mdl-100907 and Lung-Diseases--Interstitial

Interstitial lung disease (ILD) encompasses a heterogeneous group of more than 200 conditions, of which primarily idiopathic pulmonary fibrosis (IPF), idiopathic nonspecific interstitial pneumonia, hypersensitivity pneumonitis, ILD associated with autoimmune diseases and sarcoidosis may present a progressive fibrosing (PF) phenotype. Despite different aetiology and histopathological patterns, the PF-ILDs have similarities regarding disease mechanisms with self-sustaining fibrosis, which suggests that the diseases may share common pathogenetic pathways. Previous studies show an enhanced activation of serotonergic signaling in pulmonary fibrosis, and the serotonin (5-HT)

Topics: Animals; Humans; Idiopathic Pulmonary Fibrosis; Inflammation; Lung Diseases, Interstitial; Models, Biological; Receptor, Serotonin, 5-HT2B; Serotonin 5-HT2 Receptor Antagonists