mart-1-antigen and Parotid-Neoplasms

A 60-year Brazilian woman, presented with an enlarged lymph node in the neck for one year, and a superficial nonulcerated lesion was observed in the scalp. Fine needle aspiration and biopsy of the lymph node revealed amelanocytic metastasis, and immunohistochemistry study showed Melan-A/ Mart-1 antigen (clone A103 and S-100 protein). The entire suspected area of the scalp was further resected and an amelanotic melanoma without angiolymphatic invasion was diagnosed. Ultrasonography and PET-computed tomography showed hypermetabolic cystic area in the right parotid. Furthermore, aspiration biopsy and surgical samples from parotid cyst confirmed the malignant amelanotic melanoma. Cystic metastases are scarcely reported in parotid gland, and can pose diagnostic challenges.

Topics: Antigens, Neoplasm; Biopsy, Fine-Needle; Female; Humans; Immunohistochemistry; Lymph Nodes; Lymphatic Metastasis; MART-1 Antigen; Melanoma, Amelanotic; Middle Aged; Neoplasm Proteins; Parotid Gland; Parotid Neoplasms; Positron Emission Tomography Computed Tomography; S100 Proteins; Scalp; Skin Neoplasms; Treatment Outcome; Ultrasonography