mazindol has been researched along with Prader-Willi Syndrome in 3 studies
Mazindol: Tricyclic anorexigenic agent unrelated to and less toxic than AMPHETAMINE, but with some similar side effects. It inhibits uptake of catecholamines and blocks the binding of cocaine to the dopamine uptake transporter.
Prader-Willi Syndrome: An autosomal dominant disorder caused by deletion of the proximal long arm of the paternal chromosome 15 (15q11-q13) or by inheritance of both of the pair of chromosomes 15 from the mother (UNIPARENTAL DISOMY) which are imprinted (GENETIC IMPRINTING) and hence silenced. Clinical manifestations include MENTAL RETARDATION; MUSCULAR HYPOTONIA; HYPERPHAGIA; OBESITY; short stature; HYPOGONADISM; STRABISMUS; and HYPERSOMNOLENCE. (Menkes, Textbook of Child Neurology, 5th ed, p229)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Mazindol was given orally, 1." | 5.29 | Effects of mazindol in two patients with Prader-Willi syndrome. ( Itoh, M; Koeda, T; Ohno, K; Takeshita, K, 1995) |
| "Obesity is a major cause of increased morbidity and mortality among patients with PWS." | 2.44 | [Therapeutical approach of obesity in Prader-Willi Syndrome]. ( Almeida, MQ; Carvalho, DF; Cercato, C; Halpern, A; Mancini, MC, 2007) |
| "Mazindol was given orally, 1." | 1.29 | Effects of mazindol in two patients with Prader-Willi syndrome. ( Itoh, M; Koeda, T; Ohno, K; Takeshita, K, 1995) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (66.67) | 18.2507 |
| 2000's | 1 (33.33) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Carvalho, DF | 1 |
| Cercato, C | 1 |
| Almeida, MQ | 1 |
| Mancini, MC | 1 |
| Halpern, A | 1 |
| Itoh, M | 1 |
| Koeda, T | 1 |
| Ohno, K | 1 |
| Takeshita, K | 1 |
| Inui, A | 1 |
| Uemoto, M | 1 |
| Takamiya, S | 1 |
| Shibuya, Y | 1 |
| Baba, S | 1 |
| Kasuga, M | 1 |
1 review available for mazindol and Prader-Willi Syndrome
| Article | Year |
|---|---|
[Therapeutical approach of obesity in Prader-Willi Syndrome].
Topics: Adolescent; Anti-Obesity Agents; Bariatric Surgery; Child; Child, Preschool; Female; Fluoxetine; Fru | 2007 |
2 other studies available for mazindol and Prader-Willi Syndrome
| Article | Year |
|---|---|
Effects of mazindol in two patients with Prader-Willi syndrome.
Topics: Adolescent; Appetite Depressants; Central Nervous System Stimulants; Child; Humans; Male; Mazindol; | 1995 |
A case of Prader-Willi syndrome with long-term mazindol treatment.
Topics: Adult; Appetite Depressants; Diabetes Mellitus; Drug Therapy, Combination; Humans; Insulin; Male; Ma | 1997 |