Page last updated: 2024-10-30

mazindol and Ache

mazindol has been researched along with Ache in 5 studies

Mazindol: Tricyclic anorexigenic agent unrelated to and less toxic than AMPHETAMINE, but with some similar side effects. It inhibits uptake of catecholamines and blocks the binding of cocaine to the dopamine uptake transporter.

Research Excerpts

ExcerptRelevanceReference
" Synthesis and testing of a series of cyclohexanol ethylpiperazines identified ( S)-(-)- 17i (WAY-256805), a potent norepinephrine reuptake inhibitor (IC 50 = 82 nM, K i = 50 nM) that exhibited excellent selectivity over both the serotonin and dopamine transporters and was efficacious in animal models of depression, pain, and thermoregulatory dysfunction."3.74Structure-activity relationships of the cycloalkanol ethylamine scaffold: discovery of selective norepinephrine reuptake inhibitors. ( Belardi, JK; Bray, JA; Burroughs, KD; Cohn, ST; Cosmi, SA; Deecher, DC; Gavrin, LK; Ho, DM; Johnston, GH; Koury, EJ; Leiter, J; Leventhal, L; Mahaney, PE; Mugford, CA; Platt, B; Rosenzweig-Lipson, SJ; Sabatucci, JP; Santilli, AA; Smith, VA; Stack, GP; Trybulski, EJ; Vu, TA; Ye, F; Zhang, Y, 2008)

Research

Studies (5)

TimeframeStudies, this research(%)All Research%
pre-19902 (40.00)18.7374
1990's0 (0.00)18.2507
2000's3 (60.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Mahaney, PE1
Gavrin, LK1
Trybulski, EJ1
Stack, GP1
Vu, TA1
Cohn, ST1
Ye, F1
Belardi, JK1
Santilli, AA1
Sabatucci, JP1
Leiter, J1
Johnston, GH1
Bray, JA1
Burroughs, KD1
Cosmi, SA1
Leventhal, L1
Koury, EJ1
Zhang, Y1
Mugford, CA1
Ho, DM1
Rosenzweig-Lipson, SJ1
Platt, B1
Smith, VA1
Deecher, DC1
Vendruscolo, LF1
Takahashi, RN1
McEwen, J1
Meyboom, RH1
Toda, Y1
Kobayashi, T1
Zahorska-Markiewicz, B1
Kucio, C1

Trials

1 trial available for mazindol and Ache

ArticleYear
The usefulness of walking for preventing sarcopenia in dieting postmenopausal women complaining of knee pain.
    Annals of the New York Academy of Sciences, 2000, Volume: 904

    Topics: Aged; Anti-Inflammatory Agents, Non-Steroidal; Appetite Depressants; Body Composition; Combined Moda

2000

Other Studies

4 other studies available for mazindol and Ache

ArticleYear
Structure-activity relationships of the cycloalkanol ethylamine scaffold: discovery of selective norepinephrine reuptake inhibitors.
    Journal of medicinal chemistry, 2008, Jul-10, Volume: 51, Issue:13

    Topics: Animals; Cell Line; Cyclohexanols; Ethylamines; Female; Humans; Male; Mice; Models, Molecular; Molec

2008
Synergistic interaction between mazindol, an anorectic drug, and swim-stress on analgesic responses in the formalin test in mice.
    Neuroscience letters, 2004, Jan-23, Volume: 355, Issue:1-2

    Topics: Animals; Brain; Dopamine; Dopamine Antagonists; Dopamine Uptake Inhibitors; Dose-Response Relationsh

2004
Testicular pain caused by mazindol.
    British medical journal (Clinical research ed.), 1983, Dec-10, Volume: 287, Issue:6407

    Topics: Adult; Humans; Indoles; Male; Mazindol; Middle Aged; Pain; Testicular Diseases

1983
[Effect of eating and mazindol on the pain threshold in obese and lean persons].
    Polskie Archiwum Medycyny Wewnetrznej, 1985, Volume: 74, Issue:3

    Topics: Adult; Eating; Female; Humans; Indoles; Mazindol; Obesity; Pain; Pain Measurement; Sensory Threshold

1985