moorhead, A; Ndongmo, PC; Njouendou, JA; O'Neill, M; Wanji, S, 2018)
"Treatment with mebendazole (1."1.27Treatment of recurrent, filarial, Calabar-type oedema with mebendazole. ( Flocard, F; Van Hoegaerden, M, 1986)
"Patients harbouring Loa loa and/or Mansonella perstans infections, or presenting typical filarial symptomatology, were treated with mebendazole, a drug shown to be efficient in other parasitoses."1.27The use of mebendazole in the treatment of filariases due to Loa loa and Mansonella perstans. ( Chabaud, B; Flocard, F; Ivanoff, B; Salle, A; Van Hoegaerden, M, 1987)

Research

Studies (9)

TimeframeStudies, this research(%)All Research%
pre-19905 (55.56)18.7374
1990's0 (0.00)18.2507
2000's1 (11.11)29.6817
2010's3 (33.33)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
O'Neill, M1
Njouendou, JA1
Dzimianski, M1
Burkman, E1
Ndongmo, PC2
Kengne-Ouafo, JA1
Wanji, S2
Moorhead, A1
Mackenzie, CD2
Geary, TG1
Fombad, FF1
Njouendou, AJ1
Ritter, M1
Chunda, VC1
Metuge, HM1
Gandjui, NVT1
Enyong, P1
Njiokou, F1
Hoerauf, A1
Moliner, JV1
Valverde, AG1
Sorolla, JM1
Kamgno, J1
Boussinesq, M1
Van Hoegaerden, M3
Flocard, F3
Burchard, GD1
Kern, P1
Ivanoff, B1
Salle, A1
Chabaud, B1
Richard-Lenoble, D1
Kombila, M1
Burnier, I1
Maganga, ML1

Trials

2 trials available for mebendazole and Loiasis

ArticleYear
Effect of a single dose (600 mg) of albendazole on Loa loa microfilaraemia.
    Parasite (Paris, France), 2002, Volume: 9, Issue:1

    Topics: Adolescent; Adult; Albendazole; Animals; Child; Dietary Fats; Female; Filaricides; Humans; Loa; Loia

2002
Failure of high dose mebendazole as a microfilaricide in patients with loiasis.
    Transactions of the Royal Society of Tropical Medicine and Hygiene, 1987, Volume: 81, Issue:3

    Topics: Clinical Trials as Topic; Filariasis; Humans; Loiasis; Mebendazole

1987

Other Studies

7 other studies available for mebendazole and Loiasis

ArticleYear
Potential Role for Flubendazole in Limiting Filariasis Transmission: Observations of Microfilarial Sensitivity.
    The American journal of tropical medicine and hygiene, 2018, Volume: 98, Issue:1

    Topics: Animals; Brugia malayi; Culicidae; Filariasis; Filaricides; Humans; Loa; Loiasis; Mebendazole; Micro

2018
Effect of flubendazole on developing stages of Loa loa in vitro and in vivo: a new approach for screening filaricidal agents.
    Parasites & vectors, 2019, Jan-08, Volume: 12, Issue:1

    Topics: Africa, Central; Africa, Western; Animals; Cell Line; Elephantiasis, Filarial; Filaricides; Hydrolys

2019
[Loa loa meningoencephalitis secondary to treatment with mebendazol].
    Medicina clinica, 2011, Feb-26, Volume: 136, Issue:5

    Topics: Adolescent; Albendazole; Animals; Anthelmintics; Brain Damage, Chronic; Central Nervous System Helmi

2011
Mebendazole treatment of loaiasis.
    Lancet (London, England), 1985, Jun-01, Volume: 1, Issue:8440

    Topics: Benzimidazoles; Diethylcarbamazine; Filariasis; Humans; Loiasis; Mebendazole

1985
Treatment of recurrent, filarial, Calabar-type oedema with mebendazole.
    Tropical and geographical medicine, 1986, Volume: 38, Issue:3

    Topics: Adult; Dipetalonema Infections; Edema; Filariasis; Gabon; Humans; Loa; Loiasis; Male; Mebendazole; R

1986
The use of mebendazole in the treatment of filariases due to Loa loa and Mansonella perstans.
    Annals of tropical medicine and parasitology, 1987, Volume: 81, Issue:3

    Topics: Adolescent; Adult; Animals; Filariasis; Humans; Loiasis; Mansonelliasis; Mebendazole; Microfilariae;

1987
[Filariasis in Gabon: treatment with mebendazole of filariasis due to M. perstans and Loa loa].
    Bulletin de la Societe de pathologie exotique et de ses filiales, 1985, Volume: 78, Issue:4

    Topics: Filariasis; Gabon; Humans; Loiasis; Mansonelliasis; Mebendazole

1985