masticadienonic-acid and Prostatic-Neoplasms

masticadienonic-acid has been researched along with Prostatic-Neoplasms* in 2 studies

Other Studies

2 other study(ies) available for masticadienonic-acid and Prostatic-Neoplasms

Article	Year
Masticadienonic and 3α-OH Masticadienoic Acids Induce Apoptosis and Inhibit Cell Proliferation and Tumor Growth in Prostate Cancer Xenografts in Vivo. Molecules (Basel, Switzerland), 2017, Sep-06, Volume: 22, Issue:9 The triterpenes have been constituted as a group of interesting molecules as possible antitumor agents. Despite several of them not presenting a potent cytotoxic activity in vitro against cancer cells, in vivo in xenotransplant tumors studies, they show promising results. Based on the above considerations, we investigated the antitumor activity of both masticadienonic (MDA) and 3α-OH masticadienoic (3α-OH MDA) acids in a mouse prostate cancer xenograft model. Immunohistochemical assays were used to evaluate the decrease in the expression of the Proliferating Cell Nuclear Antigen (PCNA) and the Ki-67 induced by MDA and 3α-OH MDA. Terminal deoxynucleotidyl transferase dUTP nick end labeling (TUNEL) assay was performed to demonstrate the fragmentation of DNA. Our results showed that the two triterpenes inhibited tumor growth, had anti-proliferative effect in vivo and induced cell death by apoptosis. Collectively, our data suggested that the antitumor mechanism of MDA and 3α-OH MDA involves several molecular targets related to cell proliferation and apoptosis. Topics: Animals; Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Cell Proliferation; Dose-Response Relationship, Drug; Female; Heterografts; Humans; Male; Mice; Mice, Nude; Neoplasm Transplantation; Prostatic Neoplasms; Triterpenes	2017
Cytotoxic activity and effect on nitric oxide production of tirucallane-type triterpenes. The Journal of pharmacy and pharmacology, 2005, Volume: 57, Issue:9 Hexane extract from the bark of Amphipterygium adstringens, as well as its principal constituents, masticadienonic acid and 3alpha-hydroxymasticadienolic acid, inhibited the growth of five human cancer cell lines. Derivatives of, namely 24,25 S-dihydromasticadienonic acid and masticadienolic acid, were also evaluated. The results showed that both and had greater activity than on colon cancer cell lines. The effects of on the production of nitric oxide (NO) from both resting and lipopolysaccharide-activated macrophages were determined. It was found that and caused an increase in NO release from resting macrophages; in lipopolysaccharide-activated macrophages, only and caused an increase in NO production. Topics: Anacardiaceae; Animals; Antineoplastic Agents, Phytogenic; Breast Neoplasms; Cell Death; Cell Line, Tumor; Central Nervous System Neoplasms; Colonic Neoplasms; Drug Screening Assays, Antitumor; Female; Hexanes; Humans; Leukemia; Lipopolysaccharides; Macrophages, Peritoneal; Male; Medicine, Traditional; Mexico; Mice; Nitric Oxide; Plant Extracts; Prostatic Neoplasms; Rhodamines; Triterpenes; Ursolic Acid	2005

Article

Year

Masticadienonic and 3α-OH Masticadienoic Acids Induce Apoptosis and Inhibit Cell Proliferation and Tumor Growth in Prostate Cancer Xenografts in Vivo.

Molecules (Basel, Switzerland), 2017, Sep-06, Volume: 22, Issue:9

The triterpenes have been constituted as a group of interesting molecules as possible antitumor agents. Despite several of them not presenting a potent cytotoxic activity in vitro against cancer cells, in vivo in xenotransplant tumors studies, they show promising results. Based on the above considerations, we investigated the antitumor activity of both masticadienonic (MDA) and 3α-OH masticadienoic (3α-OH MDA) acids in a mouse prostate cancer xenograft model. Immunohistochemical assays were used to evaluate the decrease in the expression of the Proliferating Cell Nuclear Antigen (PCNA) and the Ki-67 induced by MDA and 3α-OH MDA. Terminal deoxynucleotidyl transferase dUTP nick end labeling (TUNEL) assay was performed to demonstrate the fragmentation of DNA. Our results showed that the two triterpenes inhibited tumor growth, had anti-proliferative effect in vivo and induced cell death by apoptosis. Collectively, our data suggested that the antitumor mechanism of MDA and 3α-OH MDA involves several molecular targets related to cell proliferation and apoptosis.

Topics: Animals; Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Cell Proliferation; Dose-Response Relationship, Drug; Female; Heterografts; Humans; Male; Mice; Mice, Nude; Neoplasm Transplantation; Prostatic Neoplasms; Triterpenes

2017

Cytotoxic activity and effect on nitric oxide production of tirucallane-type triterpenes.

The Journal of pharmacy and pharmacology, 2005, Volume: 57, Issue:9

Hexane extract from the bark of Amphipterygium adstringens, as well as its principal constituents, masticadienonic acid and 3alpha-hydroxymasticadienolic acid, inhibited the growth of five human cancer cell lines. Derivatives of, namely 24,25 S-dihydromasticadienonic acid and masticadienolic acid, were also evaluated. The results showed that both and had greater activity than on colon cancer cell lines. The effects of on the production of nitric oxide (NO) from both resting and lipopolysaccharide-activated macrophages were determined. It was found that and caused an increase in NO release from resting macrophages; in lipopolysaccharide-activated macrophages, only and caused an increase in NO production.

Topics: Anacardiaceae; Animals; Antineoplastic Agents, Phytogenic; Breast Neoplasms; Cell Death; Cell Line, Tumor; Central Nervous System Neoplasms; Colonic Neoplasms; Drug Screening Assays, Antitumor; Female; Hexanes; Humans; Leukemia; Lipopolysaccharides; Macrophages, Peritoneal; Male; Medicine, Traditional; Mexico; Mice; Nitric Oxide; Plant Extracts; Prostatic Neoplasms; Rhodamines; Triterpenes; Ursolic Acid

2005