mebendazole has been researched along with Abnormalities, Autosome in 3 studies
Mebendazole: A benzimidazole that acts by interfering with CARBOHYDRATE METABOLISM and inhibiting polymerization of MICROTUBULES.
mebendazole : A carbamate ester that is methyl 1H-benzimidazol-2-ylcarbamate substituted by a benzoyl group at position 5.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Analysis of dose-response curves from the in vitro tests, using recently developed point of departure approaches, demonstrate that the aneugenic potency of flubendazole is very similar to related anti-parasitic benzimidazoles, including albendazole, which is used in mass drug administration programmes to combat endemic filarial diseases." | 1.43 | Genotoxicity of flubendazole and its metabolites in vitro and the impact of a new formulation on in vivo aneugenicity. ( Evans, DB; Johnson, GE; Scandale, I; Tweats, DJ; Whitwell, J, 2016) |
| "The ability of flubendazole to induce polyploidy may be part of the mechanism by which this compound induces morphological transformation." | 1.29 | Induction of chromosomal aberrations, cytotoxicity, and morphological transformation in mammalian cells by the antiparasitic drug flubendazole and the antineoplastic drug harringtonine. ( Cerepnalkoski, L; Dews, M; Huang, N; Landolph, JR; Nwankwo, JO, 1994) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (33.33) | 18.7374 |
| 1990's | 1 (33.33) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (33.33) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Tweats, DJ | 1 |
| Johnson, GE | 1 |
| Scandale, I | 1 |
| Whitwell, J | 1 |
| Evans, DB | 1 |
| Huang, N | 1 |
| Cerepnalkoski, L | 1 |
| Nwankwo, JO | 1 |
| Dews, M | 1 |
| Landolph, JR | 1 |
| Léonard, A | 1 |
3 other studies available for mebendazole and Abnormalities, Autosome
| Article | Year |
|---|---|
Genotoxicity of flubendazole and its metabolites in vitro and the impact of a new formulation on in vivo aneugenicity.
Topics: Activation, Metabolic; Aneugens; Animals; Antinematodal Agents; Cells, Cultured; Chromosome Aberrati | 2016 |
Induction of chromosomal aberrations, cytotoxicity, and morphological transformation in mammalian cells by the antiparasitic drug flubendazole and the antineoplastic drug harringtonine.
Topics: Animals; Antinematodal Agents; Antineoplastic Agents; Cell Division; Cell Line, Transformed; Cell Su | 1994 |
Heritable chromosome aberrations in mammals after exposure to chemicals.
Topics: Aflatoxins; Alkylating Agents; Aminoquinolines; Animals; Antimalarials; beta-Aminoethyl Isothiourea; | 1976 |