mart-1-antigen and Palatal-Neoplasms

This paper describes the first documented case of mucoepidermoid carcinoma (MEC) with melanin pigmentation manifested in the palate. Histopathological sections showed a neoplasm composed of epidermoid, mucous-producing and intermediate cells. Numerous large cells contained dark pigmented materials. Fontana Masson staining revealed dendritic melanocytes and melanin granules. HMB-45, Melan A and S-100 protein were all positive for melanocytes. Histopathological examination was not typical for malignant melanoma; the lesion was diagnosed as a low-grade MEC with melanin pigmentation.

Topics: Adult; Antigens, Neoplasm; Biomarkers, Tumor; Carcinoma, Mucoepidermoid; Dendritic Cells; Diagnosis, Differential; Female; Humans; Immunohistochemistry; MART-1 Antigen; Melanins; Melanocytes; Melanoma; Melanoma-Specific Antigens; Melanosis; Neoplasm Proteins; Palatal Neoplasms; S100 Proteins; Salivary Glands, Minor