mdl-100907 and Disruptive--Impulse-Control--and-Conduct-Disorders

Parkinson's disease (PD) is the second most common neurodegenerative disorder. Although its major manifestation is motor symptoms, resulting from the loss of dopaminergic neurons in the substantia nigra, psychiatric symptoms, such as depression, anxiety, hallucination, delusion, apathy and anhedonia, impulsive and compulsive behaviors, and cognitive dysfunction, may also manifest in most patients with PD. Given that the quality of life - and the need for institutionalization - is so highly dependent on the psychiatric well-being of patients with PD, psychiatric symptoms are of high clinical significance. We reviewed the prevalence, risk factors, pathophysiology, and treatment of psychiatric symptoms to get a better understanding of PD for improved management.

Topics: Anxiety; Dementia; Depression; Disruptive, Impulse Control, and Conduct Disorders; Dopamine; Humans; Parkinson Disease; Psychotic Disorders; Selective Serotonin Reuptake Inhibitors; Serotonin 5-HT2 Receptor Antagonists