mebendazole has been researched along with Filariasis in 43 studies
Mebendazole: A benzimidazole that acts by interfering with CARBOHYDRATE METABOLISM and inhibiting polymerization of MICROTUBULES.
mebendazole : A carbamate ester that is methyl 1H-benzimidazol-2-ylcarbamate substituted by a benzoyl group at position 5.
Filariasis: Infections with nematodes of the superfamily FILARIOIDEA. The presence of living worms in the body is mainly asymptomatic but the death of adult worms leads to granulomatous inflammation and permanent fibrosis. Organisms of the genus Elaeophora infect wild elk and domestic sheep causing ischemic necrosis of the brain, blindness, and dermatosis of the face.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The effectiveness of mebendazole as a microfilaricide in patients with loiasis was studied." | 9.06 | Failure of high dose mebendazole as a microfilaricide in patients with loiasis. ( Burchard, GD; Kern, P, 1987) |
| "Mebendazole (Vermox 500) in long duration treatment 2 g/day for 3 to 4 weeks, is sometimes indicated in therapy of Loa Loa filariasis but remains the only active therapy on M." | 7.67 | [Filariasis in Gabon: treatment with mebendazole of filariasis due to M. perstans and Loa loa]. ( Burnier, I; Kombila, M; Maganga, ML; Richard-Lenoble, D, 1985) |
| "Flubendazole (FLBZ) is a potent and efficacious macrofilaricide after parenteral administration." | 5.48 | Potential Role for Flubendazole in Limiting Filariasis Transmission: Observations of Microfilarial Sensitivity. ( Burkman, E; Dzimianski, M; Geary, TG; Kengne-Ouafo, JA; Mackenzie, CD; Moorhead, A; Ndongmo, PC; Njouendou, JA; O'Neill, M; Wanji, S, 2018) |
| "Treatment with mebendazole (1." | 5.27 | Treatment of recurrent, filarial, Calabar-type oedema with mebendazole. ( Flocard, F; Van Hoegaerden, M, 1986) |
| "The effectiveness of mebendazole as a microfilaricide in patients with loiasis was studied." | 5.06 | Failure of high dose mebendazole as a microfilaricide in patients with loiasis. ( Burchard, GD; Kern, P, 1987) |
| "Mebendazole (Vermox 500) in long duration treatment 2 g/day for 3 to 4 weeks, is sometimes indicated in therapy of Loa Loa filariasis but remains the only active therapy on M." | 3.67 | [Filariasis in Gabon: treatment with mebendazole of filariasis due to M. perstans and Loa loa]. ( Burnier, I; Kombila, M; Maganga, ML; Richard-Lenoble, D, 1985) |
| " Levamisole at a dosage of 3 mg/kg daily for 8 days showed marked reduction in both microfilaria rate and microfilaria density and immediately thereafter mf-rate steadily increased almost up to pre-treatment level, the mf-density however showed only marginal increase." | 2.64 | Levamisole and mebendazole in the treatment of bancroftian infection. ( Das, M; Narasimham, MV; Rao, CK; Roychowdhury, SP, 1978) |
| " In summary, oral doses of ASD formulated FBZ did not significantly reduce total worm burden but longer treatments, extended takedown times or a second dosing regimen, may decrease female fecundity and the number of mf shed by female worms." | 1.51 | Efficacy of subcutaneous doses and a new oral amorphous solid dispersion formulation of flubendazole on male jirds (Meriones unguiculatus) infected with the filarial nematode Brugia pahangi. ( Baeten, B; Beerntsen, B; Bulman, CA; Engelen, M; Fischer, C; Gut, J; Ibiricu Urriza, I; Lachau-Durand, S; Lim, KC; Lustigman, S; Quirynen, L; Sakanari, J; Tekle, F, 2019) |
| "Flubendazole (FLBZ) is a potent and efficacious macrofilaricide after parenteral administration." | 1.48 | Potential Role for Flubendazole in Limiting Filariasis Transmission: Observations of Microfilarial Sensitivity. ( Burkman, E; Dzimianski, M; Geary, TG; Kengne-Ouafo, JA; Mackenzie, CD; Moorhead, A; Ndongmo, PC; Njouendou, JA; O'Neill, M; Wanji, S, 2018) |
| " Oral absorption is rapid compared with IM dosing; the absorption half-life (K01-HL) for the IM treatment is approximately 14 hr compared with 1 and 2 hr for the PO regimen of salt and free base forms, respectively." | 1.31 | Pharmacokinetics of UMF-078, a candidate antifilarial drug, in infected dogs. ( Dzimianski, MT; Fleckenstein, L; McCall, JW; Theplertboon, R, 2000) |
| "Mebendazole was given to infected animals for 2 weeks beginning 5 weeks (prepatent) or 16 weeks (patent) after infection." | 1.28 | Eosinophil hyporesponse of jirds induced by microfilariae of Brugia pahangi. ( Fujita, K; Horii, Y; Kurokawa, K; Mori, A; Nakanishi, H; Oda, T; Ueda, M; Zaitsu, M, 1989) |
| "Treatment with mebendazole (1." | 1.27 | Treatment of recurrent, filarial, Calabar-type oedema with mebendazole. ( Flocard, F; Van Hoegaerden, M, 1986) |
| "Patients harbouring Loa loa and/or Mansonella perstans infections, or presenting typical filarial symptomatology, were treated with mebendazole, a drug shown to be efficient in other parasitoses." | 1.27 | The use of mebendazole in the treatment of filariases due to Loa loa and Mansonella perstans. ( Chabaud, B; Flocard, F; Ivanoff, B; Salle, A; Van Hoegaerden, M, 1987) |
| "Flubendazole was macrofilaricidal at 5 x 2." | 1.26 | The anthelmintic effects of flubendazole on Brugia pahangi. ( Cho, SY; Denham, DA; Samad, R; Skippins, SC; Suswillo, RR, 1979) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 33 (76.74) | 18.7374 |
| 1990's | 4 (9.30) | 18.2507 |
| 2000's | 2 (4.65) | 29.6817 |
| 2010's | 3 (6.98) | 24.3611 |
| 2020's | 1 (2.33) | 2.80 |
| Authors | Studies |
|---|---|
| Abuzar, S | 1 |
| Sharma, S | 2 |
| Fatma, N | 2 |
| Gupta, S | 1 |
| Murthy, PK | 1 |
| Katiyar, JC | 1 |
| Chatterjee, RK | 2 |
| Sen, AB | 1 |
| Stetter, N | 1 |
| Hartmann, W | 1 |
| Brunn, ML | 1 |
| Stanelle-Bertram, S | 1 |
| Gabriel, G | 1 |
| Breloer, M | 1 |
| O'Neill, M | 1 |
| Njouendou, JA | 1 |
| Dzimianski, M | 1 |
| Burkman, E | 1 |
| Ndongmo, PC | 1 |
| Kengne-Ouafo, JA | 1 |
| Wanji, S | 1 |
| Moorhead, A | 1 |
| Mackenzie, CD | 2 |
| Geary, TG | 1 |
| Fischer, C | 1 |
| Ibiricu Urriza, I | 1 |
| Bulman, CA | 1 |
| Lim, KC | 1 |
| Gut, J | 1 |
| Lachau-Durand, S | 2 |
| Engelen, M | 2 |
| Quirynen, L | 2 |
| Tekle, F | 2 |
| Baeten, B | 2 |
| Beerntsen, B | 1 |
| Lustigman, S | 1 |
| Sakanari, J | 1 |
| Hübner, MP | 1 |
| Ehrens, A | 1 |
| Koschel, M | 1 |
| Dubben, B | 1 |
| Lenz, F | 1 |
| Frohberger, SJ | 1 |
| Specht, S | 1 |
| Hoerauf, A | 1 |
| Saunders, M | 1 |
| Taubert, A | 1 |
| Dafa'alla, T | 1 |
| Zahner, H | 2 |
| Chand, P | 1 |
| Rai, RN | 1 |
| Dey, KP | 1 |
| Chakravertty, RK | 1 |
| Rao, CK | 2 |
| Mak, JW | 3 |
| Chan, WC | 1 |
| Sim, BK | 1 |
| Kwa, BH | 1 |
| Chusattayanond, W | 2 |
| Denham, DA | 6 |
| Almaviva, M | 1 |
| Galli, M | 1 |
| Rizzi, M | 1 |
| Simonelli, E | 1 |
| Negri, C | 1 |
| Vigevani, GM | 1 |
| Olumide, YM | 1 |
| Obembe, BM | 1 |
| Wahlgren, M | 2 |
| Frolov, I | 1 |
| Brandt, E | 1 |
| Van den Bossche, H | 1 |
| Horii, Y | 2 |
| Makimura, S | 1 |
| Ramanathan, S | 1 |
| Nair, NK | 1 |
| Mansor, SM | 1 |
| Navaratnam, V | 1 |
| Theplertboon, R | 1 |
| Fleckenstein, L | 1 |
| Dzimianski, MT | 1 |
| McCall, JW | 1 |
| Goldsmid, JM | 2 |
| Rogers, S | 2 |
| Narasimham, MV | 1 |
| Roychowdhury, SP | 1 |
| Das, M | 1 |
| Shibuya, T | 2 |
| Oikawa, Y | 1 |
| Saito, M | 1 |
| Tanaka, H | 2 |
| Samad, R | 1 |
| Cho, SY | 1 |
| Suswillo, RR | 2 |
| Skippins, SC | 1 |
| Bernberg, HC | 1 |
| Clarke, VV | 1 |
| Gelfand, M | 1 |
| Rogers, R | 1 |
| Karnad, DR | 1 |
| Meisheri, YV | 1 |
| Franz, M | 1 |
| Benten, P | 1 |
| Huseen, AM | 1 |
| Tanganelli, E | 1 |
| Nakanishi, H | 1 |
| Mori, A | 1 |
| Zaitsu, M | 1 |
| Ueda, M | 1 |
| Kurokawa, K | 1 |
| Oda, T | 1 |
| Fujita, K | 1 |
| Van Hoegaerden, M | 3 |
| Flocard, F | 3 |
| Sarma, RV | 1 |
| Vallishayee, RS | 1 |
| Rao, RS | 1 |
| Prabhakar, R | 1 |
| Tripathy, SP | 1 |
| Van Kerckhoven, I | 1 |
| Kumar, V | 1 |
| Burchard, GD | 1 |
| Kern, P | 1 |
| Maeda, R | 2 |
| Hayashi, Y | 2 |
| Nogami, S | 1 |
| Nakamura, M | 1 |
| Ivanoff, B | 1 |
| Salle, A | 1 |
| Chabaud, B | 1 |
| Richard-Lenoble, D | 1 |
| Kombila, M | 1 |
| Burnier, I | 1 |
| Maganga, ML | 1 |
3 trials available for mebendazole and Filariasis
| Article | Year |
|---|---|
Treatment of Brugia malayi infection with mebendazole and levamisole.
Topics: Adolescent; Adult; Aged; Benzimidazoles; Brugia; Clinical Trials as Topic; Drug Therapy, Combination | 1983 |
Levamisole and mebendazole in the treatment of bancroftian infection.
Topics: Benzimidazoles; Diethylcarbamazine; Filariasis; Humans; Levamisole; Mebendazole; Placebos; Wuchereri | 1978 |
Failure of high dose mebendazole as a microfilaricide in patients with loiasis.
Topics: Clinical Trials as Topic; Filariasis; Humans; Loiasis; Mebendazole | 1987 |
40 other studies available for mebendazole and Filariasis
| Article | Year |
|---|---|
Studies in potential filaricides. 18. Synthesis of 2,2'-disubstituted 5,5'-dibenzimidazolyl ketones and related compounds as potential anthelmintics.
Topics: Animals; Anthelmintics; Arvicolinae; Cestode Infections; Cricetinae; Drug Evaluation, Preclinical; F | 1986 |
A Combination of Deworming and Prime-Boost Vaccination Regimen Restores Efficacy of Vaccination Against Influenza in Helminth-Infected Mice.
Topics: Animals; Antinematodal Agents; Coinfection; Disease Models, Animal; Female; Filariasis; Filarioidea; | 2021 |
Potential Role for Flubendazole in Limiting Filariasis Transmission: Observations of Microfilarial Sensitivity.
Topics: Animals; Brugia malayi; Culicidae; Filariasis; Filaricides; Humans; Loa; Loiasis; Mebendazole; Micro | 2018 |
Efficacy of subcutaneous doses and a new oral amorphous solid dispersion formulation of flubendazole on male jirds (Meriones unguiculatus) infected with the filarial nematode Brugia pahangi.
Topics: Administration, Oral; Animals; Brugia pahangi; Disease Models, Animal; Female; Filariasis; Filaricid | 2019 |
Macrofilaricidal efficacy of single and repeated oral and subcutaneous doses of flubendazole in Litomosoides sigmodontis infected jirds.
Topics: Administration, Oral; Animals; Disease Models, Animal; Embryonic Development; Female; Filariasis; Fi | 2019 |
Effect of chemotherapeutic treatment on cytokine (IFN-gamma, IL-2, IL-4, IL-5, IL-10) gene transcription in response to specific antigens in Brugia malayi-infected Mastomys coucha.
Topics: Animals; Anthelmintics; Brugia malayi; Cytokines; Filariasis; Lymphocytes; Mebendazole; Murinae; Pep | 2008 |
Observations on mebendazole as a filaricide.
Topics: Adolescent; Adult; Benzimidazoles; Child; Female; Filariasis; Humans; Male; Mebendazole; Middle Aged | 1983 |
Effects of serum from treated patients on antibody-dependent cell adherence to the infective larvae of Brugia malayi.
Topics: Anthelmintics; Antibodies; Brugia; Cell Adhesion; Complement System Proteins; Diethylcarbamazine; Fi | 1983 |
Induction of host resistance to Brugia pahangi in jirds (Meriones unguiculatus) protected by chemoprophylaxis.
Topics: Animals; Antinematodal Agents; Benzimidazoles; Brugia; Female; Filariasis; Filarioidea; Gerbillinae; | 1984 |
Immune response in a symptomatic case of Tetrapetalonema perstans infection.
Topics: Antibody Formation; Cameroon; Diethylcarbamazine; Dipetalonema Infections; Female; Filariasis; Human | 1984 |
Dipetalonema perstans in a patient with chronic lymphoedema. Case report.
Topics: Adult; Dipetalonema Infections; Female; Filariasis; Humans; Levamisole; Lymphedema; Mebendazole | 1983 |
Treatment of Dipetalonema perstans infections with mebendazole.
Topics: Adult; Benzimidazoles; Child; Dipetalonema Infections; Female; Filariasis; Humans; Male; Mebendazole | 1983 |
Chemoprophylactic activity of flubendazole against Brugia pahangi in jirds.
Topics: Animals; Antinematodal Agents; Benzimidazoles; Brugia; Female; Filariasis; Filarioidea; Gerbillinae; | 1984 |
The successful treatment of Dipetalonema perstans filariasis with mebendazole.
Topics: Adult; Benzimidazoles; Diethylcarbamazine; Dipetalonema Infections; Female; Filariasis; Humans; Male | 1982 |
Anthelmintic properties of flubendazole against Dipetalonema viteae in jirds.
Topics: Animals; Antinematodal Agents; Benzimidazoles; Dipetalonema; Dipetalonema Infections; Filariasis; Ge | 1980 |
Chemoprophylactic activity of flubendazole against adult Brugia pahangi transplanted into the peritoneal cavity of jirds.
Topics: Animals; Anthelmintics; Benzimidazoles; Brugia; Female; Filariasis; Filaricides; Gerbillinae; Male; | 1980 |
A new look at the mode of action of some old and new antifilarial compounds.
Topics: Anthelmintics; Diethylcarbamazine; Filariasis; Filarioidea; Humans; Levamisole; Mebendazole; Suramin | 1981 |
Antifilarial activity of mebendazole and flubendazole on Breinlia booliati.
Topics: Animals; Antinematodal Agents; Benzimidazoles; Female; Filariasis; Filarioidea; Male; Mebendazole; R | 1981 |
Protective immunity against multiple challenges of Brugia pahangi in Mongolian gerbils induced by drug-abbreviated infection.
Topics: Animals; Brugia pahangi; Filariasis; Gerbillinae; Immunization; Larva; Male; Mebendazole; Rodent Dis | 1994 |
Determination of a new antifilarial drug, UMF-058, and mebendazole in whole blood by high-performance liquid chromatography.
Topics: Animals; Brugia malayi; Cercopithecidae; Chromatography, High Pressure Liquid; Filariasis; Filaricid | 1993 |
Pharmacokinetics of UMF-078, a candidate antifilarial drug, in infected dogs.
Topics: Administration, Oral; Animals; Antinematodal Agents; Area Under Curve; Biological Availability; Brug | 2000 |
Studies on the diagnosis and treatment of human filariasis in Rhodesia.
Topics: Adult; Aged; Blood; Dipetalonema; Dipetalonema Infections; Filariasis; Humans; Male; Mebendazole; St | 1976 |
Mebendazole--a slow acting macro- and microfilaricide against Litomosoides carinii in cotton rat.
Topics: Administration, Oral; Animals; Anthelmintics; Benzimidazoles; Female; Filariasis; Filaricides; Filar | 1979 |
The anthelmintic effects of flubendazole on Brugia pahangi.
Topics: Animals; Anthelmintics; Benzimidazoles; Brugia; Cats; Drug Administration Schedule; Female; Filarias | 1979 |
A preliminary study on the treatment of filariasis due to dipetalonema perstans.
Topics: Adult; Aged; Dipetalonema Infections; Filariasis; Humans; Levamisole; Male; Mebendazole | 1979 |
The combined treatment with levamisole and mebendazole for a perstans-like filarial infection in Rhodesia.
Topics: Adult; Benzimidazoles; Dipetalonema Infections; Drug Therapy, Combination; Female; Filariasis; Human | 1979 |
Studies with Brugia pahangi 19. Anthelmintic effects of mebendazole.
Topics: Animals; Benzimidazoles; Brugia; Cats; Female; Filariasis; Male; Mebendazole | 1978 |
Mebendazole with levamisole in tropical pulmonary eosinophilia: an alternative in diethylcarbamazine allergy.
Topics: Animals; Diethylcarbamazine; Drug Hypersensitivity; Drug Therapy, Combination; Filariasis; Humans; L | 1992 |
Fine-structure alterations in female Brugia malayi and Litomosoides carinii after in vivo treatment with flubendazole.
Topics: Animals; Antinematodal Agents; Brugia; Elephantiasis, Filarial; Female; Filariasis; Filarioidea; Meb | 1990 |
2,2'-Dicarbomethoxyamino-5,5'-dibenzimidazolyl ketone--a new antifilarial agent.
Topics: Administration, Oral; Animals; Anthelmintics; Arvicolinae; Benzimidazoles; Diethylcarbamazine; Dose- | 1989 |
[Elephantiasis of the vulva and the legs. Medical and surgical treatment of a case of lymphatic filariasis].
Topics: Adult; Combined Modality Therapy; Elephantiasis, Filarial; Female; Filariasis; Humans; Leg; Mebendaz | 1989 |
Eosinophil hyporesponse of jirds induced by microfilariae of Brugia pahangi.
Topics: Animals; Brugia; Chronic Disease; Eosinophils; Filariasis; Gerbillinae; Male; Mebendazole; Microfila | 1989 |
Mebendazole treatment of loaiasis.
Topics: Benzimidazoles; Diethylcarbamazine; Filariasis; Humans; Loiasis; Mebendazole | 1985 |
Use of mebendazole in combination with DEC in bancroftian filariasis.
Topics: Adolescent; Adult; Animals; Diethylcarbamazine; Drug Therapy, Combination; Elephantiasis, Filarial; | 1988 |
Macrofilaricidal activity of oral flubendazole on Brugia pahangi.
Topics: Administration, Oral; Animals; Antinematodal Agents; Brugia; Female; Filariasis; Heart; Lung; Male; | 1988 |
Basic studies on the laboratory assessment of macrofilaricides using Brugia malayi in the jird, Meriones unguiculatus. 2. Establishment and evaluation of a new method of macrofilaricide assessment.
Topics: Animals; Anthelmintics; Arsenicals; Brugia; Diethylcarbamazine; Drug Evaluation, Preclinical; Elepha | 1988 |
Effect of milbemycin D on Dipetalonema viteae in the hamster and in vitro.
Topics: Animals; Anti-Bacterial Agents; Cricetinae; Dipetalonema; Dipetalonema Infections; Female; Filariasi | 1987 |
Treatment of recurrent, filarial, Calabar-type oedema with mebendazole.
Topics: Adult; Dipetalonema Infections; Edema; Filariasis; Gabon; Humans; Loa; Loiasis; Male; Mebendazole; R | 1986 |
The use of mebendazole in the treatment of filariases due to Loa loa and Mansonella perstans.
Topics: Adolescent; Adult; Animals; Filariasis; Humans; Loiasis; Mansonelliasis; Mebendazole; Microfilariae; | 1987 |
[Filariasis in Gabon: treatment with mebendazole of filariasis due to M. perstans and Loa loa].
Topics: Filariasis; Gabon; Humans; Loiasis; Mansonelliasis; Mebendazole | 1985 |