Page last updated: 2024-10-30

mazindol and Chemical Dependence

mazindol has been researched along with Chemical Dependence in 18 studies

Mazindol: Tricyclic anorexigenic agent unrelated to and less toxic than AMPHETAMINE, but with some similar side effects. It inhibits uptake of catecholamines and blocks the binding of cocaine to the dopamine uptake transporter.

Research Excerpts

ExcerptRelevanceReference
"Mazindol is a catecholamine reuptake inhibitor that blocks binding of cocaine at the dopamine reuptake site."2.67Effects of cocaine alone and in combination with mazindol in human cocaine abusers. ( Berger, P; Bigelow, GE; Preston, KL; Sullivan, JT, 1993)

Research

Studies (18)

TimeframeStudies, this research(%)All Research%
pre-19902 (11.11)18.7374
1990's12 (66.67)18.2507
2000's4 (22.22)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Bailey, A1
Metaxas, A1
Yoo, JH1
McGee, T1
Kitchen, I1
Alevizos, B1
Trigo, JM1
Panayi, F1
Soria, G1
Maldonado, R1
Robledo, P1
Preston, KL1
Sullivan, JT1
Berger, P2
Bigelow, GE1
Stine, SM1
Krystal, JH2
Kosten, TR5
Charney, DS2
Margolin, A1
Avants, SK1
Gorelick, DA1
Villemagne, V1
Yuan, J1
Wong, DF1
Dannals, RF1
Hatzidimitriou, G1
Mathews, WB1
Ravert, HT1
Musachio, J1
McCann, UD1
Ricaurte, GA1
Malison, RT1
McCance, E1
Carpenter, LL1
Baldwin, RM1
Seibyl, JP2
Price, LH1
Innis, RB1
McMahon, LR1
Cunningham, KA1
Brenner, L1
Johnson, R1
Pickworth, WB1
Klein, SA1
Bunker, EB1
Henningfield, JE1
Diakogiannis, IA1
Steinberg, M1
Goeders, NE1
Bienvenu, OJ1
De Souza, EB1
Rothman, RB1
Yutrzenka, GJ1
Patrick, GA1
Rosenberger, W1
Gawin, F1
Jaffe, JH1
Witkin, JM1
Goldberg, SR1
Katz, JL1

Trials

4 trials available for mazindol and Chemical Dependence

ArticleYear
Effects of cocaine alone and in combination with mazindol in human cocaine abusers.
    The Journal of pharmacology and experimental therapeutics, 1993, Volume: 267, Issue:1

    Topics: Adult; Affect; Blood Pressure; Body Temperature Regulation; Cocaine; Dose-Response Relationship, Dru

1993
Mazindol treatment for cocaine dependence.
    Drug and alcohol dependence, 1995, Volume: 39, Issue:3

    Topics: Adult; Central Nervous System Stimulants; Cocaine; Double-Blind Method; Female; Humans; Male; Mazind

1995
Mazindol for relapse prevention to cocaine abuse in methadone-maintained patients.
    The American journal of drug and alcohol abuse, 1995, Volume: 21, Issue:4

    Topics: Adult; Cocaine; Combined Modality Therapy; Double-Blind Method; Drug Therapy, Combination; Female; H

1995
[123I]beta-CIT SPECT imaging of dopamine transporter availability after mazindol administration in human cocaine addicts.
    Psychopharmacology, 1998, Volume: 137, Issue:4

    Topics: Adult; Carrier Proteins; Cocaine; Dopamine Plasma Membrane Transport Proteins; Dopamine Uptake Inhib

1998

Other Studies

14 other studies available for mazindol and Chemical Dependence

ArticleYear
Decrease of D2 receptor binding but increase in D2-stimulated G-protein activation, dopamine transporter binding and behavioural sensitization in brains of mice treated with a chronic escalating dose 'binge' cocaine administration paradigm.
    The European journal of neuroscience, 2008, Volume: 28, Issue:4

    Topics: Animals; Behavior, Animal; Cocaine; Dopamine Agonists; Dopamine Antagonists; Dopamine Plasma Membran

2008
Dependence and chronic psychosis with D-nor-pseudoephedrine.
    European psychiatry : the journal of the Association of European Psychiatrists, 2003, Volume: 18, Issue:8

    Topics: Antipsychotic Agents; Appetite; Appetite Depressants; Benzodiazepines; Central Nervous System Stimul

2003
A reliable model of intravenous MDMA self-administration in naïve mice.
    Psychopharmacology, 2006, Volume: 184, Issue:2

    Topics: Animals; Autoradiography; Conditioning, Operant; Dopamine Plasma Membrane Transport Proteins; Dopami

2006
The rate hypothesis and agonist substitution approaches to cocaine abuse treatment.
    Advances in pharmacology (San Diego, Calif.), 1998, Volume: 42

    Topics: Animals; Bupropion; Cocaine; Dopamine Uptake Inhibitors; Humans; Mazindol; Piperazines; Substance-Re

1998
Brain dopamine neurotoxicity in baboons treated with doses of methamphetamine comparable to those recreationally abused by humans: evidence from [11C]WIN-35,428 positron emission tomography studies and direct in vitro determinations.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 1998, Jan-01, Volume: 18, Issue:1

    Topics: Animals; Carbon Radioisotopes; Carrier Proteins; Cocaine; Dopamine; Dopamine Plasma Membrane Transpo

1998
Role of 5-HT(2a) and 5-HT(2B/2C) receptors in the behavioral interactions between serotonin and catecholamine reuptake inhibitors.
    Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2001, Volume: 24, Issue:3

    Topics: Animals; Antidepressive Agents; Behavior, Animal; Biogenic Monoamines; Catecholamines; Depression; D

2001
Mazindol and cocaine addiction in schizophrenia.
    Biological psychiatry, 1992, Jun-01, Volume: 31, Issue:11

    Topics: Adult; Cocaine; Humans; Male; Mazindol; Schizophrenia; Substance-Related Disorders

1992
Assessment of mazindol for abuse liability.
    NIDA research monograph, 1990, Volume: 105

    Topics: Dose-Response Relationship, Drug; Humans; Male; Mazindol; Methylphenidate; Psychomotor Performance;

1990
Mazindol treatment of cocaine abuse. A double-blind investigation.
    NIDA research monograph, 1990, Volume: 105

    Topics: Adult; Cocaine; Double-Blind Method; Female; Humans; Mazindol; Methadone; Opioid-Related Disorders;

1990
Chronic cocaine administration alters corticotropin-releasing factor receptors in the rat brain.
    Brain research, 1990, Oct-29, Volume: 531, Issue:1-2

    Topics: Animals; Autoradiography; Brain; Cerebral Ventricles; Cocaine; Corticotropin-Releasing Hormone; Desi

1990
High affinity dopamine reuptake inhibitors as potential cocaine antagonists: a strategy for drug development.
    Life sciences, 1990, Volume: 46, Issue:20

    Topics: Benztropine; Bupropion; Cocaine; Dopamine; Drug Evaluation, Preclinical; Humans; Mazindol; Nomifensi

1990
Substitution of psychoactive drugs in pentobarbital-dependent rats.
    Drug and alcohol dependence, 1990, Volume: 26, Issue:1

    Topics: Animals; Antidepressive Agents; Arousal; Body Weight; Brain; Bromazepam; Bupropion; Diazepam; Dose-R

1990
Treatment of cocaine abuse with mazindol.
    Lancet (London, England), 1989, Feb-04, Volume: 1, Issue:8632

    Topics: Cocaine; Humans; Indoles; Mazindol; Substance-Related Disorders; Time Factors

1989
Potential toxic interactions of cocaine and mazindol.
    Lancet (London, England), 1989, Jul-08, Volume: 2, Issue:8654

    Topics: Animals; Cocaine; Drug Synergism; Humans; Indoles; Mazindol; Rodentia; Substance-Related Disorders

1989