mcc-950 and Ischemic-Stroke

mcc-950 has been researched along with Ischemic-Stroke* in 1 studies

Other Studies

1 other study(ies) available for mcc-950 and Ischemic-Stroke

Article	Year
Structure-activity relationship studies of phenothiazine derivatives as a new class of ferroptosis inhibitors together with the therapeutic effect in an ischemic stroke model. European journal of medicinal chemistry, 2021, Jan-01, Volume: 209 Ferroptosis is a new type of programmed cell death discovered recently and has been demonstrated to be involved in a number of human diseases such as ischemic stroke. Ferroptosis inhibitors are expected to have potential to treat these diseases. Herein, we report the identification of promethazine derivatives as a new type of ferroptosis inhibitors. Structure-activity relationship (SAR) analyses led to the discovery of the most potent compound 2-(1-(4-(4-methylpiperazin-1-yl)phenyl)ethyl)-10H-phenothiazine (51), which showed an EC Topics: Animals; Cell Line; Ferroptosis; Humans; Ischemic Stroke; Male; Phenothiazines; Rats, Sprague-Dawley	2021

Article

Year

Structure-activity relationship studies of phenothiazine derivatives as a new class of ferroptosis inhibitors together with the therapeutic effect in an ischemic stroke model.

European journal of medicinal chemistry, 2021, Jan-01, Volume: 209

Ferroptosis is a new type of programmed cell death discovered recently and has been demonstrated to be involved in a number of human diseases such as ischemic stroke. Ferroptosis inhibitors are expected to have potential to treat these diseases. Herein, we report the identification of promethazine derivatives as a new type of ferroptosis inhibitors. Structure-activity relationship (SAR) analyses led to the discovery of the most potent compound 2-(1-(4-(4-methylpiperazin-1-yl)phenyl)ethyl)-10H-phenothiazine (51), which showed an EC

Topics: Animals; Cell Line; Ferroptosis; Humans; Ischemic Stroke; Male; Phenothiazines; Rats, Sprague-Dawley

2021