mart-1-antigen and Paget-Disease--Extramammary

Topics: Humans; Male; MART-1 Antigen; Middle Aged; Neoplasm Invasiveness; Paget Disease, Extramammary; Skin Neoplasms

Topics: Administration, Intravenous; Aged; Asian People; Docetaxel; Fatal Outcome; Humans; Keratin-7; Male; MART-1 Antigen; Melanoma; Neoplasm Metastasis; Neoplasms, Second Primary; Paget Disease, Extramammary; Scrotum; Skin Neoplasms; Tubulin Modulators

Extra-mammary Paget disease (EMPD) is a rare intra-epithelial carcinoma that is usually found on the apocrine-rich skin of the perineum. We report 2 cases in which EMPD was initially misdiagnosed on the initial punch biopsy as melanoma-in-situ and Bowen disease respectively. Reasons for the misdiagnoses included a rare pigmented axillary variant of EMPD in the first case and atypical bowenoid features on H&E in the second. The cases are described with a critical review of the histopathological findings, along with a review of the current literature. This highlights the necessity of a comprehensive immunohistochemical panel for the assessment of intra-epithelial pagetoid atypical cells.

Topics: Adenocarcinoma; Aged; Biopsy; Bowen's Disease; Carcinoembryonic Antigen; Diagnostic Errors; Humans; Immunohistochemistry; Keratin-7; Male; MART-1 Antigen; Mohs Surgery; Mucins; Neoplasm Grading; Paget Disease, Extramammary; Prostate-Specific Antigen; Prostatic Neoplasms; Skin Neoplasms; Treatment Outcome

Topics: Adult; Aged; Antigens, Neoplasm; Dendrites; Female; Humans; Immunohistochemistry; Male; MART-1 Antigen; Melanocytes; Melanoma; Middle Aged; Neoplasm Proteins; Paget Disease, Extramammary; Skin Neoplasms; Staining and Labeling