mebendazole has been researched along with Acute Liver Injury, Drug-Induced in 14 studies
Mebendazole: A benzimidazole that acts by interfering with CARBOHYDRATE METABOLISM and inhibiting polymerization of MICROTUBULES.
mebendazole : A carbamate ester that is methyl 1H-benzimidazol-2-ylcarbamate substituted by a benzoyl group at position 5.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Mebendazole was administered to 7 adult Dachshunds and 2 adult Doberman Pinschers at 6-month intervals for routine parasite control." | 5.26 | Acute hepatic necrosis associated with the administration of mebendazole to dogs. ( Hardy, RM; O'Leary, TP; Polzin, DJ; Stevens, JB; Stowe, CM, 1981) |
| "Mebendazole (MBZ) is a broad-spectrum antihelminthic agent of the benzimidazole type." | 1.51 | Hepatotoxicity caused by mebendazole in a patient with Gilbert's syndrome. ( Cascio, A; Colomba, C; Meli, M; Tolomeo, M, 2019) |
| " We proposed a systematic classification scheme using FDA-approved drug labeling to assess the DILI potential of drugs, which yielded a benchmark dataset with 287 drugs representing a wide range of therapeutic categories and daily dosage amounts." | 1.37 | FDA-approved drug labeling for the study of drug-induced liver injury. ( Chen, M; Fang, H; Liu, Z; Shi, Q; Tong, W; Vijay, V, 2011) |
| " An understanding of structure-activity relationships (SARs) of chemicals can make a significant contribution to the identification of potential toxic effects early in the drug development process and aid in avoiding such problems." | 1.36 | Developing structure-activity relationships for the prediction of hepatotoxicity. ( Fisk, L; Greene, N; Naven, RT; Note, RR; Patel, ML; Pelletier, DJ, 2010) |
| "When mebendazole was given at 15 times the therapeutic dose prior to an hypoxic episode in dogs pretreated with a barbiturate and high protein diet, there was no evidence of any adverse effect on liver function." | 1.27 | Safety studies evaluating the effect of mebendazole on liver function in dogs. ( Marsboom, R; Van Cauteren, H; Vandenberghe, J; Will, JA, 1983) |
| "Mebendazole was administered to 7 adult Dachshunds and 2 adult Doberman Pinschers at 6-month intervals for routine parasite control." | 1.26 | Acute hepatic necrosis associated with the administration of mebendazole to dogs. ( Hardy, RM; O'Leary, TP; Polzin, DJ; Stevens, JB; Stowe, CM, 1981) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 5 (35.71) | 18.7374 |
| 1990's | 1 (7.14) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 8 (57.14) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Fourches, D | 1 |
| Barnes, JC | 1 |
| Day, NC | 1 |
| Bradley, P | 1 |
| Reed, JZ | 1 |
| Tropsha, A | 1 |
| Greene, N | 1 |
| Fisk, L | 1 |
| Naven, RT | 1 |
| Note, RR | 1 |
| Patel, ML | 1 |
| Pelletier, DJ | 1 |
| Ekins, S | 1 |
| Williams, AJ | 1 |
| Xu, JJ | 1 |
| Chen, M | 2 |
| Vijay, V | 1 |
| Shi, Q | 2 |
| Liu, Z | 2 |
| Fang, H | 2 |
| Tong, W | 3 |
| Ding, D | 1 |
| Kelly, R | 1 |
| Morgan, RE | 1 |
| van Staden, CJ | 1 |
| Chen, Y | 1 |
| Kalyanaraman, N | 1 |
| Kalanzi, J | 1 |
| Dunn, RT | 1 |
| Afshari, CA | 1 |
| Hamadeh, HK | 1 |
| Suzuki, A | 1 |
| Thakkar, S | 1 |
| Yu, K | 1 |
| Hu, C | 1 |
| Tolomeo, M | 1 |
| Colomba, C | 1 |
| Meli, M | 1 |
| Cascio, A | 1 |
| Seitz, R | 1 |
| Schwerk, W | 1 |
| Arnold, R | 1 |
| Van Cauteren, H | 1 |
| Marsboom, R | 1 |
| Vandenberghe, J | 1 |
| Will, JA | 1 |
| Swanson, JF | 1 |
| Breider, MA | 1 |
| Polzin, DJ | 1 |
| Stowe, CM | 1 |
| O'Leary, TP | 1 |
| Stevens, JB | 1 |
| Hardy, RM | 1 |
| Colle, I | 1 |
| Naegels, S | 1 |
| Hoorens, A | 1 |
| Hautekeete, M | 1 |
| Bekhti, A | 1 |
| Pirotte, J | 1 |
1 review available for mebendazole and Acute Liver Injury, Drug-Induced
| Article | Year |
|---|---|
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Pr | 2016 |
13 other studies available for mebendazole and Acute Liver Injury, Drug-Induced
| Article | Year |
|---|---|
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLI | 2010 |
Developing structure-activity relationships for the prediction of hepatotoxicity.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Humans; Structure-Activity Relationship; | 2010 |
A predictive ligand-based Bayesian model for human drug-induced liver injury.
Topics: Bayes Theorem; Chemical and Drug Induced Liver Injury; Humans; Ligands | 2010 |
FDA-approved drug labeling for the study of drug-induced liver injury.
Topics: Animals; Benchmarking; Biomarkers, Pharmacological; Chemical and Drug Induced Liver Injury; Drug Des | 2011 |
Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps).
Topics: Animals; Anti-Infective Agents; Anti-Inflammatory Agents; Chemical and Drug Induced Liver Injury; Da | 2011 |
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily | 2013 |
Hepatotoxicity caused by mebendazole in a patient with Gilbert's syndrome.
Topics: Antinematodal Agents; Bilirubin; Chemical and Drug Induced Liver Injury; Gilbert Disease; Humans; Li | 2019 |
[Hepatocellular drug reaction caused by mebendazole therapy in cystic echinococcosis].
Topics: Aged; Benzimidazoles; Chemical and Drug Induced Liver Injury; Echinococcosis, Hepatic; Female; Human | 1983 |
Safety studies evaluating the effect of mebendazole on liver function in dogs.
Topics: Animals; Benzimidazoles; Chemical and Drug Induced Liver Injury; Dog Diseases; Dogs; Drug Evaluation | 1983 |
Hepatic failure following mebendazole administration to a dog.
Topics: Animals; Benzimidazoles; Chemical and Drug Induced Liver Injury; Dog Diseases; Dogs; Female; Hemorrh | 1982 |
Acute hepatic necrosis associated with the administration of mebendazole to dogs.
Topics: Acute Disease; Animals; Benzimidazoles; Chemical and Drug Induced Liver Injury; Dog Diseases; Dogs; | 1981 |
Granulomatous hepatitis due to mebendazole.
Topics: Antinematodal Agents; Ascariasis; Biopsy; Chemical and Drug Induced Liver Injury; Eosinophilia; Gran | 1999 |
Hepatotoxicity of mebendazole. Relationship with serum concentrations of the drug.
Topics: Alanine Transaminase; Chemical and Drug Induced Liver Injury; Echinococcosis, Hepatic; Female; Human | 1987 |