mazindol has been researched along with Muscle Contraction in 3 studies
Mazindol: Tricyclic anorexigenic agent unrelated to and less toxic than AMPHETAMINE, but with some similar side effects. It inhibits uptake of catecholamines and blocks the binding of cocaine to the dopamine uptake transporter.
Muscle Contraction: A process leading to shortening and/or development of tension in muscle tissue. Muscle contraction occurs by a sliding filament mechanism whereby actin filaments slide inward among the myosin filaments.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Side effects attributable to mazindol included decreased appetite (36%), dry mouth (10%), behavioral change (22%), and gastrointestinal symptoms (18%); mazindol dosage was reduced in 43% of patients." | 2.67 | Randomized, double-blind trial of mazindol in Duchenne dystrophy. ( Brooke, MH; Fenichel, GM; Florence, J; Griggs, RC; Kaiser, KK; Mandel, S; Mendell, JR; Miller, PJ; Moxley, RT; Schierbecker, J, 1990) |
| " Mazindol leftwardly shifted the dose-response curve to norepinephrine in a dose-dependent manner; the dose-ratio was 6." | 1.28 | Effects of mazindol on the contractions in the rat vas deferens. ( Gomi, Y; Suzuki, N, 1990) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (33.33) | 18.7374 |
| 1990's | 2 (66.67) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Zarrindast, MR | 1 |
| Suzuki, N | 1 |
| Gomi, Y | 1 |
| Griggs, RC | 1 |
| Moxley, RT | 1 |
| Mendell, JR | 1 |
| Fenichel, GM | 1 |
| Brooke, MH | 1 |
| Miller, PJ | 1 |
| Mandel, S | 1 |
| Florence, J | 1 |
| Schierbecker, J | 1 |
| Kaiser, KK | 1 |
1 trial available for mazindol and Muscle Contraction
| Article | Year |
|---|---|
Randomized, double-blind trial of mazindol in Duchenne dystrophy.
Topics: Behavior; Double-Blind Method; Feeding and Eating Disorders; Humans; Male; Mazindol; Muscle Contract | 1990 |
2 other studies available for mazindol and Muscle Contraction
| Article | Year |
|---|---|
Sympathomimetic activity of mazindol on rat anococcygeus muscle and vas deferens.
Topics: Animals; Electric Stimulation; In Vitro Techniques; Indoles; Male; Mazindol; Muscle Contraction; Mus | 1984 |
Effects of mazindol on the contractions in the rat vas deferens.
Topics: Animals; Dopamine; Electric Stimulation; In Vitro Techniques; Male; Mazindol; Methacholine Chloride; | 1990 |