mazindol has been researched along with MPTP Neurotoxicity Syndrome in 13 studies
Mazindol: Tricyclic anorexigenic agent unrelated to and less toxic than AMPHETAMINE, but with some similar side effects. It inhibits uptake of catecholamines and blocks the binding of cocaine to the dopamine uptake transporter.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Modafinil treatment dose-dependently reduced the loss of specific [3H]-mazindol binding." | 1.31 | Antiparkinsonian and neuroprotective effects of modafinil in the mptp-treated common marmoset. ( Chancharme, L; Jenner, P; Moachon, G; Pearce, RK; Smith, LA; Tel, B; Zeng, BY, 2000) |
| " Although L-DOPA treatment provides the most effective symptomatic relief for PD it does not prevent the progression of the disease, and its long-term use is associated with the onset of dyskinesia." | 1.31 | GDNF reverses priming for dyskinesia in MPTP-treated, L-DOPA-primed common marmosets. ( Cannizzaro, C; Costa, S; Iravani, MM; Jackson, MJ; Jenner, P; Pearce, RK; Tel, BC, 2001) |
| " Protection was more profound with an acute dosing regimen than with daily MPTP administration over 5 d." | 1.30 | 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyride neurotoxicity is attenuated in mice overexpressing Bcl-2. ( Beal, MF; Hyman, BT; Klockgether, T; Liao, AW; Martinou, JC; Matthews, RT; Penney, JB; Schulz, JB; Yang, L, 1998) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 10 (76.92) | 18.2507 |
| 2000's | 3 (23.08) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Wüllner, U | 1 |
| Brouillet, E | 1 |
| Isacson, O | 1 |
| Young, AB | 1 |
| Penney, JB | 2 |
| Takada, M | 1 |
| Sugimoto, T | 1 |
| Hattori, T | 1 |
| Mackenzie, GM | 1 |
| Jackson, MJ | 2 |
| Jenner, P | 3 |
| Marsden, CD | 1 |
| Rothblat, DS | 1 |
| Schneider, JS | 1 |
| Yang, L | 1 |
| Matthews, RT | 1 |
| Schulz, JB | 1 |
| Klockgether, T | 1 |
| Liao, AW | 1 |
| Martinou, JC | 1 |
| Hyman, BT | 1 |
| Beal, MF | 1 |
| Tanji, H | 2 |
| Araki, T | 2 |
| Fujihara, K | 1 |
| Nagasawa, H | 1 |
| Itoyama, Y | 2 |
| Itzhak, Y | 1 |
| Martin, JL | 1 |
| Ali, SF | 1 |
| Zeng, BY | 1 |
| Smith, LA | 1 |
| Pearce, RK | 2 |
| Tel, B | 1 |
| Chancharme, L | 1 |
| Moachon, G | 1 |
| Mikami, T | 1 |
| Matsubara, M | 1 |
| Imai, Y | 1 |
| Mizugaki, M | 1 |
| Iravani, MM | 1 |
| Costa, S | 1 |
| Tel, BC | 1 |
| Cannizzaro, C | 1 |
| Moratalla, R | 1 |
| Quinn, B | 1 |
| DeLanney, LE | 1 |
| Irwin, I | 1 |
| Langston, JW | 1 |
| Graybiel, AM | 1 |
| Marshall, JF | 1 |
| Navarrete, RJ | 1 |
| Hess, A | 1 |
13 other studies available for mazindol and MPTP Neurotoxicity Syndrome
| Article | Year |
|---|---|
Glutamate receptor binding sites in MPTP-treated mice.
Topics: Animals; Autoradiography; Binding Sites; Brain; Male; Mazindol; Mice; Mice, Inbred C57BL; MPTP Poiso | 1993 |
MPTP neurotoxicity to cerebellar Purkinje cells in mice.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Benztropine; Dose-Response Relationship, Drug | 1993 |
Nitric oxide synthase inhibition and MPTP-induced toxicity in the common marmoset.
Topics: Adrenergic Uptake Inhibitors; Animals; Autoradiography; Behavior, Animal; Brain Chemistry; Callithri | 1997 |
Effects of GM1 ganglioside treatment on dopamine innervation of the striatum of MPTP-treated mice.
Topics: Animals; Corpus Striatum; Dopamine; G(M1) Ganglioside; Mazindol; Mice; Mice, Inbred C57BL; MPTP Pois | 1998 |
1-Methyl-4-phenyl-1,2,3,6-tetrahydropyride neurotoxicity is attenuated in mice overexpressing Bcl-2.
Topics: 1-Methyl-4-phenylpyridinium; 3,4-Dihydroxyphenylacetic Acid; Animals; Apoptosis; Brain Chemistry; Ca | 1998 |
Alteration of neurotensin receptors in MPTP-treated mice.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Autoradiography; Corpus Striatum; Dopamine; D | 1999 |
Methamphetamine- and 1-methyl-4-phenyl- 1,2,3, 6-tetrahydropyridine-induced dopaminergic neurotoxicity in inducible nitric oxide synthase-deficient mice.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Body Temperature; Carrier Proteins; Dopamine; Dopamine Plas | 1999 |
Antiparkinsonian and neuroprotective effects of modafinil in the mptp-treated common marmoset.
Topics: Animals; Autoradiography; Behavior, Animal; Benzhydryl Compounds; Callithrix; Dopamine; Dopamine Upt | 2000 |
Biochemical and immunohistological changes in the brain of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-treated mouse.
Topics: Animals; Benzazepines; Brain Chemistry; Dopamine Agents; Dopamine Uptake Inhibitors; Glial Fibrillar | 2001 |
GDNF reverses priming for dyskinesia in MPTP-treated, L-DOPA-primed common marmosets.
Topics: Animals; Antiparkinson Agents; Body Weight; Callithrix; Corpus Striatum; Disease Models, Animal; Dop | 2001 |
Differential vulnerability of primate caudate-putamen and striosome-matrix dopamine systems to the neurotoxic effects of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine.
Topics: Animals; Binding Sites; Caudate Nucleus; Corpus Striatum; Dose-Response Relationship, Drug; Mazindol | 1992 |
Contrasting tissue factors predict heterogeneous striatal dopamine neurotoxicity after MPTP or methamphetamine treatment.
Topics: Animals; Corpus Striatum; Dopamine; Male; Mazindol; Methamphetamine; Mice; MPTP Poisoning; Nervous S | 1990 |
The effects of monoamine oxidase inhibition and dopamine uptake blockade on MPTP-induced increase of 2-[3H]deoxyglucose uptake in specific mesencephalic catecholaminergic nuclei.
Topics: Animals; Clorgyline; Deoxy Sugars; Deoxyglucose; Dopamine; Indoles; Mazindol; Mice; Mice, Inbred C57 | 1990 |