mebendazole has been researched along with Experimental Neoplasms in 3 studies
Mebendazole: A benzimidazole that acts by interfering with CARBOHYDRATE METABOLISM and inhibiting polymerization of MICROTUBULES.
mebendazole : A carbamate ester that is methyl 1H-benzimidazol-2-ylcarbamate substituted by a benzoyl group at position 5.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Mebendazole (MBZ), first used as an antiparasitic drug, shows preclinical efficacy in models of glioblastoma and medulloblastoma." | 3.81 | Brain Penetration and Efficacy of Different Mebendazole Polymorphs in a Mouse Brain Tumor Model. ( Bai, RY; Gallia, GL; Joshi, A; Riggins, GJ; Rudek, MA; Staedtke, V; Wanjiku, T, 2015) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 2 (66.67) | 24.3611 |
| 2020's | 1 (33.33) | 2.80 |
| Authors | Studies |
|---|---|
| Cheong, JE | 1 |
| Zaffagni, M | 1 |
| Chung, I | 1 |
| Xu, Y | 1 |
| Wang, Y | 1 |
| Jernigan, FE | 1 |
| Zetter, BR | 1 |
| Sun, L | 1 |
| Popović, KJ | 1 |
| Popović, DJ | 1 |
| Miljković, D | 1 |
| Popović, JK | 1 |
| Lalošević, D | 1 |
| Poša, M | 1 |
| Čapo, I | 1 |
| Bai, RY | 1 |
| Staedtke, V | 1 |
| Wanjiku, T | 1 |
| Rudek, MA | 1 |
| Joshi, A | 1 |
| Gallia, GL | 1 |
| Riggins, GJ | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Phase I Study of Mebendazole Therapy for Recurrent/Progressive Pediatric Brain Tumors[NCT02644291] | Phase 1 | 16 participants (Actual) | Interventional | 2016-05-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
3 other studies available for mebendazole and Experimental Neoplasms
| Article | Year |
|---|---|
Synthesis and anticancer activity of novel water soluble benzimidazole carbamates.
Topics: Animals; Antineoplastic Agents; Benzimidazoles; Carbamates; Cell Proliferation; Cell Survival; Dose- | 2018 |
Disulfiram and metformin combination anticancer effect reversible partly by antioxidant nitroglycerin and completely by NF-κB activator mebendazole in hamster fibrosarcoma.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Antioxidants; Disulfiram; Female; Fibrosarc | 2021 |
Brain Penetration and Efficacy of Different Mebendazole Polymorphs in a Mouse Brain Tumor Model.
Topics: Animals; Brain Neoplasms; Chemistry, Pharmaceutical; Disease Models, Animal; Humans; Mebendazole; Me | 2015 |