mebendazole has been researched along with Arachnoidal Cerebellar Sarcoma, Circumscribed in 5 studies
Mebendazole: A benzimidazole that acts by interfering with CARBOHYDRATE METABOLISM and inhibiting polymerization of MICROTUBULES.
mebendazole : A carbamate ester that is methyl 1H-benzimidazol-2-ylcarbamate substituted by a benzoyl group at position 5.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Mebendazole (MBZ) has a long safety record as antiparasitic in children and has been recently implicated in inhibition of various tyrosine kinases in vitro." | 5.42 | Effective treatment of diverse medulloblastoma models with mebendazole and its impact on tumor angiogenesis. ( Bai, RY; Bunz, F; Riggins, GJ; Rudin, CM; Staedtke, V, 2015) |
| " Here, we show that mebendazole, a benzamidazole with a long history of safe use against nematode infestations and hydatid disease, potently inhibited Hh signaling and slowed the growth of Hh-driven human medulloblastoma cells at clinically attainable concentrations." | 3.81 | Repurposing the antihelmintic mebendazole as a hedgehog inhibitor. ( Bai, RY; Borodovsky, A; Bunz, F; Chung, JH; Larsen, AR; Riggins, GJ; Rudin, CM, 2015) |
| "Mebendazole (MBZ), first used as an antiparasitic drug, shows preclinical efficacy in models of glioblastoma and medulloblastoma." | 3.81 | Brain Penetration and Efficacy of Different Mebendazole Polymorphs in a Mouse Brain Tumor Model. ( Bai, RY; Gallia, GL; Joshi, A; Riggins, GJ; Rudek, MA; Staedtke, V; Wanjiku, T, 2015) |
| "Mebendazole (MBZ) has a long safety record as antiparasitic in children and has been recently implicated in inhibition of various tyrosine kinases in vitro." | 1.42 | Effective treatment of diverse medulloblastoma models with mebendazole and its impact on tumor angiogenesis. ( Bai, RY; Bunz, F; Riggins, GJ; Rudin, CM; Staedtke, V, 2015) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 4 (80.00) | 24.3611 |
| 2020's | 1 (20.00) | 2.80 |
| Authors | Studies |
|---|---|
| Wen, J | 1 |
| Hadden, MK | 1 |
| Bai, RY | 3 |
| Staedtke, V | 2 |
| Rudin, CM | 2 |
| Bunz, F | 2 |
| Riggins, GJ | 3 |
| Larsen, AR | 1 |
| Chung, JH | 1 |
| Borodovsky, A | 1 |
| Bodhinayake, I | 1 |
| Symons, M | 1 |
| Boockvar, JA | 1 |
| Wanjiku, T | 1 |
| Rudek, MA | 1 |
| Joshi, A | 1 |
| Gallia, GL | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Phase I Study of Mebendazole Therapy for Recurrent/Progressive Pediatric Brain Tumors[NCT02644291] | Phase 1 | 16 participants (Actual) | Interventional | 2016-05-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for mebendazole and Arachnoidal Cerebellar Sarcoma, Circumscribed
| Article | Year |
|---|---|
Medulloblastoma drugs in development: Current leads, trials and drawbacks.
Topics: Animals; Antineoplastic Agents; Cell Line, Tumor; Cerebellar Neoplasms; Humans; Medulloblastoma; Pro | 2021 |
4 other studies available for mebendazole and Arachnoidal Cerebellar Sarcoma, Circumscribed
| Article | Year |
|---|---|
Effective treatment of diverse medulloblastoma models with mebendazole and its impact on tumor angiogenesis.
Topics: Animals; Antineoplastic Agents; Cell Line, Tumor; Cerebellar Neoplasms; Female; Humans; Mebendazole; | 2015 |
Repurposing the antihelmintic mebendazole as a hedgehog inhibitor.
Topics: Anilides; Animals; Antineoplastic Agents; Brain Neoplasms; Cell Line, Tumor; Cell Proliferation; Dru | 2015 |
Repurposing mebendazole for the treatment of medulloblastoma.
Topics: Animals; Anthelmintics; Antineoplastic Agents; Cerebellar Neoplasms; Humans; Mebendazole; Medullobla | 2015 |
Brain Penetration and Efficacy of Different Mebendazole Polymorphs in a Mouse Brain Tumor Model.
Topics: Animals; Brain Neoplasms; Chemistry, Pharmaceutical; Disease Models, Animal; Humans; Mebendazole; Me | 2015 |