maytansine and Leukemia--Monocytic--Acute

Trewiasine (TWS) is a mytansinoid compound. It possessed a significant cytotoxic activity against various human cancer cell lines in vitro. U937 cells, which were more sensitive to the TWS, required TWS 1 microgram.ml-1 to inhibit cell growth over 90% (P less than 0.01). TWS also showed activities against murine tumors in vivo, such as the ascitic tumors S180, hepatoma, U14, and solid tumor Lewis lung carcinoma. Depression of leukocytes was not seen when mice were given ip TWS 10 or 50 micrograms.kg-1.d-1 x 7 d. TWS 0.1-1 micrograms.ml-1 caused no sister chromatid exchange induction in Chinese hamster cell line V79.

Topics: Animals; Antineoplastic Agents, Phytogenic; Cell Division; Humans; Leukemia, Monocytic, Acute; Lung Neoplasms; Maytansine; Mice; Mice, Inbred C57BL; Neoplasms, Experimental; Tumor Cells, Cultured