mazindol has been researched along with Alzheimer Disease in 3 studies
Mazindol: Tricyclic anorexigenic agent unrelated to and less toxic than AMPHETAMINE, but with some similar side effects. It inhibits uptake of catecholamines and blocks the binding of cocaine to the dopamine uptake transporter.
Alzheimer Disease: A degenerative disease of the BRAIN characterized by the insidious onset of DEMENTIA. Impairment of MEMORY, judgment, attention span, and problem solving skills are followed by severe APRAXIAS and a global loss of cognitive abilities. The condition primarily occurs after age 60, and is marked pathologically by severe cortical atrophy and the triad of SENILE PLAQUES; NEUROFIBRILLARY TANGLES; and NEUROPIL THREADS. (From Adams et al., Principles of Neurology, 6th ed, pp1049-57)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Distinguishing Alzheimer's disease from DLB is clinically relevant in terms of prognosis and appropriate treatment." | 1.30 | Striatal dopaminergic markers in dementia with Lewy bodies, Alzheimer's and Parkinson's diseases: rostrocaudal distribution. ( Ballard, C; Burn, D; Court, JA; Jaros, E; Johnson, M; Lloyd, S; Marshall, EF; McKeith, IG; Perry, EK; Perry, RH; Piggott, MA; Thomas, N, 1999) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (33.33) | 18.7374 |
| 1990's | 2 (66.67) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Murray, AM | 1 |
| Weihmueller, FB | 1 |
| Marshall, JF | 1 |
| Hurtig, HI | 1 |
| Gottleib, GL | 1 |
| Joyce, JN | 1 |
| Piggott, MA | 1 |
| Marshall, EF | 1 |
| Thomas, N | 1 |
| Lloyd, S | 1 |
| Court, JA | 1 |
| Jaros, E | 1 |
| Burn, D | 1 |
| Johnson, M | 1 |
| Perry, RH | 1 |
| McKeith, IG | 1 |
| Ballard, C | 1 |
| Perry, EK | 1 |
| D'Amato, RJ | 1 |
| Zweig, RM | 1 |
| Whitehouse, PJ | 1 |
| Wenk, GL | 1 |
| Singer, HS | 1 |
| Mayeux, R | 1 |
| Price, DL | 1 |
| Snyder, SH | 1 |
3 other studies available for mazindol and Alzheimer Disease
| Article | Year |
|---|---|
Damage to dopamine systems differs between Parkinson's disease and Alzheimer's disease with parkinsonism.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Analysis of Variance; Autoradiography; Benzamides; Bindi | 1995 |
Striatal dopaminergic markers in dementia with Lewy bodies, Alzheimer's and Parkinson's diseases: rostrocaudal distribution.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Autoradiography; Corpus Striatum; Dementia; Dopamine; Fe | 1999 |
Aminergic systems in Alzheimer's disease and Parkinson's disease.
Topics: Alzheimer Disease; Biogenic Amines; Brain; Choline O-Acetyltransferase; Citalopram; Humans; Imiprami | 1987 |