mazindol has been researched along with Disease Models, Animal in 13 studies
Mazindol: Tricyclic anorexigenic agent unrelated to and less toxic than AMPHETAMINE, but with some similar side effects. It inhibits uptake of catecholamines and blocks the binding of cocaine to the dopamine uptake transporter.
Disease Models, Animal: Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Although L-DOPA treatment provides the most effective symptomatic relief for PD it does not prevent the progression of the disease, and its long-term use is associated with the onset of dyskinesia." | 1.31 | GDNF reverses priming for dyskinesia in MPTP-treated, L-DOPA-primed common marmosets. ( Cannizzaro, C; Costa, S; Iravani, MM; Jackson, MJ; Jenner, P; Pearce, RK; Tel, BC, 2001) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 5 (38.46) | 18.2507 |
| 2000's | 6 (46.15) | 29.6817 |
| 2010's | 1 (7.69) | 24.3611 |
| 2020's | 1 (7.69) | 2.80 |
| Authors | Studies |
|---|---|
| Abrams, RPM | 1 |
| Yasgar, A | 1 |
| Teramoto, T | 1 |
| Lee, MH | 1 |
| Dorjsuren, D | 1 |
| Eastman, RT | 1 |
| Malik, N | 1 |
| Zakharov, AV | 1 |
| Li, W | 1 |
| Bachani, M | 1 |
| Brimacombe, K | 1 |
| Steiner, JP | 1 |
| Hall, MD | 1 |
| Balasubramanian, A | 1 |
| Jadhav, A | 1 |
| Padmanabhan, R | 1 |
| Simeonov, A | 1 |
| Nath, A | 1 |
| Nikiforuk, A | 1 |
| GoĊembiowska, K | 1 |
| Popik, P | 1 |
| Wiley, RG | 1 |
| Harrison, MB | 1 |
| Levey, AI | 1 |
| Lappi, DA | 1 |
| Lundblad, M | 1 |
| Picconi, B | 1 |
| Lindgren, H | 1 |
| Cenci, MA | 1 |
| Porritt, MJ | 1 |
| Batchelor, PE | 1 |
| Howells, DW | 1 |
| Gnanalingham, KK | 1 |
| Milkowski, NA | 1 |
| Smith, LA | 1 |
| Hunter, AJ | 1 |
| Jenner, P | 2 |
| Marsden, CD | 1 |
| Przedborski, S | 3 |
| Levivier, M | 4 |
| Jiang, H | 1 |
| Ferreira, M | 1 |
| Jackson-Lewis, V | 2 |
| Donaldson, D | 2 |
| Togasaki, DM | 1 |
| Henry, B | 1 |
| Crossman, AR | 1 |
| Brotchie, JM | 1 |
| Iravani, MM | 1 |
| Costa, S | 1 |
| Jackson, MJ | 1 |
| Tel, BC | 1 |
| Cannizzaro, C | 1 |
| Pearce, RK | 1 |
| Wade, TV | 1 |
| Schneider, JS | 1 |
| Popilskis, S | 1 |
| Kostic, V | 1 |
| Fahn, S | 1 |
| Cadet, JL | 1 |
1 review available for mazindol and Disease Models, Animal
| Article | Year |
|---|---|
Unilateral MPTP-induced parkinsonism in monkeys. A quantitative autoradiographic study of dopamine D1 and D2 receptors and re-uptake sites.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Autoradiography; Brain Chemistry; Carotid Art | 1991 |
12 other studies available for mazindol and Disease Models, Animal
| Article | Year |
|---|---|
Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors.
Topics: Animals; Antiviral Agents; Artificial Intelligence; Chlorocebus aethiops; Disease Models, Animal; Dr | 2020 |
Mazindol attenuates ketamine-induced cognitive deficit in the attentional set shifting task in rats.
Topics: Analysis of Variance; Animals; Antipsychotic Agents; Attention; Behavior, Animal; Brain Chemistry; C | 2010 |
Destruction of midbrain dopaminergic neurons by using immunotoxin to dopamine transporter.
Topics: Animals; Antibodies, Monoclonal; Binding, Competitive; Cell Death; Denervation; Disease Models, Anim | 2003 |
A model of L-DOPA-induced dyskinesia in 6-hydroxydopamine lesioned mice: relation to motor and cellular parameters of nigrostriatal function.
Topics: Animals; Corpus Striatum; Disease Models, Animal; Dyskinesia, Drug-Induced; Levodopa; Male; Mazindol | 2004 |
Inhibiting BDNF expression by antisense oligonucleotide infusion causes loss of nigral dopaminergic neurons.
Topics: Animals; Binding, Competitive; Brain-Derived Neurotrophic Factor; Cell Death; Cell Survival; Disease | 2005 |
Short- and long-term changes in striatal and extrastriatal dopamine uptake sites in the MPTP-treated common marmoset.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Analysis of Variance; Animals; Autoradiography; Callit | 1995 |
Dose-dependent lesions of the dopaminergic nigrostriatal pathway induced by intrastriatal injection of 6-hydroxydopamine.
Topics: Animals; Apomorphine; Autoradiography; Behavior, Animal; Disease Models, Animal; Dose-Response Relat | 1995 |
Quinolinic acid-induced lesions of the rat striatum: quantitative autoradiographic binding assessment.
Topics: Animals; Autoradiography; Benzazepines; Binding, Competitive; Cholinergic Agents; Corpus Striatum; D | 1998 |
Characterization of enhanced behavioral responses to L-DOPA following repeated administration in the 6-hydroxydopamine-lesioned rat model of Parkinson's disease.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Antiparkinson Agents; Behavior, An | 1998 |
Metabolic changes after injection of quinolinic acid or 6-hydroxydopamine in the rat striatum: a time-course study using cytochrome oxidase and glycogene phosphorylase a histochemistry.
Topics: Animals; Autoradiography; Benzazepines; Biomarkers; Corpus Striatum; Disease Models, Animal; Dopamin | 2000 |
GDNF reverses priming for dyskinesia in MPTP-treated, L-DOPA-primed common marmosets.
Topics: Animals; Antiparkinson Agents; Body Weight; Callithrix; Corpus Striatum; Disease Models, Animal; Dop | 2001 |
Expression of striatal preprotachykinin mRNA in symptomatic and asymptomatic 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-exposed monkeys is related to parkinsonian motor signs.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Autoradiography; Cognition Disorders; Corpus | 2001 |