mazindol has been researched along with Chemical Dependence in 18 studies
Mazindol: Tricyclic anorexigenic agent unrelated to and less toxic than AMPHETAMINE, but with some similar side effects. It inhibits uptake of catecholamines and blocks the binding of cocaine to the dopamine uptake transporter.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Mazindol is a catecholamine reuptake inhibitor that blocks binding of cocaine at the dopamine reuptake site." | 2.67 | Effects of cocaine alone and in combination with mazindol in human cocaine abusers. ( Berger, P; Bigelow, GE; Preston, KL; Sullivan, JT, 1993) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (11.11) | 18.7374 |
| 1990's | 12 (66.67) | 18.2507 |
| 2000's | 4 (22.22) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Bailey, A | 1 |
| Metaxas, A | 1 |
| Yoo, JH | 1 |
| McGee, T | 1 |
| Kitchen, I | 1 |
| Alevizos, B | 1 |
| Trigo, JM | 1 |
| Panayi, F | 1 |
| Soria, G | 1 |
| Maldonado, R | 1 |
| Robledo, P | 1 |
| Preston, KL | 1 |
| Sullivan, JT | 1 |
| Berger, P | 2 |
| Bigelow, GE | 1 |
| Stine, SM | 1 |
| Krystal, JH | 2 |
| Kosten, TR | 5 |
| Charney, DS | 2 |
| Margolin, A | 1 |
| Avants, SK | 1 |
| Gorelick, DA | 1 |
| Villemagne, V | 1 |
| Yuan, J | 1 |
| Wong, DF | 1 |
| Dannals, RF | 1 |
| Hatzidimitriou, G | 1 |
| Mathews, WB | 1 |
| Ravert, HT | 1 |
| Musachio, J | 1 |
| McCann, UD | 1 |
| Ricaurte, GA | 1 |
| Malison, RT | 1 |
| McCance, E | 1 |
| Carpenter, LL | 1 |
| Baldwin, RM | 1 |
| Seibyl, JP | 2 |
| Price, LH | 1 |
| Innis, RB | 1 |
| McMahon, LR | 1 |
| Cunningham, KA | 1 |
| Brenner, L | 1 |
| Johnson, R | 1 |
| Pickworth, WB | 1 |
| Klein, SA | 1 |
| Bunker, EB | 1 |
| Henningfield, JE | 1 |
| Diakogiannis, IA | 1 |
| Steinberg, M | 1 |
| Goeders, NE | 1 |
| Bienvenu, OJ | 1 |
| De Souza, EB | 1 |
| Rothman, RB | 1 |
| Yutrzenka, GJ | 1 |
| Patrick, GA | 1 |
| Rosenberger, W | 1 |
| Gawin, F | 1 |
| Jaffe, JH | 1 |
| Witkin, JM | 1 |
| Goldberg, SR | 1 |
| Katz, JL | 1 |
4 trials available for mazindol and Chemical Dependence
| Article | Year |
|---|---|
Effects of cocaine alone and in combination with mazindol in human cocaine abusers.
Topics: Adult; Affect; Blood Pressure; Body Temperature Regulation; Cocaine; Dose-Response Relationship, Dru | 1993 |
Mazindol treatment for cocaine dependence.
Topics: Adult; Central Nervous System Stimulants; Cocaine; Double-Blind Method; Female; Humans; Male; Mazind | 1995 |
Mazindol for relapse prevention to cocaine abuse in methadone-maintained patients.
Topics: Adult; Cocaine; Combined Modality Therapy; Double-Blind Method; Drug Therapy, Combination; Female; H | 1995 |
[123I]beta-CIT SPECT imaging of dopamine transporter availability after mazindol administration in human cocaine addicts.
Topics: Adult; Carrier Proteins; Cocaine; Dopamine Plasma Membrane Transport Proteins; Dopamine Uptake Inhib | 1998 |
14 other studies available for mazindol and Chemical Dependence
| Article | Year |
|---|---|
Decrease of D2 receptor binding but increase in D2-stimulated G-protein activation, dopamine transporter binding and behavioural sensitization in brains of mice treated with a chronic escalating dose 'binge' cocaine administration paradigm.
Topics: Animals; Behavior, Animal; Cocaine; Dopamine Agonists; Dopamine Antagonists; Dopamine Plasma Membran | 2008 |
Dependence and chronic psychosis with D-nor-pseudoephedrine.
Topics: Antipsychotic Agents; Appetite; Appetite Depressants; Benzodiazepines; Central Nervous System Stimul | 2003 |
A reliable model of intravenous MDMA self-administration in naïve mice.
Topics: Animals; Autoradiography; Conditioning, Operant; Dopamine Plasma Membrane Transport Proteins; Dopami | 2006 |
The rate hypothesis and agonist substitution approaches to cocaine abuse treatment.
Topics: Animals; Bupropion; Cocaine; Dopamine Uptake Inhibitors; Humans; Mazindol; Piperazines; Substance-Re | 1998 |
Brain dopamine neurotoxicity in baboons treated with doses of methamphetamine comparable to those recreationally abused by humans: evidence from [11C]WIN-35,428 positron emission tomography studies and direct in vitro determinations.
Topics: Animals; Carbon Radioisotopes; Carrier Proteins; Cocaine; Dopamine; Dopamine Plasma Membrane Transpo | 1998 |
Role of 5-HT(2a) and 5-HT(2B/2C) receptors in the behavioral interactions between serotonin and catecholamine reuptake inhibitors.
Topics: Animals; Antidepressive Agents; Behavior, Animal; Biogenic Monoamines; Catecholamines; Depression; D | 2001 |
Mazindol and cocaine addiction in schizophrenia.
Topics: Adult; Cocaine; Humans; Male; Mazindol; Schizophrenia; Substance-Related Disorders | 1992 |
Assessment of mazindol for abuse liability.
Topics: Dose-Response Relationship, Drug; Humans; Male; Mazindol; Methylphenidate; Psychomotor Performance; | 1990 |
Mazindol treatment of cocaine abuse. A double-blind investigation.
Topics: Adult; Cocaine; Double-Blind Method; Female; Humans; Mazindol; Methadone; Opioid-Related Disorders; | 1990 |
Chronic cocaine administration alters corticotropin-releasing factor receptors in the rat brain.
Topics: Animals; Autoradiography; Brain; Cerebral Ventricles; Cocaine; Corticotropin-Releasing Hormone; Desi | 1990 |
High affinity dopamine reuptake inhibitors as potential cocaine antagonists: a strategy for drug development.
Topics: Benztropine; Bupropion; Cocaine; Dopamine; Drug Evaluation, Preclinical; Humans; Mazindol; Nomifensi | 1990 |
Substitution of psychoactive drugs in pentobarbital-dependent rats.
Topics: Animals; Antidepressive Agents; Arousal; Body Weight; Brain; Bromazepam; Bupropion; Diazepam; Dose-R | 1990 |
Treatment of cocaine abuse with mazindol.
Topics: Cocaine; Humans; Indoles; Mazindol; Substance-Related Disorders; Time Factors | 1989 |
Potential toxic interactions of cocaine and mazindol.
Topics: Animals; Cocaine; Drug Synergism; Humans; Indoles; Mazindol; Rodentia; Substance-Related Disorders | 1989 |