mebendazole has been researched along with Colonic Neoplasms in 6 studies
Mebendazole: A benzimidazole that acts by interfering with CARBOHYDRATE METABOLISM and inhibiting polymerization of MICROTUBULES.
mebendazole : A carbamate ester that is methyl 1H-benzimidazol-2-ylcarbamate substituted by a benzoyl group at position 5.
Colonic Neoplasms: Tumors or cancer of the COLON.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Mebendazole was well tolerated and its addition to bevacizumab and FOLFOX4 enhanced tumor response to treatment which was translated by significant improvement of overall response rate 12 weeks after intervention [10 % (2) versus 65% (13) for control and mebendazole groups, respectively; p = 0." | 7.11 | Mebendazole; from an anti-parasitic drug to a promising candidate for drug repurposing in colorectal cancer. ( El-Azab, GA; El-Ghoneimy, RA; Hegazy, SK; Mostafa, MF; Zakaria, F, 2022) |
| "Mebendazole was well tolerated and its addition to bevacizumab and FOLFOX4 enhanced tumor response to treatment which was translated by significant improvement of overall response rate 12 weeks after intervention [10 % (2) versus 65% (13) for control and mebendazole groups, respectively; p = 0." | 3.11 | Mebendazole; from an anti-parasitic drug to a promising candidate for drug repurposing in colorectal cancer. ( El-Azab, GA; El-Ghoneimy, RA; Hegazy, SK; Mostafa, MF; Zakaria, F, 2022) |
| "We compare their efficacy in breast and colon cancer cell lines as well as in non-cancerous cells and elucidate their mechanism of action." | 1.62 | Treatment of breast and colon cancer cell lines with anti-helmintic benzimidazoles mebendazole or albendazole results in selective apoptotic cell death. ( Baird, SK; Petersen, JSSM, 2021) |
| "In our study, colon cancer cells derived from a primary tumor (SW480) and lymph node metastasis (SW620) from the same patient were used and compared." | 1.48 | The Effect of Flubendazole on Adhesion and Migration in SW480 and SW620 Colon Cancer Cells. ( Hanušová, V; Králová, V; Matoušková, P; Skálová, L, 2018) |
| "Two established colon cancer cell lines were tested using the fluorometric microculture cytotoxicity assay (FMCA)." | 1.39 | Repositioning of the anthelmintic drug mebendazole for the treatment for colon cancer. ( Agerup, B; Fryknäs, M; Larsson, R; Nygren, P, 2013) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 4 (66.67) | 24.3611 |
| 2020's | 2 (33.33) | 2.80 |
| Authors | Studies |
|---|---|
| Hegazy, SK | 1 |
| El-Azab, GA | 1 |
| Zakaria, F | 1 |
| Mostafa, MF | 1 |
| El-Ghoneimy, RA | 1 |
| Petersen, JSSM | 1 |
| Baird, SK | 1 |
| Hanušová, V | 1 |
| Skálová, L | 1 |
| Králová, V | 1 |
| Matoušková, P | 1 |
| Nygren, P | 2 |
| Fryknäs, M | 1 |
| Agerup, B | 1 |
| Larsson, R | 2 |
| Williamson, T | 1 |
| Bai, RY | 1 |
| Staedtke, V | 1 |
| Huso, D | 1 |
| Riggins, GJ | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Clinical Study Evaluating Mebendazole as Adjuvant Therapy in Patients With Colorectal Cancer[NCT03925662] | Phase 3 | 40 participants (Anticipated) | Interventional | 2019-04-01 | Recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 trial available for mebendazole and Colonic Neoplasms
| Article | Year |
|---|---|
Mebendazole; from an anti-parasitic drug to a promising candidate for drug repurposing in colorectal cancer.
Topics: Antibodies, Monoclonal, Humanized; Antineoplastic Combined Chemotherapy Protocols; Bevacizumab; Carc | 2022 |
5 other studies available for mebendazole and Colonic Neoplasms
| Article | Year |
|---|---|
Treatment of breast and colon cancer cell lines with anti-helmintic benzimidazoles mebendazole or albendazole results in selective apoptotic cell death.
Topics: Albendazole; Anthelmintics; Apoptosis; Breast Neoplasms; Cell Cycle; Cell Proliferation; Colonic Neo | 2021 |
The Effect of Flubendazole on Adhesion and Migration in SW480 and SW620 Colon Cancer Cells.
Topics: Antineoplastic Agents; Cell Adhesion; Cell Movement; Cell Proliferation; Colonic Neoplasms; Dose-Res | 2018 |
Repositioning of the anthelmintic drug mebendazole for the treatment for colon cancer.
Topics: Anthelmintics; Antineoplastic Agents; Cell Survival; Colonic Neoplasms; Dose-Response Relationship, | 2013 |
Drug repositioning from bench to bedside: tumour remission by the antihelmintic drug mebendazole in refractory metastatic colon cancer.
Topics: Aged; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Colonic Neoplasms; Drug | 2014 |
Mebendazole and a non-steroidal anti-inflammatory combine to reduce tumor initiation in a colon cancer preclinical model.
Topics: Adenomatous Polyposis Coli; Animals; Anti-Inflammatory Agents, Non-Steroidal; Antineoplastic Combine | 2016 |