mebendazole has been researched along with Angiogenesis, Pathologic in 5 studies
Mebendazole: A benzimidazole that acts by interfering with CARBOHYDRATE METABOLISM and inhibiting polymerization of MICROTUBULES.
mebendazole : A carbamate ester that is methyl 1H-benzimidazol-2-ylcarbamate substituted by a benzoyl group at position 5.
| Excerpt | Relevance | Reference |
|---|---|---|
| "In recent years, treatment of melanoma and a range of other deadly cancers has involved immunotherapy with programmed cell death protein-1 (PD-1)/PD-1 ligand (PD-L1) checkpoint blockade which has improved survival." | 5.51 | The anthelmintic flubendazole blocks human melanoma growth and metastasis and suppresses programmed cell death protein-1 and myeloid-derived suppressor cell accumulation. ( Acharya, G; Elahy, M; Khachigian, LM; Li, Y; Xin, H, 2019) |
| "Mebendazole (MBZ) has a long safety record as antiparasitic in children and has been recently implicated in inhibition of various tyrosine kinases in vitro." | 5.42 | Effective treatment of diverse medulloblastoma models with mebendazole and its impact on tumor angiogenesis. ( Bai, RY; Bunz, F; Riggins, GJ; Rudin, CM; Staedtke, V, 2015) |
| "Adrenocortical carcinoma is a rare tumor of the adrenal gland which requires new therapeutic approaches as its early diagnosis is difficult and prognosis poor despite therapies used." | 5.35 | Mebendazole inhibits growth of human adrenocortical carcinoma cell lines implanted in nude mice. ( Baldi, C; Martarelli, D; Mazzoni, G; Pompei, P, 2008) |
| "In recent years, treatment of melanoma and a range of other deadly cancers has involved immunotherapy with programmed cell death protein-1 (PD-1)/PD-1 ligand (PD-L1) checkpoint blockade which has improved survival." | 1.51 | The anthelmintic flubendazole blocks human melanoma growth and metastasis and suppresses programmed cell death protein-1 and myeloid-derived suppressor cell accumulation. ( Acharya, G; Elahy, M; Khachigian, LM; Li, Y; Xin, H, 2019) |
| "Mebendazole (MBZ) has a long safety record as antiparasitic in children and has been recently implicated in inhibition of various tyrosine kinases in vitro." | 1.42 | Effective treatment of diverse medulloblastoma models with mebendazole and its impact on tumor angiogenesis. ( Bai, RY; Bunz, F; Riggins, GJ; Rudin, CM; Staedtke, V, 2015) |
| "Adrenocortical carcinoma is a rare tumor of the adrenal gland which requires new therapeutic approaches as its early diagnosis is difficult and prognosis poor despite therapies used." | 1.35 | Mebendazole inhibits growth of human adrenocortical carcinoma cell lines implanted in nude mice. ( Baldi, C; Martarelli, D; Mazzoni, G; Pompei, P, 2008) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (40.00) | 29.6817 |
| 2010's | 3 (60.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Dakshanamurthy, S | 1 |
| Issa, NT | 1 |
| Assefnia, S | 1 |
| Seshasayee, A | 1 |
| Peters, OJ | 1 |
| Madhavan, S | 1 |
| Uren, A | 1 |
| Brown, ML | 1 |
| Byers, SW | 1 |
| Li, Y | 1 |
| Acharya, G | 1 |
| Elahy, M | 1 |
| Xin, H | 1 |
| Khachigian, LM | 1 |
| Bai, RY | 1 |
| Staedtke, V | 1 |
| Rudin, CM | 1 |
| Bunz, F | 1 |
| Riggins, GJ | 1 |
| Mukhopadhyay, T | 1 |
| Sasaki, J | 1 |
| Ramesh, R | 1 |
| Roth, JA | 1 |
| Martarelli, D | 1 |
| Pompei, P | 1 |
| Baldi, C | 1 |
| Mazzoni, G | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Phase I Study of Mebendazole Therapy for Recurrent/Progressive Pediatric Brain Tumors[NCT02644291] | Phase 1 | 16 participants (Actual) | Interventional | 2016-05-31 | Completed | ||
| A Phase I Study of Mebendazole for the Treatment of Pediatric Gliomas[NCT01837862] | Phase 1/Phase 2 | 36 participants (Anticipated) | Interventional | 2013-10-22 | Recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
5 other studies available for mebendazole and Angiogenesis, Pathologic
| Article | Year |
|---|---|
Predicting new indications for approved drugs using a proteochemometric method.
Topics: Animals; Antineoplastic Agents; Antirheumatic Agents; Cadherins; Celecoxib; Cell Line, Tumor; Crysta | 2012 |
The anthelmintic flubendazole blocks human melanoma growth and metastasis and suppresses programmed cell death protein-1 and myeloid-derived suppressor cell accumulation.
Topics: Animals; Antinematodal Agents; Antineoplastic Agents; Cell Growth Processes; Cell Line, Tumor; Femal | 2019 |
Effective treatment of diverse medulloblastoma models with mebendazole and its impact on tumor angiogenesis.
Topics: Animals; Antineoplastic Agents; Cell Line, Tumor; Cerebellar Neoplasms; Female; Humans; Mebendazole; | 2015 |
Mebendazole elicits a potent antitumor effect on human cancer cell lines both in vitro and in vivo.
Topics: Animals; Antineoplastic Agents; Apoptosis; Carcinoma, Non-Small-Cell Lung; Cell Division; Cell Line; | 2002 |
Mebendazole inhibits growth of human adrenocortical carcinoma cell lines implanted in nude mice.
Topics: Adrenocortical Carcinoma; Animals; Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Cell Movement | 2008 |