mazindol has been researched along with Nerve Degeneration in 8 studies
Mazindol: Tricyclic anorexigenic agent unrelated to and less toxic than AMPHETAMINE, but with some similar side effects. It inhibits uptake of catecholamines and blocks the binding of cocaine to the dopamine uptake transporter.
Nerve Degeneration: Loss of functional activity and trophic degeneration of nerve axons and their terminal arborizations following the destruction of their cells of origin or interruption of their continuity with these cells. The pathology is characteristic of neurodegenerative diseases. Often the process of nerve degeneration is studied in research on neuroanatomical localization and correlation of the neurophysiology of neural pathways.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The influence of embryonic mesencephalic, striatal and mesencephalic/striatal co-grafts on amphetamine- and apomorphine-induced rotation behaviour was assessed in a rat model of multiple system atrophy/striatonigral degeneration type using dopamine D1 ([3H]SCH23390) and D2 ([3H]spiperone) receptor and dopamine re-uptake ([3H]mazindol) autoradiography." | 7.70 | Autoradiographic study of striatal dopamine re-uptake sites and dopamine D1 and D2 receptors in a 6-hydroxydopamine and quinolinic acid double-lesion rat model of striatonigral degeneration (multiple system atrophy) and effects of embryonic ventral mesenc ( Granata, R; Jenner, P; Laboyrie, P; Poewe, W; Puschban, Z; Quinn, NP; Scherfler, C; Wenning, GK, 2000) |
| "The influence of embryonic mesencephalic, striatal and mesencephalic/striatal co-grafts on amphetamine- and apomorphine-induced rotation behaviour was assessed in a rat model of multiple system atrophy/striatonigral degeneration type using dopamine D1 ([3H]SCH23390) and D2 ([3H]spiperone) receptor and dopamine re-uptake ([3H]mazindol) autoradiography." | 3.70 | Autoradiographic study of striatal dopamine re-uptake sites and dopamine D1 and D2 receptors in a 6-hydroxydopamine and quinolinic acid double-lesion rat model of striatonigral degeneration (multiple system atrophy) and effects of embryonic ventral mesenc ( Granata, R; Jenner, P; Laboyrie, P; Poewe, W; Puschban, Z; Quinn, NP; Scherfler, C; Wenning, GK, 2000) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (25.00) | 18.7374 |
| 1990's | 1 (12.50) | 18.2507 |
| 2000's | 5 (62.50) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Wiley, RG | 1 |
| Harrison, MB | 1 |
| Levey, AI | 1 |
| Lappi, DA | 1 |
| Porritt, MJ | 1 |
| Batchelor, PE | 1 |
| Howells, DW | 1 |
| Puschban, Z | 1 |
| Scherfler, C | 1 |
| Granata, R | 1 |
| Laboyrie, P | 1 |
| Quinn, NP | 1 |
| Jenner, P | 2 |
| Poewe, W | 1 |
| Wenning, GK | 1 |
| Levivier, M | 1 |
| Donaldson, D | 1 |
| Gallagher, IM | 1 |
| Glover, V | 1 |
| Clow, A | 1 |
| Moratalla, R | 1 |
| Quinn, B | 1 |
| DeLanney, LE | 2 |
| Irwin, I | 2 |
| Langston, JW | 2 |
| Graybiel, AM | 1 |
| Sundström, E | 1 |
| Luthman, J | 1 |
| Goldstein, M | 1 |
| Jonsson, G | 1 |
| Ricaurte, GA | 1 |
| Peroutka, SJ | 1 |
| Forno, LS | 1 |
8 other studies available for mazindol and Nerve Degeneration
| Article | Year |
|---|---|
Destruction of midbrain dopaminergic neurons by using immunotoxin to dopamine transporter.
Topics: Animals; Antibodies, Monoclonal; Binding, Competitive; Cell Death; Denervation; Disease Models, Anim | 2003 |
Inhibiting BDNF expression by antisense oligonucleotide infusion causes loss of nigral dopaminergic neurons.
Topics: Animals; Binding, Competitive; Brain-Derived Neurotrophic Factor; Cell Death; Cell Survival; Disease | 2005 |
Autoradiographic study of striatal dopamine re-uptake sites and dopamine D1 and D2 receptors in a 6-hydroxydopamine and quinolinic acid double-lesion rat model of striatonigral degeneration (multiple system atrophy) and effects of embryonic ventral mesenc
Topics: Amphetamine; Animals; Apomorphine; Atrophy; Autoradiography; Behavior, Animal; Brain Tissue Transpla | 2000 |
Metabolic changes after injection of quinolinic acid or 6-hydroxydopamine in the rat striatum: a time-course study using cytochrome oxidase and glycogene phosphorylase a histochemistry.
Topics: Animals; Autoradiography; Benzazepines; Biomarkers; Corpus Striatum; Disease Models, Animal; Dopamin | 2000 |
CuZn-superoxide dismutase transgenic mice: no effect on longevity, locomotor activity and 3H-mazindol and 3H-spiperone binding over 19 months.
Topics: Animals; Binding Sites; Longevity; Male; Mazindol; Mice; Mice, Transgenic; Motor Activity; Neostriat | 2000 |
Differential vulnerability of primate caudate-putamen and striosome-matrix dopamine systems to the neurotoxic effects of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine.
Topics: Animals; Binding Sites; Caudate Nucleus; Corpus Striatum; Dose-Response Relationship, Drug; Mazindol | 1992 |
Time course of MPTP-induced degeneration of the nigrostriatal dopamine system in C57 BL/6 mice.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Dopamine; Hydroxydopamines; Male; Mazindol; M | 1988 |
Fate of nigrostriatal neurons in young mature mice given 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine: a neurochemical and morphological reassessment.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Corpus Striatum; Dopamine; Male; Mazindol; Mi | 1986 |