mci 9038 has been researched along with Blood Clot in 191 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 5 (2.62) | 18.7374 |
| 1990's | 35 (18.32) | 18.2507 |
| 2000's | 90 (47.12) | 29.6817 |
| 2010's | 49 (25.65) | 24.3611 |
| 2020's | 12 (6.28) | 2.80 |
| Authors | Studies |
|---|---|
| Appleby, SD; Baskin, EP; Chen, IW; Dancheck, KB; Gardell, SJ; Lewis, SD; Lucas, BJ; Lumma, WC; Lyle, EA; Lynch, JJ; Tucker, TJ; Vacca, JP; Woltmann, R | 1 |
| Allen, MC; Ambler, J; Brundish, D; Bull, A; Butler, K; Donovan, V; Fullerton, JD; Garman, SM; Hayler, JF; Howarth, G; Hoyle, W; Janus, D; Kane, PD; McDonnell, M; Smith, GP; Talbot, MD; Wakeford, R; Walker, CV | 1 |
| Das, J; Kimball, SD; Lau, WF; Ogletree, ML; Reid, JA; Roberts, DG; Schumacher, WA; Seiler, SM; Wang, TC | 1 |
| Chang, CY; Chong, S; Das, J; Hall, SE; Han, WC; Iwanowicz, E; Kimball, SD; Lin, J; Malley, MF; Moquin, RV; Ogletree, ML; Reid, JA; Roberts, DG; Sack, JS; Schumacher, WA; Seiler, SM; Wang-Iverson, DB | 1 |
| Adang, AE; de Man, AP; Grootenhuis, PD; Kelder, J; Lucas, H; Meuleman, DG; Peters, CA; Rewinkel, JB; Smit, MJ; van Aelst, S; van Boeckel, CA; van Dinther, T; Visser, A; Vogel, GM | 1 |
| Cho, KH; Kim, A; Kim, TH; Lee, SH; Park, HD | 1 |
| Chattopadhyay, P; Deka, RC; Gogoi, D; Mukherjee, AK; Pal, A; Paul, S | 1 |
| Bai, T; Feng, Q; Guo, T; Jia, J; Li, X; Liu, Y; Pei, J; Song, Y; Wu, L; Wu, S; Zhang, Y; Zheng, X | 1 |
| González-Rodríguez, M; Lázaro-García, A; Llamas-Sillero, P; Martínez-Alfonzo, I; Tomás-Mallebrera, M; Velasco-Rodríguez, D; Vidal-Laso, R | 1 |
| Asmis, LM; Bachler, M; Fries, D; Koscielny, J; Lang, T; Nowak, H; Paulus, P; Schewe, JC; von Heymann, C | 1 |
| Li, X; Li, Y; Sun, B; Tang, X; Tong, Z; Wang, R; Zhang, Z | 1 |
| Ahmeti, M; Durrani, AK; Seiler, JA | 1 |
| Butler, A; Gudgin, E; Mindlina, I; Nelmes, E; Sharp, M; Thomas, W | 1 |
| Jindong, H; Na, L | 1 |
| Singh Lubana, S; Singh, N; Tsai, HM | 1 |
| Curtis, BR; Erdil, RM; Gilyard, SN; Knelson, EH; Leaf, RK; Malhotra, R; Puram, RV; Ranganathan, R; Van Beuningen, AM; Wallwork, R; Weber, BN | 1 |
| Boyle, G; Buchholz, H; Cantor, RS; Conway, J; Fynn-Thompson, F; Griffiths, E; Hawkins, B; Lorts, A; Lytrivi, ID; Machado, D; May, L; Niebler, RA; Rossano, J; Sutcliffe, DL; VanderPluym, CJ | 1 |
| Enright, H; Fahy, A; McGlynn, F; McGrath, J; McHugh, J; Ryan, B; Varghese, C | 1 |
| Gandotra, P; Garra, G; Gruberg, L; Selim, S; Supariwala, A | 1 |
| Bartlett, RH; Bellomo, TR; Jeakle, MA; Major, TC; Meyerhoff, ME | 1 |
| Male, C; van Ommen, CH; Young, G | 1 |
| Abramov, D; Birks, E; Bitar, A; Lenneman, A; Massey, T; Slaughter, M; Vijayakrishnan, R | 1 |
| Lopez, ND; Sin, JH | 1 |
| Greinacher, A; Heid, J; Katus, HA; Müller, OJ | 1 |
| Gleichgerrcht, E; Lim, MY; Turan, TN | 1 |
| Faraoni, D; Koster, A; Levy, JH | 1 |
| Gheysens, O; Goffin, KE; Hoylaerts, MF; Jacquemin, M; Liesenborghs, L; Peerlinck, K; Peetermans, M; Peetermans, WE; Vanassche, T; Verhaegen, J; Verhamme, P; Wijngaerden, EV | 1 |
| Fu, X; Ning, JP | 1 |
| Ascaso, M; Pereda, D; Quintana, E; Sandoval, E | 1 |
| Ahadizadeh, EN; Buethe, DJ; Honda, K; Manzoor, NF; Merati, M; Mowry, SE; Semaan, M | 1 |
| Forman, DA; Mohanty, E; Nazir, S; Sheppard, JI; Warkentin, TE | 1 |
| Burger, CF; Schlesinger, JJ | 1 |
| Cao, FF; Feng, X; Jiao, RN; Zhang, HT | 1 |
| Hatakeyama, M; Munakata, M; Ono, Y | 1 |
| Cervera, A; Chamorro, Á; de la Rosa, X; Durduran, T; Justicia, C; Kristoffersen, AK; Planas, AM; Valdés, CP; Varma, HM | 1 |
| Annich, GM; Bartlett, RH; Brisbois, EJ; Handa, H; Jones, AM; Major, TC; Zanetti, ME | 1 |
| Forsyth, LL; Shannon, F; Sheppard, JA; Smith, MD; Smythe, MA; Warkentin, TE | 1 |
| Davison, SP; Endara, M; Shuck, J | 1 |
| Hillebrand, J; Martens, S; Mesters, R; Scherer, M; Schmidt, C; Sindermann, J | 1 |
| Ito, S; McAlister, RK | 1 |
| Li, Q; Peng, J; Wei, S; Wu, W; Zhou, J | 1 |
| Young, G | 1 |
| Imoto, K; Isoda, S; Karube, N; Masuda, M; Matsuki, Y; Uchida, K; Yasuda, S | 1 |
| Lei, BZ; Sendowski, M; Shatzel, JJ | 1 |
| Baumgarten, G; Kim, S; Koster, A; Riedel, R; Schewe, JC; Schmieder, A | 1 |
| Alarcón Pérez, L; Duque González, P; Rodríguez Huerta, AM | 1 |
| Hursting, MJ; Murray, PT | 2 |
| Lineaweaver, WC; Oswald, TM; Schleich, AR | 1 |
| Janssens, U; Kroner, S; Lejczyk, J; Niedeggen, A; Reith, S; Stortz, C | 1 |
| Hursting, MJ; Jang, IK | 2 |
| Hursting, MJ; Verme-Gibboney, CN | 1 |
| Beyer, J; Halbritter, K; Schellong, S; Weise, M | 1 |
| Chong, BH; Isaacs, A | 1 |
| Matsuo, T; Sugimoto, T; Wanaka, K | 1 |
| Hursting, MJ; Soffer, J | 1 |
| Aloia, TA; Goss, JA | 1 |
| Asada, Y; Imamura, T; Kitamura, K; Matsuda, S; Matsumoto, T; Moriguchi-Goto, S; Shima, M; Sugita, C; Sumi, T; Takahashi, M; Yamashita, A | 1 |
| Buerke, M; Friedrich, I; Hamilton, K; Hauroeder, B; Linde, T; Maegdefessel, L; Michel, T; Raaz, U; Schlitt, A; Schubert, S; Steinseifer, U; Werdan, K | 1 |
| Chong, BH; Lip, GYH; Shantsila, E | 1 |
| Dhillon, S | 1 |
| Balasubramaniam, M; Forsyth, LL; Koerber, JM; Mattson, JC; Priziola, JL; Smythe, MA | 1 |
| Ichinoe, M; Mikami, T; Okayasu, I; Suzuki, K; Ujiie, S | 1 |
| Heil, S | 1 |
| Barash, P; Coady, M; Fareed, J; Genzen, JR; Hoppensteadt, D; Kurup, V; Wu, YY | 1 |
| Buerke, M; Busshardt, M; Ebelt, H; Kaeberich, A; Maegdefessel, L; Plehn, A; Raaz, U; Russ, M; Schlitt, A; Schubert, S; Werdan, K | 1 |
| Alatri, A; Foramitti, M; Paoletti, O; Testa, S; Zimmermann, A | 1 |
| Bark, N; Blombäck, M; He, S; Johnsson, H; Wallén, NH | 1 |
| Buerke, M; Desaga, M; Genth-Zotz, S; Gulba, DC; Harder, S; Heyndrickx, GR; Rau, M; Rössig, L; Schneider, T; Zeiher, AM | 1 |
| Bartholomew, JR; Frame, JN; Rice, L; Whelton, A | 1 |
| Agnihotri, AK; Hoffman, WD; Jang, IK; Nam, KH; Yeh, RW; Yoon, JH | 1 |
| Bandyk, DF; Bartholomew, JR; Boyce, SW; Frame, JN; Rice, L | 1 |
| Fareed, J; Hoppensteadt, DA; Jeske, WP; Lewis, B; Walenga, JM | 1 |
| Boshkov, LK; Boyle, DA; Cox, DS; Hursting, MJ; Kallender, H; Raffini, LJ; Soffer, J; Sullivan, JE; Tarka, EA; Young, G | 1 |
| Donovan, JL; Kanaan, AO; Tran, MT | 1 |
| Hirano, K; Hirano, M; Kameda, K; Kikkawa, Y; Matsuo, S; Sasaki, T | 1 |
| Baglin, TP; Garcia, DA; Samama, MM; Weitz, JI | 1 |
| Demma, LJ; Levy, JH; Paciullo, CA | 1 |
| Gulseth, MP; Hellwig, TR; Peitz, GJ | 1 |
| Eno, S; Hondo, T; Iwamoto, A; Kimura, M; Matsuda, K; Matsumura, H | 1 |
| Cruz-González, I; López-Jiménez, R; Perez-Rivera, A; Yan, BP | 1 |
| Coppens, M; Eikelboom, JW; Gustafsson, D; Hirsh, J; Weitz, JI | 1 |
| Mizuno, Y; Noda, K; Tanaka, R; Urabe, T | 1 |
| Cohen, M; Hursting, MJ; Lewis, BE; Leya, F; Matthai, WH; Moses, JW | 1 |
| Bittl, JA | 1 |
| Greinacher, A; Lubenow, N | 1 |
| Kato, H; Kimura, S; Nakagawa, K; Nakagawa, M; Tsuji, H; Ukimura, N; Yamada, K; Yamada, Y; Yano, S | 1 |
| Giddings, JC; Hashimoto, M; Matsuo, O; Oiwa, K; Okada, K; Okada, Y; Okamoto, S; Ueshima, S; Yamamoto, J | 1 |
| Walenga, JM | 1 |
| LaMonte, MP | 1 |
| de Denus, S; Spinler, SA | 1 |
| Buijsman, R; Meuleman, DG; Princen, AW; Smit, MJ; Van Dinther, TG; Vogel, GM | 1 |
| Greinacher, A | 1 |
| Arruda, MJ; Cetta, F; Graham, LC; Walenga, JM; Wrona, LL | 1 |
| Heddle, N; Hirsh, J; Kelton, JG | 1 |
| Itoh, T; Naito, K; Natsuaki, M; Ohtsubo, S; Okazaki, Y; Rikitake, K | 1 |
| Dager, WE; Gosselin, RC; Owings, JT | 1 |
| Fritsma, GA | 1 |
| Goto, S; Ishida, H; Tamura, N | 1 |
| Hayashi, T; Kaneko, M; Nakao, Y; Nomura, T; Nonaka, Y; Okamura, J; Suyama, Y | 1 |
| Nakagawa, P; Nugent, DJ; Yonekawa, KE; Young, G | 1 |
| Warkentin, TE | 1 |
| Aranki, SF; Fitzgerald, D; Gasparovic, H; Nathan, NS | 1 |
| Ferrell, J; Grossman, EJ; Hammes, MS; Hursting, MJ; Murray, PT; Reddy, BV; Shamp, TR; Swan, SK; Tang, I; Trevino, S | 1 |
| White, CM | 1 |
| Bhatt, DL; Gurm, HS | 1 |
| Bartholomew, JR | 1 |
| Woodyard, DN | 1 |
| Kam, PC; Kaur, N; Thong, CL | 1 |
| Alfrey, EJ; Braun, J; Dawson, L; Dick, A; Farrell, C; Lerner, SM; Pagano, CR; Smith, MA; Valenia, T | 1 |
| Kawano, HA; Nakajima, T; Suzuki, J; Tomaru, T; Tsujiuchi, Y; Uchida, Y | 1 |
| Bartholomew, JR; Hursting, MJ | 1 |
| Abrams, CS; Pollak, ES | 1 |
| Büller, HR; Di Nisio, M; Middeldorp, S | 1 |
| Chesebro, JH; Grill, DE; Hassinger, NL; McBane, RD; Mruk, JS | 1 |
| Pengo, V | 1 |
| Katz, E; Kim, KY; McNulty, I | 1 |
| Boshkov, L; Giacomuzzi, C; Mejak, B; Shen, I; Ungerleider, R | 1 |
| Dubb, J; Hursting, MJ; Verme-Gibboney, CN | 1 |
| Graff, J; Harder, S | 1 |
| Pendleton, R; Rodgers, GM; Wheeler, MM | 1 |
| Baxi, SM; Chi, L; Gould, WR; Johnson, TR; Leadley, RJ; McClanahan, TB; Saiya-Cork, K; Welch, KM | 1 |
| Hursting, MJ; Levine, RL; McCollum, D | 1 |
| Warkentin, TW | 1 |
| Hursting, MJ; Levine, RL; Lewis, BE; Leya, F; Wallis, DE | 1 |
| Das, P; Hamdalla, H; Jozic, J; Moliterno, DJ; Mukherjee, D; Steinhubl, SR; Ziada, K | 1 |
| Funaki, B; Van Ha, TG; Zangan, SM | 1 |
| Hursting, MJ; Lewis, BE | 1 |
| Haas, S; Höhnke, C | 1 |
| Kloecker, GH; Laber, DA; Martin, ME | 1 |
| Greinacher, A; Selleng, K; Warkentin, TE | 1 |
| Dager, WE; Dougherty, JA; Militello, MA; Nguyen, PH; Smythe, MA | 1 |
| Bong, M; Di Cesare, PE; Patel, VP | 1 |
| Hamada, M; Matsui, H; Mizuno, T; Shida, Y; Sugimoto, M; Yoshioka, A | 1 |
| Lepor, NE | 1 |
| Bozlar, U; Simsek, S; Turba, UC | 1 |
| Diez-Ewald, M | 1 |
| Rolfes, C; Steinfeldt, T | 1 |
| Allegretto, N; Barbera, F; Bird, JE; Giancarli, MR; Ogletree, ML; Schumacher, WA; Seiffert, D; Wong, P | 1 |
| Brüggener, E; Hauptmann, J; Müller, H | 1 |
| Nakashima, M; Nishiyama, H; Saniabadi, AR; Takiguchi, Y; Uematsu, T; Umemura, K | 1 |
| Berry, CN; Girard, D; Lecoffre, C; Lochot, S | 1 |
| Matsuoka, A; Sasaki, Y; Yamamoto, J; Yamashita, T | 1 |
| Hirase, T; Matsuo, T; Miki, T; Sakamoto, S; Suzuki, S; Tsukamoto, T; Yamada, T | 1 |
| Kawai, H; Tamao, Y | 1 |
| Berry, CN; Gauffeny, C; Lecoffre, C; Lunven, C; O'Brien, DP; Roome, NO | 1 |
| Donkin, J; Iaffaldano, R; Lewis, BE; McKiernan, TL; Rao, L; Wallenga, JM | 1 |
| Heran, CL; Schumacher, WA; Steinbacher, TE | 1 |
| Berry, CN; Girard, D; Girardot, C; Lochot, S; Lunven, C; Visconte, C | 1 |
| Börjesson, I; Elg, M; Gustafsson, D; Lenfors, S; Teger-Nilsson, AC | 1 |
| Kinjoh, K; Kosugi, T; Masuda, Y; Nakamura, M; Sunagawa, M; Yamashita, S | 1 |
| Aoki, N; Fujimori, Y; Morita, T; Nakamura, F; Omata, M; Sakamoto, Y; Tomaru, T; Uchida, Y | 1 |
| Giddings, JC; Kawano, M; Sasaki, Y; Watanabe, S; Yamamoto, J | 1 |
| Lewis, BE; Walenga, JM; Wallis, DE | 1 |
| Kambayashi, J; Kawasaki, T; Kim, DI; Sakon, M; Shibuya, T | 1 |
| Fareed, J; Hoppensteadt, DA; Kahn, S | 1 |
| Hara, T; Kunitada, S; Morishima, Y; Tanabe, K; Terada, Y | 1 |
| Fareed, J; Lewis, BE; Rangel, Y | 1 |
| Berry, CN; Charles, MC; Ferrari, P; Girard, D; Girardot, C; Lechaire, I; Lunven, C; O'Brien, DP | 1 |
| Hirayama, F; Hisamichi, N; Kawasaki, T; Koshio, H; Matsumoto, Y; Sato, K; Taniuchi, Y | 1 |
| Deschenes, I; DiMaio, J; Finkle, CD; Leblond, L; St Pierre, A; Winocour, PD | 1 |
| Berry, CN; Girardot, C; Lechaire, I; Lunven, C; O'Connor, SE | 1 |
| Koide, M; Matsuo, T | 1 |
| Fukazawa, T; Goto, Y; Hayashi, H; Inoue, Y; Komatsu, Y | 1 |
| Matthai, WH | 1 |
| Kobayakawa, N; Morita, T; Nakamura, F; Onitake, A; Tomaru, T; Uchida, Y | 1 |
| Jang, IK; Sabatine, MS; Tu, TM | 1 |
| Aisaka, K; Hayashi, M; Matsuo, A; Nakamoto, H | 1 |
| Baglin, TP | 1 |
| Fleischer, K; Gulba, DC; Lankes, W | 1 |
| Bode, C; Darius, H; Diehm, C; Encke, A; Gulba, DC; Haas, S; Hacke, W; Puhl, W; Quante, M; Riess, H; Scharf, R; Schellong, S; Schrör, T; Schulte, KL; Tebbe, U; Van Aken, H | 1 |
| Corno, A; Horisberger, J; Marty, B; Mueller, X; von Segesser, LK | 1 |
| Aida, H; Aoki, Y; Ohki, I; Tanaka, K | 1 |
| Kozawa, O; Matsuno, H; Matsuo, O; Okada, K; Uematsu, T; Ueshima, S | 1 |
| Giddings, JC; Hashimoto, M; Oiwa, K; Watanabe, S; Yamamoto, J; Yamashita, T | 1 |
| Ahmad, S; Hoppensteadt, D; Hursting, MJ; Iqbal, O; Lewis, BE; Walenga, JM | 1 |
| Collen, D; Gold, HK; Imura, Y; Lesaffre, E; Stassen, JM; Vreys, I | 1 |
| Collen, D; Imura, Y; Stassen, JM | 1 |
| Schneider, J | 1 |
| Iwamoto, M; Kumada, T; Morishita, K; Tanaka, T; Tomikawa, M; Wada, M | 1 |
| Collen, D; Fallon, JT; Gold, HK; Jang, IK; Leinbach, RC | 1 |
| Bush, LR; Connolly, TM; Mellott, MJ; York, SJ | 1 |
| Maruyama, I | 1 |
| Collen, D; Fallon, JT; Gold, HK; Jang, IK; Leinbach, RC; Ziskind, AA | 1 |
| Breddin, HK; Haarmann, W; Krupinski, K; Markwardt, F | 1 |
| Matsui, N | 1 |
| Abiko, Y; Hara, T; Iwamoto, M; Kumada, T; Ogawa, H; Tomikawa, M | 1 |
| Matsuo, T | 1 |
45 review(s) available for mci 9038 and Blood Clot
| Article | Year |
|---|---|
Progress of thrombus formation and research on the structure-activity relationship for antithrombotic drugs.
Topics: Fibrinolytic Agents; Humans; Molecular Structure; Thrombosis | 2022 |
Thromboprophylaxis with argatroban in critically ill patients with sepsis: a review.
Topics: Anticoagulants; Arginine; COVID-19; Critical Illness; Heparin; Heparin, Low-Molecular-Weight; Humans; Pipecolic Acids; Sepsis; Sulfonamides; Thrombocytopenia; Thrombosis; Venous Thromboembolism | 2022 |
Argatroban and Bivalirudin for Perioperative Anticoagulation in Cardiac Surgery.
Topics: Antithrombins; Arginine; Cardiac Surgical Procedures; Hirudins; Humans; Peptide Fragments; Perioperative Care; Pipecolic Acids; Recombinant Proteins; Sulfonamides; Thrombosis | 2018 |
[Meta-analysis of the role of Argatroban in renal replacement therapy].
Topics: Antithrombins; Arginine; Hemorrhage; Humans; Incidence; Pipecolic Acids; Renal Dialysis; Renal Insufficiency; Renal Replacement Therapy; Sulfonamides; Thrombosis | 2013 |
Anticoagulants in children and adolescents.
Topics: Adolescent; Anticoagulants; Arginine; Child; Clinical Trials as Topic; Fondaparinux; Hematology; Heparin; Heparin, Low-Molecular-Weight; Hirudins; Humans; Peptide Fragments; Pipecolic Acids; Polysaccharides; Recombinant Proteins; Sulfonamides; Thrombin; Thrombosis; Treatment Outcome; Warfarin | 2015 |
[Heparin-induced thrombocytopenia type II (HIT II) : A medical-economic view].
Topics: Arginine; Chondroitin Sulfates; Costs and Cost Analysis; Dermatan Sulfate; Germany; Hemorrhage; Heparin; Heparitin Sulfate; Hospitalization; Humans; Pipecolic Acids; Risk Factors; Sulfonamides; Thrombocytopenia; Thrombosis; Treatment Outcome | 2017 |
Argatroban anticoagulation in renal dysfunction: a literature analysis.
Topics: Anticoagulants; Arginine; Comorbidity; Humans; Pipecolic Acids; Prevalence; Renal Insufficiency; Sulfonamides; Thrombosis; Treatment Outcome | 2008 |
Heparin-induced thrombocytopenia: what clinicians need to know.
Topics: Anticoagulants; Arginine; Autoantibodies; Chondroitin Sulfates; Dermatan Sulfate; Drug Monitoring; Fondaparinux; Heparin; Heparitin Sulfate; Hirudins; Humans; Peptide Fragments; Pipecolic Acids; Platelet Count; Platelet Factor 4; Polysaccharides; Recombinant Proteins; Sulfonamides; Thrombocytopenia; Thrombosis; Warfarin | 2009 |
Reducing harm associated with anticoagulation: practical considerations of argatroban therapy in heparin-induced thrombocytopenia.
Topics: Angioplasty, Balloon, Coronary; Anticoagulants; Arginine; Dose-Response Relationship, Drug; Heparin; Humans; International Normalized Ratio; Partial Thromboplastin Time; Pipecolic Acids; Platelet Aggregation Inhibitors; Sulfonamides; Thrombocytopenia; Thrombosis | 2009 |
Heparin-induced thrombocytopenia. A contemporary clinical approach to diagnosis and management.
Topics: Anticoagulants; Arginine; Chondroitin Sulfates; Dermatan Sulfate; Female; Heparin; Heparitin Sulfate; Hirudins; Humans; Male; Monitoring, Physiologic; Peptide Fragments; Pipecolic Acids; Platelet Aggregation Inhibitors; Platelet Count; Prognosis; Randomized Controlled Trials as Topic; Recombinant Proteins; Risk Factors; Safety Management; Severity of Illness Index; Sulfonamides; Survival Rate; Thrombocytopenia; Thrombosis; Time Factors | 2009 |
Argatroban: a review of its use in the management of heparin-induced thrombocytopenia.
Topics: Angioplasty, Balloon, Coronary; Anticoagulants; Arginine; Heparin; Humans; Pipecolic Acids; Sulfonamides; Thrombin; Thrombocytopenia; Thrombosis | 2009 |
Pharmacology of argatroban.
Topics: Acute Coronary Syndrome; Antithrombins; Arginine; European Union; Female; Heparin; Humans; Isomerism; Japan; Male; Peptidomimetics; Pipecolic Acids; Stroke; Sulfonamides; Thrombin; Thrombocytopenia; Thrombosis; United States | 2010 |
An overview of heparin-induced thrombocytopenia.
Topics: Anticoagulants; Antithrombins; Arginine; Heparin; Humans; Pipecolic Acids; Sulfonamides; Thrombocytopenia; Thrombosis; Time Factors | 2010 |
Parenteral anticoagulants: Antithrombotic Therapy and Prevention of Thrombosis, 9th ed: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines.
Topics: Antithrombins; Arginine; Chondroitin Sulfates; Dermatan Sulfate; Dose-Response Relationship, Drug; Evidence-Based Medicine; Fibrinolytic Agents; Fondaparinux; Heparin; Heparin, Low-Molecular-Weight; Heparitin Sulfate; Hirudins; Humans; Infusions, Intravenous; Peptide Fragments; Pipecolic Acids; Polysaccharides; Practice Guidelines as Topic; Recombinant Proteins; Societies, Medical; Sulfonamides; Thrombin; Thrombosis; United States | 2012 |
Pharmacokinetic evaluation of argatroban for the treatment of acute coronary syndrome.
Topics: Acute Coronary Syndrome; Animals; Antithrombins; Arginine; Disease Models, Animal; Drug Evaluation; Heparin; Hirudins; Humans; Peptide Fragments; Percutaneous Coronary Intervention; Pipecolic Acids; Randomized Controlled Trials as Topic; Recombinant Proteins; Sulfonamides; Thrombocytopenia; Thrombosis | 2012 |
Translational success stories: development of direct thrombin inhibitors.
Topics: Anticoagulants; Antithrombins; Arginine; Hirudin Therapy; Hirudins; Humans; Peptide Fragments; Pipecolic Acids; Recombinant Proteins; Sulfonamides; Thrombosis; Translational Research, Biomedical | 2012 |
Hirudin in heparin-induced thrombocytopenia.
Topics: Anticoagulants; Antithrombins; Arginine; Blood Coagulation; Chondroitin Sulfates; Clinical Trials as Topic; Dermatan Sulfate; Drug Combinations; Fibrinolytic Agents; Heparin; Heparitin Sulfate; Hirudin Therapy; Hirudins; Humans; Pipecolic Acids; Recombinant Proteins; Sulfonamides; Thrombocytopenia; Thrombosis; Time Factors | 2002 |
An overview of the direct thrombin inhibitor argatroban.
Topics: Arginine; Humans; Pipecolic Acids; Sulfonamides; Thrombin; Thrombocytopenia; Thrombosis; Treatment Outcome | 2002 |
Argatroban in thrombotic stroke.
Topics: Animals; Anticoagulants; Arginine; Brain Ischemia; Collateral Circulation; Humans; Pipecolic Acids; Stroke; Sulfonamides; Thrombin; Thrombosis | 2002 |
Treatment of heparin-induced thrombocytopenia: a critical review.
Topics: Anticoagulants; Arginine; Heparin; Hirudins; Humans; Pipecolic Acids; Recombinant Proteins; Risk Assessment; Sulfonamides; Thrombocytopenia; Thrombosis | 2004 |
Argatroban therapy for antithrombin deficiency and mesenteric thrombosis: case report and review of the literature.
Topics: Adult; Anticoagulants; Antithrombins; Arginine; Humans; Male; Partial Thromboplastin Time; Pipecolic Acids; Sulfonamides; Thrombosis | 2004 |
Direct thrombin inhibitors.
Topics: Anticoagulants; Arginine; Fibrinolytic Agents; Humans; Pipecolic Acids; Sulfonamides; Thrombin; Thrombosis; Warfarin | 2004 |
Heparin-induced thrombocytopenia: diagnosis and management.
Topics: Anticoagulants; Aortic Valve Insufficiency; Arginine; Autoantibodies; Autoimmune Diseases; Female; Fingers; Heart Valve Prosthesis Implantation; Heparin; Hirudins; Humans; Ischemia; Middle Aged; Necrosis; Pipecolic Acids; Platelet Activation; Platelet Factor 4; Postoperative Complications; Raynaud Disease; Recombinant Proteins; Sulfonamides; Thrombocytopenia; Thrombosis; Toes; Warfarin | 2004 |
Thrombin-directed inhibitors: pharmacology and clinical use.
Topics: Anticoagulants; Arginine; Azetidines; Benzylamines; Blood Coagulation; Fondaparinux; Heparin; Hirudins; Humans; Peptide Fragments; Pipecolic Acids; Polysaccharides; Recombinant Proteins; Sulfonamides; Thrombin; Thrombosis; Warfarin | 2005 |
Thrombin, an ideal target for pharmacological inhibition: a review of direct thrombin inhibitors.
Topics: Acute Disease; Angioplasty, Balloon, Coronary; Anticoagulants; Arginine; Atrial Fibrillation; Azetidines; Benzylamines; Clinical Trials as Topic; Coronary Disease; Heparin; Hirudins; Humans; Myocardial Infarction; Peptide Fragments; Pipecolic Acids; Recombinant Proteins; Sulfonamides; Syndrome; Thrombin; Thromboembolism; Thrombosis; Venous Thrombosis | 2005 |
Transition to an oral anticoagulant in patients with heparin-induced thrombocytopenia.
Topics: Administration, Oral; Anticoagulants; Arginine; Blood Coagulation; Blood Coagulation Factors; Chondroitin Sulfates; Dermatan Sulfate; Drug Combinations; Gangrene; Heparin; Heparitin Sulfate; Hirudins; Humans; Ischemia; Leg; Necrosis; Pipecolic Acids; Recombinant Proteins; Skin; Sulfonamides; Thrombocytopenia; Thrombosis; Warfarin | 2005 |
An anesthesia provider's perspective of heparin-induced thrombocytopenia.
Topics: Anesthesia, General; Anticoagulants; Arginine; Drug Monitoring; Enzyme-Linked Immunosorbent Assay; Heparin; Hirudins; Humans; Intraoperative Care; Nurse Anesthetists; Pipecolic Acids; Platelet Count; Recombinant Proteins; Risk Factors; Sensitivity and Specificity; Severity of Illness Index; Sulfonamides; Thrombocytopenia; Thrombosis; Time Factors | 2005 |
Direct thrombin inhibitors: pharmacology and clinical relevance.
Topics: Anticoagulants; Antithrombins; Arginine; Azetidines; Benzylamines; Fibrinolytic Agents; Hirudins; Humans; Pipecolic Acids; Sulfonamides; Thrombosis | 2005 |
Clinical presentation and laboratory diagnosis of heparin-induced thrombocytopenia.
Topics: Anticoagulants; Arginine; Dose-Response Relationship, Drug; Female; Follow-Up Studies; Heparin, Low-Molecular-Weight; Hirudins; Humans; Male; Pipecolic Acids; Recombinant Proteins; Risk Assessment; Severity of Illness Index; Sulfonamides; Thrombocytopenia; Thrombosis; Treatment Outcome | 2005 |
New trends in anticoagulant treatments.
Topics: Anticoagulants; Arginine; Azetidines; Benzylamines; Drug Design; Fibrinolytic Agents; Hirudins; Humans; Peptide Fragments; Pipecolic Acids; Platelet Aggregation Inhibitors; Prodrugs; Recombinant Proteins; Sulfonamides; Thrombosis | 2005 |
Argatroban anticoagulation in pediatric patients: a literature analysis.
Topics: Anticoagulants; Arginine; Child; Humans; Pipecolic Acids; Sulfonamides; Thrombosis | 2006 |
Heparin-induced thrombocytopenia and cardiovascular diseases.
Topics: Anticoagulants; Arginine; Cardiac Surgical Procedures; Cardiovascular Diseases; Chondroitin Sulfates; Dermatan Sulfate; Diagnosis, Differential; Fondaparinux; Heparin; Heparitin Sulfate; Hirudins; Humans; Peptide Fragments; Pipecolic Acids; Platelet Aggregation Inhibitors; Platelet Factor 4; Polysaccharides; Recombinant Proteins; Sensitivity and Specificity; Sulfonamides; Thrombocytopenia; Thrombosis | 2006 |
Direct thrombin inhibition during percutaneous coronary intervention in patients with heparin-induced thrombocytopenia.
Topics: Angioplasty, Balloon, Coronary; Antithrombins; Arginine; Drug Interactions; Economics, Pharmaceutical; Fibrinolytic Agents; Hemorrhage; Heparin; Hirudins; Humans; Peptide Fragments; Pipecolic Acids; Platelet Aggregation Inhibitors; Recombinant Proteins; Sulfonamides; Thrombocytopenia; Thrombosis | 2007 |
Argatroban for anticoagulation during cardiac surgery.
Topics: Adult; Aged; Anticoagulants; Arginine; Cardiac Surgical Procedures; Coronary Artery Bypass; Coronary Artery Bypass, Off-Pump; Drug Monitoring; Endocarditis, Bacterial; Female; Heart Valve Prosthesis Implantation; Heparin; Humans; Intra-Aortic Balloon Pumping; Intraoperative Complications; Male; Middle Aged; Mitral Valve; Pipecolic Acids; Postoperative Complications; Retrospective Studies; Staphylococcal Infections; Subclavian Vein; Sulfonamides; Thrombosis; Venous Thrombosis; Warfarin; Whole Blood Coagulation Time | 2007 |
Heparin-induced thrombocytopenia in intensive care patients.
Topics: Anticoagulants; Arginine; Chondroitin Sulfates; Dermatan Sulfate; Extracorporeal Circulation; Heparin; Heparitin Sulfate; Hirudins; Humans; Intensive Care Units; Pipecolic Acids; Recombinant Proteins; Sulfonamides; Thrombin; Thrombocytopenia; Thrombosis | 2007 |
Heparin-induced thrombocytopenia: treatment options and special considerations.
Topics: Anticoagulants; Antithrombins; Arginine; Heparin; Hirudins; Humans; Peptide Fragments; Pipecolic Acids; Recombinant Proteins; Sulfonamides; Thrombocytopenia; Thrombosis | 2007 |
Heparin-induced thrombocytopenia and thrombosis.
Topics: Anticoagulants; Arginine; Chondroitin Sulfates; Dermatan Sulfate; Heparin; Heparitin Sulfate; Hirudins; Humans; Pipecolic Acids; Recombinant Proteins; Sulfonamides; Thrombocytopenia; Thrombosis | 2007 |
Anticoagulation for acute coronary syndromes: from heparin to direct thrombin inhibitors.
Topics: Acute Disease; Angina Pectoris; Angina, Unstable; Angioplasty, Balloon, Coronary; Anticoagulants; Arginine; Fondaparinux; Hemorrhage; Heparin; Heparin, Low-Molecular-Weight; Hirudins; Humans; Models, Molecular; Molecular Structure; Myocardial Ischemia; Peptide Fragments; Pipecolic Acids; Platelet Activation; Polysaccharides; Recombinant Proteins; Sulfonamides; Syndrome; Thrombin; Thrombosis | 2007 |
Anticoagulation with Novastan (argatroban) in patients with heparin-induced thrombocytopenia and heparin-induced thrombocytopenia and thrombosis syndrome.
Topics: Antibodies; Antithrombins; Arginine; Heparin; Humans; Pipecolic Acids; Sulfonamides; Syndrome; Thrombocytopenia; Thrombosis | 1997 |
[Heparin-induced thrombocytopenia].
Topics: Anticoagulants; Antithrombins; Arginine; Aspirin; Diagnosis, Differential; Fibrinolytic Agents; Heparin; Humans; Pipecolic Acids; Platelet Activation; Platelet Aggregation Inhibitors; Sulfonamides; Thrombocytopenia; Thrombosis | 1998 |
Heparin induced thrombocytopenia thrombosis (HIT/T) syndrome: diagnosis and treatment.
Topics: Anticoagulants; Arginine; Heparin; Hirudin Therapy; Hirudins; Humans; Pipecolic Acids; Platelet Count; Recombinant Proteins; Sulfonamides; Thrombocytopenia; Thrombosis | 2001 |
[Direct thrombin antagonists].
Topics: Acute Disease; Angina, Unstable; Angioplasty, Balloon, Coronary; Animals; Anticoagulants; Antithrombins; Arginine; Azetidines; Benzylamines; Fibrinolytic Agents; Glycine; Hirudin Therapy; Hirudins; Humans; Myocardial Infarction; Peptide Fragments; Pipecolic Acids; Platelet Aggregation Inhibitors; Rabbits; Recombinant Proteins; Sulfonamides; Syndrome; Thrombin; Thromboembolism; Thrombosis; Time Factors | 2001 |
Anticoagulation: the present and future.
Topics: Administration, Oral; Amino Acid Chloromethyl Ketones; Anticoagulants; Arginine; Azetidines; Benzylamines; Binding Sites; Biological Availability; Blood Coagulation; Comorbidity; Coumarins; Drug Design; Embolism; Female; Forecasting; Glycine; Guanidines; Heart Diseases; Hemorrhage; Heparin; Heparin, Low-Molecular-Weight; Hirudin Therapy; Humans; Neoplasms; Pipecolic Acids; Pregnancy; Pregnancy Complications, Hematologic; Prodrugs; Safety; Serine; Stroke; Sulfonamides; Thrombin; Thrombophilia; Thrombosis | 2001 |
Alternatives to unfractionated heparin for anticoagulation in cardiopulmonary bypass.
Topics: Abciximab; Ancrod; Antibodies, Monoclonal; Anticoagulants; Arginine; Cardiopulmonary Bypass; Chondroitin Sulfates; Cross Reactions; Dermatan Sulfate; Drug Combinations; Drug Hypersensitivity; Factor Xa Inhibitors; Hemodilution; Hemorrhage; Heparin; Heparin, Low-Molecular-Weight; Heparitin Sulfate; Hirudin Therapy; Humans; Immunoglobulin Fab Fragments; Perfusion; Pipecolic Acids; Platelet Aggregation Inhibitors; Protamines; Sulfonamides; Thrombocytopenia; Thrombophilia; Thrombosis; Tirofiban; Tyrosine | 2001 |
[Artificial organs and thrombosis: hemodialysis].
Topics: Arginine; Blood Coagulation; Blood Coagulation Factors; Calcium; Gabexate; Guanidines; Heparin; Humans; Pipecolic Acids; Platelet Aggregation; Platelet Count; Renal Dialysis; Sulfonamides; Thrombosis | 1986 |
10 trial(s) available for mci 9038 and Blood Clot
| Article | Year |
|---|---|
Clinical study of argatroban for preventing vascular thrombosis in the early period after pediatric living-related donor liver transplantation.
Topics: Adolescent; Anticoagulants; Arginine; Child; Child, Preschool; Female; Heparin; Humans; Incidence; Infant; Infant, Newborn; Liver Transplantation; Living Donors; Male; Pipecolic Acids; Platelet Aggregation Inhibitors; Postoperative Care; Postoperative Complications; Sulfonamides; Thrombosis; Treatment Outcome | 2020 |
Targeting Coagulase Activity in Staphylococcus aureus Bacteraemia: A Randomized Controlled Single-Centre Trial of Staphylothrombin Inhibition.
Topics: Administration, Intravenous; Administration, Oral; Aged; Aged, 80 and over; Anticoagulants; Antithrombins; Arginine; Bacteremia; Belgium; Blood Coagulation; Coagulase; Dabigatran; Enoxaparin; Feasibility Studies; Female; Hemorrhage; Humans; Injections, Subcutaneous; Male; Middle Aged; Partial Thromboplastin Time; Pilot Projects; Pipecolic Acids; Prospective Studies; Staphylococcal Infections; Staphylococcus aureus; Sulfonamides; Thrombin; Thrombosis; Time Factors; Treatment Outcome | 2018 |
Argatroban for elective percutaneous coronary intervention: the ARG-E04 multi-center study.
Topics: Aged; Angina, Unstable; Angioplasty, Balloon, Coronary; Anticoagulants; Antithrombins; Arginine; Blood Coagulation; Dose-Response Relationship, Drug; Female; Follow-Up Studies; Hemorrhage; Heparin; Humans; Male; Middle Aged; Pipecolic Acids; Sulfonamides; Thrombosis | 2011 |
Rationale and design of the PREVENT-HIT study: a randomized, open-label pilot study to compare desirudin and argatroban in patients with suspected heparin-induced thrombocytopenia with or without thrombosis.
Topics: Anticoagulants; Arginine; Female; Heparin; Hirudins; Humans; Male; Pilot Projects; Pipecolic Acids; Prospective Studies; Recombinant Proteins; Research Design; Sulfonamides; Thrombocytopenia; Thrombosis | 2010 |
A randomized, open-label pilot study comparing desirudin and argatroban in patients with suspected heparin-induced thrombocytopenia with or without thrombosis: PREVENT-HIT Study.
Topics: Adolescent; Adult; Aged; Anticoagulants; Arginine; Disease Progression; Female; Hemorrhage; Heparin; Hirudins; Humans; Male; Middle Aged; Pilot Projects; Pipecolic Acids; Platelet Count; Postoperative Complications; Postoperative Period; Recombinant Proteins; Sulfonamides; Thrombin; Thrombocytopenia; Thrombosis; Treatment Outcome; Young Adult | 2011 |
Anticoagulant therapy with a selective thrombin inhibitor for acute cerebral infarction: usefulness of coagulation markers for evaluation of efficacy.
Topics: Acute Disease; Aged; Anticoagulants; Antithrombins; Arginine; Biomarkers; Blood Coagulation; Blood Coagulation Tests; Blood Proteins; Cerebral Infarction; Embolism; Female; Hemorrhage; Humans; Male; Middle Aged; Pipecolic Acids; Stroke; Sulfonamides; Thrombosis; Treatment Outcome | 2002 |
A prospective comparison of three argatroban treatment regimens during hemodialysis in end-stage renal disease.
Topics: Adult; Aged; Anticoagulants; Arginine; Cross-Over Studies; Female; Humans; Kidney Failure, Chronic; Male; Middle Aged; Pipecolic Acids; Prospective Studies; Renal Dialysis; Sulfonamides; Thrombosis | 2004 |
Transitioning from argatroban to warfarin in heparin-induced thrombocytopenia: an analysis of outcomes in patients with elevated international normalized ratio (INR).
Topics: Adult; Aged; Amputation, Surgical; Arginine; Cause of Death; Female; Hemorrhage; Heparin; Humans; Incidence; International Normalized Ratio; Male; Middle Aged; Pipecolic Acids; Retrospective Studies; Risk Assessment; Sulfonamides; Survival Rate; Thrombocytopenia; Thrombosis; Treatment Outcome; Warfarin | 2005 |
Thrombocytopenia following heparin flush.
Topics: Amputation, Surgical; Anticoagulants; Arginine; Catheters, Indwelling; Cause of Death; Diagnosis, Differential; Female; Hemorrhage; Heparin; Humans; Infusions, Intravenous; Male; Middle Aged; Partial Thromboplastin Time; Patient Selection; Pipecolic Acids; Platelet Count; Prospective Studies; Recurrence; Sulfonamides; Therapeutic Irrigation; Thrombocytopenia; Thrombosis; Treatment Outcome | 2005 |
Inhibitory effect of argatroban on thrombin-antithrombin III complex after percutaneous transluminal coronary angioplasty.
Topics: Aged; Angioplasty, Balloon, Coronary; Antithrombin III; Antithrombins; Arginine; Biomarkers; Female; Heparin; Humans; Male; Myocardial Ischemia; Peptide Hydrolases; Pipecolic Acids; Sulfonamides; Thrombin; Thrombosis | 1995 |
136 other study(ies) available for mci 9038 and Blood Clot
| Article | Year |
|---|---|
Potent noncovalent thrombin inhibitors that utilize the unique amino acid D-dicyclohexylalanine in the P3 position. Implications on oral bioavailability and antithrombotic efficacy.
Topics: Animals; Biological Availability; Dipeptides; Dogs; Fibrinolytic Agents; Lipid Metabolism; Male; Molecular Structure; Partial Thromboplastin Time; Phenylalanine; Rats; Rats, Sprague-Dawley; Structure-Activity Relationship; Thrombin; Thrombosis | 1997 |
Design and synthesis of thrombin inhibitors: analogues of MD-805 with reduced stereogenicity and improved potency.
Topics: Animals; Antithrombins; Arginine; Cattle; Drug Design; Humans; Injections, Intravenous; Injections, Subcutaneous; Models, Molecular; Pipecolic Acids; Piperidines; Rats; Stereoisomerism; Structure-Activity Relationship; Sulfonamides; Thrombin; Thrombosis | 1999 |
Thrombin active site inhibitors: chemical synthesis, in vitro and in vivo pharmacological profile of a novel and selective agent BMS-189090 and analogues.
Topics: Animals; Binding Sites; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Design; Drug Evaluation, Preclinical; Fibrinolytic Agents; Humans; Mice; Nipecotic Acids; Rats; Serine; Serine Proteinase Inhibitors; Structure-Activity Relationship; Substrate Specificity; Thrombin; Thrombosis | 2002 |
Molecular design and structure--activity relationships leading to the potent, selective, and orally active thrombin active site inhibitor BMS-189664.
Topics: Administration, Oral; Animals; Binding Sites; Crystallography, X-Ray; Dipeptides; Disease Models, Animal; Dogs; Drug Design; Drug Evaluation, Preclinical; Fibrinolytic Agents; Humans; Inhibitory Concentration 50; Macaca fascicularis; Mice; Serine Proteinase Inhibitors; Structure-Activity Relationship; Sulfonamides; Thrombin; Thrombosis | 2002 |
Unique overlap in the prerequisites for thrombin inhibition and oral bioavailability resulting in potent oral antithrombotics.
Topics: Administration, Oral; Animals; Aorta; Biological Availability; Biological Transport, Active; Caco-2 Cells; Crystallography, X-Ray; Dogs; Dose-Response Relationship, Drug; Enzyme Inhibitors; Fibrinolytic Agents; Half-Life; Humans; In Vitro Techniques; Models, Molecular; Oligopeptides; Rats; Structure-Activity Relationship; Thrombin; Thrombosis | 2002 |
Antithrombotic effects of LB30870, a potent, orally active, selective and direct thrombin inhibitor, and pharmacokinetics of its prodrug.
Topics: Amidines; Animals; Antithrombins; Dipeptides; Dogs; Fluoroacetates; Haplorhini; Humans; Prodrugs; Rabbits; Rats; Thrombin; Thrombosis | 2013 |
First Report of Plant-Derived β-Sitosterol with Antithrombotic, in Vivo Anticoagulant, and Thrombus-Preventing Activities in a Mouse Model.
Topics: Animals; Anticoagulants; Antithrombins; Catalysis; Disease Models, Animal; Female; Fibrinogen; Humans; Male; Mice; Plants; Platelet Aggregation Inhibitors; Sitosterols; Thrombin; Thrombosis | 2018 |
A journey through anticoagulant therapies in the treatment of left ventricular thrombus in post-COVID-19 heparin-induced thrombocytopenia: a case report.
Topics: Acenocoumarol; Anticoagulants; Arginine; COVID-19; COVID-19 Drug Treatment; Heparin; Hirudins; Humans; Male; Middle Aged; Peptide Fragments; Percutaneous Coronary Intervention; Pipecolic Acids; Recombinant Proteins; SARS-CoV-2; Sulfonamides; Thrombocytopenia; Thrombosis | 2022 |
[Application of argatroban in patients receiving extracorporeal membrane oxygenation support: a case-control study].
Topics: Anticoagulants; Case-Control Studies; Extracorporeal Membrane Oxygenation; Fibrinolytic Agents; Hemorrhage; Heparin; Humans; Retrospective Studies; Thrombosis | 2022 |
A Case of Argatroban Refractory Heparin Induced Thrombocytopenia and Thrombosis.
Topics: Anticoagulants; Heparin; Humans; Thrombocytopenia; Thrombosis | 2023 |
Argatroban to achieve therapeutic anticoagulation in two patients with acute thrombosis and heparin resistance.
Topics: Acute Disease; Adult; Anticoagulants; Arginine; Drug Resistance; Female; Heparin; Humans; Male; Middle Aged; Pipecolic Acids; Sulfonamides; Thrombosis | 2019 |
Myocardial Infarction with Limb Arterial and Venous Thrombosis in a Patient with Enoxaparin-Induced Thrombocytopenia.
Topics: Aged; Antithrombins; Arginine; Enoxaparin; Factor Xa Inhibitors; Female; Humans; Pipecolic Acids; Pyrazoles; Pyridones; ST Elevation Myocardial Infarction; Sulfonamides; Thrombocytopenia; Thrombosis | 2020 |
Thrombocytopenia and Thromboses in Myocardial Infarction Associated with Eptifibatide-Dependent Activating Antiplatelet Antibodies.
Topics: Antigens, Human Platelet; Arginine; Aspirin; Autoantibodies; Combined Modality Therapy; Coronary Thrombosis; Drug Substitution; Drug Therapy, Combination; Eptifibatide; Humans; Male; Middle Aged; Percutaneous Coronary Intervention; Pipecolic Acids; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIIb-IIIa Complex; Platelet Transfusion; Purpura, Thrombocytopenic, Idiopathic; Shock, Cardiogenic; ST Elevation Myocardial Infarction; Stents; Sulfonamides; Thrombectomy; Thrombolytic Therapy; Thrombosis; Ticagrelor; Warfarin | 2020 |
Utilization and Outcomes of Children Treated with Direct Thrombin Inhibitors on Paracorporeal Ventricular Assist Device Support.
Topics: Adolescent; Antithrombins; Arginine; Child; Child, Preschool; Female; Heart-Assist Devices; Hemorrhage; Hirudins; Humans; Infant; Male; North America; Peptide Fragments; Pipecolic Acids; Recombinant Proteins; Retrospective Studies; Stroke; Sulfonamides; Thrombosis; Treatment Outcome | 2020 |
Argatroban for therapeutic anticoagulation for heparin resistance associated with Covid-19 infection.
Topics: Adult; Anticoagulants; Arginine; Catheter Obstruction; COVID-19; Drug Resistance; Drug Substitution; Fibrin Fibrinogen Degradation Products; Heparin; Humans; Male; Middle Aged; Pipecolic Acids; Pulmonary Embolism; Respiration, Artificial; SARS-CoV-2; Sulfonamides; Thrombosis; Tomography, X-Ray Computed; Treatment Outcome | 2021 |
Aortic Arch Thrombus and Pulmonary Embolism in a COVID-19 Patient.
Topics: Anticoagulants; Antithrombins; Aorta, Thoracic; Arginine; Biomarkers; COVID-19; Female; Heparin; Humans; Middle Aged; Pipecolic Acids; Pneumonia, Viral; Pulmonary Embolism; SARS-CoV-2; Sulfonamides; Thrombosis | 2021 |
The Effects of the Combined Argatroban/Nitric Oxide-Releasing Polymer on Platelet Microparticle-Induced Thrombogenicity in Coated Extracorporeal Circuits.
Topics: Animals; Antithrombins; Arginine; Blood Platelets; Cell-Derived Microparticles; Extracorporeal Circulation; Nitric Oxide; Pipecolic Acids; Platelet Activation; Polymers; Rabbits; Sulfonamides; Thrombosis | 2021 |
Anticoagulation in children: Making the most of little patients and little evidence.
Topics: Anticoagulants; Arginine; Blood Coagulation; Child; Drug Monitoring; Fondaparinux; Heparin; Hirudins; Humans; Peptide Fragments; Pipecolic Acids; Polysaccharides; Recombinant Proteins; Sulfonamides; Thrombosis; Venous Thromboembolism; Warfarin | 2017 |
The Use of Eptifibatide Alone or in Combination With Heparin or Argatroban for Suspected Thrombosis in Patients With Left Ventricular Assist Devices.
Topics: Adult; Aged; Anticoagulants; Arginine; Eptifibatide; Female; Heart Failure; Heart-Assist Devices; Hemolysis; Heparin; Humans; Male; Middle Aged; Peptides; Pipecolic Acids; Platelet Aggregation Inhibitors; Retrospective Studies; Sulfonamides; Thrombosis; Warfarin; Young Adult | 2017 |
Argatroban for Heparin-Induced Thrombocytopenia during Venovenous Extracorporeal Membrane Oxygenation with Continuous Venovenous Hemofiltration.
Topics: Adult; Anticoagulants; Antithrombins; Arginine; Dose-Response Relationship, Drug; Extracorporeal Membrane Oxygenation; Hemofiltration; Heparin; Humans; Male; Pipecolic Acids; Sulfonamides; Thrombocytopenia; Thrombosis; Treatment Outcome | 2017 |
Idiopathic catastrophic thrombosis with happy ending.
Topics: Anticoagulants; Antithrombins; Arginine; Awareness; Blood Coagulation Tests; Coronary Artery Bypass; Heparin; Humans; Male; Middle Aged; Phenprocoumon; Pipecolic Acids; Platelet Aggregation Inhibitors; ST Elevation Myocardial Infarction; Sulfonamides; Thrombocytopenia; Thrombosis; Treatment Outcome; Ultrasonography; Venous Thrombosis | 2017 |
Cerebral Venous Sinus Thrombosis Due to Low-molecular-weight Heparin-induced Thrombocytopenia.
Topics: Anticoagulants; Arginine; Female; Heparin, Low-Molecular-Weight; Humans; Middle Aged; Pipecolic Acids; Platelet Count; Sulfonamides; Thrombocytopenia; Thrombosis; Venous Thrombosis | 2017 |
Synthesis and biocompatibility of an argatroban-modified polysulfone membrane that directly inhibits thrombosis.
Topics: Adsorption; Adult; Anticoagulants; Arginine; Blood Coagulation; Blood Coagulation Tests; Humans; Hydrophobic and Hydrophilic Interactions; Male; Materials Testing; Membranes, Artificial; Pipecolic Acids; Platelet Adhesiveness; Polymers; Renal Dialysis; Sulfonamides; Sulfones; Thrombosis | 2018 |
An infrequent complication of a not so infrequent disease. Hit by HIT.
Topics: Acute Coronary Syndrome; Aged; Anticoagulants; Antithrombins; Aortic Valve; Arginine; Drug Substitution; Echocardiography, Transesophageal; Electrocardiography; Extracorporeal Membrane Oxygenation; Fatal Outcome; Heart Arrest; Heart Valve Prosthesis; Heart Valve Prosthesis Implantation; Heparin; Humans; Male; Pipecolic Acids; Sulfonamides; Thrombectomy; Thrombocytopenia; Thrombosis; Treatment Outcome | 2019 |
Reversible Auricular Necrosis Secondary to Systemic Thrombosis.
Topics: Anticoagulants; Antiphospholipid Syndrome; Arginine; Ear Auricle; Ear Diseases; Female; Heparin; Humans; Necrosis; Pipecolic Acids; Sulfonamides; Thrombocytopenia; Thrombosis | 2018 |
High-dose intravenous immunoglobulin to treat spontaneous heparin-induced thrombocytopenia syndrome.
Topics: Anticoagulants; Arginine; Arthroplasty, Replacement, Knee; Female; Fondaparinux; Gastrointestinal Hemorrhage; Heparin; Humans; Immunoglobulins, Intravenous; Middle Aged; Pipecolic Acids; Platelet Activation; Platelet Count; Serotonin; Sulfonamides; Thrombocytopenia; Thrombosis; Venous Thromboembolism | 2019 |
Intravenous warfarin and heparin-induced thrombocytopenia: making the diagnosis, management, modern monitoring, and multidisciplinary care.
Topics: Aged; Anticoagulants; Antithrombins; Arginine; Cardiac Surgical Procedures; Hemorrhage; Heparin; Humans; Infusions, Intravenous; Male; Pipecolic Acids; Pulmonary Embolism; Sulfonamides; Thrombocytopenia; Thrombosis; Warfarin | 2014 |
Thrombosis of biatrial appendages due to heparin-induced thrombocytopenia.
Topics: Aged, 80 and over; Antibodies; Anticoagulants; Arginine; Arterial Occlusive Diseases; Atrial Appendage; Atrial Fibrillation; Biomarkers; Coronary Artery Bypass; Drug Administration Schedule; Drug Substitution; Female; Heart Diseases; Heparin; Humans; Pipecolic Acids; Sulfonamides; Thrombectomy; Thrombocytopenia; Thrombosis; Tomography, X-Ray Computed | 2013 |
Mannose-binding lectin promotes local microvascular thrombosis after transient brain ischemia in mice.
Topics: Animals; Antithrombins; Arginine; Brain Ischemia; Cerebrovascular Circulation; Disease Models, Animal; Fibrinogen; Infarction, Middle Cerebral Artery; Magnetic Resonance Imaging; Male; Mannose-Binding Lectin; Mice; Mice, Inbred C57BL; Mice, Knockout; Microcirculation; Pipecolic Acids; Reperfusion Injury; Sulfonamides; Thrombosis | 2014 |
The effect of a polyurethane coating incorporating both a thrombin inhibitor and nitric oxide on hemocompatibility in extracorporeal circulation.
Topics: Animals; Antithrombins; Arginine; Blood Coagulation; Blood Platelets; Coated Materials, Biocompatible; Extracorporeal Circulation; Isocyanates; Nitric Oxide; Pipecolic Acids; Platelet Activation; Platelet Function Tests; Polyethylene Glycols; Polymers; Polyurethanes; Rabbits; Sulfonamides; Thrombin; Thrombosis | 2014 |
Progressive, Fatal Thrombosis Associated With Heparin-Induced Thrombocytopenia After Cardiac Surgery Despite "Therapeutic" Anticoagulation With Argatroban: Potential Role for PTT and ACT Confounding.
Topics: Adult; Antithrombins; Aortic Valve Stenosis; Arginine; Fatal Outcome; Fibrinolytic Agents; Heart Valve Prosthesis Implantation; Heparin; Humans; Infusions, Intravenous; Male; Partial Thromboplastin Time; Pipecolic Acids; Sulfonamides; Thrombocytopenia; Thrombosis; Whole Blood Coagulation Time | 2015 |
Management of intraoperative free flap arterial thrombosis with argatroban in the heparin-allergic patient.
Topics: Anticoagulants; Antithrombins; Arginine; Drug Hypersensitivity; Female; Free Tissue Flaps; Heparin; Humans; Intraoperative Complications; Middle Aged; Pipecolic Acids; Sulfonamides; Thrombosis | 2014 |
Implantation of left ventricular assist devices under extracorporeal life support in patients with heparin-induced thrombocytopenia.
Topics: Acute Disease; Adult; Aged; Anticoagulants; Arginine; Cohort Studies; Extracorporeal Circulation; Female; Heart Failure; Heart-Assist Devices; Heparin; Humans; Male; Middle Aged; Pipecolic Acids; Prosthesis Implantation; Sulfonamides; Thrombocytopenia; Thrombosis | 2015 |
Minimal Prolongation of Prothrombin Time with Extended Exposure to Argatroban.
Topics: Anticoagulants; Antithrombins; Arginine; Carcinoma, Squamous Cell; Drug Substitution; Female; Heparin; Humans; International Normalized Ratio; Mandibular Neoplasms; Middle Aged; Mouth Mucosa; Pipecolic Acids; Prothrombin Time; Sulfonamides; Syndrome; Thrombocytopenia; Thrombosis; Treatment Failure; Warfarin | 2015 |
[Monitoring of 4 patients with heparin-induced thrombocytopenia after complex congenital heart surgery].
Topics: Anticoagulants; Arginine; Cardiac Surgical Procedures; Heparin; Humans; Incidence; Infant; Pipecolic Acids; Platelet Count; Prognosis; Sulfonamides; Thrombocytopenia; Thrombosis | 2015 |
Heparin-Induced-Thrombocytopenia Causing Massive Aortic Thrombosis after Ascending Aortic Replacement for Type A Acute Aortic Dissection.
Topics: Acute Disease; Aged; Anticoagulants; Aortic Aneurysm; Aortic Diseases; Aortic Dissection; Aortography; Arginine; Blood Vessel Prosthesis Implantation; Computed Tomography Angiography; Drug Substitution; Emergencies; Fatal Outcome; Female; Gastrointestinal Hemorrhage; Heparin; Humans; Mesenteric Ischemia; Pipecolic Acids; Sulfonamides; Thrombocytopenia; Thrombosis; Time Factors; Treatment Outcome | 2016 |
Rapid and durable response to intravenous immunoglobulin in delayed heparin-induced thrombocytopenia: a case report.
Topics: Arginine; Cardiac Surgical Procedures; Heparin; Hirudins; Humans; Immunoglobulins, Intravenous; Male; Middle Aged; Peptide Fragments; Pipecolic Acids; Postoperative Complications; Recombinant Proteins; Sulfonamides; Thrombocytopenia; Thrombosis | 2017 |
Heparin-induced thrombocytopenia with aortoiliac thrombosis treated with argatroban.
Topics: Anticoagulants; Antithrombins; Aortic Diseases; Arginine; Heparin; Humans; Iliac Artery; Male; Middle Aged; Pipecolic Acids; Sulfonamides; Thrombocytopenia; Thrombosis | 2017 |
Complete salvage of impending free flap failure in heparin induced thrombocytopenia by emergent institution of therapy with argatroban.
Topics: Anastomosis, Surgical; Anticoagulants; Arginine; Carcinoma, Squamous Cell; Female; Graft Rejection; Heparin; Humans; Middle Aged; Mouth Neoplasms; Pipecolic Acids; Reoperation; Salvage Therapy; Sulfonamides; Surgical Flaps; Thrombocytopenia; Thrombosis; Veins | 2008 |
Treatment of intracardiac thrombi with argatroban.
Topics: Adult; Aged; Aged, 80 and over; Anticoagulants; Arginine; Female; Heart Diseases; Humans; Male; Middle Aged; Partial Thromboplastin Time; Pipecolic Acids; Platelet Aggregation Inhibitors; Sulfonamides; Thrombosis; Treatment Outcome; Whole Blood Coagulation Time | 2008 |
Dosing patterns and outcomes in African American, Asian, and Hispanic patients with heparin-induced thrombocytopenia treated with argatroban.
Topics: Adult; Aged; Aged, 80 and over; Anticoagulants; Arginine; Asian; Black or African American; Female; Fibrinolytic Agents; Heparin; Hispanic or Latino; Humans; Male; Middle Aged; Pipecolic Acids; Prospective Studies; Retrospective Studies; Sulfonamides; Thrombocytopenia; Thrombosis | 2009 |
Risk factors for major bleeding in patients with heparin-induced thrombocytopenia treated with argatroban: a retrospective study.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Anticoagulants; Arginine; Blood Coagulation; Drug Monitoring; Female; Hemorrhage; Heparin; Humans; Lung Diseases; Male; Middle Aged; Odds Ratio; Partial Thromboplastin Time; Pipecolic Acids; Retrospective Studies; Risk Assessment; Risk Factors; Sulfonamides; Thrombocytopenia; Thrombosis; Young Adult | 2008 |
Influence of antithrombin and argatroban on disseminated intravascular coagulation parameters in a patient with septic shock.
Topics: Aged; Anticoagulants; Antithrombins; Arginine; Blood Coagulation; Female; Humans; Pipecolic Acids; Shock, Septic; Sulfonamides; Thrombosis | 2009 |
Heparin-induced thrombocytopenia in two patients undergoing abdominal aortic aneurysm surgery.
Topics: Aged; Anticoagulants; Aortic Aneurysm, Abdominal; Arginine; Autoantibodies; Disseminated Intravascular Coagulation; Heparin; Humans; Male; Mesenteric Arteries; Pipecolic Acids; Platelet Factor 4; Postoperative Complications; Sulfonamides; Thrombocytopenia; Thrombosis | 2010 |
A report of outcomes after orthotopic liver transplant with allografts from heparin antibody-positive donors.
Topics: Algorithms; Antibodies; Anticoagulants; Arginine; Clinical Protocols; Female; Heparin; Humans; Liver Transplantation; Male; Middle Aged; Pipecolic Acids; Sulfonamides; Thrombocytopenia; Thrombosis; Tissue Donors; Transplantation, Homologous; Young Adult | 2009 |
Thrombin generation by intimal tissue factor contributes to thrombus formation on macrophage-rich neointima but not normal intima of hyperlipidemic rabbits.
Topics: Angioplasty, Balloon; Animals; Arginine; Femoral Artery; Humans; Hyperlipidemias; Lipoproteins; Macrophages; Male; Pipecolic Acids; Rabbits; Sulfonamides; Thrombin; Thromboplastin; Thrombosis; Tunica Intima | 2009 |
Argatroban and bivalirudin compared to unfractionated heparin in preventing thrombus formation on mechanical heart valves. Results of an in-vitro study.
Topics: Anticoagulants; Arginine; Diagnostic Techniques, Cardiovascular; Drug Therapy, Combination; Feasibility Studies; Heart Diseases; Heart-Assist Devices; Heparin; Hirudins; Humans; In Vitro Techniques; Infusion Pumps; Male; Peptide Fragments; Pipecolic Acids; Recombinant Proteins; Sulfonamides; Thrombin; Thrombocytopenia; Thrombosis | 2009 |
Impact of renal function on argatroban therapy during percutaneous coronary intervention.
Topics: Aged; Angioplasty, Balloon, Coronary; Anticoagulants; Arginine; Clinical Trials as Topic; Female; Heparin; Humans; Male; Middle Aged; Pipecolic Acids; Renal Insufficiency; Retrospective Studies; Sulfonamides; Thrombocytopenia; Thrombosis; Treatment Outcome | 2010 |
Argatroban dosage requirements and outcomes in intensive care versus non-intensive care patients.
Topics: Aged; Aged, 80 and over; Anticoagulants; Arginine; Critical Care; Dose-Response Relationship, Drug; Female; Heparin; Humans; Intensive Care Units; Male; Middle Aged; Partial Thromboplastin Time; Pipecolic Acids; Retrospective Studies; Sulfonamides; Thrombocytopenia; Thrombosis; Treatment Outcome | 2009 |
Heparin-induced thrombocytopenia with multiple organized thrombi accompanied by unusual cholesterin deposition: autopsy case after long-term follow up.
Topics: Aged; Anticoagulants; Arginine; Embolism, Cholesterol; Fatal Outcome; Heparin; Humans; Male; Pipecolic Acids; Platelet Count; Sulfonamides; Thrombocytopenia; Thrombosis; Warfarin | 2009 |
[Heparin-induced thrombocytopenia type II with thrombosis in an intensive care patient: therapy management using the direct thrombin inhibitor argatroban].
Topics: Aged; Anticoagulants; Aortic Aneurysm, Abdominal; Aortic Rupture; Arginine; Exanthema; Heparin; Humans; Male; Partial Thromboplastin Time; Pipecolic Acids; Platelet Count; Sulfonamides; Thrombin; Thrombocytopenia; Thrombosis | 2009 |
Prolonged elevation of plasma argatroban in a cardiac transplant patient with a suspected history of heparin-induced thrombocytopenia with thrombosis.
Topics: Aged; Arginine; Blood Coagulation Disorders; Cardiopulmonary Bypass; Child; Heart Transplantation; Heparin; Humans; Infusions, Intravenous; Pipecolic Acids; Platelet Aggregation Inhibitors; Sulfonamides; Thrombocytopenia; Thrombosis | 2010 |
The direct thrombin inhibitor argatroban effectively prevents cardiac catheter thrombosis in vitro.
Topics: Anticoagulants; Antithrombin III; Arginine; Blood Coagulation; Blood Platelets; Cardiac Catheterization; Enoxaparin; Factor Xa; Factor Xa Inhibitors; Fibrin; Heparin; Humans; Male; Peptide Hydrolases; Pipecolic Acids; Stress, Mechanical; Sulfonamides; Thrombin; Thrombosis; Time Factors | 2010 |
Treatment with argatroban in one haemodialysed patient with a heparin-induced thrombocytopenia and thrombotic complications.
Topics: Aged, 80 and over; Arginine; Female; Heparin; Humans; Pipecolic Acids; Platelet Aggregation Inhibitors; Renal Dialysis; Sulfonamides; Thrombocytopenia; Thrombosis | 2010 |
The direct thrombin inhibitors (argatroban, bivalirudin and lepirudin) and the indirect Xa-inhibitor (danaparoid) increase fibrin network porosity and thus facilitate fibrinolysis.
Topics: Antithrombins; Arginine; Chondroitin Sulfates; Chromatography, Gel; Dermatan Sulfate; Factor VIII; Factor Xa Inhibitors; Fibrin; Fibrinolysis; Heparinoids; Heparitin Sulfate; Hirudins; Humans; In Vitro Techniques; Microscopy, Confocal; Peptide Fragments; Pipecolic Acids; Plasma; Porosity; Protein Multimerization; Recombinant Proteins; Sulfonamides; Thrombosis; Tissue Plasminogen Activator | 2010 |
Safety and efficacy of the argatroban therapy during the early post-cardiac surgery period.
Topics: Aged; Aged, 80 and over; Arginine; Cardiac Surgical Procedures; Drug-Related Side Effects and Adverse Reactions; Female; Hemorrhage; Hospital Mortality; Humans; Male; Middle Aged; Pipecolic Acids; Postoperative Care; Postoperative Complications; Retrospective Studies; Sulfonamides; Thrombin; Thrombosis; Treatment Outcome | 2010 |
Argatroban therapy in pediatric patients requiring nonheparin anticoagulation: an open-label, safety, efficacy, and pharmacokinetic study.
Topics: Anticoagulants; Arginine; Child; Child, Preschool; Female; Hemorrhage; Heparin; Humans; Infant; Liver Function Tests; Male; Pipecolic Acids; Platelet Aggregation Inhibitors; Prospective Studies; Sulfonamides; Survival Rate; Thrombocytopenia; Thrombosis; Tissue Distribution; Treatment Outcome | 2011 |
Combined argatroban and anti-oxidative agents prevents increased vascular contractility to thrombin and other ligands after subarachnoid haemorrhage.
Topics: Animals; Antioxidants; Arginine; Ascorbic Acid; Drug Therapy, Combination; Male; Pipecolic Acids; Rabbits; Receptor, PAR-1; Signal Transduction; Subarachnoid Hemorrhage; Sulfonamides; Thiobarbituric Acid Reactive Substances; Thrombin; Thrombosis; Vasoconstriction | 2012 |
Recognition of heparin-induced thrombocytopenia and initiation of argatroban therapy after cardiothoracic surgery in the intensive care unit.
Topics: Antibodies; Anticoagulants; Arginine; Cardiac Surgical Procedures; Drug Substitution; Georgia; Hemorrhage; Heparin; Humans; Intensive Care Units; Pipecolic Acids; Platelet Factor 4; Predictive Value of Tests; Retrospective Studies; Risk Assessment; Risk Factors; Sulfonamides; Thoracic Surgical Procedures; Thrombocytopenia; Thrombosis; Time Factors; Treatment Outcome | 2012 |
High-dose argatroban for treatment of heparin-induced thrombocytopenia with thrombosis: a case report and review of laboratory considerations.
Topics: Anticoagulants; Arginine; Dose-Response Relationship, Drug; Drug Monitoring; Female; Heparin; Humans; International Normalized Ratio; Middle Aged; Pipecolic Acids; Platelet Aggregation Inhibitors; Sulfonamides; Thrombocytopenia; Thrombosis | 2012 |
A case of acute coronary artery occlusion associated with very rapid onset heparin-induced thrombosis without thrombocytopenia.
Topics: Aged, 80 and over; Angioplasty, Balloon, Coronary; Anticoagulants; Arginine; Aspirin; Autoantibodies; Cilostazol; Clopidogrel; Coronary Angiography; Coronary Occlusion; Drug Therapy, Combination; Female; Heart Failure; Heparin; Humans; Pipecolic Acids; Platelet Count; Platelet Factor 4; Stents; Sulfonamides; Tetrazoles; Thrombosis; Ticlopidine; Time Factors | 2012 |
Argatroban anticoagulation during percutaneous coronary intervention in patients with heparin-induced thrombocytopenia.
Topics: Adult; Angioplasty, Balloon, Coronary; Anticoagulants; Antithrombins; Arginine; Atherectomy, Coronary; Female; Heparin; Humans; Male; Pipecolic Acids; Stents; Sulfonamides; Thrombocytopenia; Thrombosis; Treatment Outcome | 2002 |
Argatroban for percutaneous coronary interventions: hit or miss?
Topics: Angioplasty, Balloon, Coronary; Anticoagulants; Arginine; Heparin; Humans; Pipecolic Acids; Sulfonamides; Thrombocytopenia; Thrombosis | 2002 |
Effects of argatroban and heparin on thrombus formation and tissue plasminogen activator-induced thrombolysis in a microvascular thrombosis model.
Topics: Animals; Arginine; Cricetinae; Disease Models, Animal; Drug Interactions; Fibrinolytic Agents; Heparin; Mesocricetus; Microcirculation; Partial Thromboplastin Time; Pipecolic Acids; Sulfonamides; Thrombolytic Therapy; Thrombosis; Time Factors; Tissue Plasminogen Activator | 2003 |
Suppression of argatroban-induced endogenous thrombolysis by PKSI-527, and antibodies to TPA and UPA, evaluated in a rat arterial thrombolysis model.
Topics: Animals; Antibodies; Arginine; Drug Antagonism; Fibrinolysin; Fibrinolysis; Fibrinolytic Agents; Kallikreins; Male; Mesenteric Arteries; Phenylalanine; Pipecolic Acids; Plasma Kallikrein; Rats; Rats, Wistar; Sulfonamides; Thrombolytic Therapy; Thrombosis; Tissue Plasminogen Activator; Tranexamic Acid; Urokinase-Type Plasminogen Activator | 2003 |
Decreased argatroban clearance unaffected by hemodialysis in anasarca.
Topics: Acute Kidney Injury; Arginine; Edema; Female; Humans; Middle Aged; Pipecolic Acids; Renal Dialysis; Sulfonamides; Thrombin; Thrombosis | 2003 |
Antithrombotic properties of a direct thrombin inhibitor with a prolonged half-life and AT-mediated factor Xa inhibitory activity.
Topics: Animals; Antithrombin III; Arginine; Blood Coagulation Tests; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Factor Xa Inhibitors; Fibrinolytic Agents; Fondaparinux; Half-Life; Hemorrhage; Heparin; Male; Molecular Structure; Oligosaccharides; Pipecolic Acids; Polysaccharides; Rabbits; Rats; Rats, Wistar; Sulfonamides; Thrombin; Thrombolytic Therapy; Thrombosis | 2003 |
Treatment options for heparin-induced thrombocytopenia.
Topics: Antithrombins; Arginine; Heparin; Hirudins; Humans; Pipecolic Acids; Recombinant Proteins; Sulfonamides; Thrombocytopenia; Thrombosis; United States | 2003 |
Argatroban use during pediatric interventional cardiac catheterization.
Topics: Antithrombins; Arginine; Cardiac Catheterization; Child; Embolization, Therapeutic; Fibrinolytic Agents; Heart Diseases; Heparin; Humans; Male; Pipecolic Acids; Sulfonamides; Thrombocytopenia; Thrombosis | 2004 |
Heparinless cardiopulmonary bypass with argatroban in dogs.
Topics: Animals; Anticoagulants; Arginine; Blood Coagulation; Cardiopulmonary Bypass; Dogs; Dose-Response Relationship, Drug; Fibrinolysis; Heparin; Intraoperative Care; Kidney; Pipecolic Acids; Postoperative Complications; Sulfonamides; Thrombosis | 2004 |
Ability of anti-glycoprotein IIb/IIIa agents to dissolve platelet thrombi formed on a collagen surface under blood flow conditions.
Topics: Abciximab; Adult; Antibodies, Monoclonal; Anticoagulants; Arginine; Blood Platelets; Collagen; Eptifibatide; Fibrinolytic Agents; Hemorheology; Humans; Immunoglobulin Fab Fragments; In Vitro Techniques; Peptides; Pipecolic Acids; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIIb-IIIa Complex; Sulfonamides; Thrombosis; Tirofiban; Tyrosine | 2004 |
Heparin-induced thrombocytopenia and thrombosis in a patient with polycythemia vera.
Topics: Aged; Arginine; Female; Follow-Up Studies; Heparin; Humans; Japan; Pipecolic Acids; Polycythemia Vera; Pulmonary Embolism; Risk Assessment; Severity of Illness Index; Sulfonamides; Thrombocytopenia; Thrombosis; Treatment Outcome | 2004 |
Argatroban as an alternative to heparin in extracorporeal membrane oxygenation circuits.
Topics: Arginine; Biomarkers; Blood Coagulation Tests; Equipment Failure; Extracorporeal Membrane Oxygenation; Heparin; Humans; Pipecolic Acids; Sulfonamides; Thrombelastography; Thrombin; Thrombosis | 2004 |
Severe argatroban-induced coagulopathy in a patient with a history of heparin-induced thrombocytopenia.
Topics: Aged; Aged, 80 and over; Anticoagulants; Aortic Valve; Aortic Valve Stenosis; Arginine; Blood Coagulation Disorders; Heart Valve Prosthesis Implantation; Heparin; Humans; Male; Pipecolic Acids; Sulfonamides; Thrombocytopenia; Thrombosis | 2004 |
No increase in rejection or graft loss in kidney transplant recipients with thrombophilia treated with anticoagulation and triple immunosuppression.
Topics: Anticoagulants; Arginine; Creatinine; Drug Therapy, Combination; Factor V; Female; Graft Rejection; Graft Survival; Heparin; Histocompatibility Testing; Humans; Immunosuppressive Agents; Kidney Transplantation; Male; Middle Aged; Mutation; Pipecolic Acids; Sulfonamides; Thrombophilia; Thrombosis | 2005 |
Mechanism of antithrombotic effect of heparin and antithrombin in balloon-injured arteries.
Topics: Angiography; Animals; Antithrombins; Arginine; Arteries; Catheterization; Dogs; Fibrinogen; Fibrinolytic Agents; Heparin; Iliac Artery; Microscopy, Fluorescence; Partial Thromboplastin Time; Pipecolic Acids; Prothrombin Time; Sulfonamides; Thrombosis | 2005 |
Direct thrombin inhibitors.
Topics: Angioplasty, Balloon, Coronary; Anticoagulants; Antithrombins; Arginine; Benzimidazoles; Blood Coagulation; Dabigatran; Heart Diseases; Heparin; Humans; Pipecolic Acids; Prodrugs; Pyridines; Sulfonamides; Thrombin; Thromboembolism; Thrombosis; Venous Thrombosis | 2005 |
Direct thrombin inhibitors are not equally effective in vivo against arterial thrombosis: in vivo evaluation of DuP714 and argatroban in a porcine angioplasty model and comparison to r-hirudin.
Topics: Angioplasty, Balloon; Animals; Anticoagulants; Arginine; Boron Compounds; Drug Evaluation, Preclinical; Hirudins; Oligopeptides; Pipecolic Acids; Recombinant Proteins; Sulfonamides; Swine; Thrombin; Thrombosis | 2005 |
Cardiopulmonary bypass using argatroban as an anticoagulant for a 6.0-kg pediatric patient.
Topics: Anticoagulants; Arginine; Cardiopulmonary Bypass; Extracorporeal Membrane Oxygenation; Heart Defects, Congenital; Humans; Infant; Pipecolic Acids; Sulfonamides; Thrombosis | 2005 |
[Argatroban].
Topics: Anticoagulants; Arginine; Drug Monitoring; Humans; Pipecolic Acids; Sulfonamides; Thrombosis | 2006 |
Argatroban dosing of patients with heparin-induced thrombocytopenia and an elevated aPTT due to antiphospholipid antibody syndrome.
Topics: Adult; Anticoagulants; Antiphospholipid Syndrome; Arginine; Female; Fondaparinux; Heparin; Humans; Middle Aged; Partial Thromboplastin Time; Pipecolic Acids; Polysaccharides; Sulfonamides; Thrombocytopenia; Thrombosis | 2006 |
Inhibitors of blood coagulation factors Xa and IIa synergize to reduce thrombus weight and thrombin generation in vivo and in vitro.
Topics: Animals; Arginine; Bleeding Time; Factor Xa Inhibitors; Fibrinolytic Agents; Humans; In Vitro Techniques; Partial Thromboplastin Time; Pipecolic Acids; Piperidines; Platelet Aggregation Inhibitors; Prothrombin; Rabbits; Sulfonamides; Thrombin; Thrombosis | 2006 |
Argatroban therapy in heparin-induced thrombocytopenia with hepatic dysfunction.
Topics: Aged; Anticoagulants; Arginine; Bilirubin; Chemical and Drug Induced Liver Injury; Dose-Response Relationship, Drug; Female; Follow-Up Studies; Heparin; Humans; Liver Diseases; Male; Middle Aged; Partial Thromboplastin Time; Pipecolic Acids; Platelet Aggregation Inhibitors; Retrospective Studies; Sulfonamides; Thrombocytopenia; Thrombosis; Treatment Outcome | 2006 |
Thrombotic end point for assessing argatroban therapy for heparin-induced thrombocytopenia: learning from secondary analyses of prospective studies.
Topics: Anticoagulants; Arginine; Cohort Studies; Heparin; Humans; Pipecolic Acids; Sulfonamides; Thrombocytopenia; Thrombosis; Treatment Outcome | 2006 |
Effects of argatroban therapy, demographic variables, and platelet count on thrombotic risks in heparin-induced thrombocytopenia.
Topics: Aged; Amputation, Surgical; Anticoagulants; Arginine; Cohort Studies; Controlled Clinical Trials as Topic; Female; Heparin; Humans; Male; Middle Aged; Pipecolic Acids; Platelet Count; Retrospective Studies; Sulfonamides; Thrombocytopenia; Thrombosis; Treatment Outcome | 2006 |
Heparin-induced thrombocytopenia in patients administered heparin solely for hemodialysis.
Topics: Adult; Aged; Amputation, Surgical; Anticoagulants; Arginine; Dose-Response Relationship, Drug; Female; Heparin; Humans; Male; Middle Aged; Partial Thromboplastin Time; Pipecolic Acids; Platelet Count; Registries; Renal Dialysis; Retrospective Studies; Sulfonamides; Thrombocytopenia; Thrombosis; Treatment Outcome | 2006 |
Systemic anticoagulation with argatroban during arteriovenous dialysis graft thrombolysis.
Topics: Anticoagulants; Arginine; Hemofiltration; Humans; Infusions, Intravenous; Kidney Failure, Chronic; Male; Middle Aged; Pipecolic Acids; Renal Dialysis; Sulfonamides; Thrombolytic Therapy; Thrombosis | 2006 |
[Two surgical case reports showing atypical heparin-induced thrombocytopenia].
Topics: Adult; Anticoagulants; Arginine; Chondroitin Sulfates; Dermatan Sulfate; Drug Eruptions; Female; Heparin; Heparin, Low-Molecular-Weight; Heparitin Sulfate; Hirudins; Humans; Male; Pipecolic Acids; Platelet Count; Platelet Factor 4; Postoperative Complications; Recombinant Proteins; Sulfonamides; Thrombocytopenia; Thrombosis; Time Factors | 2007 |
Visual evaluation of blood coagulation during mural thrombogenesis under high shear blood flow.
Topics: Adult; Anticoagulants; Arginine; Blood Coagulation; Blood Flow Velocity; Blood Platelets; Collagen; Dose-Response Relationship, Drug; Factor VIIa; Fibrin; Hemolysis; Hemophilia A; Hemorheology; Heparin; Humans; Male; Microscopy, Confocal; Microscopy, Electron, Scanning; Middle Aged; Perfusion; Pipecolic Acids; Sulfonamides; Surface Properties; Thrombosis | 2008 |
Catheter-directed thrombolysis of acute lower extremity arterial thrombosis in a patient with heparin-induced thrombocytopenia.
Topics: Aged; Anticoagulants; Arginine; Arterial Occlusive Diseases; Catheterization, Peripheral; Fibrinolytic Agents; Heparin; Humans; Infusions, Intra-Arterial; Lower Extremity; Male; Pipecolic Acids; Radiography; Sulfonamides; Thrombocytopenia; Thrombolytic Therapy; Thrombosis; Tissue Plasminogen Activator; Treatment Outcome | 2007 |
[Are new anticoagulants better?].
Topics: Anticoagulants; Arginine; Drugs, Investigational; Factor Xa Inhibitors; Heparin; Humans; Pipecolic Acids; Sulfonamides; Thrombin; Thrombosis; Warfarin | 2007 |
[Heparin induced thrombocytopenia and anticoagulation in renal replacemant therapy].
Topics: Acute Kidney Injury; Anticoagulants; Arginine; Blood Coagulation Tests; Chondroitin Sulfates; Citrates; Critical Care; Dermatan Sulfate; Diagnostic Errors; Dose-Response Relationship, Drug; Epoprostenol; Fondaparinux; Hemofiltration; Heparin; Heparin, Low-Molecular-Weight; Heparitin Sulfate; Hirudins; Humans; Iloprost; Pipecolic Acids; Polysaccharides; Recombinant Proteins; Sodium Citrate; Sulfonamides; Thrombocytopenia; Thrombosis | 2008 |
Prediction of the therapeutic index of marketed anti-coagulants and anti-platelet agents by guinea pig models of thrombosis and hemostasis.
Topics: Animals; Anticoagulants; Arginine; Arteriovenous Shunt, Surgical; Aspirin; Bleeding Time; Chlorides; Ferric Compounds; Guinea Pigs; Hemostasis; Male; Pipecolic Acids; Platelet Aggregation Inhibitors; Sulfonamides; Thrombosis; Tirofiban; Tyrosine | 2008 |
[Substitution of antithrombin III by synthetic thrombin inhibitors].
Topics: Animals; Antithrombin III; Antithrombin III Deficiency; Arginine; Carbon Tetrachloride Poisoning; Fibrinogen; Heparin; Phenylpyruvic Acids; Pipecolic Acids; Platelet Count; Rats; Sulfonamides; Thrombin; Thrombosis | 1984 |
Enhancement of thrombolytic efficacy of tissue-type plasminogen activator by adjuvants in the guinea pig thrombosis model.
Topics: Adjuvants, Pharmaceutic; Animals; Antithrombins; Arginine; Biphenyl Compounds; Disease Models, Animal; Drug Therapy, Combination; Endothelium, Vascular; Femoral Artery; Fibrinolytic Agents; Guinea Pigs; Heptanoic Acids; Indoles; Leukotriene Antagonists; Male; Microscopy, Electron, Scanning; Neutrophils; Pipecolic Acids; Platelet Aggregation Inhibitors; Receptors, Thromboxane; Recombinant Proteins; Sulfonamides; Thrombolytic Therapy; Thrombosis; Tissue Plasminogen Activator | 1994 |
Antithrombotic actions of argatroban in rat models of venous, 'mixed' and arterial thrombosis, and its effects on the tail transection bleeding time.
Topics: Animals; Arginine; Arteriovenous Shunt, Surgical; Bleeding Time; Carotid Arteries; Electric Stimulation; Fibrinolytic Agents; Heparin; Male; Pipecolic Acids; Rats; Sulfonamides; Tail; Thrombophlebitis; Thrombosis | 1994 |
The antithrombotic effect of low molecular weight synthetic thrombin inhibitors, argatroban and PPACK, on He-Ne laser-induced thrombosis in rat mesenteric microvessels.
Topics: Amino Acid Chloromethyl Ketones; Animals; Antithrombins; Arginine; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Male; Mesentery; Microcirculation; Pipecolic Acids; Platelet Aggregation; Rats; Rats, Wistar; Sulfonamides; Thrombin; Thrombosis | 1993 |
The combination of thrombin inhibitor and thromboxane synthase inhibitor on experimental thrombosis and bleeding.
Topics: Animals; Antithrombins; Arginine; Bleeding Time; Drug Synergism; Drug Therapy, Combination; Infusions, Intravenous; Male; Methacrylates; Pipecolic Acids; Rabbits; Sulfonamides; Thrombin; Thrombosis; Thromboxane-A Synthase | 1995 |
Inhibition by Argatroban, a specific thrombin inhibitor, of platelet activation by fibrin clot-associated thrombin.
Topics: Animals; Antithrombin III; Antithrombins; Arginine; Fibrin; Fibrinolytic Agents; Heparin; Hirudins; Pipecolic Acids; Platelet Activation; Platelet Aggregation Inhibitors; Rabbits; Recombinant Proteins; Sulfonamides; Thrombosis | 1996 |
Report of successful use of argatroban as an alternative anticoagulant during coronary stent implantation in a patient with heparin-induced thrombocytopenia and thrombosis syndrome.
Topics: Aged; Angioplasty, Balloon, Coronary; Arginine; Coronary Angiography; Coronary Disease; Female; Heparin; Humans; Myocardial Infarction; Pipecolic Acids; Platelet Aggregation Inhibitors; Stents; Sulfonamides; Syndrome; Thrombocytopenia; Thrombosis | 1996 |
Low-molecular-weight heparin (fragmin) and thrombin active-site inhibitor (argatroban) compared in experimental arterial and venous thrombosis and bleeding time.
Topics: Animals; Antithrombins; Arginine; Bleeding Time; Dalteparin; Dose-Response Relationship, Drug; Fibrinolytic Agents; Male; Partial Thromboplastin Time; Pipecolic Acids; Rats; Rats, Sprague-Dawley; Sulfonamides; Thrombosis | 1996 |
Antithrombotic activity of argatroban in experimental thrombosis in the rabbit.
Topics: Animals; Antithrombins; Arginine; Disease Models, Animal; Dose-Response Relationship, Drug; Femoral Artery; Infusions, Intravenous; Pipecolic Acids; Rabbits; Sulfonamides; Thrombosis | 1996 |
Effects of inogatran, a new low-molecular-weight thrombin inhibitor, in rat models of venous and arterial thrombosis, thrombolysis and bleeding time.
Topics: Animals; Antithrombins; Arginine; Aspirin; Bleeding Time; Disease Models, Animal; Fibrinolytic Agents; Glycine; Heparin; Male; Molecular Weight; Pipecolic Acids; Piperidines; Platelet Aggregation Inhibitors; Rats; Rats, Sprague-Dawley; Sulfonamides; Thrombolytic Therapy; Thrombophlebitis; Thrombosis | 1996 |
Effect of argatroban on the formation of artificial thrombus on dogs.
Topics: Animals; Arginine; Dogs; Male; Osmolar Concentration; Pipecolic Acids; Platelet Aggregation Inhibitors; Sulfonamides; Thrombosis; Ticlopidine | 1995 |
Local delivery of antithrombotic drug prevents restenosis after balloon angioplasty in atherosclerotic rabbit artery.
Topics: Angiography; Angioplasty, Balloon, Coronary; Angioscopy; Animals; Antithrombins; Arginine; Arteriosclerosis; Batroxobin; Constriction, Pathologic; Fibrinolytic Agents; Fluorescein-5-isothiocyanate; Heparin, Low-Molecular-Weight; Iliac Artery; Male; Microscopy, Confocal; Pipecolic Acids; Rabbits; Sulfonamides; Thrombosis | 1996 |
Adjuvant effect of argatroban on staphylokinase induced thrombolysis of platelet rich thrombi in rat mesenteric venules in vivo.
Topics: Animals; Antithrombins; Arginine; Blood Platelets; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Synergism; Fibrinolysis; Fibrinolytic Agents; Image Processing, Computer-Assisted; Male; Metalloendopeptidases; Microscopy, Electron; Pipecolic Acids; Rats; Rats, Wistar; Recombinant Proteins; Sulfonamides; Thrombosis | 1997 |
In vivo evaluation of DX-9065a, a synthetic factor Xa inhibitor, in experimental vein graft.
Topics: Animals; Anticoagulants; Antithrombins; Arginine; Blood Vessel Prosthesis; Disease Models, Animal; Factor Xa Inhibitors; Graft Occlusion, Vascular; Heparin; Male; Microscopy, Electron, Scanning; Naphthalenes; Pipecolic Acids; Propionates; Rabbits; Sulfonamides; Thrombosis | 1996 |
Factor X values as a means to assess the extent of oral anticoagulation in patients receiving antithrombin drugs.
Topics: Administration, Oral; Angioplasty, Balloon, Coronary; Anticoagulants; Antithrombins; Arginine; Blood Coagulation Factors; Blood Coagulation Tests; Drug Monitoring; Drug Therapy, Combination; Factor X; False Positive Reactions; Female; Heparin; Humans; Indicators and Reagents; Male; Pipecolic Acids; Prothrombin Time; Reference Values; Reproducibility of Results; Sulfonamides; Thrombocytopenia; Thrombosis; Warfarin | 1997 |
Antithrombotic and hemorrhagic effects of DX-9065a, a direct and selective factor Xa inhibitor: comparison with a direct thrombin inhibitor and antithrombin III-dependent anticoagulants.
Topics: Animals; Anticoagulants; Antithrombin III; Arginine; Bleeding Time; Blood Coagulation; Disease Models, Animal; Factor Xa Inhibitors; Hemorrhage; Heparin, Low-Molecular-Weight; Male; Naphthalenes; Peptide Hydrolases; Pipecolic Acids; Propionates; Rats; Rats, Wistar; Sulfonamides; Thrombin; Thrombosis | 1997 |
The first report of successful carotid stent implant using argatroban anticoagulation in a patient with heparin-induced thrombocytopenia and thrombosis syndrome: a case report.
Topics: Aged; Anticoagulants; Antithrombins; Arginine; Carotid Arteries; Carotid Stenosis; Catheterization; Cerebrovascular Disorders; Femoral Artery; Follow-Up Studies; Heparin; Humans; Male; Paresis; Pipecolic Acids; Platelet Aggregation Inhibitors; Recurrence; Stents; Sulfonamides; Syndrome; Thrombocytopenia; Thrombosis | 1998 |
Ecarin Clotting Time: a predictive coagulation assay for the antithrombotic activity of argatroban in the rat.
Topics: Animals; Antithrombins; Arginine; Arteriovenous Shunt, Surgical; Blood Coagulation Tests; Disease Models, Animal; Male; Pipecolic Acids; Rats; Rats, Inbred Strains; Reference Values; Sulfonamides; Thrombophlebitis; Thromboplastin; Thrombosis; Treatment Outcome | 1998 |
Antithrombotic effects of YM-60828, a newly synthesized factor Xa inhibitor, in rat thrombosis models and its effects on bleeding time.
Topics: Animals; Anticoagulants; Arginine; Arteriovenous Shunt, Surgical; Bleeding Time; Blood Proteins; Dalteparin; Factor Xa Inhibitors; Fibrinolytic Agents; Heparin; In Vitro Techniques; Male; Naphthalenes; Partial Thromboplastin Time; Pipecolic Acids; Piperidines; Platelet Aggregation Inhibitors; Rats; Rats, Sprague-Dawley; Sulfonamides; Thrombophlebitis; Thrombosis | 1998 |
BCH-2763, a novel potent parenteral thrombin inhibitor, is an effective antithrombotic agent in rodent models of arterial and venous thrombosis--comparisons with heparin, r-hirudin, hirulog, inogatran and argatroban.
Topics: Animals; Anticoagulants; Arginine; Arteries; Glycine; Heparin; Hirudins; Humans; Infusions, Intravenous; Oligopeptides; Peptide Fragments; Pipecolic Acids; Piperidines; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Sulfonamides; Thrombin; Thrombosis; Veins | 1998 |
Antithrombotic activity of a monoclonal antibody inducing the substrate form of plasminogen activator inhibitor type 1 in rat models of venous and arterial thrombosis.
Topics: Animals; Antibodies, Monoclonal; Anticoagulants; Arginine; Bleeding Time; Cross Reactions; Fibrinolytic Agents; Heparin; Humans; Male; Pipecolic Acids; Plasminogen Activator Inhibitor 1; Platelet Aggregation Inhibitors; Rats; Sulfonamides; Thrombosis; Venous Thrombosis | 1998 |
Pharmacological effects of a novel recombinant hirudin, CX-397, in vivo and in vitro: comparison with recombinant hirudin variant-1, heparin, and argatroban.
Topics: Amino Acid Sequence; Animals; Arginine; Arterial Occlusive Diseases; Arteriovenous Shunt, Surgical; Chlorides; Drug Evaluation, Preclinical; Ferric Compounds; Fibrinolytic Agents; Glass; Hemorrhage; Heparin; Hirudin Therapy; Hirudins; Molecular Sequence Data; Pipecolic Acids; Platelet Aggregation; Platelet Aggregation Inhibitors; Rats; Recombinant Proteins; Sequence Alignment; Sequence Homology, Amino Acid; Serine Proteinase Inhibitors; Sulfonamides; Thrombin; Thrombosis; Vena Cava, Inferior; Venous Thrombosis | 1999 |
Use of argatroban during percutaneous coronary interventions in patients with heparin-induced thrombocytopenia.
Topics: Angioplasty, Balloon, Coronary; Anticoagulants; Arginine; Coronary Disease; Drug Evaluation; Heparin; Humans; Pipecolic Acids; Sulfonamides; Thrombocytopenia; Thrombosis | 1999 |
Local antithrombotic therapy using a novel porous balloon catheter.
Topics: Angioscopy; Animals; Arginine; Catheterization; Catheterization, Peripheral; Dogs; Fibrinolytic Agents; Heparin; Iliac Artery; Pipecolic Acids; Porosity; Sulfonamides; Thrombolytic Therapy; Thrombosis | 2000 |
Combination of a direct thrombin inhibitor and a platelet glycoprotein IIb/IIIa blocking peptide facilitates and maintains reperfusion of platelet-rich thrombus with alteplase.
Topics: Animals; Antithrombins; Arginine; Bleeding Time; Blood Flow Velocity; Blood Platelets; Disease Models, Animal; Drug Combinations; Drug Evaluation; Female; Femoral Artery; Fibrinolytic Agents; Heparin; Male; Partial Thromboplastin Time; Peptides; Peptides, Cyclic; Pipecolic Acids; Plasminogen Activators; Platelet Glycoprotein GPIIb-IIIa Complex; Rabbits; Reperfusion; Sulfonamides; Sulfoxides; Thrombosis; Tissue Plasminogen Activator | 2000 |
Antithrombotic effects of a synthetic inhibitor of activated factor X, JTV-803, in animals.
Topics: Animals; Anticoagulants; Antithrombin III; Arginine; Bleeding Time; Factor Xa Inhibitors; Fibrinolytic Agents; Heparin, Low-Molecular-Weight; Isoquinolines; Macaca fascicularis; Male; Partial Thromboplastin Time; Peptide Hydrolases; Pipecolic Acids; Piperidines; Pyridines; Rats; Rats, Sprague-Dawley; Sulfonamides; Tetrahydroisoquinolines; Thrombosis | 2001 |
Argatroban for treatment of heparin-induced thrombocytopenia.
Topics: Arginine; Health Expenditures; Hemorrhage; Heparin; Humans; Pipecolic Acids; Sulfonamides; Thrombocytopenia; Thrombosis | 2001 |
Anticoagulation with a selective thrombin inhibitor in a woman with heparin-induced thrombocytopenia.
Topics: Anticoagulants; Arginine; Catheterization, Central Venous; Female; Heparin; Humans; Middle Aged; Pipecolic Acids; Postoperative Complications; Sulfonamides; Thrombectomy; Thrombocytopenia; Thrombosis | 2001 |
Argatroban.
Topics: Antithrombins; Arginine; Drug Interactions; Humans; Pipecolic Acids; Sulfonamides; Thrombosis | 2001 |
Inhibitors of fibrinolytic components play different roles in the formation and removal of arterial thrombus in mice.
Topics: alpha-2-Antiplasmin; Animals; Arginine; Bleeding Time; Blood Coagulation; Carotid Artery Injuries; Endothelium, Vascular; Mice; Mice, Inbred C57BL; Mice, Knockout; Pipecolic Acids; Piperazines; Piperidines; Plasminogen Activator Inhibitor 1; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIIb-IIIa Complex; Serine Proteinase Inhibitors; Sulfonamides; Thrombin; Thrombin Time; Thrombosis; Vascular Patency | 2002 |
Enhancement of endogenous plasminogen activator-induced thrombolysis by argatroban and APC and its control by TAFI, measured in an arterial thrombolysis model in vivo using rat mesenteric arterioles.
Topics: Animals; Arginine; Arterial Occlusive Diseases; Arterioles; Binding, Competitive; Carboxypeptidase B2; Enzyme Activation; Enzyme Inhibitors; Fibrinolysis; Fibrinolytic Agents; Image Processing, Computer-Assisted; Lasers; Male; Mesenteric Arteries; Models, Animal; Pipecolic Acids; Plant Proteins; Plasminogen Activators; Protease Inhibitors; Protein C; Rats; Rats, Wistar; Reproducibility of Results; Sensitivity and Specificity; Sulfonamides; Swine; Thrombosis | 2002 |
Argatroban therapy does not generate antibodies that alter its anticoagulant activity in patients with heparin-induced thrombocytopenia.
Topics: Antibodies; Anticoagulants; Arginine; Dose-Response Relationship, Drug; Heparin; Humans; Partial Thromboplastin Time; Pipecolic Acids; Sulfonamides; Thrombocytopenia; Thrombosis | 2002 |
Synergistic antithrombotic properties of G4120, a RGD-containing synthetic peptide, and argatroban, a synthetic thrombin inhibitor, in a hamster femoral vein platelet-rich thrombosis model.
Topics: Animals; Antithrombins; Arginine; Aspirin; Blood Coagulation; Cricetinae; Disease Models, Animal; Drug Synergism; Femoral Vein; Fibrinolytic Agents; Hemostasis; Heparin; Injections, Intravenous; Male; Peptides, Cyclic; Pipecolic Acids; Platelet Aggregation Inhibitors; Platelet Count; Sulfonamides; Sulfoxides; Thrombosis | 1992 |
Comparative antithrombotic effects of heparin, recombinant hirudin and argatroban in a hamster femoral vein platelet-rich mural thrombosis model.
Topics: Animals; Antithrombins; Arginine; Cricetinae; Femoral Vein; Heparin; Hirudin Therapy; Injections, Intravenous; Male; Models, Cardiovascular; Partial Thromboplastin Time; Pipecolic Acids; Sulfonamides; Thrombin Time; Thrombosis | 1992 |
Heparin and the thrombin inhibitor argatroban enhance fibrinolysis by infused or bolus-injected saruplase (r-scu-PA) in rabbit femoral artery thrombosis.
Topics: Animals; Anticoagulants; Antithrombins; Arginine; Drug Synergism; Drug Therapy, Combination; Enzyme Precursors; Femoral Artery; Fibrinolysis; Heparin; Infusions, Intravenous; Injections, Intravenous; Pipecolic Acids; Plasminogen Activators; Rabbits; Recombinant Proteins; Sulfonamides; Thrombosis; Urokinase-Type Plasminogen Activator | 1991 |
Effect of ticlopidine and other antithrombotics on the venous thrombosis induced by endothelial damage of jugular vein in rats.
Topics: Animals; Arginine; Endothelium, Vascular; Fibrinolytic Agents; Freezing; Jugular Veins; Male; Microscopy, Electron, Scanning; Pipecolic Acids; Platelet Adhesiveness; Platelet Aggregation; Platelet Aggregation Inhibitors; Rats; Rats, Inbred Strains; Sulfonamides; Thrombosis; Ticlopidine; Urokinase-Type Plasminogen Activator | 1991 |
In vivo thrombin inhibition enhances and sustains arterial recanalization with recombinant tissue-type plasminogen activator.
Topics: Animals; Antithrombins; Arginine; Blood Coagulation Tests; Female; Femoral Artery; Male; Pipecolic Acids; Rabbits; Sulfonamides; Thrombolytic Therapy; Thrombosis; Tissue Plasminogen Activator | 1990 |
Prevention of reocclusion by MCI-9038, a thrombin inhibitor, following t-PA-induced thrombolysis in a canine model of femoral arterial thrombosis.
Topics: Animals; Arginine; Arterial Occlusive Diseases; Disease Models, Animal; Dogs; Femoral Artery; Hemodynamics; Male; Pipecolic Acids; Recurrence; Regional Blood Flow; Sulfonamides; Thrombin; Thrombin Time; Thrombolytic Therapy; Thrombosis; Tissue Plasminogen Activator | 1990 |
[Synthetic anticoagulant].
Topics: Animals; Antithrombins; Arginine; Dose-Response Relationship, Drug; Endothelins; Endothelium; Humans; Mice; Pipecolic Acids; Protein C; Receptors, Cell Surface; Receptors, Thrombin; Recombinant Proteins; Sulfonamides; Thrombosis | 1990 |
Prevention of platelet-rich arterial thrombosis by selective thrombin inhibition.
Topics: Animals; Antithrombins; Arginine; Arterial Occlusive Diseases; Bleeding Time; Blood Platelets; Femoral Artery; Graft Occlusion, Vascular; Heparin; In Vitro Techniques; Injections, Intra-Arterial; Injections, Intravenous; Pipecolic Acids; Rabbits; Regional Blood Flow; Sulfonamides; Thrombosis | 1990 |
Antithrombotic effects of three thrombin inhibitors in a rat model of laser-induced thrombosis.
Topics: Animals; Antithrombins; Arginine; Disease Models, Animal; Hirudins; Humans; Injections, Intravenous; Lasers; Light Coagulation; Pipecolic Acids; Rats; Rats, Inbred Strains; Sulfonamides; Thrombosis | 1989 |
[Preventive effects of synthetic antithrombin, MD-805, on animal thrombosis models].
Topics: Acute Disease; Animals; Antithrombin III Deficiency; Antithrombins; Arginine; Arterial Occlusive Diseases; Mice; Pipecolic Acids; Pulmonary Embolism; Rats; Rats, Inbred Strains; Sulfonamides; Thrombosis; Vena Cava, Inferior | 1987 |
[Clinical evaluation of MD-805].
Topics: Aged; Antithrombins; Arginine; Disseminated Intravascular Coagulation; Drug Therapy, Combination; Female; Fibrinopeptide A; Heparin; Humans; Male; Middle Aged; Pipecolic Acids; Platelet Aggregation Inhibitors; Renal Dialysis; Sulfonamides; Thrombocytopenia; Thrombosis | 1987 |