maxadilan-protein--insect and Insect-Bites-and-Stings

maxadilan-protein--insect has been researched along with Insect-Bites-and-Stings* in 2 studies

Other Studies

2 other study(ies) available for maxadilan-protein--insect and Insect-Bites-and-Stings

ArticleYear
Pemphigus foliaceus and sand fly bites: assessing the humoral immune response to the salivary proteins maxadilan and LJM11.
    The British journal of dermatology, 2020, Volume: 183, Issue:5

    Topics: Animals; Humans; Immunity, Humoral; Insect Bites and Stings; Insect Proteins; Pemphigus; Psychodidae; Salivary Proteins and Peptides

2020
Negative effect of antibodies against maxadilan on the fitness of the sand fly vector of American visceral leishmaniasis.
    The American journal of tropical medicine and hygiene, 2004, Volume: 70, Issue:3

    Lutzomyia longipalpis expresses a salivary protein called maxadilan (MAX) that functions to dilate vertebrate blood vessels and thereby to facilitate the sand fly's acquisition of blood. We hypothesized that antibodies specific for one of many MAX variants would inhibit vasodilatory function of that variant. In vitro and in vivo experiments showed that antibodies against a specific MAX variant decreased vasodilatory function. More specifically, antibodies against MAX blocked vasodilation of a constricted rabbit aorta. Additionally, a strain of Lu. longipalpis, with a nearly uniform MAX genotype, obtained a larger blood meal from naive BALB/c mice compared with mice that were either immunized with a homologous MAX genotype or sensitized to bites of flies from the same strain. Those flies taking blood from mice sensitized by sand fly bites also laid significantly fewer eggs than when they took blood from naive mice. These results have potential epidemiologic importance in light of the potential use of MAX in a vaccine or as part of a diagnostic test because they imply that a uniform MAX genotype is selected against by the vertebrate host immune response and that antigenic diversity is selected for.

    Topics: Animals; Antibodies; Female; Immunization; In Vitro Techniques; Insect Bites and Stings; Insect Proteins; Insect Vectors; Leishmaniasis, Cutaneous; Leishmaniasis, Visceral; Mice; Mice, Inbred BALB C; Oviposition; Psychodidae; Rabbits; Salivary Proteins and Peptides; Vasodilation

2004