mebendazole has been researched along with Benign Neoplasms, Brain in 8 studies
Mebendazole: A benzimidazole that acts by interfering with CARBOHYDRATE METABOLISM and inhibiting polymerization of MICROTUBULES.
mebendazole : A carbamate ester that is methyl 1H-benzimidazol-2-ylcarbamate substituted by a benzoyl group at position 5.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Although mebendazole (MBZ) has demonstrated antitumor activity in glioblastoma models, the drug has low aqueous solubility and therefore is poorly absorbed." | 7.96 | Preparation and Evaluation of Mebendazole Microemulsion for Intranasal Delivery: an Alternative Approach for Glioblastoma Treatment. ( Barragán-Aroche, F; Ganem-Rondero, A; García-López, P; Jung-Cook, H; Llaguno-Munive, M; López-Ramírez, S; Mayet-Cruz, L; Mena-Hernández, J; Rivera-Huerta, M, 2020) |
| "Mebendazole has been approved by the US Food and Drug Administration for parasitic infections, has a long track-record of safe human use, and was effective in our animal models with doses documented as safe in humans." | 5.37 | Antiparasitic mebendazole shows survival benefit in 2 preclinical models of glioblastoma multiforme. ( Aprhys, CM; Bai, RY; Gallia, GL; Riggins, GJ; Staedtke, V, 2011) |
| "Although mebendazole (MBZ) has demonstrated antitumor activity in glioblastoma models, the drug has low aqueous solubility and therefore is poorly absorbed." | 3.96 | Preparation and Evaluation of Mebendazole Microemulsion for Intranasal Delivery: an Alternative Approach for Glioblastoma Treatment. ( Barragán-Aroche, F; Ganem-Rondero, A; García-López, P; Jung-Cook, H; Llaguno-Munive, M; López-Ramírez, S; Mayet-Cruz, L; Mena-Hernández, J; Rivera-Huerta, M, 2020) |
| " Here, we show that mebendazole, a benzamidazole with a long history of safe use against nematode infestations and hydatid disease, potently inhibited Hh signaling and slowed the growth of Hh-driven human medulloblastoma cells at clinically attainable concentrations." | 3.81 | Repurposing the antihelmintic mebendazole as a hedgehog inhibitor. ( Bai, RY; Borodovsky, A; Bunz, F; Chung, JH; Larsen, AR; Riggins, GJ; Rudin, CM, 2015) |
| "Mebendazole (MBZ), first used as an antiparasitic drug, shows preclinical efficacy in models of glioblastoma and medulloblastoma." | 3.81 | Brain Penetration and Efficacy of Different Mebendazole Polymorphs in a Mouse Brain Tumor Model. ( Bai, RY; Gallia, GL; Joshi, A; Riggins, GJ; Rudek, MA; Staedtke, V; Wanjiku, T, 2015) |
| "A patient with hydatid cyst affecting the vermis and right cerebellar hemisphere is presented." | 2.38 | [Hydatidosis of the posterior fossa]. ( Cuello Contreras, JA; Jiménez-Mejías, ME; Pachón Díaz, J; Palomico Nicas, J; Polaina Bailón, M; Trujillo Madroñal, E, 1989) |
| "Mebendazole has been shown to inhibit microtubule formation, but it is not known whether its potency against tumor cells is mediated by this inhibitory effect." | 1.46 | Repurposing Mebendazole as a Replacement for Vincristine for the Treatment of Brain Tumors. ( Al Dimassi, S; Atlas, M; Boockvar, J; De Witt, M; Gamble, A; Hanson, D; Markowitz, D; Powell, C; Ruggieri, R; Symons, M, 2017) |
| "Mebendazole has been approved by the US Food and Drug Administration for parasitic infections, has a long track-record of safe human use, and was effective in our animal models with doses documented as safe in humans." | 1.37 | Antiparasitic mebendazole shows survival benefit in 2 preclinical models of glioblastoma multiforme. ( Aprhys, CM; Bai, RY; Gallia, GL; Riggins, GJ; Staedtke, V, 2011) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (12.50) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 4 (50.00) | 24.3611 |
| 2020's | 3 (37.50) | 2.80 |
| Authors | Studies |
|---|---|
| Meco, D | 1 |
| Attinà, G | 1 |
| Mastrangelo, S | 1 |
| Navarra, P | 1 |
| Ruggiero, A | 1 |
| Vítovcová, B | 1 |
| Skarková, V | 1 |
| Havelek, R | 1 |
| Soukup, J | 1 |
| Pande, A | 1 |
| Caltová, K | 1 |
| Rudolf, E | 1 |
| Mena-Hernández, J | 1 |
| Jung-Cook, H | 1 |
| Llaguno-Munive, M | 1 |
| García-López, P | 1 |
| Ganem-Rondero, A | 1 |
| López-Ramírez, S | 1 |
| Barragán-Aroche, F | 1 |
| Rivera-Huerta, M | 1 |
| Mayet-Cruz, L | 1 |
| De Witt, M | 1 |
| Gamble, A | 1 |
| Hanson, D | 1 |
| Markowitz, D | 1 |
| Powell, C | 1 |
| Al Dimassi, S | 1 |
| Atlas, M | 1 |
| Boockvar, J | 1 |
| Ruggieri, R | 1 |
| Symons, M | 1 |
| Larsen, AR | 1 |
| Bai, RY | 3 |
| Chung, JH | 1 |
| Borodovsky, A | 1 |
| Rudin, CM | 1 |
| Riggins, GJ | 3 |
| Bunz, F | 1 |
| Staedtke, V | 2 |
| Wanjiku, T | 1 |
| Rudek, MA | 1 |
| Joshi, A | 1 |
| Gallia, GL | 2 |
| Aprhys, CM | 1 |
| Jiménez-Mejías, ME | 1 |
| Trujillo Madroñal, E | 1 |
| Polaina Bailón, M | 1 |
| Cuello Contreras, JA | 1 |
| Palomico Nicas, J | 1 |
| Pachón Díaz, J | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Phase I Study of Mebendazole Therapy for Recurrent/Progressive Pediatric Brain Tumors[NCT02644291] | Phase 1 | 16 participants (Actual) | Interventional | 2016-05-31 | Completed | ||
| A Phase I Study of Mebendazole for the Treatment of Pediatric Gliomas[NCT01837862] | Phase 1/Phase 2 | 36 participants (Anticipated) | Interventional | 2013-10-22 | Recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 reviews available for mebendazole and Benign Neoplasms, Brain
| Article | Year |
|---|---|
Emerging Perspectives on the Antiparasitic Mebendazole as a Repurposed Drug for the Treatment of Brain Cancers.
Topics: Animals; Anti-Infective Agents; Antineoplastic Agents; Antiparasitic Agents; Brain Neoplasms; Cell L | 2023 |
[Hydatidosis of the posterior fossa].
Topics: Astrocytoma; Brain Neoplasms; Cerebellar Diseases; Child; Combined Modality Therapy; Diagnostic Erro | 1989 |
6 other studies available for mebendazole and Benign Neoplasms, Brain
| Article | Year |
|---|---|
Flubendazole exhibits anti-glioblastoma effect by inhibiting STAT3 and promoting cell cycle arrest.
Topics: Adult; Apoptosis; Brain Neoplasms; Cell Cycle; Cell Cycle Checkpoints; Cell Line, Tumor; Cell Prolif | 2023 |
Preparation and Evaluation of Mebendazole Microemulsion for Intranasal Delivery: an Alternative Approach for Glioblastoma Treatment.
Topics: Administration, Intranasal; Animals; Antineoplastic Agents; Biological Availability; Brain Neoplasms | 2020 |
Repurposing Mebendazole as a Replacement for Vincristine for the Treatment of Brain Tumors.
Topics: Animals; Antineoplastic Agents; Brain Neoplasms; Cell Line, Tumor; Drug Repositioning; Female; Human | 2017 |
Repurposing the antihelmintic mebendazole as a hedgehog inhibitor.
Topics: Anilides; Animals; Antineoplastic Agents; Brain Neoplasms; Cell Line, Tumor; Cell Proliferation; Dru | 2015 |
Brain Penetration and Efficacy of Different Mebendazole Polymorphs in a Mouse Brain Tumor Model.
Topics: Animals; Brain Neoplasms; Chemistry, Pharmaceutical; Disease Models, Animal; Humans; Mebendazole; Me | 2015 |
Antiparasitic mebendazole shows survival benefit in 2 preclinical models of glioblastoma multiforme.
Topics: Animals; Antinematodal Agents; Apoptosis; Blotting, Western; Brain Neoplasms; Cell Line, Tumor; Cell | 2011 |
Antiparasitic mebendazole shows survival benefit in 2 preclinical models of glioblastoma multiforme.
Topics: Animals; Antinematodal Agents; Apoptosis; Blotting, Western; Brain Neoplasms; Cell Line, Tumor; Cell | 2011 |
Antiparasitic mebendazole shows survival benefit in 2 preclinical models of glioblastoma multiforme.
Topics: Animals; Antinematodal Agents; Apoptosis; Blotting, Western; Brain Neoplasms; Cell Line, Tumor; Cell | 2011 |
Antiparasitic mebendazole shows survival benefit in 2 preclinical models of glioblastoma multiforme.
Topics: Animals; Antinematodal Agents; Apoptosis; Blotting, Western; Brain Neoplasms; Cell Line, Tumor; Cell | 2011 |