mazindol has been researched along with Parkinson Disease, Secondary in 16 studies
Mazindol: Tricyclic anorexigenic agent unrelated to and less toxic than AMPHETAMINE, but with some similar side effects. It inhibits uptake of catecholamines and blocks the binding of cocaine to the dopamine uptake transporter.
Parkinson Disease, Secondary: Conditions which feature clinical manifestations resembling primary Parkinson disease that are caused by a known or suspected condition. Examples include parkinsonism caused by vascular injury, drugs, trauma, toxin exposure, neoplasms, infections and degenerative or hereditary conditions. Clinical features may include bradykinesia, rigidity, parkinsonian gait, and masked facies. In general, tremor is less prominent in secondary parkinsonism than in the primary form. (From Joynt, Clinical Neurology, 1998, Ch38, pp39-42)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Mazindol binding was decreased 30-98% in the caudate nucleus, 20-97% in the putamen, 0-26% in the nucleus accumbens, 80-96% in the substantia nigra pars compacta and 49-94% in the ventral tegmental area." | 1.28 | Changes in brain catecholamines and dopamine uptake sites at different stages of MPTP parkinsonism in monkeys. ( Alexander, GM; Brainard, L; Gordon, SW; Grothusen, JR; Schwartzman, RJ, 1992) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 14 (87.50) | 18.2507 |
| 2000's | 2 (12.50) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Oueslati, A | 1 |
| Breysse, N | 1 |
| Amalric, M | 1 |
| Kerkerian-Le Goff, L | 1 |
| Salin, P | 1 |
| Frohna, PA | 1 |
| Rothblat, DS | 2 |
| Joyce, JN | 1 |
| Schneider, JS | 4 |
| Soghomonian, JJ | 1 |
| Pedneault, S | 1 |
| Audet, G | 1 |
| Parent, A | 1 |
| Gnanalingham, KK | 1 |
| Smith, LA | 1 |
| Hunter, AJ | 1 |
| Jenner, P | 1 |
| Marsden, CD | 1 |
| Graybiel, AM | 1 |
| Moratalla, R | 1 |
| Quinn, B | 1 |
| DeLanney, LE | 1 |
| Irwin, I | 1 |
| Langston, JW | 1 |
| Hashitani, T | 1 |
| Mizukawa, K | 1 |
| Kumazaki, M | 1 |
| Nishino, H | 1 |
| Henry, B | 2 |
| Crossman, AR | 3 |
| Brotchie, JM | 2 |
| Decamp, E | 1 |
| Wade, T | 1 |
| Wade, TV | 1 |
| Alexander, GM | 1 |
| Schwartzman, RJ | 1 |
| Brainard, L | 1 |
| Gordon, SW | 1 |
| Grothusen, JR | 1 |
| Cadet, JL | 3 |
| Zhu, SM | 2 |
| Kujirai, K | 1 |
| Dollison, A | 1 |
| Angulo, J | 1 |
| Fahn, S | 2 |
| Przedborski, S | 1 |
| Jackson-Lewis, V | 1 |
| Popilskis, S | 1 |
| Kostic, V | 1 |
| Levivier, M | 1 |
| Graham, WC | 1 |
| Hill, DR | 1 |
| Woodruff, GN | 1 |
| Sambrook, MA | 1 |
1 review available for mazindol and Parkinson Disease, Secondary
| Article | Year |
|---|---|
Unilateral MPTP-induced parkinsonism in monkeys. A quantitative autoradiographic study of dopamine D1 and D2 receptors and re-uptake sites.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Autoradiography; Brain Chemistry; Carotid Art | 1991 |
15 other studies available for mazindol and Parkinson Disease, Secondary
| Article | Year |
|---|---|
Dysfunction of the cortico-basal ganglia-cortical loop in a rat model of early parkinsonism is reversed by metabotropic glutamate receptor 5 antagonism.
Topics: Animals; Basal Ganglia; Cerebral Cortex; Denervation; Dopamine Uptake Inhibitors; Electron Transport | 2005 |
Alterations in dopamine uptake sites and D1 and D2 receptors in cats symptomatic for and recovered from experimental parkinsonism.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Autoradiography; Cats; Corpus Striatum; Mazin | 1995 |
Increased glutamate decarboxylase mRNA levels in the striatum and pallidum of MPTP-treated primates.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Autoradiography; Axons; Corpus Striatum; Gene | 1994 |
Alterations in striatal and extrastriatal D-1 and D-2 dopamine receptors in the MPTP-treated common marmoset: an autoradiographic study.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Autoradiography; Benzazepines; Brain; Callith | 1993 |
Early-stage loss of dopamine uptake-site binding in MPTP-treated monkeys.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Autoradiography; Brain Mapping; Caudate Nucle | 1993 |
Dopamine metabolism in the striatum of hemiparkinsonian model rats with dopaminergic grafts.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Autoradiography; Brain Tissue Transplantation; Carrier Prot | 1998 |
Characterization of enhanced behavioral responses to L-DOPA following repeated administration in the 6-hydroxydopamine-lesioned rat model of Parkinson's disease.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Antiparkinson Agents; Behavior, An | 1998 |
Effects of GM1 ganglioside treatment on dopamine innervation of the striatum of MPTP-treated mice.
Topics: Animals; Corpus Striatum; Dopamine; G(M1) Ganglioside; Mazindol; Mice; Mice, Inbred C57BL; MPTP Pois | 1998 |
Effect of repeated L-DOPA, bromocriptine, or lisuride administration on preproenkephalin-A and preproenkephalin-B mRNA levels in the striatum of the 6-hydroxydopamine-lesioned rat.
Topics: Animals; Autoradiography; Behavior, Animal; Bromocriptine; Dopamine Agents; Dopamine Agonists; Dopam | 1999 |
Striatal preproenkephalin gene expression is upregulated in acute but not chronic parkinsonian monkeys: implications for the contribution of the indirect striatopallidal circuit to parkinsonian symptomatology.
Topics: Acute Disease; Animals; Autoradiography; Behavior, Animal; Chronic Disease; Corpus Striatum; Enkepha | 1999 |
Expression of striatal preprotachykinin mRNA in symptomatic and asymptomatic 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-exposed monkeys is related to parkinsonian motor signs.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Autoradiography; Cognition Disorders; Corpus | 2001 |
Changes in brain catecholamines and dopamine uptake sites at different stages of MPTP parkinsonism in monkeys.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Brain; Brain Chemistry; Catecholamines; Dopam | 1992 |
The intrastriatal 6-hydroxydopamine model of hemiparkinsonism: quantitative receptor autoradiographic evidence of correlation between circling behavior and presynaptic as well as postsynaptic nigrostriatal markers in the rat.
Topics: Amphetamine; Animals; Apomorphine; Autoradiography; Biomarkers; Corpus Striatum; Immunohistochemistr | 1992 |
Implantation of genetically modified mesencephalic fetal cells into the rat striatum.
Topics: Amphetamine; Animals; Autoradiography; Brain Tissue Transplantation; Cell Line; Corpus Striatum; Fem | 1992 |
Reduction of [125I]Bolton Hunter CCK8 and [3H]MK-329 (devazepide) binding to CCK receptors in the substantia nigra/VTA complex and its forebrain projection areas following MPTP-induced hemi-parkinsonism in the monkey.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Autoradiography; Benzodiazepinones; Cholecyst | 1991 |