mart-1-antigen and Salivary-Gland-Neoplasms

Clear-cell sarcoma is a rare, malignant soft tissue tumor that displays melanocytic differentiation with a distinct molecular profile. It is rarely localized in the gastrointestinal tract. Herein we reported a case of multiple synchronous clear-cell sarcomas of the gastrointestinal tract with parotid gland metastasis. A 51-year-old male patient presented with a growing painless mass under the right ear. A preoperative positron emission tomography/computed tomography showed multiple intestinal masses and a mass in the right parotid with increased glucose uptake, and he underwent operative treatment with resection of three tumors in the jejunum and ileum and then received a right parotidectomy. Postoperative pathological examination showed that cells in the intestinal tumor were consistent with clear-cell sarcoma of the gastrointestinal tract, and the malignant cells in the parotid gland were similar to the intestinal tumor. Immunohistochemical studies revealed positive expression of HMB-45, Melan-A, and S-100. EWSR1 gene fusion transcripts were undetectable by fluorescence

Topics: Biomarkers, Tumor; gp100 Melanoma Antigen; Humans; Immunohistochemistry; Intestinal Neoplasms; Intestine, Small; Male; MART-1 Antigen; Melanoma-Specific Antigens; Middle Aged; Neoplasm Metastasis; Parotid Gland; Positron Emission Tomography Computed Tomography; S100 Proteins; Salivary Gland Neoplasms; Sarcoma, Clear Cell

The aim of this study was to describe a method for analysing histological fragments derived from fine- needle aspirate biopsy (FNAB) of salivary gland tumours (SGTs), and to evaluate the use of immunohistochemistry (IHC) on them.. We reviewed all 509 FNAB pathology reports taken from SGTs at Helsinki University Hospital, Finland, between 1999 and 2009. In 51% of the cases (n = 209) "histo-fragments" had been obtained and 31 had been further analysed by IHC. Of these, 25 (81%) were available for review. We evaluated the benefit of IHC by relating its added value to the preoperative cytological diagnosis and its accuracy compared with the postoperative histological diagnosis.. Most of the samples analysed by IHC were assigned a malignant diagnosis, with 12 different types of malignancy represented. IHC was advantageous in 76% of the cases. In the 108 studies using IHC in this series, antibodies to 36 different antigens were used.. Analysis of histo-fragments in FNABs using IHC can be valuable in specific differential diagnostics and raises diagnostic accuracy in SGTs.

Topics: Adenolymphoma; Adenoma, Pleomorphic; Biomarkers, Tumor; Biopsy, Fine-Needle; Diagnosis, Differential; DNA-Binding Proteins; Gene Expression; Humans; Immunohistochemistry; MART-1 Antigen; Neoplasms; Retrospective Studies; Salivary Gland Neoplasms; Salivary Glands; Sensitivity and Specificity; Transcription Factors