mart-1-antigen and Seminoma

mart-1-antigen has been researched along with Seminoma* in 1 studies

Other Studies

1 other study(ies) available for mart-1-antigen and Seminoma

Article	Year
Immunoreactivity of A103, an antibody to Melan A, in canine steroid-producing tissues and their tumors. Journal of veterinary diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians, Inc, 2001, Volume: 13, Issue:4 The monoclonal antibody A103 to the melanocytic differentiation antigen Melan A stains human steroid-producing cells and their tumors. A total of 200 formalin-fixed, paraffin-embedded canine normal tissues and hyperplastic and neoplastic lesions of the adrenal gland, testis, and ovary were immunohistochemically tested for Melan A with antibody A103. Leydig cell tumors (23/23, 100%), Sertoli cell tumors (14/15, 93%), and adrenocortical adenomas (12/13, 92%) were consistently positive. Adrenocortical carcinomas (23/35, 65%) and granulosa cell tumors (10/17, 59%) were less frequently positive. All pheochromocytomas, seminomas, and dysgerminomas were negative. The pattern of staining was cytoplasmic, but nuclear staining was also frequently seen in normal Leydig cells and their tumors. As in human tumors, immunohistochemistry for Melan A stains many canine steroid-producing tumors and can be used to distinguish these tumors from those of nonstereidogenic cells. Topics: Adenoma; Adrenal Gland Neoplasms; Animals; Antibodies, Monoclonal; Antigens, Neoplasm; Diagnosis, Differential; Dog Diseases; Dogs; Dysgerminoma; Female; Humans; Immunohistochemistry; Male; MART-1 Antigen; Neoplasm Proteins; Ovarian Neoplasms; Seminoma; Testicular Neoplasms	2001

Article

Year

Immunoreactivity of A103, an antibody to Melan A, in canine steroid-producing tissues and their tumors.

Journal of veterinary diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians, Inc, 2001, Volume: 13, Issue:4

The monoclonal antibody A103 to the melanocytic differentiation antigen Melan A stains human steroid-producing cells and their tumors. A total of 200 formalin-fixed, paraffin-embedded canine normal tissues and hyperplastic and neoplastic lesions of the adrenal gland, testis, and ovary were immunohistochemically tested for Melan A with antibody A103. Leydig cell tumors (23/23, 100%), Sertoli cell tumors (14/15, 93%), and adrenocortical adenomas (12/13, 92%) were consistently positive. Adrenocortical carcinomas (23/35, 65%) and granulosa cell tumors (10/17, 59%) were less frequently positive. All pheochromocytomas, seminomas, and dysgerminomas were negative. The pattern of staining was cytoplasmic, but nuclear staining was also frequently seen in normal Leydig cells and their tumors. As in human tumors, immunohistochemistry for Melan A stains many canine steroid-producing tumors and can be used to distinguish these tumors from those of nonstereidogenic cells.

Topics: Adenoma; Adrenal Gland Neoplasms; Animals; Antibodies, Monoclonal; Antigens, Neoplasm; Diagnosis, Differential; Dog Diseases; Dogs; Dysgerminoma; Female; Humans; Immunohistochemistry; Male; MART-1 Antigen; Neoplasm Proteins; Ovarian Neoplasms; Seminoma; Testicular Neoplasms

2001